{
	"name":"shao02022",
	"children":[
	{
		"name":"OmpR family",
		"children":[
		{
			"name":"PhoR-PhoB (phosphate starvation response)",
			"children":[
			{
				"name":"K0H81_05945 phoR; phosphate regulon sensor histidine kinase PhoR\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_05940 phoB; phosphate regulon transcriptional regulator PhoB\tK07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB"
			}
			]
		},
		{
			"name":"SenX3-RegX3 (phosphate starvation response)"
		},
		{
			"name":"PhoQ-PhoP (magnesium transport)",
			"children":[
			{
				"name":"K0H81_06220 GHKL domain-containing protein\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_07935 sensor histidine kinase\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_06225 response regulator transcription factor\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
			},
			{
				"name":"K0H81_07940 response regulator\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
			}
			]
		},
		{
			"name":"EnvZ-OmpR (osmotic stress response)",
			"children":[
			{
				"name":"K0H81_19130 envZ; two-component system sensor histidine kinase EnvZ\tK07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_19125 ompR; two-component system response regulator OmpR\tK07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR"
			}
			]
		},
		{
			"name":"RstB-RstA",
			"children":[
			{
				"name":"K0H81_00395 two-component sensor histidine kinase\tK07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_00400 response regulator\tK07661 rstA; two-component system, OmpR family, response regulator RstA"
			},
			{
				"name":"K0H81_08625 response regulator transcription factor\tK07661 rstA; two-component system, OmpR family, response regulator RstA"
			}
			]
		},
		{
			"name":"CpxA-CpxR (envelope stress response)",
			"children":[
			{
				"name":"K0H81_18730 HAMP domain-containing protein\tK07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_18725 response regulator\tK07662 cpxR; two-component system, OmpR family, response regulator CpxR"
			}
			]
		},
		{
			"name":"CssS-CssR (secretion stress response)"
		},
		{
			"name":"CreC-CreB (phosphate regulation)"
		},
		{
			"name":"BaeS-BaeR (envelope stress response)"
		},
		{
			"name":"BasS-BasR (antimicrobial peptide resistance)"
		},
		{
			"name":"CusS-CusR (copper tolerance)"
		},
		{
			"name":"CrdS-CrdR (copper resistance)"
		},
		{
			"name":"HprS-HprR (hydrogen peroxide response)"
		},
		{
			"name":"QseC-QseB (quorum sensing)"
		},
		{
			"name":"KdpD-KdpE (potassium transport)"
		},
		{
			"name":"TorS-TorR (TMAO respiration)",
			"children":[
			{
				"name":"K0H81_05630 torS; TMAO reductase system sensor histidine kinase\/response regulator TorS\tK07647 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_05620 torR; two-component system response regulator TorR\tK07772 torR; two-component system, OmpR family, torCAD operon response regulator TorR"
			}
			]
		},
		{
			"name":"ArcB-ArcA (anoxic redox control)",
			"children":[
			{
				"name":"K0H81_16185 arcA; two-component system response regulator ArcA\tK07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA"
			}
			]
		},
		{
			"name":"TctE-TctD (tricarboxylic acid transport)"
		},
		{
			"name":"ResE-ResD (aerobic and anaerobic respiration)"
		},
		{
			"name":"VicK-VicR (cell wall metabolism)"
		},
		{
			"name":"MprB-MprA (maintenance of persistent infection)"
		},
		{
			"name":"MtrB-MtrA (osmotic stress response)"
		},
		{
			"name":"PrrB-PrrA (intracellular multiplication)"
		},
		{
			"name":"TrcS-TrcR"
		},
		{
			"name":"NrsS-NrsR (nickel tolerance)"
		},
		{
			"name":"ManS-ManR (manganese homeostasis)"
		},
		{
			"name":"NblS-NblR (photosynthesis)"
		},
		{
			"name":"SasA-RpaAB (circadian timing mediating)"
		},
		{
			"name":"SaeS-SaeR (staphylococcal virulence regulation)"
		},
		{
			"name":"BceS-BceR (bacitracin transport)"
		},
		{
			"name":"BraS-BraR (bacitracin transport)"
		},
		{
			"name":"GraS-GraR (cationic antimicrobial peptide transport)"
		},
		{
			"name":"YxdK-YxdJ (antimicrobial peptide response)"
		},
		{
			"name":"ChvG-ChvI (acidity sensing)"
		},
		{
			"name":"CiaH-CiaR"
		},
		{
			"name":"ParS-ParR (polymyxin-adaptive resistance)",
			"children":[
			{
				"name":"K0H81_16055 two-component sensor histidine kinase\tK18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"AdeS-AdeR"
		},
		{
			"name":"VanS-VanR (VanB type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (VanE type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (actinomycete type vancomycin resistance)"
		},
		{
			"name":"ArlS-ArlR (virulence regulation)"
		},
		{
			"name":"Ihk-Irr (virulence regulation)"
		},
		{
			"name":"PfeS-PfeR (enterobactin-dependent iron acquisition)"
		},
		{
			"name":"NisK-NisR (lantibiotic biosynthesis)"
		},
		{
			"name":"QarB-QarCA (disk-forming signal response)"
		},
		{
			"name":"HssS-HssR (heme sensing)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"K0H81_15595 ATP-binding protein\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_00480 response regulator transcription factor\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"K0H81_03040 response regulator transcription factor\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"K0H81_10050 response regulator transcription factor\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"K0H81_10840 pdsR; proteobacterial dedicated sortase system response regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"K0H81_15590 response regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"K0H81_16050 response regulator transcription factor\tK02483 K02483; two-component system, OmpR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NarL family",
		"children":[
		{
			"name":"NarX-NarL (nitrate respiration)"
		},
		{
			"name":"NarQ-NarP (nitrate respiration)",
			"children":[
			{
				"name":"K0H81_15855 narQ; nitrate\/nitrite two-component system sensor histidine kinase NarQ\tK07674 narQ; two-component system, NarL family, nitrate\/nitrite sensor histidine kinase NarQ [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_15860 response regulator\tK07685 narP; two-component system, NarL family, nitrate\/nitrite response regulator NarP"
			}
			]
		},
		{
			"name":"UhpB-UhpA (hexose phosphates uptake)"
		},
		{
			"name":"FusK-FusR (virulence regulation)"
		},
		{
			"name":"RcsC-RcsD-RcsB (capsule synthesis)"
		},
		{
			"name":"BarA-UvrY (central carbon metabolism)",
			"children":[
			{
				"name":"K0H81_14055 barA; two-component sensor histidine kinase BarA\tK07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_10645 uvrY; UvrY\/SirA\/GacA family response regulator transcription factor\tK07689 uvrY; two-component system, NarL family, invasion response regulator UvrY"
			}
			]
		},
		{
			"name":"ComP-ComA (competence)"
		},
		{
			"name":"EvgS-EvgA (acid and drug tolerance)"
		},
		{
			"name":"DegS-DegU (multicellular behavior control)"
		},
		{
			"name":"DesK-DesR (membrane lipid fluidity regulation)",
			"children":[
			{
				"name":"K0H81_18325 sensor histidine kinase\tK07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_18330 response regulator transcription factor\tK07693 desR; two-component system, NarL family, response regulator DesR"
			}
			]
		},
		{
			"name":"VraS-VraR (cell-wall peptidoglycan synthesis)"
		},
		{
			"name":"LiaS-LiaR (cell wall stress response)"
		},
		{
			"name":"DevS-DevR (redox response)"
		},
		{
			"name":"NreB-NreC (dissimilatory nitrate\/nitrite reduction)"
		},
		{
			"name":"YdfH-YdfI"
		},
		{
			"name":"SalK-SalR"
		},
		{
			"name":"PprA–PprB (biofilm formation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"Spo family",
		"children":[
		{
			"name":"KinABCDE-Spo0FA (sporulation control)"
		}
		]
	},
	{
		"name":"CitB family",
		"children":[
		{
			"name":"CitA-CitB (citrate fermentation)"
		},
		{
			"name":"CitS-CitT (magnesium-citrate transport)"
		},
		{
			"name":"DcuS-DcuR (C4-dicarboxylate metabolism)"
		},
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"MalK-MalR (malate transport)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"LytTR family",
		"children":[
		{
			"name":"LysS-LysR"
		},
		{
			"name":"AlgZ-AlgR (alginate production)"
		},
		{
			"name":"NatK-NatR (sodium extrusion)"
		},
		{
			"name":"AgrC-AgrA (exoprotein synthesis)"
		},
		{
			"name":"AgrC2-AgrA2 (virulence regulation)"
		},
		{
			"name":"ComD-ComE (competence)"
		},
		{
			"name":"BtsS-BtsR (pyruvate reutilization)",
			"children":[
			{
				"name":"K0H81_08045 sensor histidine kinase\tK27882 btsS; two-component system, LytTR family, low-concentration pyruvate sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_08040 btsR; two-component system response regulator BtsR\tK27883 btsR; two-component system, LytTR family, low-concentration pyruvate response regulator"
			}
			]
		},
		{
			"name":"PyrS-PyrR (pyruvate reutilization)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"NtrC family",
		"children":[
		{
			"name":"GlnL-GlnG (nitrogen regulation)",
			"children":[
			{
				"name":"K0H81_18675 glnL; nitrogen regulation protein NR(II)\tK07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_18680 glnG; nitrogen regulation protein NR(I)\tK07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG"
			}
			]
		},
		{
			"name":"NtrY-NtrX (nitrogen regulation)"
		},
		{
			"name":"HydH-HydG (metal tolerance)"
		},
		{
			"name":"AtoS-AtoC (cPHB biosynthesis)"
		},
		{
			"name":"PilS-PilR (type 4 fimbriae synthesis)"
		},
		{
			"name":"GlrK-GlrR (amino sugar metabolism)"
		},
		{
			"name":"PgtB-PgtA (phosphoglycerate transport)"
		},
		{
			"name":"DctB-DctD (C4-dicarboxylate transport)",
			"children":[
			{
				"name":"K0H81_12755 sensor histidine kinase\tK10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_12760 sigma-54 dependent transcriptional regulator\tK10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD"
			}
			]
		},
		{
			"name":"KinB-AlgB (alginate production)"
		},
		{
			"name":"HupT-HupR (hydrogenase synthesis regulation)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"K0H81_19345 cache domain-containing protein\tK02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_07975 sigma-54 dependent transcriptional regulator\tK02481 flgR; two-component system, NtrC family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"CheA family",
		"children":[
		{
			"name":"CheA-CheYBV (chemotaxis)",
			"children":[
			{
				"name":"K0H81_00560 chemotaxis protein CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_13125 chemotaxis protein CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_00565 response regulator\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"K0H81_13135 cheY; chemotaxis response regulator CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"K0H81_00540 chemotaxis response regulator protein-glutamate methylesterase\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"K0H81_13120 chemotaxis response regulator protein-glutamate methylesterase\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"K0H81_08925 chemotaxis protein CheV\tK03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV"
			},
			{
				"name":"K0H81_12605 chemotaxis protein CheV\tK03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV"
			},
			{
				"name":"K0H81_13340 chemotaxis protein CheV\tK03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV"
			}
			]
		},
		{
			"name":"ChpA-ChpB\/PilGH (chemosensory)"
		},
		{
			"name":"PixL-PixGH (positive phototaxis)"
		},
		{
			"name":"WspE-WspRF (chemosensory)"
		},
		{
			"name":"Cph1-Rcp1 (light response)"
		}
		]
	},
	{
		"name":"Cell cycle family",
		"children":[
		{
			"name":"PleC-PleD (cell fate control)"
		},
		{
			"name":"CckA-CtrA\/CpdR (cell cycle control)"
		},
		{
			"name":"Hk1-Rrp1 (glycerol uptake and utilization)"
		}
		]
	},
	{
		"name":"Lux family",
		"children":[
		{
			"name":"LuxQN\/CqsS-LuxU-LuxO (quorum sensing)",
			"children":[
			{
				"name":"K0H81_12845 sigma-54 dependent transcriptional regulator\tK10912 luxO; two-component system, repressor protein LuxO"
			}
			]
		}
		]
	},
	{
		"name":"LuxR family",
		"children":[
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"TtrS-TtrR (tetrathionate respiration)",
			"children":[
			{
				"name":"K0H81_03180 PhnD\/SsuA\/transferrin family substrate-binding protein\tK13040 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_09880 PhnD\/SsuA\/transferrin family substrate-binding protein\tK13040 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_03175 LuxR C-terminal-related transcriptional regulator\tK13041 ttrR; two-component system, LuxR family, response regulator TtrR"
			},
			{
				"name":"K0H81_09885 response regulator\tK13041 ttrR; two-component system, LuxR family, response regulator TtrR"
			}
			]
		},
		{
			"name":"FixL-FixJ (nitrogen fixation)",
			"children":[
			{
				"name":"K0H81_16870 hypothetical protein\tK14986 fixL; two-component system, LuxR family, sensor kinase FixL [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"SsrA-SsrB"
		}
		]
	},
	{
		"name":"Other families",
		"children":[
		{
			"name":"FlrB-FlrC (polar flagellar synthesis)",
			"children":[
			{
				"name":"K0H81_13240 HAMP domain-containing histidine kinase\tK10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_13235 sigma-54 dependent transcriptional regulator\tK10943 flrC; two-component system, response regulator FlrC"
			}
			]
		},
		{
			"name":"AauS-AauR (acidic amino acids utilization)"
		},
		{
			"name":"SLN1-YPD1-SSK1\/SKN7 (osmosensing)"
		},
		{
			"name":"RpfC-RpfG (cell-to-cell signaling)"
		},
		{
			"name":"GlnK-GlnL (glutamine utilization)"
		},
		{
			"name":"HspS-HspR (hexose phosphates uptake)"
		},
		{
			"name":"YesM-YesN"
		},
		{
			"name":"CikA"
		},
		{
			"name":"RegB-RegA (redox response)",
			"children":[
			{
				"name":"K0H81_17400 sensor histidine kinase\tK15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]"
			},
			{
				"name":"K0H81_17395 response regulator\tK15012 regA; two-component system, response regulator RegA"
			}
			]
		},
		{
			"name":"FitF-FitH (insecticidal toxin regulation)"
		},
		{
			"name":"PhcS-PhcRQ"
		},
		{
			"name":"SagS-HptB-HsbR (swarming activity and biofilm formation)"
		},
		{
			"name":"PdtaS-PdtaR"
		},
		{
			"name":"NasS-NasT"
		},
		{
			"name":"Unclassified"
		}
		]
	}
	]
}