{
	"name":"sine01008",
	"children":[
	{
		"name":"Polyketide synthase (PKS)",
		"children":[
		{
			"name":"Modular type I PKS",
			"children":[
			{
				"name":"cis-AT PKS",
				"children":[
				{
					"name":"Erythronolide PKS"
				},
				{
					"name":"Oleandomycin synthase"
				},
				{
					"name":"Pikromycin PKS"
				},
				{
					"name":"Avermectin PKS"
				},
				{
					"name":"Tylactone synthase"
				},
				{
					"name":"Protomycinolide IV synthase"
				},
				{
					"name":"Niddamycin PKS"
				},
				{
					"name":"Rapamycin PKS"
				},
				{
					"name":"Immunomycin PKS"
				},
				{
					"name":"Ansamitocin PKS"
				},
				{
					"name":"Rifamycin PKS"
				},
				{
					"name":"Polyene macrolide PKS"
				},
				{
					"name":"Pimaricinolide synthase"
				},
				{
					"name":"Candicidin PKS"
				},
				{
					"name":"Soraphen PKS"
				},
				{
					"name":"Stigmatellin PKS"
				},
				{
					"name":"Mycolactone PKS"
				},
				{
					"name":"Coelimycin PKS"
				},
				{
					"name":"Aureothin PKS"
				},
				{
					"name":"Spectinabilin PKS"
				},
				{
					"name":"Phthiocerol \/ Phenolphthiocerol PKS"
				}
				]
			},
			{
				"name":"trans-AT PKS",
				"children":[
				{
					"name":"Bacillanene hybrid PKS-NRPS"
				},
				{
					"name":"Macrolactin PKS"
				},
				{
					"name":"Difficidin PKS"
				},
				{
					"name":"Rhizoxin hybrid PKS-NRPS"
				},
				{
					"name":"Albicidin synthase, hybrid PKS-NRPS"
				}
				]
			}
			]
		},
		{
			"name":"Iterative type I PKS",
			"children":[
			{
				"name":"Fungal nonreducing PKS (NR-PKS)"
			},
			{
				"name":"Fungal partially reducing PKS (PR-PKS)"
			},
			{
				"name":"Fungal highly reducing PKS (HR-PKS)"
			},
			{
				"name":"Fungal hybrid type",
				"children":[
				{
					"name":"Zearalenone synthase"
				}
				]
			},
			{
				"name":"Bacterial type"
			}
			]
		},
		{
			"name":"Type II PKS",
			"children":[
			{
				"name":"C9-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Spore pigment PKS",
					"children":[
					{
						"name":"KI385_06515 beta-ketoacyl-[acyl-carrier-protein] synthase family protein\tK14667 whiEIII; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.-]"
					},
					{
						"name":"KI385_06510 ketosynthase chain-length factor\tK14668 whiEIV; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.-]"
					},
					{
						"name":"KI385_06505 acyl carrier protein\tK14669 whiEV; minimal PKS acyl carrier protein"
					},
					{
						"name":"KI385_06500 SRPBCC family protein\tK14670 whiEVI; aromatase"
					},
					{
						"name":"KI385_06495 TcmI family type II polyketide cyclase\tK14671 whiEVII; cyclase"
					}
					]
				}
				]
			},
			{
				"name":"C7-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Octaketide PKS",
					"children":[
					{
						"name":"KI385_25175 beta-ketoacyl-[acyl-carrier-protein] synthase family protein\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"KI385_25170 ketosynthase chain-length factor\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"KI385_25165 acyl carrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					},
					{
						"name":"KI385_10700 MBL fold metallo-hydrolase\tK05555 actIV; cyclase [EC:4.-.-.-]"
					}
					]
				},
				{
					"name":"Nonaketide PKS",
					"children":[
					{
						"name":"KI385_25175 beta-ketoacyl-[acyl-carrier-protein] synthase family protein\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"KI385_25170 ketosynthase chain-length factor\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"KI385_25165 acyl carrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					},
					{
						"name":"KI385_25245 cyclase family protein\tK14250 oxyN; cyclase"
					}
					]
				},
				{
					"name":"Decaketide PKS",
					"children":[
					{
						"name":"KI385_25175 beta-ketoacyl-[acyl-carrier-protein] synthase family protein\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"KI385_25170 ketosynthase chain-length factor\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"KI385_25165 acyl carrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					},
					{
						"name":"KI385_25245 cyclase family protein\tK14250 oxyN; cyclase"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"Type III PKS",
			"children":[
			{
				"name":"Plant type"
			},
			{
				"name":"Fungal type"
			},
			{
				"name":"Bacterial type",
				"children":[
				{
					"name":"KI385_05065 type III polyketide synthase\tK19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233]"
				}
				]
			}
			]
		},
		{
			"name":"PKS-NRPS hybrid",
			"children":[
			{
				"name":"Bacterial type (modular)",
				"children":[
				{
					"name":"Myxalamid hybrid PKS-NRPS"
				},
				{
					"name":"Coronatine hybrid PKS-NRPS"
				},
				{
					"name":"Microcystin synthetase"
				},
				{
					"name":"Epothilone synthetase"
				},
				{
					"name":"Bleomycin synthetase"
				},
				{
					"name":"Colibactin synthetase"
				},
				{
					"name":"Myxothiazol hybrid PKS-NRPS"
				}
				]
			},
			{
				"name":"Fungal type (trans-ER, iterative)",
				"children":[
				{
					"name":"Aspyridone synthetase"
				}
				]
			},
			{
				"name":"Fungal type (iterative)"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide synthetase (NRPS)",
		"children":[
		{
			"name":"Linear NRPS",
			"children":[
			{
				"name":"Emericellamide synthetase"
			},
			{
				"name":"Cyanopeptolin synthetase"
			},
			{
				"name":"ACV synthetase"
			},
			{
				"name":"Bacitracin synthetase"
			},
			{
				"name":"Viomycin synthetase"
			},
			{
				"name":"Pristinamycin I synthetase"
			},
			{
				"name":"Tyrocidine synthetase"
			},
			{
				"name":"Surfactin family lipopeptide synthetase"
			},
			{
				"name":"Iturin family lipopeptide synthetase"
			},
			{
				"name":"Fengycin family lipopeptide synthetase"
			},
			{
				"name":"Arthrofactin type cyclic lipopeptide synthetase"
			},
			{
				"name":"Vancomycin synthetase"
			},
			{
				"name":"Nocardicin synthetase",
				"children":[
				{
					"name":"KI385_25360 MbtH family protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"KI385_34410 MbtH family NRPS accessory protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"KI385_42875 MbtH family protein\tK05375 mbtH; MbtH protein"
				}
				]
			},
			{
				"name":"Bialaphos synthetase"
			},
			{
				"name":"L-2-amino-4-methoxy-trans-3-butenoic acid synthetase"
			},
			{
				"name":"Anabaenopeptin synthetase"
			},
			{
				"name":"Linear gramicidin synthetase"
			}
			]
		},
		{
			"name":"Iterative NRPS",
			"children":[
			{
				"name":"Enterobactin synthetase",
				"children":[
				{
					"name":"KI385_34260 4'-phosphopantetheinyl transferase superfamily protein\tK02362 entD; enterobactin synthetase component D \/ holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]"
				}
				]
			},
			{
				"name":"Bacillibactin synthetase"
			},
			{
				"name":"Gramicidin synthetase"
			}
			]
		},
		{
			"name":"Nonlinear NRPS",
			"children":[
			{
				"name":"Yersiniabactin synthetase"
			},
			{
				"name":"Pyochelin synthetase"
			},
			{
				"name":"Mycobactin synthetase"
			},
			{
				"name":"Vibriobactin synthetase"
			},
			{
				"name":"Myxochelin synthetase"
			},
			{
				"name":"Petrobacin synthetase"
			},
			{
				"name":"Syringomycin synthetase"
			},
			{
				"name":"Vanchrobactin synthetase"
			},
			{
				"name":"Isonitrile lipopeptide synthase"
			}
			]
		}
		]
	},
	{
		"name":"Polyketide tailoring proteins",
		"children":[
		{
			"name":"Hydrolase"
		},
		{
			"name":"Ketoreductase"
		},
		{
			"name":"Oxygenase",
			"children":[
			{
				"name":"KI385_15970 cytochrome P450\tK20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]"
			},
			{
				"name":"KI385_25240 FAD-dependent oxidoreductase\tK14252 oxyL; 6-methylpretetramide 4-monooxygenase \/ 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233]"
			},
			{
				"name":"KI385_06520 cupin domain-containing protein\tK14673 whiEII; putative monooxygenase"
			},
			{
				"name":"KI385_06530 FAD-dependent monooxygenase\tK14672 whiEVIII; putative polyketide hydroxylase"
			}
			]
		},
		{
			"name":"Methylase",
			"children":[
			{
				"name":"KI385_06490 acetylserotonin O-methyltransferase\tK14251 oxyF; C-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"KI385_25225 methyltransferase\tK14251 oxyF; C-methyltransferase [EC:2.1.1.-]"
			}
			]
		},
		{
			"name":"Glycosyltransferase"
		},
		{
			"name":"Halogenase"
		},
		{
			"name":"beta-Branched incorporating proteins"
		},
		{
			"name":"Others"
		}
		]
	},
	{
		"name":"Nonribosomal peptide tailoring proteins",
		"children":[
		{
			"name":"Reductase"
		},
		{
			"name":"Thioesterase"
		},
		{
			"name":"Oxygenase"
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"KI385_00245 glycosyltransferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]"
			},
			{
				"name":"KI385_04200 glycosyltransferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]"
			},
			{
				"name":"KI385_41035 glycosyltransferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]"
			}
			]
		},
		{
			"name":"Aminotransferase",
			"children":[
			{
				"name":"KI385_01590 PLP-dependent aminotransferase family protein\tK16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103]"
			}
			]
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"KI385_01575 hppD; 4-hydroxyphenylpyruvate dioxygenase\tK16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46]"
			},
			{
				"name":"KI385_38530 hppD; 4-hydroxyphenylpyruvate dioxygenase\tK16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46]"
			},
			{
				"name":"KI385_01580 alpha-hydroxy-acid oxidizing protein\tK16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]"
			}
			]
		}
		]
	}
	]
}