{
	"name":"sis03009",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Sno RNPs",
			"children":[
			{
				"name":"Box C\/D snoRNPs",
				"children":[
				{
					"name":"LS215_1374 Pre-mRNA processing ribonucleoprotein, binding domain protein\tK14564 NOP56; nucleolar protein 56"
				}
				]
			},
			{
				"name":"Box H\/ACA snoRNPs",
				"children":[
				{
					"name":"LS215_1265 RNA-binding protein Nop10p\tK11130 NOP10; H\/ACA ribonucleoprotein complex subunit 3"
				}
				]
			}
			]
		},
		{
			"name":"90S particles",
			"children":[
			{
				"name":"U3 small nucleolar RNA-associated proteins",
				"children":[
				{
					"name":"LS215_1504 conserved hypothetical protein\tK14561 IMP4; U3 small nucleolar ribonucleoprotein protein IMP4"
				}
				]
			},
			{
				"name":"Helicases"
			},
			{
				"name":"GTPase"
			},
			{
				"name":"RNase"
			},
			{
				"name":"Kinase"
			},
			{
				"name":"Other 90S particles",
				"children":[
				{
					"name":"LS215_0043 Suppressor Mra1 family protein\tK14568 EMG1; rRNA small subunit pseudouridine methyltransferase Nep1 [EC:2.1.1.260]"
				},
				{
					"name":"LS215_0201 KH type 1 domain protein\tK06961 KRR1; ribosomal RNA assembly protein"
				}
				]
			}
			]
		},
		{
			"name":"Pre-40S particles",
			"children":[
			{
				"name":"Kinases",
				"children":[
				{
					"name":"LS215_0202 Non-specific serine\/threonine protein kinase\tK07178 RIOK1; RIO kinase 1 [EC:2.7.11.1]"
				},
				{
					"name":"LS215_2100 protein of unknown function RIO1\tK07179 RIOK2; RIO kinase 2 [EC:2.7.11.1]"
				}
				]
			},
			{
				"name":"Export and cytoplasmic maturation factors",
				"children":[
				{
					"name":"LS215_1772 conserved hypothetical protein\tK18532 AK6; adenylate kinase [EC:2.7.4.3]"
				},
				{
					"name":"LS215_1685 Protein of unknown function DUF367\tK09140 TSR3; rRNA small subunit aminocarboxypropyltransferase [EC:2.5.1.157]"
				}
				]
			},
			{
				"name":"Other pre-40S particles",
				"children":[
				{
					"name":"LS215_1953 ABC transporter related\tK06174 ABCE1; ATP-binding cassette, sub-family E, member 1"
				}
				]
			}
			]
		},
		{
			"name":"Pre-60S particles",
			"children":[
			{
				"name":"Helicases"
			},
			{
				"name":"GTPases",
				"children":[
				{
					"name":"LS215_1616 small GTP-binding protein\tK06943 NOG1; nucleolar GTP-binding protein"
				}
				]
			},
			{
				"name":"RNases",
				"children":[
				{
					"name":"RNase MRP",
					"children":[
					{
						"name":"LS215_1523 ribonuclease P, Rpp29\tK03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]"
					},
					{
						"name":"LS215_1497 Ribonuclease P-related\tK03537 POP5; ribonuclease P\/MRP protein subunit POP5 [EC:3.1.26.5]"
					},
					{
						"name":"LS215_1496 RNase P subunit p30\tK03539 RPP1; ribonuclease P\/MRP protein subunit RPP1 [EC:3.1.26.5]"
					}
					]
				}
				]
			},
			{
				"name":"Kinases",
				"children":[
				{
					"name":"LS215_1457 conserved hypothetical protein\tK06947 GRC3; polynucleotide 5'-hydroxyl-kinase GRC3\/NOL9 [EC:2.7.1.-]"
				}
				]
			},
			{
				"name":"Export and cytoplasmic maturation factors",
				"children":[
				{
					"name":"LS215_1895 translation initiation factor eIF-6\tK03264 EIF6; translation initiation factor 6"
				},
				{
					"name":"LS215_0208 NMD3 family protein\tK07562 NMD3; 60S ribosomal export protein NMD3"
				},
				{
					"name":"LS215_1499 Shwachman-Bodian-Diamond syndrome protein\tK14574 SDO1; ribosome maturation protein SDO1"
				}
				]
			},
			{
				"name":"55LCC heterohexameric ATPase complex"
			},
			{
				"name":"5-FMC complex"
			},
			{
				"name":"Ribosome quality control proteins",
				"children":[
				{
					"name":"LS215_1814 AAA family ATPase, CDC48 subfamily\tK13525 VCP; transitional endoplasmic reticulum ATPase"
				},
				{
					"name":"LS215_2122 AAA family ATPase, CDC48 subfamily\tK13525 VCP; transitional endoplasmic reticulum ATPase"
				}
				]
			},
			{
				"name":"Other pre-60S particles"
			}
			]
		},
		{
			"name":"Other ribosome biogenesis factors"
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Sno RNPs",
			"children":[
			{
				"name":"Box C\/D snoRNPs",
				"children":[
				{
					"name":"LS215_1374 Pre-mRNA processing ribonucleoprotein, binding domain protein\tK14564 NOP56; nucleolar protein 56"
				},
				{
					"name":"LS215_1373 Non-specific serine\/threonine protein kinase\tK04795 flpA; fibrillarin-like pre-rRNA processing protein"
				},
				{
					"name":"LS215_2197 ribosomal protein L7Ae\/L30e\/S12e\/Gadd45\tK02936 RP-L7Ae; large subunit ribosomal protein L7Ae"
				}
				]
			},
			{
				"name":"Box H\/ACA snoRNPs",
				"children":[
				{
					"name":"LS215_1265 RNA-binding protein Nop10p\tK11130 NOP10; H\/ACA ribonucleoprotein complex subunit 3"
				}
				]
			}
			]
		},
		{
			"name":"rRNA transcription factors"
		},
		{
			"name":"rRNA modification factors",
			"children":[
			{
				"name":"16S rRNA modification factors",
				"children":[
				{
					"name":"LS215_1488 ribosomal RNA adenine methylase transferase\tK02528 ksgA; 16S rRNA (adenine1518-N6\/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]"
				},
				{
					"name":"LS215_1872 Fmu (Sun) domain protein\tK03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]"
				},
				{
					"name":"LS215_2168 Fmu (Sun) domain protein\tK03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]"
				}
				]
			},
			{
				"name":"23S rRNA modification factors"
			}
			]
		},
		{
			"name":"ribosomal protein modification factors",
			"children":[
			{
				"name":"LS215_2034 ribosomal-protein-alanine acetyltransferase\tK03789 rimI; [ribosomal protein S18]-alanine N-acetyltransferase \/ [ribosomal protein L31]-L-lysine N-acetyltransferase [EC:2.3.1.266 2.3.1.338]"
			},
			{
				"name":"LS215_2204 ribosomal-protein-alanine acetyltransferase\tK03789 rimI; [ribosomal protein S18]-alanine N-acetyltransferase \/ [ribosomal protein L31]-L-lysine N-acetyltransferase [EC:2.3.1.266 2.3.1.338]"
			}
			]
		},
		{
			"name":"rRNA processing factors",
			"children":[
			{
				"name":"LS215_1229 protein of unknown function DUF402\tK22469 fau-1; ribonuclease FAU-1 [EC:3.1.26.-]"
			}
			]
		},
		{
			"name":"rRNA helicases"
		},
		{
			"name":"GTPases",
			"children":[
			{
				"name":"LS215_1971 GTP-binding proten HflX\tK03665 hflX; GTPase"
			}
			]
		},
		{
			"name":"Other maturation factors",
			"children":[
			{
				"name":"LS215_1581 Sua5\/YciO\/YrdC\/YwlC family protein\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
			},
			{
				"name":"LS215_0041 protein of unknown function UPF0044\tK07574 yhbY; RNA-binding protein"
			},
			{
				"name":"LS215_1493 GTPase of unknown function domain protein\tK06942 ychF; ribosome-binding ATPase"
			}
			]
		}
		]
	},
	{
		"name":"Related small nucleolar RNAs",
		"children":[
		{
			"name":"Box C\/D snoRNAs",
			"children":[
			{
				"name":"SnoRNAs involved in processing reactions"
			},
			{
				"name":"SnoRNAs act as guides for 2'-O-ribose methylation"
			}
			]
		},
		{
			"name":"Box H\/ACA snoRNAs",
			"children":[
			{
				"name":"SnoRNAs involved in processing reactions"
			},
			{
				"name":"SnoRNAs act as guides for pseudouridynation"
			}
			]
		},
		{
			"name":"Other snoRNA"
		}
		]
	}
	]
}