{
	"name":"smd04147",
	"children":[
	{
		"name":"Exosomal proteins",
		"children":[
		{
			"name":"Proteins found in most exosomes",
			"children":[
			{
				"name":"Smed_4673 heat shock protein Hsp90\tK04079 HSP90A; molecular chaperone HtpG"
			},
			{
				"name":"Smed_2654 Fructose-bisphosphate aldolase\tK01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]"
			},
			{
				"name":"Smed_1072 Phosphopyruvate hydratase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
			},
			{
				"name":"Smed_2651 glyceraldehyde-3-phosphate dehydrogenase, type I\tK00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]"
			},
			{
				"name":"Smed_2653 Phosphoglycerate kinase\tK00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]"
			},
			{
				"name":"Smed_2676 pyruvate kinase\tK00873 PK; pyruvate kinase [EC:2.7.1.40]"
			},
			{
				"name":"Smed_2327 peptidase M19 renal dipeptidase\tK01273 DPEP; membrane dipeptidase [EC:3.4.13.19]"
			},
			{
				"name":"Smed_3733 Membrane dipeptidase\tK01273 DPEP; membrane dipeptidase [EC:3.4.13.19]"
			}
			]
		},
		{
			"name":"Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)",
			"children":[
			{
				"name":"Smed_0408 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_0804 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_1281 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_4130 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_6084 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_3389 chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
			},
			{
				"name":"Smed_0109 Glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"Smed_5316 Gluconolactonase\tK01053 gnl; gluconolactonase [EC:3.1.1.17]"
			},
			{
				"name":"Smed_0379 inosine-5'-monophosphate dehydrogenase\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]"
			},
			{
				"name":"Smed_0969 translation elongation factor Tu\tK02358 tuf; elongation factor Tu"
			},
			{
				"name":"Smed_0984 translation elongation factor Tu\tK02358 tuf; elongation factor Tu"
			},
			{
				"name":"Smed_1120 histidine triad (HIT) protein\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
			}
			]
		},
		{
			"name":"Exosomal proteins of oligodendrocytes"
		},
		{
			"name":"Exosomal proteins of cortical neuronal cells"
		},
		{
			"name":"Exosomal proteins of microglial cells"
		},
		{
			"name":"Exosomal proteins of epithelial cells"
		},
		{
			"name":"Exosomal proteins of hepatic cells",
			"children":[
			{
				"name":"Smed_2714 Bile acid:sodium symporter\tK14347 SLC10A7; solute carrier family 10 (sodium\/bile acid cotransporter), member 7"
			}
			]
		},
		{
			"name":"Exosomal proteins of breast milk",
			"children":[
			{
				"name":"Smed_0110 AMP-dependent synthetase and ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			}
			]
		},
		{
			"name":"Exosomal proteins of other body fluids (saliva and urine)",
			"children":[
			{
				"name":"Smed_0408 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_0804 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_1281 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_4130 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_6084 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_0145 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"Smed_0499 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"Smed_1439 Propanoyl-CoA C-acyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"Smed_3117 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"Smed_5096 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"Smed_3247 adenosylhomocysteinase\tK01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1]"
			},
			{
				"name":"Smed_1007 adenylate kinase\tK00939 adk; adenylate kinase [EC:2.7.4.3]"
			},
			{
				"name":"Smed_2270 adenine phosphoribosyltransferase\tK00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7]"
			},
			{
				"name":"Smed_2536 argininosuccinate lyase\tK01755 argH; argininosuccinate lyase [EC:4.3.2.1]"
			},
			{
				"name":"Smed_4987 argininosuccinate lyase\tK01755 argH; argininosuccinate lyase [EC:4.3.2.1]"
			},
			{
				"name":"Smed_3063 Argininosuccinate synthase\tK01940 argG; argininosuccinate synthase [EC:6.3.4.5]"
			},
			{
				"name":"Smed_4635 amidinotransferase\tK01482 DDAH; dimethylargininase [EC:3.5.3.18]"
			},
			{
				"name":"Smed_2367 dihydropyrimidinase\tK01464 DPYS; dihydropyrimidinase [EC:3.5.2.2]"
			},
			{
				"name":"Smed_2983 dihydropyrimidinase\tK01464 DPYS; dihydropyrimidinase [EC:3.5.2.2]"
			},
			{
				"name":"Smed_3920 Inositol phosphatase\/fructose-16-bisphosphatase\tK03841 FBP; fructose-1,6-bisphosphatase I [EC:3.1.3.11]"
			},
			{
				"name":"Smed_2740 1,4-alpha-glucan branching enzyme\tK00700 GBE1; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]"
			},
			{
				"name":"Smed_3130 carbohydrate kinase FGGY\tK00864 glpK; glycerol kinase [EC:2.7.1.30]"
			},
			{
				"name":"Smed_4501 glycerol kinase\tK00864 glpK; glycerol kinase [EC:2.7.1.30]"
			},
			{
				"name":"Smed_0302 Glutamate--putrescine ligase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"Smed_1389 glutamine synthetase, type I\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"Smed_2130 glutamine synthetase catalytic region\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"Smed_2416 glutamine synthetase catalytic region\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"Smed_3294 glutamine synthetase catalytic region\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"Smed_4251 Glutamate--ammonia ligase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"Smed_5349 glutamine synthetase catalytic region\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"Smed_6005 glutamine synthetase catalytic region\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"Smed_0109 Glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"Smed_0812 Porphobilinogen synthase\tK01698 hemB; porphobilinogen synthase [EC:4.2.1.24]"
			},
			{
				"name":"Smed_2836 4-hydroxyphenylpyruvate dioxygenase\tK00457 HPD; 4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]"
			},
			{
				"name":"Smed_3071 transcriptional coactivator\/pterin dehydratase\tK01724 PCBD; 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]"
			},
			{
				"name":"Smed_2158 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"Smed_2466 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"Smed_2618 D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"Smed_5864 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"Smed_5903 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"Smed_3189 phosphoribosylaminoimidazolecarboxamide formyltransferase\/IMP cyclohydrolase\tK00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase \/ IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]"
			}
			]
		},
		{
			"name":"Exosomal proteins of breast cancer cells",
			"children":[
			{
				"name":"Smed_0110 AMP-dependent synthetase and ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"Smed_1081 dihydrolipoamide dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]"
			},
			{
				"name":"Smed_2829 dihydrolipoamide dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]"
			},
			{
				"name":"Smed_2936 dihydrolipoamide dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]"
			},
			{
				"name":"Smed_2533 Electron transfer flavoprotein alpha subunit\tK03522 fixB; electron transfer flavoprotein alpha subunit"
			},
			{
				"name":"Smed_6229 Electron transfer flavoprotein alpha\/beta-subunit\tK03522 fixB; electron transfer flavoprotein alpha subunit"
			},
			{
				"name":"Smed_0300 glucose-6-phosphate 1-dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]"
			},
			{
				"name":"Smed_0379 inosine-5'-monophosphate dehydrogenase\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]"
			},
			{
				"name":"Smed_3389 chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
			},
			{
				"name":"Smed_0408 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_0804 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_1281 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_4130 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_6084 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_0969 translation elongation factor Tu\tK02358 tuf; elongation factor Tu"
			},
			{
				"name":"Smed_0984 translation elongation factor Tu\tK02358 tuf; elongation factor Tu"
			}
			]
		},
		{
			"name":"Exosomal proteins of ovarian cancer cells"
		},
		{
			"name":"Exosomal proteins of colorectal cancer cells",
			"children":[
			{
				"name":"Smed_0408 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_0804 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_1281 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_4130 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_6084 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_0109 Glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"Smed_0300 glucose-6-phosphate 1-dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]"
			},
			{
				"name":"Smed_3389 chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
			},
			{
				"name":"Smed_1067 Triose-phosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			},
			{
				"name":"Smed_0969 translation elongation factor Tu\tK02358 tuf; elongation factor Tu"
			},
			{
				"name":"Smed_0984 translation elongation factor Tu\tK02358 tuf; elongation factor Tu"
			}
			]
		},
		{
			"name":"Exosomal proteins of pancreatic cancer cells"
		},
		{
			"name":"Exosomal proteins of bladder cancer cells",
			"children":[
			{
				"name":"Smed_0408 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_0804 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_1281 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_4130 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_6084 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"Smed_0300 glucose-6-phosphate 1-dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]"
			},
			{
				"name":"Smed_3372 phosphoglycerate mutase 1 family\tK01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"
			},
			{
				"name":"Smed_1067 Triose-phosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			}
			]
		},
		{
			"name":"Exosomal proteins of melanoma cells",
			"children":[
			{
				"name":"Smed_3372 phosphoglycerate mutase 1 family\tK01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"
			},
			{
				"name":"Smed_1067 Triose-phosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			}
			]
		},
		{
			"name":"Exosomal proteins of other cancer cells"
		}
		]
	},
	{
		"name":"Exosomal RNA",
		"children":[
		{
			"name":"Exosomal RNA of haemopoietic cells"
		},
		{
			"name":"Exosomal RNA of muscle cells"
		},
		{
			"name":"Exosomal RNA of hepatic cells"
		},
		{
			"name":"Exosomal RNA of pancreatic cells"
		},
		{
			"name":"Exosomal RNA of neural cells"
		},
		{
			"name":"Exosomal RNA of breast milk"
		},
		{
			"name":"Exosomal RNA of saliva"
		},
		{
			"name":"Exosomal RNA of breast cancer cells"
		},
		{
			"name":"Exosomal RNA of ovarian cancer cells"
		},
		{
			"name":"Exosomal RNA of colorectal cancer cells"
		},
		{
			"name":"Exosomal RNA of hepatic cancer cells"
		},
		{
			"name":"Exosomal RNA of renal carcinoma cells"
		},
		{
			"name":"Exosomal RNA of pancreatic cancer cells"
		},
		{
			"name":"Exosomal RNA of melanoma cells"
		},
		{
			"name":"Exosomal RNA of lung cancer cells"
		},
		{
			"name":"Exosomal RNA of other cancer cells"
		}
		]
	}
	]
}