{
	"name":"sov01008",
	"children":[
	{
		"name":"Polyketide synthase (PKS)",
		"children":[
		{
			"name":"Modular type I PKS",
			"children":[
			{
				"name":"cis-AT PKS",
				"children":[
				{
					"name":"Erythronolide PKS"
				},
				{
					"name":"Oleandomycin synthase"
				},
				{
					"name":"Pikromycin PKS"
				},
				{
					"name":"Avermectin PKS"
				},
				{
					"name":"Tylactone synthase"
				},
				{
					"name":"Protomycinolide IV synthase"
				},
				{
					"name":"Niddamycin PKS"
				},
				{
					"name":"Rapamycin PKS"
				},
				{
					"name":"Immunomycin PKS"
				},
				{
					"name":"Ansamitocin PKS"
				},
				{
					"name":"Rifamycin PKS"
				},
				{
					"name":"Polyene macrolide PKS",
					"children":[
					{
						"name":"QZH56_02575 SDR family NAD(P)-dependent oxidoreductase\tK16384 amphC; polyene macrolide polyketide synthase"
					},
					{
						"name":"QZH56_07140 SDR family NAD(P)-dependent oxidoreductase\tK16384 amphC; polyene macrolide polyketide synthase"
					}
					]
				},
				{
					"name":"Pimaricinolide synthase",
					"children":[
					{
						"name":"QZH56_02555 beta-ketoacyl synthase N-terminal-like domain-containing protein\tK16391 pimS0; pimaricinolide synthase, loading module"
					},
					{
						"name":"QZH56_02970 type I polyketide synthase\tK19203 pimS1; pimaricinolide synthase PimS1"
					},
					{
						"name":"QZH56_02600 type I polyketide synthase\tK19204 pimS2; pimaricinolide synthase PimS2"
					},
					{
						"name":"QZH56_02595 type I polyketide synthase\tK19205 pimS3; pimaricinolide synthase PimS3"
					}
					]
				},
				{
					"name":"Candicidin PKS",
					"children":[
					{
						"name":"QZH56_07150 type I polyketide synthase\tK20787 fscC; candicidin polyketide synthase FscC"
					}
					]
				},
				{
					"name":"Soraphen PKS"
				},
				{
					"name":"Stigmatellin PKS"
				},
				{
					"name":"Mycolactone PKS"
				},
				{
					"name":"Coelimycin PKS"
				},
				{
					"name":"Aureothin PKS"
				},
				{
					"name":"Spectinabilin PKS"
				},
				{
					"name":"Phthiocerol \/ Phenolphthiocerol PKS"
				}
				]
			},
			{
				"name":"trans-AT PKS",
				"children":[
				{
					"name":"Bacillanene hybrid PKS-NRPS"
				},
				{
					"name":"Macrolactin PKS"
				},
				{
					"name":"Difficidin PKS"
				},
				{
					"name":"Rhizoxin hybrid PKS-NRPS"
				},
				{
					"name":"Albicidin synthase, hybrid PKS-NRPS"
				}
				]
			}
			]
		},
		{
			"name":"Iterative type I PKS",
			"children":[
			{
				"name":"Fungal nonreducing PKS (NR-PKS)"
			},
			{
				"name":"Fungal partially reducing PKS (PR-PKS)"
			},
			{
				"name":"Fungal highly reducing PKS (HR-PKS)"
			},
			{
				"name":"Fungal hybrid type",
				"children":[
				{
					"name":"Zearalenone synthase"
				}
				]
			},
			{
				"name":"Bacterial type"
			}
			]
		},
		{
			"name":"Type II PKS",
			"children":[
			{
				"name":"C9-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Spore pigment PKS"
				}
				]
			},
			{
				"name":"C7-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Octaketide PKS",
					"children":[
					{
						"name":"QZH56_16790 beta-ketoacyl-[acyl-carrier-protein] synthase family protein\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"QZH56_23785 beta-ketoacyl-[acyl-carrier-protein] synthase family protein\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"QZH56_16780 ketosynthase chain-length factor\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"QZH56_23790 ketosynthase chain-length factor\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"QZH56_16775 acyl carrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					},
					{
						"name":"QZH56_23795 acyl carrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					},
					{
						"name":"QZH56_16730 fabG; 3-oxoacyl-ACP reductase FabG\tK12420 actIII; ketoreductase [EC:1.1.1.-]"
					},
					{
						"name":"QZH56_23730 SDR family NAD(P)-dependent oxidoreductase\tK12420 actIII; ketoreductase [EC:1.1.1.-]"
					},
					{
						"name":"QZH56_16795 aromatase\/cyclase\tK05554 actVII; aromatase [EC:4.2.1.-]"
					},
					{
						"name":"QZH56_23800 aromatase\/cyclase\tK05554 actVII; aromatase [EC:4.2.1.-]"
					},
					{
						"name":"QZH56_23705 MBL fold metallo-hydrolase\tK05555 actIV; cyclase [EC:4.-.-.-]"
					},
					{
						"name":"QZH56_28810 MBL fold metallo-hydrolase\tK05555 actIV; cyclase [EC:4.-.-.-]"
					}
					]
				},
				{
					"name":"Nonaketide PKS",
					"children":[
					{
						"name":"QZH56_16790 beta-ketoacyl-[acyl-carrier-protein] synthase family protein\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"QZH56_23785 beta-ketoacyl-[acyl-carrier-protein] synthase family protein\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"QZH56_16780 ketosynthase chain-length factor\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"QZH56_23790 ketosynthase chain-length factor\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"QZH56_16775 acyl carrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					},
					{
						"name":"QZH56_23795 acyl carrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					},
					{
						"name":"QZH56_16730 fabG; 3-oxoacyl-ACP reductase FabG\tK12420 actIII; ketoreductase [EC:1.1.1.-]"
					},
					{
						"name":"QZH56_23730 SDR family NAD(P)-dependent oxidoreductase\tK12420 actIII; ketoreductase [EC:1.1.1.-]"
					}
					]
				},
				{
					"name":"Decaketide PKS",
					"children":[
					{
						"name":"QZH56_16790 beta-ketoacyl-[acyl-carrier-protein] synthase family protein\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"QZH56_23785 beta-ketoacyl-[acyl-carrier-protein] synthase family protein\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"QZH56_16780 ketosynthase chain-length factor\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"QZH56_23790 ketosynthase chain-length factor\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"QZH56_16775 acyl carrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					},
					{
						"name":"QZH56_23795 acyl carrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					},
					{
						"name":"QZH56_16730 fabG; 3-oxoacyl-ACP reductase FabG\tK12420 actIII; ketoreductase [EC:1.1.1.-]"
					},
					{
						"name":"QZH56_23730 SDR family NAD(P)-dependent oxidoreductase\tK12420 actIII; ketoreductase [EC:1.1.1.-]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"Type III PKS",
			"children":[
			{
				"name":"Plant type"
			},
			{
				"name":"Fungal type"
			},
			{
				"name":"Bacterial type",
				"children":[
				{
					"name":"QZH56_15095 type III polyketide synthase\tK19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233]"
				}
				]
			}
			]
		},
		{
			"name":"PKS-NRPS hybrid",
			"children":[
			{
				"name":"Bacterial type (modular)",
				"children":[
				{
					"name":"Myxalamid hybrid PKS-NRPS"
				},
				{
					"name":"Coronatine hybrid PKS-NRPS"
				},
				{
					"name":"Microcystin synthetase"
				},
				{
					"name":"Epothilone synthetase"
				},
				{
					"name":"Bleomycin synthetase"
				},
				{
					"name":"Colibactin synthetase"
				},
				{
					"name":"Myxothiazol hybrid PKS-NRPS"
				}
				]
			},
			{
				"name":"Fungal type (trans-ER, iterative)",
				"children":[
				{
					"name":"Aspyridone synthetase"
				}
				]
			},
			{
				"name":"Fungal type (iterative)"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide synthetase (NRPS)",
		"children":[
		{
			"name":"Linear NRPS",
			"children":[
			{
				"name":"Emericellamide synthetase"
			},
			{
				"name":"Cyanopeptolin synthetase"
			},
			{
				"name":"ACV synthetase"
			},
			{
				"name":"Bacitracin synthetase"
			},
			{
				"name":"Viomycin synthetase"
			},
			{
				"name":"Pristinamycin I synthetase"
			},
			{
				"name":"Tyrocidine synthetase"
			},
			{
				"name":"Surfactin family lipopeptide synthetase"
			},
			{
				"name":"Iturin family lipopeptide synthetase"
			},
			{
				"name":"Fengycin family lipopeptide synthetase"
			},
			{
				"name":"Arthrofactin type cyclic lipopeptide synthetase"
			},
			{
				"name":"Vancomycin synthetase"
			},
			{
				"name":"Nocardicin synthetase",
				"children":[
				{
					"name":"QZH56_04080 MbtH family protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"QZH56_05775 MbtH family protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"QZH56_07020 MbtH family protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"QZH56_15255 MbtH family NRPS accessory protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"QZH56_21175 MbtH family NRPS accessory protein\tK05375 mbtH; MbtH protein"
				}
				]
			},
			{
				"name":"Bialaphos synthetase"
			},
			{
				"name":"L-2-amino-4-methoxy-trans-3-butenoic acid synthetase"
			},
			{
				"name":"Anabaenopeptin synthetase"
			},
			{
				"name":"Linear gramicidin synthetase"
			}
			]
		},
		{
			"name":"Iterative NRPS",
			"children":[
			{
				"name":"Enterobactin synthetase",
				"children":[
				{
					"name":"QZH56_05440 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Bacillibactin synthetase",
				"children":[
				{
					"name":"QZH56_05440 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"QZH56_04085 amino acid adenylation domain-containing protein\tK04780 dhbF; glyine---[glycyl-carrier protein] ligase [EC:6.2.1.66]"
				}
				]
			},
			{
				"name":"Gramicidin synthetase"
			}
			]
		},
		{
			"name":"Nonlinear NRPS",
			"children":[
			{
				"name":"Yersiniabactin synthetase"
			},
			{
				"name":"Pyochelin synthetase"
			},
			{
				"name":"Mycobactin synthetase"
			},
			{
				"name":"Vibriobactin synthetase",
				"children":[
				{
					"name":"QZH56_05440 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Myxochelin synthetase",
				"children":[
				{
					"name":"QZH56_05440 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Petrobacin synthetase"
			},
			{
				"name":"Syringomycin synthetase"
			},
			{
				"name":"Vanchrobactin synthetase",
				"children":[
				{
					"name":"QZH56_05440 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Isonitrile lipopeptide synthase"
			}
			]
		}
		]
	},
	{
		"name":"Polyketide tailoring proteins",
		"children":[
		{
			"name":"Hydrolase"
		},
		{
			"name":"Ketoreductase",
			"children":[
			{
				"name":"QZH56_04645 3-hydroxyacyl-CoA dehydrogenase NAD-binding domain-containing protein\tK05556 actVI1; ketoreductase RED1 [EC:1.1.1.-]"
			},
			{
				"name":"QZH56_16735 3-hydroxyacyl-CoA dehydrogenase NAD-binding domain-containing protein\tK05556 actVI1; ketoreductase RED1 [EC:1.1.1.-]"
			},
			{
				"name":"QZH56_23740 3-hydroxyacyl-CoA dehydrogenase NAD-binding domain-containing protein\tK05556 actVI1; ketoreductase RED1 [EC:1.1.1.-]"
			}
			]
		},
		{
			"name":"Oxygenase",
			"children":[
			{
				"name":"QZH56_02545 cytochrome P450\tK16389 amphN; cytochrome P450 monooxygenase"
			},
			{
				"name":"QZH56_02580 cytochrome P450\tK16390 amphL; cytochrome P450 monooxygenase"
			},
			{
				"name":"QZH56_07280 cytochrome P450\tK20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]"
			},
			{
				"name":"QZH56_35090 cytochrome P450\tK20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]"
			},
			{
				"name":"QZH56_35575 cytochrome P450\tK20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]"
			}
			]
		},
		{
			"name":"Methylase",
			"children":[
			{
				"name":"QZH56_34125 methyltransferase domain-containing protein\tK15467 rif14; 27-O-demethylrifamycin SV methyltransferase [EC:2.1.1.315]"
			}
			]
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"QZH56_02535 glycosyltransferase\tK16388 amphDI; polyene glycosyltransferase"
			}
			]
		},
		{
			"name":"Halogenase"
		},
		{
			"name":"beta-Branched incorporating proteins"
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"QZH56_33490 3-hydroxyacyl-CoA dehydrogenase family protein\tK16024 asm13; methoxymalonate biosynthesis protein"
			},
			{
				"name":"QZH56_33495 phosphopantetheine-binding protein\tK16025 asm14; methoxymalonate biosynthesis acyl carrier protein"
			},
			{
				"name":"QZH56_33500 acyl-CoA dehydrogenase family protein\tK16026 asm15; methoxymalonate biosynthesis protein"
			},
			{
				"name":"QZH56_33505 HAD-IIIC family phosphatase\tK16027 asm16; methoxymalonate biosynthesis protein"
			},
			{
				"name":"QZH56_16725 nuclear transport factor 2 family protein\tK14626 actVIA; actinorhodin biosynthesis protein ActVIA"
			},
			{
				"name":"QZH56_23780 nuclear transport factor 2 family protein\tK14626 actVIA; actinorhodin biosynthesis protein ActVIA"
			},
			{
				"name":"QZH56_23735 flavin reductase family protein\tK14631 actVB; flavin reductase ActVB [EC:1.5.1.-]"
			},
			{
				"name":"QZH56_05190 flavin reductase family protein\tK21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36]"
			},
			{
				"name":"QZH56_16715 flavin reductase family protein\tK21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36]"
			},
			{
				"name":"QZH56_21230 flavin reductase family protein\tK21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36]"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide tailoring proteins",
		"children":[
		{
			"name":"Reductase"
		},
		{
			"name":"Thioesterase"
		},
		{
			"name":"Oxygenase"
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"QZH56_28545 glycosyltransferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]"
			}
			]
		},
		{
			"name":"Aminotransferase"
		},
		{
			"name":"Others"
		}
		]
	}
	]
}