{
	"name":"span03036",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Sister chromatid cohesion proteins",
			"children":[
			{
				"name":"Cohesin complex"
			},
			{
				"name":"Adherin complex"
			},
			{
				"name":"CTF18-RFC complex"
			},
			{
				"name":"Fork protection complex"
			},
			{
				"name":"55LCC heterohexameric ATPase complex"
			},
			{
				"name":"Other sister chromatid cohesion factors"
			}
			]
		},
		{
			"name":"Meiosis-specific proteins",
			"children":[
			{
				"name":"Cohesin complex and associated proteins"
			},
			{
				"name":"Synaptonemal complex"
			},
			{
				"name":"DSB formation-related proteins"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Nucleosome assembly factors",
			"children":[
			{
				"name":"Histones"
			},
			{
				"name":"Histone chaperones",
				"children":[
				{
					"name":"Nucleoplasmins"
				},
				{
					"name":"NAPs (Nucleosome assembly proteins)"
				},
				{
					"name":"CAF-1"
				},
				{
					"name":"FACT complex"
				},
				{
					"name":"Other Histone chaperones and regulators"
				}
				]
			},
			{
				"name":"HMG (high mobility group) proteins"
			}
			]
		},
		{
			"name":"Histone modification proteins",
			"children":[
			{
				"name":"HATs (histone acetyltransferases)"
			},
			{
				"name":"HAT complexes",
				"children":[
				{
					"name":"PCAF complex"
				},
				{
					"name":"STAGA complex"
				},
				{
					"name":"TFTC complex"
				},
				{
					"name":"TIP60 complex"
				},
				{
					"name":"HBO1 complex"
				},
				{
					"name":"MOZ\/MORF complex"
				},
				{
					"name":"SAGA complex"
				},
				{
					"name":"SLIK complex"
				},
				{
					"name":"ADA-HAT complex"
				},
				{
					"name":"HAT-A2 complex"
				},
				{
					"name":"ATAC complex"
				},
				{
					"name":"HATB complex"
				},
				{
					"name":"NSL complex"
				},
				{
					"name":"MSL complex"
				},
				{
					"name":"NuA3 complex"
				},
				{
					"name":"NuA4 complex"
				},
				{
					"name":"SAS complex"
				}
				]
			},
			{
				"name":"HDACs (histone deacetylases)",
				"children":[
				{
					"name":"Class I HDACs"
				},
				{
					"name":"Class II HDACs"
				},
				{
					"name":"SIRTs (sirtuins, class III HDACs)"
				},
				{
					"name":"Class IV HDACs"
				}
				]
			},
			{
				"name":"HDAC complexes",
				"children":[
				{
					"name":"Sin3A-HDAC complex"
				},
				{
					"name":"BRAF-HDAC complex"
				},
				{
					"name":"REST complex"
				},
				{
					"name":"SHIP complex"
				},
				{
					"name":"MiDAC complex"
				},
				{
					"name":"SMART complex"
				},
				{
					"name":"Other HDAC associated proteins"
				}
				]
			},
			{
				"name":"HMTs (histone methyltransferases)",
				"children":[
				{
					"name":"HKMTs (histone lysine methyltransferases)"
				},
				{
					"name":"PRMTs (protein arginine metyltransferases)"
				}
				]
			},
			{
				"name":"HMT complexes",
				"children":[
				{
					"name":"COMPASS\/SET1 complex"
				},
				{
					"name":"COMPASS\/SET1 complex (yeast)"
				},
				{
					"name":"MLL-HCF complex"
				},
				{
					"name":"MLL3\/MLL4 complex"
				},
				{
					"name":"Dot1-containing complex"
				},
				{
					"name":"CHTOP-methylosome complex"
				}
				]
			},
			{
				"name":"Histone demethylases"
			},
			{
				"name":"Polycomb repressive complex (PRC) and associated proteins",
				"children":[
				{
					"name":"Canonical PRC1 (PRC1.2\/1.4)",
					"children":[
					{
						"name":"PRC1.4 specific proteins"
					}
					]
				},
				{
					"name":"Noncanonical PRC1 (PRC1.1)"
				},
				{
					"name":"Noncanonical PRC1 (PRC1.3\/1.5)"
				},
				{
					"name":"Noncanonical PRC1 (PRC1.6)"
				},
				{
					"name":"PRC2.1"
				},
				{
					"name":"PRC2.2"
				},
				{
					"name":"PR-DUB complex"
				},
				{
					"name":"Other PRC associated proteins"
				}
				]
			},
			{
				"name":"Sir proteins"
			},
			{
				"name":"Other histone modification proteins"
			}
			]
		},
		{
			"name":"Chromosome condensation proteins",
			"children":[
			{
				"name":"Condensin I"
			},
			{
				"name":"Condensin II"
			},
			{
				"name":"Other regulators of chromosome condensation"
			}
			]
		},
		{
			"name":"Centromeric chromatin formation proteins",
			"children":[
			{
				"name":"Kinetochore proteins",
				"children":[
				{
					"name":"Centromere proteins"
				},
				{
					"name":"CPC (chromosomal passenger complex)"
				},
				{
					"name":"KMN network proteins",
					"children":[
					{
						"name":"MIS12 complex"
					},
					{
						"name":"NDC80 complex"
					}
					]
				},
				{
					"name":"Mis6 complex"
				},
				{
					"name":"COMA complex"
				},
				{
					"name":"NMS complex",
					"children":[
					{
						"name":"NDC80 complex"
					},
					{
						"name":"MIND kinetochore complex"
					}
					]
				},
				{
					"name":"MIS16-MIS18 complex"
				},
				{
					"name":"DASH complex"
				},
				{
					"name":"CBF3 complex"
				},
				{
					"name":"Others"
				}
				]
			},
			{
				"name":"SAC (spindle assembly checkpoint) factors",
				"children":[
				{
					"name":"Core SAC proteins"
				},
				{
					"name":"Motor proteins",
					"children":[
					{
						"name":"RZZ complex"
					},
					{
						"name":"Dynein complex"
					}
					]
				},
				{
					"name":"Protein kinases"
				},
				{
					"name":"Others"
				}
				]
			},
			{
				"name":"Other centromeric chromatin formation proteins",
				"children":[
				{
					"name":"Shugoshin"
				},
				{
					"name":"PP2A (protein phosphatase 2A)"
				}
				]
			}
			]
		},
		{
			"name":"Heterochromatin formation proteins",
			"children":[
			{
				"name":"HP1 (heterochromatin protein 1)"
			},
			{
				"name":"MBPs (metylated DNA binding proteins)"
			},
			{
				"name":"Other heterochromatin formation proteins"
			}
			]
		},
		{
			"name":"Gene silencing",
			"children":[
			{
				"name":"RISC (RNA-induced silencing complex)"
			},
			{
				"name":"piRNA pathway"
			},
			{
				"name":"RNA interference (RNAi) pathway",
				"children":[
				{
					"name":"RITS (RNA-induced transcriptional silencing) complex"
				},
				{
					"name":"RDRC (RNA-directed RNA polymerase complex)"
				},
				{
					"name":"Other RNAi proteins"
				}
				]
			},
			{
				"name":"microRNA pathway",
				"children":[
				{
					"name":"Microprocessor complex",
					"children":[
					{
						"name":"AWL63_01230 ribonuclease III\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
					}
					]
				},
				{
					"name":"RISC loading complex"
				},
				{
					"name":"Other miRNA pathway proteins"
				}
				]
			},
			{
				"name":"Transposable elements"
			}
			]
		},
		{
			"name":"Centrosome formation proteins",
			"children":[
			{
				"name":"Centriole proteins"
			},
			{
				"name":"Pericentriolar materials (PCM)",
				"children":[
				{
					"name":"Centriolar satellite"
				},
				{
					"name":"Other PCM proteins"
				}
				]
			},
			{
				"name":"Cyclins"
			},
			{
				"name":"Kinases and associated factors",
				"children":[
				{
					"name":"Kinase associated protein"
				}
				]
			},
			{
				"name":"Microtubules and associated factors",
				"children":[
				{
					"name":"gamma-tubulin ring complex"
				},
				{
					"name":"Other tubulins"
				},
				{
					"name":"Dynactin complex"
				},
				{
					"name":"BRISC complex"
				},
				{
					"name":"Microtubule-associated proteins"
				}
				]
			},
			{
				"name":"Augmin complex"
			},
			{
				"name":"Centrosome duplication proteins",
				"children":[
				{
					"name":"Centriole replication proteins"
				},
				{
					"name":"Regulators of centriole replication"
				},
				{
					"name":"Other centrosome duplication proteins"
				}
				]
			},
			{
				"name":"Nde1-Su48 complex"
			},
			{
				"name":"LINC complex"
			},
			{
				"name":"3M complex"
			},
			{
				"name":"Gypsy chromatin insulator complex"
			},
			{
				"name":"Other centrosome associated proteins",
				"children":[
				{
					"name":"AWL63_21775 class I fructose-bisphosphate aldolase\tK01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]"
				}
				]
			},
			{
				"name":"Spindle formation proteins"
			}
			]
		},
		{
			"name":"Sister chromatid separation proteins",
			"children":[
			{
				"name":"Securin and associated proteins"
			},
			{
				"name":"Separase"
			},
			{
				"name":"APC\/C complex"
			},
			{
				"name":"Aurora kinases",
				"children":[
				{
					"name":"Regulators of Aurora kinases"
				}
				]
			},
			{
				"name":"TACC proteins"
			},
			{
				"name":"Polo kinases"
			},
			{
				"name":"Early mitotic inhibitors"
			}
			]
		},
		{
			"name":"Chromatin remodeling factors",
			"children":[
			{
				"name":"BAF complex"
			},
			{
				"name":"PBAF complex"
			},
			{
				"name":"GBAF(ncBAF) complex"
			},
			{
				"name":"CHRAC complex"
			},
			{
				"name":"RSF complex"
			},
			{
				"name":"WICH complex"
			},
			{
				"name":"B-WICH complex"
			},
			{
				"name":"NORC complex"
			},
			{
				"name":"BRF complex"
			},
			{
				"name":"NuRD complex"
			},
			{
				"name":"NuRF complex"
			},
			{
				"name":"NuRF complex (fruit fly)"
			},
			{
				"name":"CERF complex"
			},
			{
				"name":"SRCAP complex"
			},
			{
				"name":"INO80 complex"
			},
			{
				"name":"INO80 complex (yeast)"
			},
			{
				"name":"RSC complex"
			},
			{
				"name":"SWI\/SNF complex"
			},
			{
				"name":"SWR1 complex"
			},
			{
				"name":"ASTRA complex"
			},
			{
				"name":"Other chromatin remodeling factors",
				"children":[
				{
					"name":"AWL63_18380 methylase\tK26273 SBNO; protein strawberry notch"
				},
				{
					"name":"AWL63_19450 methylase\tK26273 SBNO; protein strawberry notch"
				},
				{
					"name":"AWL63_23560 methylase\tK26273 SBNO; protein strawberry notch"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Nucleoid associated proteins",
			"children":[
			{
				"name":"HNS (histone-like nucleoid structuring protein)"
			},
			{
				"name":"HU (heat unstable protein)",
				"children":[
				{
					"name":"AWL63_10575 integration host factor\tK03530 hupB; DNA-binding protein HU-beta"
				},
				{
					"name":"AWL63_16705 DNA-binding protein HU\tK03530 hupB; DNA-binding protein HU-beta"
				},
				{
					"name":"AWL63_18645 DNA-binding protein HU\tK03530 hupB; DNA-binding protein HU-beta"
				},
				{
					"name":"AWL63_19260 integration host factor\tK03530 hupB; DNA-binding protein HU-beta"
				},
				{
					"name":"AWL63_19655 integration host factor\tK03530 hupB; DNA-binding protein HU-beta"
				}
				]
			},
			{
				"name":"IHF (integration host factor)",
				"children":[
				{
					"name":"AWL63_06740 integration host factor subunit alpha\tK04764 ihfA; integration host factor subunit alpha"
				},
				{
					"name":"AWL63_14580 integration host factor subunit beta\tK05788 ihfB; integration host factor subunit beta"
				}
				]
			},
			{
				"name":"Other nucleoid associated proteins",
				"children":[
				{
					"name":"AWL63_11490 chromosomal replication initiation protein DnaA\tK02313 dnaA; chromosomal replication initiator protein"
				},
				{
					"name":"AWL63_08630 DNA-binding protein\tK11940 hspQ; heat shock protein HspQ"
				},
				{
					"name":"AWL63_02635 DNA starvation\/stationary phase protection protein\tK04047 dps; starvation-inducible DNA-binding protein"
				},
				{
					"name":"AWL63_15180 RNA-binding protein hfq\tK03666 hfq; host factor-I protein"
				},
				{
					"name":"AWL63_18470 LysR family transcriptional regulator\tK05596 argP; LysR family transcriptional regulator, arginine and lysine transport system\/DNA replication regulator"
				},
				{
					"name":"AWL63_00735 ArsR family transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"AWL63_21935 transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				}
				]
			}
			]
		},
		{
			"name":"Chromosome partitioning proteins",
			"children":[
			{
				"name":"MukBEF complex"
			},
			{
				"name":"Condensin-like complex",
				"children":[
				{
					"name":"AWL63_00845 chromosome segregation protein\tK03529 smc; chromosome segregation protein"
				},
				{
					"name":"AWL63_12260 chromosome segregation protein ScpA\tK05896 scpA; segregation and condensation protein A"
				},
				{
					"name":"AWL63_12265 segregation and condensation protein B\tK06024 scpB; segregation and condensation protein B"
				}
				]
			},
			{
				"name":"Divisome proteins",
				"children":[
				{
					"name":"AWL63_11880 cell division protein FtsA\tK03590 ftsA; cell division protein FtsA"
				},
				{
					"name":"AWL63_05720 cell division ATP-binding protein FtsE\tK09812 ftsE; cell division transport system ATP-binding protein"
				},
				{
					"name":"AWL63_11825 peptidoglycan glycosyltransferase\tK03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]"
				},
				{
					"name":"AWL63_06385 cell division protein FtsK\tK03466 ftsK; DNA segregation ATPase FtsK\/SpoIIIE, S-DNA-T family"
				},
				{
					"name":"AWL63_11875 cell division protein FtsQ\tK03589 ftsQ; cell division protein FtsQ"
				},
				{
					"name":"AWL63_11850 cell division protein FtsW\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
				},
				{
					"name":"AWL63_05725 permease\tK09811 ftsX; cell division transport system permease protein"
				},
				{
					"name":"AWL63_11885 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"AWL63_21800 hypothetical protein\tK09888 zapA; cell division protein ZapA"
				},
				{
					"name":"AWL63_01990 ATPase\tK06916 zapE; cell division protein ZapE"
				},
				{
					"name":"AWL63_11225 N-acetylmuramoyl-L-alanine amidase\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]"
				},
				{
					"name":"AWL63_03180 efflux transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AWL63_05570 efflux transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AWL63_06560 efflux transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AWL63_12545 efflux transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AWL63_15440 efflux transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Inhibitors of FtsZ assembly"
			},
			{
				"name":"Other chromosome partitioning proteins",
				"children":[
				{
					"name":"AWL63_15300 rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"AWL63_15305 rod shape-determining protein MreC\tK03570 mreC; rod shape-determining protein MreC"
				},
				{
					"name":"AWL63_15310 rod shape-determining protein MreD\tK03571 mreD; rod shape-determining protein MreD"
				},
				{
					"name":"AWL63_15320 rod shape-determining protein RodA\tK05837 rodA; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
				},
				{
					"name":"AWL63_04950 chromosome partitioning protein ParA\tK03496 parA; chromosome partitioning protein"
				},
				{
					"name":"AWL63_05130 ATPase\tK03496 parA; chromosome partitioning protein"
				},
				{
					"name":"AWL63_11775 chromosome partitioning protein ParA\tK03496 parA; chromosome partitioning protein"
				},
				{
					"name":"AWL63_16320 hypothetical protein\tK03496 parA; chromosome partitioning protein"
				},
				{
					"name":"AWL63_17930 chromosome partitioning protein ParA\tK03496 parA; chromosome partitioning protein"
				},
				{
					"name":"AWL63_23580 chromosome partitioning protein\tK03496 parA; chromosome partitioning protein"
				},
				{
					"name":"AWL63_04945 chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"AWL63_10790 chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"AWL63_16155 chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"AWL63_18440 chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"AWL63_19460 chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"AWL63_23490 chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"AWL63_23555 chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"AWL63_23575 chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"AWL63_20890 DNA topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"AWL63_21080 DNA topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"AWL63_04960 tRNA uridine 5-carboxymethylaminomethyl modification protein\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				},
				{
					"name":"AWL63_04955 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG\tK03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]"
				},
				{
					"name":"AWL63_14005 tRNA (uracil-5-)-methyltransferase\tK04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]"
				},
				{
					"name":"AWL63_01400 recombinase XerC\tK03733 xerC; integrase\/recombinase XerC"
				},
				{
					"name":"AWL63_09090 integrase\tK04763 xerD; integrase\/recombinase XerD"
				},
				{
					"name":"AWL63_10305 integrase\tK04763 xerD; integrase\/recombinase XerD"
				},
				{
					"name":"AWL63_10415 integrase\tK04763 xerD; integrase\/recombinase XerD"
				},
				{
					"name":"AWL63_11705 integrase\tK04763 xerD; integrase\/recombinase XerD"
				},
				{
					"name":"AWL63_13535 recombinase XerD\tK04763 xerD; integrase\/recombinase XerD"
				},
				{
					"name":"AWL63_22630 integrase\tK04763 xerD; integrase\/recombinase XerD"
				},
				{
					"name":"AWL63_22665 integrase\tK04763 xerD; integrase\/recombinase XerD"
				},
				{
					"name":"AWL63_09560 chromosome partitioning protein ParA\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				},
				{
					"name":"AWL63_11625 GTP-binding protein\tK03978 engB; GTP-binding protein"
				}
				]
			}
			]
		}
		]
	}
	]
}