{
	"name":"spaq01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases",
				"children":[
				{
					"name":"STNY_R32040 aac(6')-Iak; aminoglycoside N-acetyltransferase AAC(6')-Iak\tK18816 aac6-I; aminoglycoside 6'-N-acetyltransferase I [EC:2.3.1.82]"
				}
				]
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases",
				"children":[
				{
					"name":"STNY_R18290 aph(3')-II; APH(3')-II family aminoglycoside O-phosphotransferase\tK19300 aph3-II; aminoglycoside 3'-phosphotransferase II [EC:2.7.1.95]"
				},
				{
					"name":"STNY_R20210 aph(6); APH(6) family putative aminoglycoside O-phosphotransferase\tK04343 strB; streptomycin 6-kinase [EC:2.7.1.72]"
				},
				{
					"name":"STNY_R18320 aminoglycoside phosphotransferase family protein\tK18844 aph; spectinomycin phosphotransferase"
				}
				]
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"STNY_R24770 MFS transporter\tK08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter",
				"children":[
				{
					"name":"STNY_R23580 MFS transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Other",
				"children":[
				{
					"name":"STNY_R10380 qnr; Qnr family pentapeptide repeat protein\tK18555 qnr; fluoroquinolone resistance protein"
				}
				]
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"STNY_R00860 transmembrane BlaR protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"STNY_R34380 hypothetical protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"STNY_R34390 BlaI\/MecI\/CopY family transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"STNY_R33540 blaL2; L2 family class A beta-lactamase\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"STNY_R33610 two-component sensor histidine kinase\tK18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]"
				},
				{
					"name":"STNY_R33600 response regulator transcription factor\tK18073 parR; two-component system, OmpR family, response regulator ParR"
				},
				{
					"name":"STNY_R23340 heavy metal sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"STNY_R23350 heavy metal response regulator transcription factor\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"STNY_R12200 D-alanyl-D-alanine carboxypeptidase family protein\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"STNY_R04150 M15 family metallopeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]",
				"children":[
				{
					"name":"STNY_R31060 mprF; bifunctional lysylphosphatidylglycerol flippase\/synthetase MprF\tK14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3]"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]",
				"children":[
				{
					"name":"STNY_R02750 sensor histidine kinase\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
				},
				{
					"name":"STNY_R02740 response regulator transcription factor\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
				}
				]
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"STNY_R17610 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"STNY_R27920 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"STNY_R34190 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"STNY_R36820 smeD; multidrug efflux RND transporter periplasmic adaptor subunit SmeD\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"STNY_R17620 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"STNY_R27930 multidrug efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"STNY_R34180 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"STNY_R36810 smeE; multidrug efflux RND transporter permease subunit SmeE\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"STNY_R14060 emrC; multidrug efflux transporter outer membrane subunit EmrC\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"STNY_R14170 TolC family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"STNY_R36800 smeF; multidrug efflux RND transporter outer membrane subunit SmeF\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]",
				"children":[
				{
					"name":"STNY_R16900 efflux transporter outer membrane subunit\tK18300 oprN; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"STNY_R35540 TetR\/AcrR family transcriptional regulator\tK18301 mexL; TetR\/AcrR family transcriptional regulator, mexJK operon transcriptional repressor"
				},
				{
					"name":"STNY_R35530 efflux RND transporter periplasmic adaptor subunit\tK18302 mexJ; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"STNY_R35520 efflux RND transporter permease subunit\tK18303 mexK; multidrug efflux pump"
				},
				{
					"name":"STNY_R14060 emrC; multidrug efflux transporter outer membrane subunit EmrC\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"STNY_R14170 TolC family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"STNY_R36800 smeF; multidrug efflux RND transporter outer membrane subunit SmeF\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"STNY_R14060 emrC; multidrug efflux transporter outer membrane subunit EmrC\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"STNY_R14170 TolC family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"STNY_R36800 smeF; multidrug efflux RND transporter outer membrane subunit SmeF\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"STNY_R21430 helix-turn-helix domain-containing protein\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				},
				{
					"name":"STNY_R25840 heavy metal-responsive transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]",
				"children":[
				{
					"name":"STNY_R18980 HAMP domain-containing protein\tK18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]"
				},
				{
					"name":"STNY_R23290 HAMP domain-containing histidine kinase\tK18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]"
				},
				{
					"name":"STNY_R18990 response regulator transcription factor\tK18144 adeR; two-component system, OmpR family, response regulator AdeR"
				},
				{
					"name":"STNY_R19000 efflux RND transporter periplasmic adaptor subunit\tK18145 adeA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"STNY_R19010 multidrug efflux RND transporter permease subunit\tK18146 adeB; multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"STNY_R12910 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"STNY_R35560 TolC family outer membrane protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"STNY_R12910 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"STNY_R35560 TolC family outer membrane protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]",
				"children":[
				{
					"name":"STNY_R23710 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"STNY_R41400 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]",
				"children":[
				{
					"name":"STNY_R23580 MFS transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}