{
	"name":"spar04121",
	"children":[
	{
		"name":"Ubiquitins and ubiquitin-like proteins",
		"children":[
		{
			"name":"Ubiquitins",
			"children":[
			{
				"name":"SPRG_00046 50S ribosomal protein L40e\tK02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e"
			},
			{
				"name":"SPRG_10819 hypothetical protein\tK02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e"
			},
			{
				"name":"SPRG_15029 hypothetical protein\tK02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e"
			},
			{
				"name":"SPRG_06789 hypothetical protein\tK02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae"
			},
			{
				"name":"SPRG_12074 ubiquitin-40S ribosomal protein S27a\tK02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae"
			},
			{
				"name":"SPRG_13450 hypothetical protein\tK02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae"
			}
			]
		},
		{
			"name":"Ubiquitin-like proteins (UBLs)",
			"children":[
			{
				"name":"SPRG_14437 autophagy-like protein 8\tK08341 GABARAP; GABA(A) receptor-associated protein"
			},
			{
				"name":"SPRG_08396 hypothetical protein\tK08336 ATG12; ubiquitin-like protein ATG12"
			},
			{
				"name":"SPRG_08737 hypothetical protein\tK12162 UFM1; ubiquitin-fold modifier 1"
			},
			{
				"name":"SPRG_11081 hypothetical protein\tK28515 UBL3; membrane-anchored ubiquitin-fold protein"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin-activating enzymes (E1)",
		"children":[
		{
			"name":"Ubiquitin activating enzyme",
			"children":[
			{
				"name":"SPRG_00337 hypothetical protein\tK03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]"
			},
			{
				"name":"SPRG_05913 hypothetical protein\tK03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]"
			},
			{
				"name":"SPRG_12020 hypothetical protein\tK03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]"
			}
			]
		},
		{
			"name":"UBL-activating enzymes",
			"children":[
			{
				"name":"SPRG_20000 hypothetical protein\tK10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]"
			},
			{
				"name":"SPRG_07085 hypothetical protein\tK10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]"
			},
			{
				"name":"SPRG_17525 hypothetical protein\tK10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]"
			},
			{
				"name":"SPRG_11296 hypothetical protein\tK10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]"
			},
			{
				"name":"SPRG_21242 hypothetical protein\tK04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit"
			},
			{
				"name":"SPRG_05179 hypothetical protein\tK11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]"
			},
			{
				"name":"SPRG_09906 hypothetical protein\tK12164 UBA5; ubiquitin-like modifier-activating enzyme 5"
			},
			{
				"name":"SPRG_09911 hypothetical protein\tK12164 UBA5; ubiquitin-like modifier-activating enzyme 5"
			},
			{
				"name":"SPRG_06486 E1-like protein-activating enzyme G\tK08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin-conjugating enzymes (E2)",
		"children":[
		{
			"name":"Ubiquitin-conjugating enzymes",
			"children":[
			{
				"name":"SPRG_03371 ubiquitin-conjugating enzyme E2 2\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
			},
			{
				"name":"SPRG_05163 ubiquitin-conjugating enzyme E2 4\tK06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]"
			},
			{
				"name":"SPRG_04632 hypothetical protein\tK10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]"
			},
			{
				"name":"SPRG_03680 hypothetical protein\tK10578 UBE2J1; ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]"
			},
			{
				"name":"SPRG_02351 hypothetical protein\tK04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]"
			},
			{
				"name":"SPRG_07036 hypothetical protein\tK04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]"
			},
			{
				"name":"SPRG_02917 hypothetical protein\tK04649 UBE2K; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]"
			},
			{
				"name":"SPRG_01784 hypothetical protein\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
			},
			{
				"name":"SPRG_14896 hypothetical protein\tK10583 UBE2S; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]"
			},
			{
				"name":"SPRG_09951 hypothetical protein\tK13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]"
			},
			{
				"name":"SPRG_14794 hypothetical protein\tK10689 PEX4; peroxin-4 [EC:2.3.2.23]"
			}
			]
		},
		{
			"name":"UBL-conjugating enzymes",
			"children":[
			{
				"name":"SPRG_13325 hypothetical protein\tK10577 UBE2I; ubiquitin-conjugating enzyme E2 I"
			},
			{
				"name":"SPRG_06670 hypothetical protein\tK10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]"
			},
			{
				"name":"SPRG_07658 hypothetical protein\tK10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]"
			},
			{
				"name":"SPRG_06126 hypothetical protein\tK08343 ATG3; ubiquitin-like-conjugating enzyme ATG3"
			},
			{
				"name":"SPRG_04511 hypothetical protein\tK17888 ATG10L; ubiquitin-like-conjugating enzyme ATG10"
			},
			{
				"name":"SPRG_11230 ubiquitin-fold modifier-conjugating enzyme 1\tK12165 UFC1; ufm1-conjugating enzyme 1"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin ligases (E3)",
		"children":[
		{
			"name":"HECT type E3",
			"children":[
			{
				"name":"SPRG_03381 hypothetical protein\tK10587 UBE3A; ubiquitin-protein ligase E3 A [EC:2.3.2.26]"
			},
			{
				"name":"SPRG_00635 hypothetical protein\tK20803 UBE3D; ubiquitin-protein ligase E3 D [EC:2.3.2.26]"
			},
			{
				"name":"SPRG_02628 hypothetical protein\tK04678 SMURF; E3 ubiquitin ligase SMURF1\/2 [EC:2.3.2.26]"
			},
			{
				"name":"SPRG_03812 hypothetical protein\tK04678 SMURF; E3 ubiquitin ligase SMURF1\/2 [EC:2.3.2.26]"
			},
			{
				"name":"SPRG_09684 hypothetical protein\tK04678 SMURF; E3 ubiquitin ligase SMURF1\/2 [EC:2.3.2.26]"
			},
			{
				"name":"SPRG_09689 hypothetical protein\tK04678 SMURF; E3 ubiquitin ligase SMURF1\/2 [EC:2.3.2.26]"
			},
			{
				"name":"SPRG_11563 hypothetical protein\tK04678 SMURF; E3 ubiquitin ligase SMURF1\/2 [EC:2.3.2.26]"
			},
			{
				"name":"SPRG_16305 hypothetical protein\tK04678 SMURF; E3 ubiquitin ligase SMURF1\/2 [EC:2.3.2.26]"
			},
			{
				"name":"SPRG_18112 hypothetical protein\tK04678 SMURF; E3 ubiquitin ligase SMURF1\/2 [EC:2.3.2.26]"
			},
			{
				"name":"SPRG_19683 hypothetical protein\tK04678 SMURF; E3 ubiquitin ligase SMURF1\/2 [EC:2.3.2.26]"
			},
			{
				"name":"SPRG_04568 hypothetical protein\tK10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]"
			},
			{
				"name":"SPRG_12726 hypothetical protein\tK10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]"
			},
			{
				"name":"HECT type E3 associated proteins"
			}
			]
		},
		{
			"name":"U-box type E3",
			"children":[
			{
				"name":"SPRG_02553 hypothetical protein\tK10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]"
			},
			{
				"name":"SPRG_02670 hypothetical protein\tK10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]"
			},
			{
				"name":"SPRG_04386 hypothetical protein\tK09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]"
			},
			{
				"name":"SPRG_01820 hypothetical protein\tK10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]"
			},
			{
				"name":"SPRG_13995 hypothetical protein\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
			}
			]
		},
		{
			"name":"Single Ring-finger type E3",
			"children":[
			{
				"name":"BRE1 proteins",
				"children":[
				{
					"name":"SPRG_07200 hypothetical protein\tK10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"CBL proteins"
			},
			{
				"name":"SINA (Seven in absentia) proteins"
			},
			{
				"name":"Ligand of Numb proteins"
			},
			{
				"name":"March proteins",
				"children":[
				{
					"name":"SPRG_04760 hypothetical protein\tK10661 MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"MDM2\/MDM4 proteins"
			},
			{
				"name":"NFX1 proteins"
			},
			{
				"name":"Pellino proteins",
				"children":[
				{
					"name":"SPRG_04724 hypothetical protein\tK11964 PELI; pellino [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"Peripheral membrane proteins",
				"children":[
				{
					"name":"SPRG_00122 hypothetical protein\tK13346 PEX10; peroxin-10 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_02387 hypothetical protein\tK13345 PEX12; peroxin-12"
				},
				{
					"name":"SPRG_07518 hypothetical protein\tK06664 PEX2; peroxin-2 [EC:2.3.2.27 2.3.2.36]"
				}
				]
			},
			{
				"name":"RBR proteins",
				"children":[
				{
					"name":"SPRG_11280 hypothetical protein\tK11968 ARIH1; ariadne-1 [EC:2.3.2.31]"
				}
				]
			},
			{
				"name":"TRAF proteins"
			},
			{
				"name":"TRIM\/RBCC proteins"
			},
			{
				"name":"UBR box proteins",
				"children":[
				{
					"name":"SPRG_12411 hypothetical protein\tK11978 UBR3; E3 ubiquitin-protein ligase UBR3 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_18892 hypothetical protein\tK11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"ATL proteins"
			},
			{
				"name":"Other single Ring-finger type E3",
				"children":[
				{
					"name":"SPRG_19886 hypothetical protein\tK10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_05320 hypothetical protein\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_03565 hypothetical protein\tK10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_11082 hypothetical protein\tK22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_01233 hypothetical protein\tK15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_00931 hypothetical protein\tK10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_01778 hypothetical protein\tK10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_13360 hypothetical protein\tK10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_07123 hypothetical protein\tK10695 RNF1_2; E3 ubiquitin-protein ligase RNF1\/2 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_11190 hypothetical protein\tK10695 RNF1_2; E3 ubiquitin-protein ligase RNF1\/2 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_14425 hypothetical protein\tK10695 RNF1_2; E3 ubiquitin-protein ligase RNF1\/2 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_07002 hypothetical protein\tK22651 RNF4; E3 ubiquitin-protein ligase RNF4 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_01982 hypothetical protein\tK10666 RNF5_185; E3 ubiquitin-protein ligase RNF5\/185 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_05830 hypothetical protein\tK11982 RNF115_126; E3 ubiquitin-protein ligase RNF115\/126 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_14354 hypothetical protein\tK11984 SART1; U4\/U6.U5 tri-snRNP-associated protein 1"
				},
				{
					"name":"SPRG_14478 hypothetical protein\tK15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]"
				},
				{
					"name":"SPRG_06240 hypothetical protein\tK10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_03761 hypothetical protein\tK11985 TRAIP; TRAF-interacting protein [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_02446 hypothetical protein\tK22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_21606 hypothetical protein\tK22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_03927 hypothetical protein\tK15716 ZSWIM2; E3 ubiquitin-protein ligase ZSWIM2 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_07021 hypothetical protein\tK16280 RGLG; E3 ubiquitin-protein ligase RGLG [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_07024 hypothetical protein\tK16280 RGLG; E3 ubiquitin-protein ligase RGLG [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_07025 hypothetical protein\tK16280 RGLG; E3 ubiquitin-protein ligase RGLG [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_07026 hypothetical protein\tK16280 RGLG; E3 ubiquitin-protein ligase RGLG [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_07027 hypothetical protein\tK16280 RGLG; E3 ubiquitin-protein ligase RGLG [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_18994 hypothetical protein\tK16280 RGLG; E3 ubiquitin-protein ligase RGLG [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_15094 hypothetical protein\tK16283 SDIR1; E3 ubiquitin-protein ligase SDIR1 [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_16480 hypothetical protein\tK23788 TUL1; transmembrane E3 ubiquitin-protein ligase [EC:2.3.2.27]"
				},
				{
					"name":"SPRG_22291 hypothetical protein\tK23788 TUL1; transmembrane E3 ubiquitin-protein ligase [EC:2.3.2.27]"
				}
				]
			}
			]
		},
		{
			"name":"Atypical E3",
			"children":[
			{
				"name":"SPRG_10380 hypothetical protein\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
			}
			]
		},
		{
			"name":"UBL E3 ligases",
			"children":[
			{
				"name":"SPRG_11654 hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
			},
			{
				"name":"SPRG_14099 hypothetical protein\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
			},
			{
				"name":"SPRG_15225 hypothetical protein\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
			},
			{
				"name":"SPRG_06122 hypothetical protein\tK22755 UFL1; E3 UFM1-protein ligase 1 [EC:2.3.2.-]"
			},
			{
				"name":"SPRG_01673 hypothetical protein\tK17822 DCUN1D1_2; DCN1-like protein 1\/2"
			},
			{
				"name":"SPRG_05966 hypothetical protein\tK17822 DCUN1D1_2; DCN1-like protein 1\/2"
			}
			]
		},
		{
			"name":"Multi subunit type E3",
			"children":[
			{
				"name":"SCF complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"SPRG_11654 hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"SPRG_01077 hypothetical protein\tK03347 CUL1; cullin 1"
					}
					]
				},
				{
					"name":"Adaptor protein",
					"children":[
					{
						"name":"SPRG_05099 hypothetical protein\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"SPRG_05334 hypothetical protein\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"SPRG_05824 hypothetical protein\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"SPRG_17573 hypothetical protein\tK03094 SKP1; S-phase kinase-associated protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit (F-box)",
					"children":[
					{
						"name":"SPRG_00468 hypothetical protein\tK10260 FBXW7; F-box and WD-40 domain protein 7"
					},
					{
						"name":"SPRG_00692 hypothetical protein\tK10260 FBXW7; F-box and WD-40 domain protein 7"
					},
					{
						"name":"SPRG_10067 hypothetical protein\tK10260 FBXW7; F-box and WD-40 domain protein 7"
					},
					{
						"name":"SPRG_00705 hypothetical protein\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"SPRG_00858 hypothetical protein\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"SPRG_00940 hypothetical protein\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"SPRG_03988 hypothetical protein\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"SPRG_04103 hypothetical protein\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"SPRG_06023 hypothetical protein\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"SPRG_19203 hypothetical protein\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"SPRG_04452 hypothetical protein\tK10295 FBXO9; F-box protein 9"
					},
					{
						"name":"SPRG_16998 hypothetical protein\tK10295 FBXO9; F-box protein 9"
					}
					]
				}
				]
			},
			{
				"name":"Cul2 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"SPRG_11654 hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"SPRG_11463 hypothetical protein\tK03872 ELOC; elongin-C"
					}
					]
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul3 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"SPRG_11654 hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"SPRG_08828 hypothetical protein\tK03869 CUL3; cullin 3"
					}
					]
				},
				{
					"name":"Adoptor and target recognizing subunit (BTB)",
					"children":[
					{
						"name":"SPRG_02824 hypothetical protein\tK21916 KCTD6; BTB\/POZ domain-containing protein KCTD6"
					},
					{
						"name":"SPRG_05832 hypothetical protein\tK21916 KCTD6; BTB\/POZ domain-containing protein KCTD6"
					},
					{
						"name":"SPRG_00155 hypothetical protein\tK10523 SPOP; speckle-type POZ protein"
					}
					]
				}
				]
			},
			{
				"name":"Cul4 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"SPRG_11654 hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"SPRG_01614 hypothetical protein\tK10609 CUL4; cullin 4"
					}
					]
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"SPRG_04038 hypothetical protein\tK10610 DDB1; DNA damage-binding protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit (DCAF)",
					"children":[
					{
						"name":"SPRG_12152 hypothetical protein\tK10570 ERCC8; DNA excision repair protein ERCC-8"
					},
					{
						"name":"SPRG_03810 hypothetical protein\tK11792 DDA1; DET1- and DDB1-associated protein 1"
					},
					{
						"name":"SPRG_08647 hypothetical protein\tK11793 CRBN; cereblon"
					},
					{
						"name":"SPRG_08673 hypothetical protein\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]"
					},
					{
						"name":"SPRG_19738 hypothetical protein\tK11790 DTL; denticleless"
					},
					{
						"name":"SPRG_08168 hypothetical protein\tK11799 DCAF4; DDB1- and CUL4-associated factor 4"
					},
					{
						"name":"SPRG_07291 hypothetical protein\tK11805 DCAF7; DDB1- and CUL4-associated factor 7"
					},
					{
						"name":"SPRG_01763 hypothetical protein\tK11807 WDTC1; WD and tetratricopeptide repeats protein 1"
					},
					{
						"name":"SPRG_03960 hypothetical protein\tK11801 DCAF11; DDB1- and CUL4-associated factor 11"
					},
					{
						"name":"SPRG_18842 hypothetical protein\tK11806 DCAF13; DDB1- and CUL4-associated factor 13"
					},
					{
						"name":"SPRG_12989 hypothetical protein\tK11798 BRWD1_3; bromodomain and WD repeat domain containing protein 1\/3"
					},
					{
						"name":"SPRG_01131 hypothetical protein\tK24752 WDR70; WD repeat-containing protein 70"
					}
					]
				}
				]
			},
			{
				"name":"Cul5 complex",
				"children":[
				{
					"name":"Ring finger protein"
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"SPRG_11463 hypothetical protein\tK03872 ELOC; elongin-C"
					}
					]
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul7 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"SPRG_11654 hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adaptor protein",
					"children":[
					{
						"name":"SPRG_05099 hypothetical protein\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"SPRG_05334 hypothetical protein\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"SPRG_05824 hypothetical protein\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"SPRG_17573 hypothetical protein\tK03094 SKP1; S-phase kinase-associated protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul8 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"SPRG_11654 hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adaptor protein"
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul9 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"SPRG_11654 hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				}
				]
			},
			{
				"name":"APC\/C",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"SPRG_01620 anaphase-promoting complex subunit 11\tK03358 APC11; anaphase-promoting complex subunit 11"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"SPRG_00198 hypothetical protein\tK03349 APC2; anaphase-promoting complex subunit 2"
					}
					]
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"SPRG_06757 hypothetical protein\tK03363 CDC20; cell division cycle 20, cofactor of APC complex"
					},
					{
						"name":"SPRG_13457 hypothetical protein\tK03363 CDC20; cell division cycle 20, cofactor of APC complex"
					},
					{
						"name":"SPRG_17665 hypothetical protein\tK03363 CDC20; cell division cycle 20, cofactor of APC complex"
					},
					{
						"name":"SPRG_18828 hypothetical protein\tK03363 CDC20; cell division cycle 20, cofactor of APC complex"
					},
					{
						"name":"SPRG_09929 hypothetical protein\tK03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex"
					}
					]
				},
				{
					"name":"Other subunits",
					"children":[
					{
						"name":"SPRG_17025 hypothetical protein\tK03348 APC1; anaphase-promoting complex subunit 1"
					},
					{
						"name":"SPRG_22263 hypothetical protein\tK03348 APC1; anaphase-promoting complex subunit 1"
					},
					{
						"name":"SPRG_11712 hypothetical protein\tK03350 APC3; anaphase-promoting complex subunit 3"
					},
					{
						"name":"SPRG_11649 hypothetical protein\tK03351 APC4; anaphase-promoting complex subunit 4"
					},
					{
						"name":"SPRG_13376 hypothetical protein\tK03352 APC5; anaphase-promoting complex subunit 5"
					},
					{
						"name":"SPRG_00695 hypothetical protein\tK03353 APC6; anaphase-promoting complex subunit 6"
					},
					{
						"name":"SPRG_20641 hypothetical protein\tK03355 APC8; anaphase-promoting complex subunit 8"
					},
					{
						"name":"SPRG_05703 hypothetical protein\tK03357 APC10; anaphase-promoting complex subunit 10"
					},
					{
						"name":"SPRG_19544 hypothetical protein\tK12456 APC13; anaphase-promoting complex subunit 13"
					}
					]
				}
				]
			},
			{
				"name":"BRCC complex",
				"children":[
				{
					"name":"SPRG_12333 DNA repair protein RAD51 1\tK04482 RAD51; DNA repair protein RAD51"
				},
				{
					"name":"SPRG_21155 hypothetical protein\tK04482 RAD51; DNA repair protein RAD51"
				}
				]
			},
			{
				"name":"KPC complex"
			},
			{
				"name":"LUBAC complex"
			},
			{
				"name":"CTLH complex",
				"children":[
				{
					"name":"SPRG_02822 hypothetical protein\tK23334 RANBP9_10; Ran-binding protein 9\/10"
				},
				{
					"name":"SPRG_08347 hypothetical protein\tK23334 RANBP9_10; Ran-binding protein 9\/10"
				},
				{
					"name":"SPRG_08355 hypothetical protein\tK23334 RANBP9_10; Ran-binding protein 9\/10"
				}
				]
			},
			{
				"name":"ERAD complex",
				"children":[
				{
					"name":"SPRG_01779 hypothetical protein\tK23340 TMUB; transmembrane and ubiquitin-like domain-containing protein"
				}
				]
			},
			{
				"name":"LMBR1L-GP78-UBAC2 complex",
				"children":[
				{
					"name":"SPRG_12179 hypothetical protein\tK25216 UBAC2; ubiquitin-associated domain-containing protein 2"
				}
				]
			},
			{
				"name":"STUB1-CHIC2  complex",
				"children":[
				{
					"name":"SPRG_04386 hypothetical protein\tK09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"SLX5-SLX8 complex"
			},
			{
				"name":"Multi subunit type E3 associated proteins",
				"children":[
				{
					"name":"SPRG_18016 hypothetical protein\tK17263 CAND1; cullin-associated NEDD8-dissociated protein 1"
				},
				{
					"name":"SPRG_20043 hypothetical protein\tK22558 COMMD2; COMM domain containing 2"
				},
				{
					"name":"SPRG_13460 hypothetical protein\tK22560 COMMD4; COMM domain containing 4"
				},
				{
					"name":"SPRG_16890 hypothetical protein\tK22560 COMMD4; COMM domain containing 4"
				},
				{
					"name":"SPRG_02158 hypothetical protein\tK22561 COMMD5; COMM domain containing 5"
				},
				{
					"name":"SPRG_04255 hypothetical protein\tK22563 COMMD7; COMM domain containing 7"
				},
				{
					"name":"SPRG_10426 hypothetical protein\tK22564 COMMD8; COMM domain containing 8"
				},
				{
					"name":"SPRG_06004 hypothetical protein\tK22565 COMMD9; COMM domain containing 9"
				},
				{
					"name":"SPRG_13928 hypothetical protein\tK22566 COMMD10; COMM domain containing 10"
				},
				{
					"name":"SPRG_02284 hypothetical protein\tK23343 CCDC22; coiled-coil domain-containing protein 22"
				},
				{
					"name":"SPRG_19913 hypothetical protein\tK23344 DDRGK1; DDRGK domain-containing protein 1"
				},
				{
					"name":"SPRG_10988 hypothetical protein\tK24350 UBXN7; UBX domain-containing protein 7"
				},
				{
					"name":"SPRG_13952 hypothetical protein\tK26163 PACRG; parkin coregulated gene protein"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Deubiquitinating enzyme (DUB)",
		"children":[
		{
			"name":"Ubiquitin-specific proteases (UBPs)",
			"children":[
			{
				"name":"UCH",
				"children":[
				{
					"name":"SPRG_02878 hypothetical protein\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_10207 hypothetical protein\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_11467 hypothetical protein\tK05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"UBP\/USP",
				"children":[
				{
					"name":"SPRG_20028 hypothetical protein\tK11833 USP2; ubiquitin carboxyl-terminal hydrolase 2 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_07945 hypothetical protein\tK11835 USP4_11; ubiquitin carboxyl-terminal hydrolase 4\/11 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_04749 hypothetical protein\tK11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5\/13 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_07869 hypothetical protein\tK11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_08958 hypothetical protein\tK11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_20178 hypothetical protein\tK11842 USP12_46; ubiquitin carboxyl-terminal hydrolase 12\/46 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_18899 hypothetical protein\tK11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_05645 hypothetical protein\tK11851 USP30; ubiquitin carboxyl-terminal hydrolase 30 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_16854 hypothetical protein\tK11851 USP30; ubiquitin carboxyl-terminal hydrolase 30 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_04658 hypothetical protein\tK11853 USP34; ubiquitin carboxyl-terminal hydrolase 34 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_20024 hypothetical protein\tK11855 USP36_42; ubiquitin carboxyl-terminal hydrolase 36\/42 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_12789 hypothetical protein\tK11857 USP47; ubiquitin carboxyl-terminal hydrolase 47 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_12891 hypothetical protein\tK11857 USP47; ubiquitin carboxyl-terminal hydrolase 47 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_15567 hypothetical protein\tK11857 USP47; ubiquitin carboxyl-terminal hydrolase 47 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"OTU",
				"children":[
				{
					"name":"SPRG_05489 hypothetical protein\tK13717 OTUD3; OTU domain-containing protein 3 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_14549 hypothetical protein\tK13717 OTUD3; OTU domain-containing protein 3 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_14827 hypothetical protein\tK12655 OTUD5; OTU domain-containing protein 5 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_07060 hypothetical protein\tK18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_17802 hypothetical protein\tK18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"MJD",
				"children":[
				{
					"name":"SPRG_11291 hypothetical protein\tK15235 JOSD; josephin [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"MINDY",
				"children":[
				{
					"name":"SPRG_09336 hypothetical protein\tK01309 MINDY1_2; ubiquitin carboxyl-terminal hydrolase MINDY-1\/2 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_07055 hypothetical protein\tK22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3\/4 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_20176 hypothetical protein\tK22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3\/4 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"JAMM",
				"children":[
				{
					"name":"SPRG_11242 26S proteasome non-ATPase regulatory subunit 14\tK03030 PSMD14; 26S proteasome regulatory subunit N11"
				},
				{
					"name":"SPRG_12561 hypothetical protein\tK11866 STAMBP; STAM-binding protein [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"PPPDE",
				"children":[
				{
					"name":"SPRG_04142 hypothetical protein\tK22763 DESI2; deubiquitinase DESI2 [EC:3.4.19.12]"
				},
				{
					"name":"SPRG_17305 hypothetical protein\tK22763 DESI2; deubiquitinase DESI2 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"ZUFSP"
			},
			{
				"name":"BRISC complex"
			}
			]
		},
		{
			"name":"UBL-specific proteases (ULPs)",
			"children":[
			{
				"name":"SPRG_08829 hypothetical protein\tK08592 SENP1; sentrin-specific protease 1 [EC:3.4.22.68]"
			},
			{
				"name":"SPRG_19192 hypothetical protein\tK08596 SENP7; sentrin-specific protease 7 [EC:3.4.22.68]"
			},
			{
				"name":"SPRG_04155 hypothetical protein\tK08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]"
			},
			{
				"name":"SPRG_02878 hypothetical protein\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
			},
			{
				"name":"SPRG_10207 hypothetical protein\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
			},
			{
				"name":"SPRG_00133 hypothetical protein\tK22762 DESI1; desumoylating isopeptidase 1 [EC:3.4.-.-]"
			},
			{
				"name":"COP9 signalosome (CSN) complex",
				"children":[
				{
					"name":"SPRG_19085 hypothetical protein\tK12175 GPS1; COP9 signalosome complex subunit 1"
				},
				{
					"name":"SPRG_02152 hypothetical protein\tK12176 COPS2; COP9 signalosome complex subunit 2"
				},
				{
					"name":"SPRG_07895 hypothetical protein\tK12176 COPS2; COP9 signalosome complex subunit 2"
				},
				{
					"name":"SPRG_19080 hypothetical protein\tK12177 COPS3; COP9 signalosome complex subunit 3"
				},
				{
					"name":"SPRG_08000 hypothetical protein\tK12178 COPS4; COP9 signalosome complex subunit 4"
				},
				{
					"name":"SPRG_10630 hypothetical protein\tK09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]"
				},
				{
					"name":"SPRG_10677 hypothetical protein\tK12179 COPS6; COP9 signalosome complex subunit 6"
				},
				{
					"name":"SPRG_08441 hypothetical protein\tK12180 COPS7; COP9 signalosome complex subunit 7"
				},
				{
					"name":"SPRG_14279 hypothetical protein\tK12181 COPS8; COP9 signalosome complex subunit 8"
				}
				]
			}
			]
		}
		]
	}
	]
}