{
	"name":"sphp03000",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Basic leucine zipper (bZIP)",
			"children":[
			{
				"name":"AP-1(-like) components, Jun"
			},
			{
				"name":"AP-1(-like) components, Fos"
			},
			{
				"name":"AP-1(-like) components, Maf"
			},
			{
				"name":"AP-1(-like) components, NF-E2"
			},
			{
				"name":"AP-1(-like) components, Fungal regulators"
			},
			{
				"name":"AP-1(-like) components, CRE-BP\/ATF"
			},
			{
				"name":"CREB"
			},
			{
				"name":"C\/EBP-like factors"
			},
			{
				"name":"bZIP\/PAR"
			},
			{
				"name":"Plant bZIP factors"
			},
			{
				"name":"ZIP only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix (bHLH)",
			"children":[
			{
				"name":"Ubiquitous (class A) factors"
			},
			{
				"name":"Myogenic transcription factors"
			},
			{
				"name":"Achaete-Scute"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Lymphoid factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesodermal Twist-like factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, HEN"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesp"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Atonal"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Pancreatic factors"
			},
			{
				"name":"Hairy, Hairy\/E(SPL)"
			},
			{
				"name":"Hairy, Fungal regulators"
			},
			{
				"name":"Factors with PAS domain"
			},
			{
				"name":"Yabby"
			},
			{
				"name":"INO"
			},
			{
				"name":"HLH domain only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix\/leucine zipper (bHLH-ZIP)",
			"children":[
			{
				"name":"Ubiquitous bHLH-ZIP factors"
			},
			{
				"name":"Cell cycle controlling factors, Myc"
			},
			{
				"name":"Cell cycle controlling factors, Mad\/Max"
			},
			{
				"name":"Other bHLH-ZIP factors"
			}
			]
		},
		{
			"name":"Other basic domains",
			"children":[
			{
				"name":"NF-1"
			},
			{
				"name":"RF-X"
			},
			{
				"name":"AP-2 (bHSH)"
			}
			]
		},
		{
			"name":"Zinc finger",
			"children":[
			{
				"name":"Cys4 thyroid hormone receptor-like"
			},
			{
				"name":"Cys4 hepatocyte nuclear factor 4-like"
			},
			{
				"name":"Cys4 estrogen receptor-like"
			},
			{
				"name":"Cys4 nerve growth factor IB-like"
			},
			{
				"name":"Cys4 Fushi tarazu-F1-like"
			},
			{
				"name":"Cys4 germ cell nuclear factor"
			},
			{
				"name":"Cys4 Knirps\/DAX1-like"
			},
			{
				"name":"Cys4 GATA-factors"
			},
			{
				"name":"Cys2His2 SP\/KLF family and related proteins"
			},
			{
				"name":"Cys2His2 GLI-like"
			},
			{
				"name":"Cys2His2 Snail"
			},
			{
				"name":"Cys2His2 BTB-ZF factors"
			},
			{
				"name":"Cys2His2 BED"
			},
			{
				"name":"Cys2His2 PRDM"
			},
			{
				"name":"Cys2His2 metabolic regulators in fungi"
			},
			{
				"name":"Cys2His2 others"
			},
			{
				"name":"Cys2HisCys zinc factors"
			},
			{
				"name":"Cys3His zinc factors"
			},
			{
				"name":"Cys2CysHis zinc factors"
			},
			{
				"name":"CXXC CpG-binding proteins",
				"children":[
				{
					"name":"LH20_04670 hypothetical protein\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"LH20_06760 cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"LH20_17815 C-5 cytosine-specific DNA methylase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Cys6 metabolic regulators in fungi"
			},
			{
				"name":"Other zinc fingers"
			}
			]
		},
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"Homeo domain ANTP: HOXL"
			},
			{
				"name":"Homeo domain ANTP: NKL"
			},
			{
				"name":"Homeo domain Paired-related"
			},
			{
				"name":"Homeo domain LIM"
			},
			{
				"name":"Homeo domain POU"
			},
			{
				"name":"Homeo domain SINE"
			},
			{
				"name":"Homeo domain ZF"
			},
			{
				"name":"Homeo domain CUT"
			},
			{
				"name":"Homeo domain PROS"
			},
			{
				"name":"Homeo domain TALE"
			},
			{
				"name":"Homeo domain other"
			},
			{
				"name":"Fork head\/winged helix developmental regulators"
			},
			{
				"name":"Fork head\/winged helix tissue-specific regulators"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, E2F"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, DP"
			},
			{
				"name":"Fork head\/winged helix other regulators"
			},
			{
				"name":"Stork head\/winged helix factors"
			},
			{
				"name":"Heat shock factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-like factors"
			},
			{
				"name":"Tryptophan clusters Ets-type"
			},
			{
				"name":"Tryptophan clusters interferon-regulating factors"
			},
			{
				"name":"TEA domain"
			},
			{
				"name":"ARID"
			}
			]
		},
		{
			"name":"beta-Scaffold factors with minor groove contacts",
			"children":[
			{
				"name":"RHR (Rel homology region) Rel\/Ankyrin"
			},
			{
				"name":"RHR (Rel homology region) Ankyrin only"
			},
			{
				"name":"RHR (Rel homology region) NF-AT"
			},
			{
				"name":"STAT"
			},
			{
				"name":"p53"
			},
			{
				"name":"MADS-box regulators of differentiation, MEF-2"
			},
			{
				"name":"MADS-box regulators of differentiation, Homeotic genes"
			},
			{
				"name":"MADS-box regulators of differentiation, Yeast regulators"
			},
			{
				"name":"MADS-box responders to external signals"
			},
			{
				"name":"SAND domain-containing proteins"
			},
			{
				"name":"TATA-binding proteins"
			},
			{
				"name":"HMG SOX"
			},
			{
				"name":"HMG TCF-1"
			},
			{
				"name":"HMG TOX"
			},
			{
				"name":"HMG2-related"
			},
			{
				"name":"UBF"
			},
			{
				"name":"Other HMG box factors"
			},
			{
				"name":"Heteromeric CCAAT factors"
			},
			{
				"name":"Grainyhead"
			},
			{
				"name":"Cold-shock domain factors, DbpA-like"
			},
			{
				"name":"Cold-shock domain factors, YB-1\/DbpB-like"
			},
			{
				"name":"Cold-shock domain factors, FRG Y2-like"
			},
			{
				"name":"Runt"
			},
			{
				"name":"MYRF"
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"HMGI(Y)"
			},
			{
				"name":"NUPR"
			},
			{
				"name":"Pocket domain Rb"
			},
			{
				"name":"Pocket domain CBP"
			},
			{
				"name":"T-box"
			},
			{
				"name":"DMRT"
			},
			{
				"name":"LRRFIP"
			},
			{
				"name":"TCP"
			},
			{
				"name":"AP2\/ERF"
			},
			{
				"name":"WRKY"
			},
			{
				"name":"LOB"
			},
			{
				"name":"GRAS"
			},
			{
				"name":"NAC"
			},
			{
				"name":"Copper-fist proteins fungal regulators"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"AraC family",
				"children":[
				{
					"name":"LH20_03790 AraC family transcriptional regulator\tK07506 K07506; AraC family transcriptional regulator"
				},
				{
					"name":"LH20_16880 6-O-methylguanine DNA methyltransferase\tK10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response \/ methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]"
				}
				]
			},
			{
				"name":"LysR family",
				"children":[
				{
					"name":"LH20_01900 LysR family transcriptional regulator, glycine cleavage system transcriptional activator\tK03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator"
				},
				{
					"name":"LH20_06835 LysR family transcriptional regulator\tK03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator"
				},
				{
					"name":"LH20_09570 LysR family transcriptional regulator, glycine cleavage system transcriptional activator\tK03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator"
				},
				{
					"name":"LH20_10780 hypothetical protein\tK03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator"
				},
				{
					"name":"LH20_12280 LysR family transcriptional regulator\tK03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator"
				},
				{
					"name":"LH20_16560 LysR family transcriptional regulator\tK03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator"
				},
				{
					"name":"LH20_09840 LysR family transcriptional regulator\tK04761 oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator"
				},
				{
					"name":"LH20_21990 hyaluronan synthase\tK04761 oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator"
				},
				{
					"name":"LH20_07165 LysR family transcriptional regulator\tK17850 ampR; LysR family transcriptional regulator, regulator of gene expression of beta-lactamase"
				},
				{
					"name":"LH20_19260 hypothetical protein\tK19338 nac; LysR family transcriptional regulator, nitrogen assimilation regulatory protein"
				},
				{
					"name":"LH20_19510 hypothetical protein\tK19338 nac; LysR family transcriptional regulator, nitrogen assimilation regulatory protein"
				},
				{
					"name":"LH20_19555 LysR family transcriptional regulator\tK19338 nac; LysR family transcriptional regulator, nitrogen assimilation regulatory protein"
				},
				{
					"name":"LH20_19590 hypothetical protein\tK19338 nac; LysR family transcriptional regulator, nitrogen assimilation regulatory protein"
				}
				]
			},
			{
				"name":"DeoR family"
			},
			{
				"name":"LacI family",
				"children":[
				{
					"name":"LH20_06990 hypothetical protein\tK02529 galR; LacI family transcriptional regulator, galactose operon repressor"
				},
				{
					"name":"LH20_18750 LacI family transcriptional regulator\tK02529 galR; LacI family transcriptional regulator, galactose operon repressor"
				}
				]
			},
			{
				"name":"GntR family",
				"children":[
				{
					"name":"LH20_14935 GntR family transcriptional regulator\tK05836 hutC; GntR family transcriptional regulator, histidine utilization repressor"
				},
				{
					"name":"LH20_19715 histidine utilization repressor\tK05836 hutC; GntR family transcriptional regulator, histidine utilization repressor"
				},
				{
					"name":"LH20_00345 GntR family transcriptional regulator\tK19775 exuR; GntR family transcriptional regulator, hexuronate regulon transcriptional repressor"
				},
				{
					"name":"LH20_04150 GntR family transcriptional regulator\tK00375 K00375; GntR family transcriptional regulator \/ MocR family aminotransferase"
				}
				]
			},
			{
				"name":"TetR\/AcrR family",
				"children":[
				{
					"name":"LH20_18020 TetR family transcriptional regulator\tK19335 bdcR; TetR\/AcrR family transcriptional regulator, repressor for divergent bdcA"
				}
				]
			},
			{
				"name":"Lrp\/AsnC family",
				"children":[
				{
					"name":"LH20_07460 ArsR family transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"LH20_08375 AsnC family transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"LH20_10510 AsnC family transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"LH20_21240 AsnC family transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"LH20_00330 transcriptional regulator\tK05800 decR; Lrp\/AsnC family transcriptional regulator, cysteine-sensing transcriptional activator"
				},
				{
					"name":"LH20_07380 AsnC family transcriptional regulator\tK05800 decR; Lrp\/AsnC family transcriptional regulator, cysteine-sensing transcriptional activator"
				},
				{
					"name":"LH20_19920 hypothetical protein\tK05800 decR; Lrp\/AsnC family transcriptional regulator, cysteine-sensing transcriptional activator"
				}
				]
			},
			{
				"name":"LuxR family",
				"children":[
				{
					"name":"LH20_20415 LuxR family transcriptional regulator\tK19731 cciR; LuxR family transcriptional regulator, quorum-sensing system regulator CciR"
				}
				]
			},
			{
				"name":"MarR family"
			},
			{
				"name":"MerR family",
				"children":[
				{
					"name":"LH20_00210 MerR family transcriptional regulator\tK08365 merR; MerR family transcriptional regulator, mercuric resistance operon regulatory protein"
				},
				{
					"name":"LH20_20330 transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				},
				{
					"name":"LH20_02065 transcriptional regulator\tK13639 soxR; MerR family transcriptional regulator, redox-sensitive transcriptional activator SoxR"
				}
				]
			},
			{
				"name":"Fur family",
				"children":[
				{
					"name":"LH20_09385 Fur family transcriptional regulator\tK03711 fur; Fur family transcriptional regulator, ferric uptake regulator"
				},
				{
					"name":"LH20_02450 Fur family transcriptional regulator\tK09823 zur; Fur family transcriptional regulator, zinc uptake regulator"
				}
				]
			},
			{
				"name":"IclR family"
			},
			{
				"name":"CRP\/FNR family",
				"children":[
				{
					"name":"LH20_08975 CRP\/FNR family transcriptional regulator, anaerobic regulatory protein\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein"
				},
				{
					"name":"LH20_09955 Crp\/Fnr family transcriptional regulator\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein"
				},
				{
					"name":"LH20_13770 hypothetical protein\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein"
				},
				{
					"name":"LH20_16065 cyclic nucleotide-binding protein\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein"
				},
				{
					"name":"LH20_13000 Crp\/Fnr family transcriptional regulator\tK01420 fnr; CRP\/FNR family transcriptional regulator, anaerobic regulatory protein"
				},
				{
					"name":"LH20_13015 cyclic nucleotide-binding protein\tK21564 nnrR; CRP\/FNR family transcriptional regulator, nitrogen oxide reductase regulator"
				}
				]
			},
			{
				"name":"Rrf2 family",
				"children":[
				{
					"name":"LH20_03460 Rrf2 family transcriptional regulator\tK13771 nsrR; Rrf2 family transcriptional regulator, nitric oxide-sensitive transcriptional repressor"
				}
				]
			},
			{
				"name":"ArsR family",
				"children":[
				{
					"name":"LH20_20055 ArsR family transcriptional regulator\tK03892 arsR; ArsR family transcriptional regulator, arsenate\/arsenite\/antimonite-responsive transcriptional repressor"
				},
				{
					"name":"LH20_22555 ArsR family transcriptional regulator\tK03892 arsR; ArsR family transcriptional regulator, arsenate\/arsenite\/antimonite-responsive transcriptional repressor"
				},
				{
					"name":"LH20_17270 ArsR family transcriptional regulator\tK22042 hlyU; ArsR family transcriptional regulator, virulence genes transcriptional regulator"
				}
				]
			},
			{
				"name":"XRE family",
				"children":[
				{
					"name":"LH20_11695 XRE family transcriptional regulator\tK21686 prpR; XRE family transcriptional regulator, fatty acid utilization regulator"
				},
				{
					"name":"LH20_09805 transcriptional regulator\tK07110 ramB; XRE family transcriptional regulator, fatty acid utilization regulator"
				}
				]
			},
			{
				"name":"PadR family"
			},
			{
				"name":"Other families",
				"children":[
				{
					"name":"LH20_02220 CopY family transcriptional repressor\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"LH20_16300 transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"LH20_11460 biotin--protein ligase\tK03524 birA; BirA family transcriptional regulator, biotin operon repressor \/ biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]"
				},
				{
					"name":"LH20_18925 sigma-54 dependent transcription regulator\tK10941 flrA; sigma-54 dependent transcriptional regulator, flagellar regulatory protein"
				},
				{
					"name":"LH20_06405 DNA-binding protein\tK07726 K07726; putative transcriptional regulator"
				},
				{
					"name":"LH20_06440 XRE family transcriptional regulator\tK07726 K07726; putative transcriptional regulator"
				},
				{
					"name":"LH20_02680 Cro\/Cl family transcriptional regulator\tK07729 K07729; putative transcriptional regulator"
				},
				{
					"name":"LH20_10365 Cro\/Cl family transcriptional regulator\tK07729 K07729; putative transcriptional regulator"
				},
				{
					"name":"LH20_16040 XRE family transcriptional regulator\tK07729 K07729; putative transcriptional regulator"
				},
				{
					"name":"LH20_17785 hypothetical protein\tK07729 K07729; putative transcriptional regulator"
				}
				]
			}
			]
		},
		{
			"name":"Ribbon-helix-helix",
			"children":[
			{
				"name":"CopG family"
			},
			{
				"name":"Other families",
				"children":[
				{
					"name":"LH20_07455 putA; transcriptional regulator\tK13821 putA; RHH-type transcriptional regulator, proline utilization regulon repressor \/ proline dehydrogenase \/ delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]"
				}
				]
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"BglG family"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"LH20_06215 transcriptional regulator\tK23239 frmR; FrmR\/RcnR family transcriptional regulator, repressor of frmRAB operon"
				},
				{
					"name":"LH20_20230 transcriptional regulator\tK23239 frmR; FrmR\/RcnR family transcriptional regulator, repressor of frmRAB operon"
				},
				{
					"name":"LH20_02485 BolA family transcriptional regulator\tK05527 bolA; BolA family transcriptional regulator, general stress-responsive regulator"
				},
				{
					"name":"LH20_01765 plasmid stablization protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"LH20_05310 plasmid stablization protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"LH20_05580 DNA-binding protein\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"LH20_17225 chromosome partitioning protein, ParB family\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"LH20_20395 plasmid partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"LH20_20685 plasmid stablization protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"LH20_20890 chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"LH20_22020 chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"LH20_22620 chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"LH20_22750 chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"LH20_08695 CarD family transcriptional regulator\tK07736 carD; CarD family transcriptional regulator, regulator of rRNA transcription"
				},
				{
					"name":"LH20_08740 hrcA; heat-inducible transcription repressor\tK03705 hrcA; heat-inducible transcriptional repressor"
				},
				{
					"name":"LH20_16755 ATPase AAA\tK03974 pspF; psp operon transcriptional activator"
				},
				{
					"name":"LH20_12365 elongation factor GreAB\tK06140 rnk; regulator of nucleoside diphosphate kinase"
				},
				{
					"name":"LH20_01995 KUP system potassium uptake protein\tK07733 alpA; prophage regulatory protein"
				},
				{
					"name":"LH20_06050 DNA-binding protein\tK07733 alpA; prophage regulatory protein"
				},
				{
					"name":"LH20_09270 AlpA family transcriptional regulator\tK07733 alpA; prophage regulatory protein"
				},
				{
					"name":"LH20_17165 phage transcriptional regulator, AlpA\tK07733 alpA; prophage regulatory protein"
				},
				{
					"name":"LH20_01430 negative transcriptional regulator\tK07734 paiB; transcriptional regulator"
				},
				{
					"name":"LH20_04155 transcriptional regulator\tK07734 paiB; transcriptional regulator"
				},
				{
					"name":"LH20_09320 transcriptional regulator\tK07734 paiB; transcriptional regulator"
				},
				{
					"name":"LH20_16455 hypothetical protein\tK07735 algH; putative transcriptional regulator"
				},
				{
					"name":"LH20_02880 molecular chaperone DnaK\tK06204 dksA; RNA polymerase-binding transcription factor"
				},
				{
					"name":"LH20_07530 NrdR family transcriptional regulator\tK07738 nrdR; transcriptional repressor NrdR"
				},
				{
					"name":"LH20_14560 hypothetical protein\tK03925 mraZ; transcriptional regulator MraZ"
				}
				]
			}
			]
		}
		]
	}
	]
}