{
	"name":"sphp03029",
	"children":[
	{
		"name":"Mitochondrial DNA transcription, translation, and replication factors",
		"children":[
		{
			"name":"Mitochondrial DNA-encoded proteins",
			"children":[
			{
				"name":"Mitochondrial respiratory chain complex I"
			},
			{
				"name":"Mitochondrial respiratory chain complex III",
				"children":[
				{
					"name":"LH20_10585 cytochrome B\tK00412 CYTB; ubiquinol-cytochrome c reductase cytochrome b subunit"
				}
				]
			},
			{
				"name":"Cytochrome c oxidase"
			},
			{
				"name":"F-type ATPase"
			}
			]
		},
		{
			"name":"Mitochondrial transcription and translation factors",
			"children":[
			{
				"name":"Mitochondrial RNA polymerase"
			},
			{
				"name":"Mitochondrial transcription factors"
			},
			{
				"name":"Mitochondrial translation factors",
				"children":[
				{
					"name":"LH20_03430 translation initiation factor IF-2\tK02519 infB; translation initiation factor IF-2"
				},
				{
					"name":"LH20_04385 translation initiation factor IF-3\tK02520 infC; translation initiation factor IF-3"
				},
				{
					"name":"LH20_13990 elongation factor Ts\tK02357 tsf; elongation factor Ts"
				},
				{
					"name":"LH20_21080 tuf; elongation factor Tu\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"LH20_21075 fusA; elongation factor G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"RNase MRP"
			},
			{
				"name":"Mitochondrial ribonuclease P"
			},
			{
				"name":"Other mitochondrial DNA transcription and translation factors",
				"children":[
				{
					"name":"LH20_21215 ubiquinol-cytochrome C chaperone\tK17662 CBP3; cytochrome b pre-mRNA-processing protein 3"
				},
				{
					"name":"LH20_16635 helicase-like protein\tK17675 SUPV3L1; ATP-dependent RNA helicase SUPV3L1\/SUV3 [EC:5.6.2.6]"
				},
				{
					"name":"LH20_11665 GTPase Era\tK03595 era; GTPase"
				},
				{
					"name":"LH20_06180 tyrosyl-tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"LH20_21530 leucyl-tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"LH20_11825 aspartyl-tRNA synthetase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"LH20_10095 arginyl-tRNA synthetase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"LH20_07975 gatA; glutamyl-tRNA amidotransferase\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"LH20_19270 aspartyl-tRNA(Asn)\/glutamyl-tRNA (Gln) amidotransferase subunit A\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"LH20_07980 gatB; glutamyl-tRNA amidotransferase\tK02434 gatB; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"LH20_07970 glutamyl-tRNA amidotransferase\tK02435 gatC; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial DNA replication factors",
			"children":[
			{
				"name":"Mitochondrial DNA polymerase"
			},
			{
				"name":"Mitochondrial DNA maintenance factors"
			},
			{
				"name":"Other Mitochondrial DNA replication factors",
				"children":[
				{
					"name":"LH20_04755 hypothetical protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"LH20_21365 single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"LH20_22245 single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial protein import machinery",
		"children":[
		{
			"name":"Endoplasmic reticulum membrane and cytosol",
			"children":[
			{
				"name":"ER-mitochondria encounter structure (ERMES) complex"
			},
			{
				"name":"Other ER-memrane and cytosol factors"
			}
			]
		},
		{
			"name":"Outer membrane",
			"children":[
			{
				"name":"Transporter outer membrane (TOM) complex"
			},
			{
				"name":"TOB\/SAM complex",
				"children":[
				{
					"name":"LH20_13955 membrane protein\tK07277 SAM50; outer membrane protein insertion porin family"
				}
				]
			},
			{
				"name":"MIM complex"
			},
			{
				"name":"Porin"
			},
			{
				"name":"Other outer membrane factor"
			}
			]
		},
		{
			"name":"Inter membrane space",
			"children":[
			{
				"name":"Transporter inner membrane (TIM) 9\/10 complex"
			},
			{
				"name":"TIM8\/13 complex"
			},
			{
				"name":"Mitochondrial intermembrane space assembly (MIA) complex"
			}
			]
		},
		{
			"name":"Inner mambrane",
			"children":[
			{
				"name":"MICOS complex"
			},
			{
				"name":"MICOS complex (yeast)"
			},
			{
				"name":"TIM22 complex"
			},
			{
				"name":"TIM23 complex"
			},
			{
				"name":"Mitochondrial calcium uniporter complex"
			},
			{
				"name":"Other inner membrane factors"
			}
			]
		},
		{
			"name":"Matrix",
			"children":[
			{
				"name":"MMC\/PAM proteins",
				"children":[
				{
					"name":"LH20_15780 dnaK; molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"LH20_08735 molecular chaperone GrpE\tK03687 GRPE; molecular chaperone GrpE"
				}
				]
			},
			{
				"name":"Other matrix factors",
				"children":[
				{
					"name":"LH20_10400 groEL; molecular chaperone GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"LH20_15800 groEL; molecular chaperone GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"LH20_10405 molecular chaperone GroES\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"LH20_15805 molecular chaperone GroES\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"LH20_15775 molecular chaperone DnaJ\tK03686 dnaJ; molecular chaperone DnaJ"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial quality control factors",
		"children":[
		{
			"name":"Regulator of mitochondrial biogenesis",
			"children":[
			{
				"name":"Ubiquitas transcription factors",
				"children":[
				{
					"name":"LH20_21075 fusA; elongation factor G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"Nuclear respiratory factors"
			},
			{
				"name":"Coactivators"
			},
			{
				"name":"Proteins involved in Fe-S cluster biogenesis",
				"children":[
				{
					"name":"LH20_07560 aminotransferase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"LH20_07565 2Fe-2S ferredoxin\tK22071 FDX2; ferredoxin-2, mitochondrial"
				},
				{
					"name":"LH20_18115 pyridine nucleotide-disulfide oxidoreductase\tK18914 FDXR; adrenodoxin-NADP+ reductase [EC:1.18.1.6]"
				},
				{
					"name":"LH20_15780 dnaK; molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"LH20_03345 glutaredoxin\tK07390 grxD; monothiol glutaredoxin"
				}
				]
			},
			{
				"name":"Other regulator of mitochondrial biogenesis"
			}
			]
		},
		{
			"name":"Mitochondrial respiratory chain complex assembly factors",
			"children":[
			{
				"name":"Complex-I assembly factors",
				"children":[
				{
					"name":"LH20_00520 chromosome partitioning protein ParA\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				}
				]
			},
			{
				"name":"Complex-II assembly factors"
			},
			{
				"name":"Complex-III assembly factors",
				"children":[
				{
					"name":"LH20_21215 ubiquinol-cytochrome C chaperone\tK17662 CBP3; cytochrome b pre-mRNA-processing protein 3"
				}
				]
			},
			{
				"name":"Complex-IV assembly factors",
				"children":[
				{
					"name":"LH20_09620 protoheme IX farnesyltransferase\tK02257 COX10; heme o synthase [EC:2.5.1.141]"
				},
				{
					"name":"LH20_09630 cytochrome C oxidase assembly protein\tK02258 COX11; cytochrome c oxidase assembly protein subunit 11"
				},
				{
					"name":"LH20_16260 heme A synthase\tK02259 COX15; heme a synthase [EC:1.17.99.9]"
				},
				{
					"name":"LH20_00065 membrane protein insertase YidC\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase"
				},
				{
					"name":"LH20_07440 Surfeit locus 1 family protein\tK14998 SURF1; surfeit locus 1 family protein"
				},
				{
					"name":"LH20_09645 hypothetical protein\tK14998 SURF1; surfeit locus 1 family protein"
				},
				{
					"name":"LH20_21415 electron transporter\tK07152 SCO1; protein SCO1"
				}
				]
			},
			{
				"name":"Complex-V assembly factors"
			}
			]
		},
		{
			"name":"Mitochondrial dynamics",
			"children":[
			{
				"name":"Fission and Fusion factors"
			},
			{
				"name":"Actin cytoskeleton organization"
			},
			{
				"name":"Mitochondrial movement"
			},
			{
				"name":"Retention of mitochondria"
			},
			{
				"name":"Morphogenesis factors"
			}
			]
		},
		{
			"name":"Mitophagy factors",
			"children":[
			{
				"name":"Autophagy-related proteins"
			},
			{
				"name":"Parkin-dependent mechanism factors"
			},
			{
				"name":"Parkin-independent mechanism factors",
				"children":[
				{
					"name":"LH20_22765 heat shock protein 90\tK04079 HSP90A; molecular chaperone HtpG"
				}
				]
			},
			{
				"name":"Other mitophagy factors"
			}
			]
		}
		]
	}
	]
}