{
	"name":"sphu03009",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Sno RNPs",
			"children":[
			{
				"name":"Box C\/D snoRNPs"
			},
			{
				"name":"Box H\/ACA snoRNPs"
			}
			]
		},
		{
			"name":"90S particles",
			"children":[
			{
				"name":"U3 small nucleolar RNA-associated proteins"
			},
			{
				"name":"Helicases"
			},
			{
				"name":"GTPase"
			},
			{
				"name":"RNase",
				"children":[
				{
					"name":"SPPYR_1877 rnc; Ribonuclease 3\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
				}
				]
			},
			{
				"name":"Kinase"
			},
			{
				"name":"Other 90S particles"
			}
			]
		},
		{
			"name":"Pre-40S particles",
			"children":[
			{
				"name":"Kinases"
			},
			{
				"name":"Export and cytoplasmic maturation factors"
			},
			{
				"name":"Other pre-40S particles"
			}
			]
		},
		{
			"name":"Pre-60S particles",
			"children":[
			{
				"name":"Helicases"
			},
			{
				"name":"GTPases"
			},
			{
				"name":"RNases",
				"children":[
				{
					"name":"RNase MRP"
				}
				]
			},
			{
				"name":"Kinases"
			},
			{
				"name":"Export and cytoplasmic maturation factors"
			},
			{
				"name":"55LCC heterohexameric ATPase complex"
			},
			{
				"name":"5-FMC complex"
			},
			{
				"name":"Ribosome quality control proteins",
				"children":[
				{
					"name":"SPPYR_1599 Cell division cycle protein 48 homolog AF_1297\tK13525 VCP; transitional endoplasmic reticulum ATPase"
				}
				]
			},
			{
				"name":"Other pre-60S particles"
			}
			]
		},
		{
			"name":"Other ribosome biogenesis factors",
			"children":[
			{
				"name":"SPPYR_1876 era; membrane-associated, 16S rRNA-binding GTPase\tK03595 era; GTPase"
			},
			{
				"name":"SPPYR_0488 obg; GTPase obg\tK03979 obgE; GTPase [EC:3.6.5.-]"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Sno RNPs",
			"children":[
			{
				"name":"Box C\/D snoRNPs"
			},
			{
				"name":"Box H\/ACA snoRNPs"
			}
			]
		},
		{
			"name":"rRNA transcription factors",
			"children":[
			{
				"name":"SPPYR_2498 dksA; RNA polymerase-binding transcription factor DksA\tK06204 dksA; RNA polymerase-binding transcription factor"
			},
			{
				"name":"SPPYR_0235 nusA; transcription termination\/antitermination L factor\tK02600 nusA; transcription termination\/antitermination protein NusA"
			},
			{
				"name":"SPPYR_2489 nusB; N utilization substance protein B homolog\tK03625 nusB; transcription antitermination protein NusB"
			},
			{
				"name":"SPPYR_2361 nusG; transcription termination factor\tK02601 nusG; transcription termination\/antitermination protein NusG"
			}
			]
		},
		{
			"name":"rRNA modification factors",
			"children":[
			{
				"name":"16S rRNA modification factors",
				"children":[
				{
					"name":"SPPYR_0995 rsmA; Ribosomal RNA small subunit methyltransferase A\tK02528 ksgA; 16S rRNA (adenine1518-N6\/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]"
				},
				{
					"name":"SPPYR_0993 Fmu (Sun)\tK03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]"
				},
				{
					"name":"SPPYR_1990 Fmu (Sun)\tK03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]"
				},
				{
					"name":"SPPYR_1976 conserved protein of unknown function\tK08316 rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171]"
				},
				{
					"name":"SPPYR_3267 Ribosomal RNA small subunit methyltransferase E\tK09761 rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]"
				},
				{
					"name":"SPPYR_3624 rsmG; Ribosomal RNA small subunit methyltransferase G\tK03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]"
				},
				{
					"name":"SPPYR_0902 mraW; S-adenosyl-dependent methyltransferase activity on membrane-located substrates\tK03438 mraW; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]"
				},
				{
					"name":"SPPYR_2469 yraL; putative methyltransferase\tK07056 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198]"
				},
				{
					"name":"SPPYR_2966 yqxC; putative rRNA methyltransferase YqxC\tK06442 tlyA; 23S rRNA (cytidine1920-2'-O)\/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]"
				}
				]
			},
			{
				"name":"23S rRNA modification factors",
				"children":[
				{
					"name":"SPPYR_1146 RNA methyltransferase TrmH, group 3\tK03218 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185]"
				},
				{
					"name":"SPPYR_3882 rlmE; Ribosomal RNA large subunit methyltransferase E\tK02427 rlmE; 23S rRNA (uridine2552-2'-O)-methyltransferase [EC:2.1.1.166]"
				},
				{
					"name":"SPPYR_0307 rlmH; Ribosomal RNA large subunit methyltransferase H\tK00783 rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177]"
				},
				{
					"name":"SPPYR_2285 SAM-dependent methyltransferase\tK06969 rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]"
				},
				{
					"name":"SPPYR_2535 rlmN; Dual-specificity RNA methyltransferase RlmN\tK06941 rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]"
				},
				{
					"name":"SPPYR_2966 yqxC; putative rRNA methyltransferase YqxC\tK06442 tlyA; 23S rRNA (cytidine1920-2'-O)\/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]"
				},
				{
					"name":"SPPYR_1853 putative enzyme\tK03215 rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]"
				},
				{
					"name":"SPPYR_0283 putative enzyme\tK06177 rluA; tRNA pseudouridine32 synthase \/ 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]"
				},
				{
					"name":"SPPYR_1975 Pseudouridine synthase\tK06178 rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]"
				},
				{
					"name":"SPPYR_3131 Pseudouridine synthase\tK06179 rluC; 23S rRNA pseudouridine955\/2504\/2580 synthase [EC:5.4.99.24]"
				},
				{
					"name":"SPPYR_1021 rluD; Ribosomal large subunit pseudouridine synthase D\tK06180 rluD; 23S rRNA pseudouridine1911\/1915\/1917 synthase [EC:5.4.99.23]"
				},
				{
					"name":"SPPYR_0036 ymfC; 23S rRNA pseudouridine synthase\tK06181 rluE; 23S rRNA pseudouridine2457 synthase [EC:5.4.99.20]"
				}
				]
			}
			]
		},
		{
			"name":"ribosomal protein modification factors",
			"children":[
			{
				"name":"SPPYR_0573 GCN5-related N-acetyltransferase\tK03789 rimI; [ribosomal protein S18]-alanine N-acetyltransferase \/ [ribosomal protein L31]-L-lysine N-acetyltransferase [EC:2.3.1.266 2.3.1.338]"
			},
			{
				"name":"SPPYR_0134 rimM; Ribosome maturation factor RimM\tK02860 rimM; 16S rRNA processing protein RimM"
			},
			{
				"name":"SPPYR_2507 yliG; putative AdoMet-dependent methyltransferase, UPF0004 family\tK14441 rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4]"
			},
			{
				"name":"SPPYR_0267 LSU ribosomal protein L11P methyltransferase\tK02687 prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]"
			}
			]
		},
		{
			"name":"rRNA processing factors",
			"children":[
			{
				"name":"SPPYR_1877 rnc; Ribonuclease 3\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
			},
			{
				"name":"SPPYR_3900 RNAse E\tK08300 rne; ribonuclease E [EC:3.1.26.12]"
			},
			{
				"name":"SPPYR_1133 putative Holliday junction resolvase\tK07447 ruvX; putative pre-16S rRNA nuclease [EC:3.1.-.-]"
			}
			]
		},
		{
			"name":"rRNA helicases",
			"children":[
			{
				"name":"SPPYR_2878 DEAD\/DEAH box helicase-like protein\tK05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]"
			}
			]
		},
		{
			"name":"GTPases",
			"children":[
			{
				"name":"SPPYR_1876 era; membrane-associated, 16S rRNA-binding GTPase\tK03595 era; GTPase"
			},
			{
				"name":"SPPYR_0508 der; GTPase Der\tK03977 engA; GTPase"
			},
			{
				"name":"SPPYR_0488 obg; GTPase obg\tK03979 obgE; GTPase [EC:3.6.5.-]"
			},
			{
				"name":"SPPYR_1937 hflX; GTPase HflX\tK03665 hflX; GTPase"
			}
			]
		},
		{
			"name":"Other maturation factors",
			"children":[
			{
				"name":"SPPYR_3077 ywlC; putative tRNA threonylcarbamoyladenosine biosynthesis protein YwlC\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
			},
			{
				"name":"SPPYR_3400 rsh; GTP pyrophosphokinase rsh\tK01139 spoT; GTP diphosphokinase \/ guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]"
			},
			{
				"name":"SPPYR_0238 rbfA; Ribosome-binding factor A\tK02834 rbfA; ribosome-binding factor A"
			},
			{
				"name":"SPPYR_0234 rimP; Ribosome maturation factor RimP\tK09748 rimP; ribosome maturation factor RimP"
			},
			{
				"name":"SPPYR_0308 rsfS; Ribosomal silencing factor RsfS\tK09710 ybeB; ribosome-associated protein"
			},
			{
				"name":"SPPYR_0585 putative rRNA maturation factor\tK07042 ybeY; probable rRNA maturation factor"
			},
			{
				"name":"SPPYR_3642 SSU ribosomal protein S30P \/ sigma 54 modulation protein\tK05808 hpf; ribosome hibernation promoting factor"
			},
			{
				"name":"SPPYR_1551 ychF; putative GTP-binding protein\tK06942 ychF; ribosome-binding ATPase"
			}
			]
		}
		]
	},
	{
		"name":"Related small nucleolar RNAs",
		"children":[
		{
			"name":"Box C\/D snoRNAs",
			"children":[
			{
				"name":"SnoRNAs involved in processing reactions"
			},
			{
				"name":"SnoRNAs act as guides for 2'-O-ribose methylation"
			}
			]
		},
		{
			"name":"Box H\/ACA snoRNAs",
			"children":[
			{
				"name":"SnoRNAs involved in processing reactions"
			},
			{
				"name":"SnoRNAs act as guides for pseudouridynation"
			}
			]
		},
		{
			"name":"Other snoRNA"
		}
		]
	}
	]
}