{
	"name":"sphx01011",
	"children":[
	{
		"name":"Precursor biosynthesis",
		"children":[
		{
			"name":"Transferase\/Dehydrogenase",
			"children":[
			{
				"name":"E5675_14555 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase\tK00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]"
			},
			{
				"name":"E5675_06585 murB; UDP-N-acetylmuramate dehydrogenase\tK00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]"
			}
			]
		},
		{
			"name":"Amino acid ligase",
			"children":[
			{
				"name":"E5675_06485 UDP-N-acetylmuramate--alanine ligase\tK01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]"
			},
			{
				"name":"E5675_06580 UDP-N-acetylmuramate--L-alanine ligase\tK01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]"
			},
			{
				"name":"E5675_06565 murD; UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase\tK01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]"
			},
			{
				"name":"E5675_06550 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase\tK01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]"
			},
			{
				"name":"E5675_06590 D-alanine--D-alanine ligase\tK01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]"
			},
			{
				"name":"E5675_07810 phosphoribosylglycinamide synthetase\tK01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]"
			}
			]
		},
		{
			"name":"Racemase",
			"children":[
			{
				"name":"E5675_10955 alanine racemase\tK01775 alr; alanine racemase [EC:5.1.1.1]"
			},
			{
				"name":"E5675_11080 glutamate racemase\tK01776 murI; glutamate racemase [EC:5.1.1.3]"
			}
			]
		},
		{
			"name":"Carboxypeptidase",
			"children":[
			{
				"name":"E5675_06490 LD-carboxypeptidase\tK01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]"
			}
			]
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"E5675_06560 phospho-N-acetylmuramoyl-pentapeptide-transferase\tK01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]"
			},
			{
				"name":"E5675_06575 murG; undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase\tK02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]"
			}
			]
		},
		{
			"name":"Diphosphatase",
			"children":[
			{
				"name":"E5675_05335 undecaprenyl-diphosphate phosphatase\tK06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]"
			}
			]
		},
		{
			"name":"Flippase",
			"children":[
			{
				"name":"E5675_02415 murJ; murein biosynthesis integral membrane protein MurJ\tK03980 murJ; putative peptidoglycan lipid II flippase"
			}
			]
		}
		]
	},
	{
		"name":"Peptidoglycan biosynthesis and degradation",
		"children":[
		{
			"name":"Glycosyltransferase\/DD-Transpeptidase (Class A PBP)",
			"children":[
			{
				"name":"E5675_02335 penicillin-binding protein\tK05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]"
			},
			{
				"name":"E5675_07605 penicillin-binding protein\tK05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]"
			},
			{
				"name":"E5675_20550 PBP1A family penicillin-binding protein\tK05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]"
			},
			{
				"name":"E5675_01070 pbpC; penicillin-binding protein 1C\tK05367 pbpC; penicillin-binding protein 1C [EC:2.4.99.28]"
			}
			]
		},
		{
			"name":"DD-Transpeptidase (Class B PBP)",
			"children":[
			{
				"name":"E5675_09810 mrdA; penicillin-binding protein 2\tK05515 mrdA; penicillin-binding protein 2 [EC:3.4.16.4]"
			},
			{
				"name":"E5675_06545 penicillin-binding protein 2\tK03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]"
			}
			]
		},
		{
			"name":"DD-Carboxypeptidase\/DD-Endopeptidase (Low molecular weight PBP)",
			"children":[
			{
				"name":"E5675_10700 D-alanyl-D-alanine carboxypeptidase\tK07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5\/6) [EC:3.4.16.4]"
			},
			{
				"name":"E5675_16770 dacB; D-alanyl-D-alanine carboxypeptidase\/D-alanyl-D-alanine-endopeptidase\tK07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase\/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]"
			},
			{
				"name":"E5675_06035 class A beta-lactamase-related serine hydrolase\tK18988 ampH; serine-type D-Ala-D-Ala carboxypeptidase\/endopeptidase [EC:3.4.16.4 3.4.21.-]"
			}
			]
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"E5675_07080 mtgA; monofunctional biosynthetic peptidoglycan transglycosylase\tK03814 mtgA; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
			},
			{
				"name":"E5675_06570 cell division protein FtsW\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
			},
			{
				"name":"E5675_09805 rodA; rod shape-determining protein RodA\tK05837 rodA; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
			}
			]
		},
		{
			"name":"Transpeptidase",
			"children":[
			{
				"name":"E5675_19260 L,D-transpeptidase\tK21470 ldtD; L,D-transpeptidase"
			}
			]
		},
		{
			"name":"Carboxypeptidase"
		},
		{
			"name":"Endopeptidase"
		},
		{
			"name":"Sortase"
		},
		{
			"name":"Lytic transglycosylase",
			"children":[
			{
				"name":"E5675_07155 lytic transglycosylase domain-containing protein\tK08309 slt; peptidoglycan lytic transglycosylase [EC:4.2.2.29]"
			},
			{
				"name":"E5675_11220 lytic transglycosylase domain-containing protein\tK08309 slt; peptidoglycan lytic transglycosylase [EC:4.2.2.29]"
			},
			{
				"name":"E5675_02430 hypothetical protein\tK08304 mltA; peptidoglycan lytic transglycosylase A [EC:4.2.2.29]"
			},
			{
				"name":"E5675_10710 lytic murein transglycosylase\tK08305 mltB; peptidoglycan lytic transglycosylase B [EC:4.2.2.29]"
			},
			{
				"name":"E5675_16660 mltG; endolytic transglycosylase MltG\tK07082 mltG; peptidoglycan lytic transglycosylase G [EC:4.2.2.29]"
			},
			{
				"name":"E5675_10705 septal ring lytic transglycosylase RlpA family protein\tK03642 rlpA; peptidoglycan lytic transglycosylase [EC:4.2.2.29]"
			},
			{
				"name":"E5675_11735 septal ring lytic transglycosylase RlpA family protein\tK03642 rlpA; peptidoglycan lytic transglycosylase [EC:4.2.2.29]"
			},
			{
				"name":"E5675_20255 septal ring lytic transglycosylase RlpA family protein\tK03642 rlpA; peptidoglycan lytic transglycosylase [EC:4.2.2.29]"
			}
			]
		},
		{
			"name":"Amidase",
			"children":[
			{
				"name":"E5675_02305 N-acetylmuramoyl-L-alanine amidase\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]"
			},
			{
				"name":"E5675_07140 N-acetylmuramoyl-L-alanine amidase\tK11066 amiD; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]"
			}
			]
		},
		{
			"name":"Structural protein"
		}
		]
	}
	]
}