{
	"name":"spy03009",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Sno RNPs",
			"children":[
			{
				"name":"Box C\/D snoRNPs"
			},
			{
				"name":"Box H\/ACA snoRNPs"
			}
			]
		},
		{
			"name":"90S particles",
			"children":[
			{
				"name":"U3 small nucleolar RNA-associated proteins"
			},
			{
				"name":"Helicases"
			},
			{
				"name":"GTPase"
			},
			{
				"name":"RNase",
				"children":[
				{
					"name":"SPy_0531 acpA; putative ribonuclease III\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
				}
				]
			},
			{
				"name":"Kinase"
			},
			{
				"name":"Other 90S particles"
			}
			]
		},
		{
			"name":"Pre-40S particles",
			"children":[
			{
				"name":"Kinases"
			},
			{
				"name":"Export and cytoplasmic maturation factors"
			},
			{
				"name":"Other pre-40S particles"
			}
			]
		},
		{
			"name":"Pre-60S particles",
			"children":[
			{
				"name":"Helicases"
			},
			{
				"name":"GTPases"
			},
			{
				"name":"RNases",
				"children":[
				{
					"name":"RNase MRP"
				}
				]
			},
			{
				"name":"Kinases"
			},
			{
				"name":"Export and cytoplasmic maturation factors"
			},
			{
				"name":"55LCC heterohexameric ATPase complex"
			},
			{
				"name":"5-FMC complex"
			},
			{
				"name":"Ribosome quality control proteins"
			},
			{
				"name":"Other pre-60S particles"
			}
			]
		},
		{
			"name":"Other ribosome biogenesis factors",
			"children":[
			{
				"name":"SPy_0476 era; GTP-binding protein (GTPase)\tK03595 era; GTPase"
			},
			{
				"name":"SPy_1333 putative GTP-binding protein\tK03979 obgE; GTPase [EC:3.6.5.-]"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Sno RNPs",
			"children":[
			{
				"name":"Box C\/D snoRNPs"
			},
			{
				"name":"Box H\/ACA snoRNPs"
			}
			]
		},
		{
			"name":"rRNA transcription factors",
			"children":[
			{
				"name":"SPy_1724 nusA; transcription termination-antitermination factor\tK02600 nusA; transcription termination\/antitermination protein NusA"
			},
			{
				"name":"SPy_1818 nusB; putative transcriptional terminator\tK03625 nusB; transcription antitermination protein NusB"
			},
			{
				"name":"SPy_0164 nusG; putative transcription antitermination factor\tK02601 nusG; transcription termination\/antitermination protein NusG"
			}
			]
		},
		{
			"name":"rRNA modification factors",
			"children":[
			{
				"name":"16S rRNA modification factors",
				"children":[
				{
					"name":"SPy_1337 rsuA; putative 16S pseudouridylate synthase\tK06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]"
				},
				{
					"name":"SPy_1398 putative 16S pseudouridylate synthetase\tK06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]"
				},
				{
					"name":"SPy_0262 ksgA; putative dimethyladenosine transferase\tK02528 ksgA; 16S rRNA (adenine1518-N6\/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]"
				},
				{
					"name":"SPy_1627 sunL; putative RNA-binding Sun protein\tK03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]"
				},
				{
					"name":"SPy_1232 conserved hypothetical protein\tK00564 rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172]"
				},
				{
					"name":"SPy_1538 conserved hypothetical protein\tK08316 rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171]"
				},
				{
					"name":"SPy_1987 conserved hypothetical protein\tK09761 rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]"
				},
				{
					"name":"SPy_0329 gidB; putative glucose-inhibited division protein\tK03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]"
				},
				{
					"name":"SPy_1666 conserved hypothetical protein\tK03438 mraW; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]"
				},
				{
					"name":"SPy_0406 conserved hypothetical protein\tK07056 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198]"
				},
				{
					"name":"SPy_1497 hlyA1; putative hemolysin\tK06442 tlyA; 23S rRNA (cytidine1920-2'-O)\/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]"
				}
				]
			},
			{
				"name":"23S rRNA modification factors",
				"children":[
				{
					"name":"SPy_1938 putative tRNA\/rRNA methyltransferase\tK03218 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185]"
				},
				{
					"name":"SPy_2215 conserved hypothetical protein\tK00783 rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177]"
				},
				{
					"name":"SPy_0808 conserved hypothetical protein\tK06969 rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]"
				},
				{
					"name":"SPy_1533 conserved hypothetical protein\tK06941 rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]"
				},
				{
					"name":"SPy_1497 hlyA1; putative hemolysin\tK06442 tlyA; 23S rRNA (cytidine1920-2'-O)\/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]"
				},
				{
					"name":"SPy_1346 putative RNA methyltransferase\tK03215 rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]"
				},
				{
					"name":"SPy_0369 putative hypothetical protein\tK06178 rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]"
				},
				{
					"name":"SPy_0827 conserved hypothetical protein\tK06180 rluD; 23S rRNA pseudouridine1911\/1915\/1917 synthase [EC:5.4.99.23]"
				},
				{
					"name":"SPy_1127 conserved hypothetical protein\tK06180 rluD; 23S rRNA pseudouridine1911\/1915\/1917 synthase [EC:5.4.99.23]"
				},
				{
					"name":"SPy_2063 conserved hypothetical protein\tK06180 rluD; 23S rRNA pseudouridine1911\/1915\/1917 synthase [EC:5.4.99.23]"
				}
				]
			}
			]
		},
		{
			"name":"ribosomal protein modification factors",
			"children":[
			{
				"name":"SPy_1873 putative ribosomal-protein-alanine acetyltransferase\tK03789 rimI; [ribosomal protein S18]-alanine N-acetyltransferase \/ [ribosomal protein L31]-L-lysine N-acetyltransferase [EC:2.3.1.266 2.3.1.338]"
			},
			{
				"name":"SPy_0847 putative 16S rRNA processing protein\tK02860 rimM; 16S rRNA processing protein RimM"
			},
			{
				"name":"SPy_1988 putative methyltransferase\tK02687 prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]"
			}
			]
		},
		{
			"name":"rRNA processing factors",
			"children":[
			{
				"name":"SPy_0531 acpA; putative ribonuclease III\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
			},
			{
				"name":"SPy_2113 conserved hypothetical protein\tK07447 ruvX; putative pre-16S rRNA nuclease [EC:3.1.-.-]"
			},
			{
				"name":"SPy_1940 conserved hypothetical proteins\tK11145 mrnC; mini-ribonuclease III [EC:3.1.26.-]"
			},
			{
				"name":"SPy_0261 conserved hypothetical protein\tK05985 rnmV; ribonuclease M5 [EC:3.1.26.8]"
			}
			]
		},
		{
			"name":"rRNA helicases",
			"children":[
			{
				"name":"SPy_1415 deaD; putative ATP-dependent RNA helicase\tK05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]"
			},
			{
				"name":"SPy_1659 putative ATP-dependent RNA helicase\tK18692 cshB; ATP-dependent RNA helicase CshB [EC:5.6.2.7]"
			}
			]
		},
		{
			"name":"GTPases",
			"children":[
			{
				"name":"SPy_0476 era; GTP-binding protein (GTPase)\tK03595 era; GTPase"
			},
			{
				"name":"SPy_0263 conserved hypothetical protein\tK06949 rsgA; ribosome biogenesis GTPase \/ thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]"
			},
			{
				"name":"SPy_0341 pgdA; putative phosphoglycerate dehydrogenase\tK03977 engA; GTPase"
			},
			{
				"name":"SPy_1333 putative GTP-binding protein\tK03979 obgE; GTPase [EC:3.6.5.-]"
			},
			{
				"name":"SPy_1161 conserved hypothetical protein\tK14540 rbgA; ribosome biogenesis GTPase A"
			},
			{
				"name":"SPy_0922 putative GTP-binding protein\tK03665 hflX; GTPase"
			},
			{
				"name":"SPy_0306 conserved hypothetical protein\tK06948 yqeH; 30S ribosome assembly GTPase"
			}
			]
		},
		{
			"name":"Other maturation factors",
			"children":[
			{
				"name":"SPy_1143 hypothetical protein\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
			},
			{
				"name":"SPy_1981 relA; (p)ppGpp synthetase\tK01139 spoT; GTP diphosphokinase \/ guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]"
			},
			{
				"name":"SPy_1719 rbfA; putative ribosome binding factor A\tK02834 rbfA; ribosome-binding factor A"
			},
			{
				"name":"SPy_1725 conserved hypothetical protein\tK09748 rimP; ribosome maturation factor RimP"
			},
			{
				"name":"SPy_2203 conserved hypothetical protein\tK14761 rlbA; ribosome-associated protein"
			},
			{
				"name":"SPy_0310 conserved hypothetical protein\tK09710 ybeB; ribosome-associated protein"
			},
			{
				"name":"SPy_0473 conserved hypothetical protein\tK07042 ybeY; probable rRNA maturation factor"
			},
			{
				"name":"SPy_0307 conserved hypothetical protein\tK07574 yhbY; RNA-binding protein"
			},
			{
				"name":"SPy_1613 conserved protein - function unknown\tK05808 hpf; ribosome hibernation promoting factor"
			},
			{
				"name":"SPy_0006 putative GTP-binding protein\tK06942 ychF; ribosome-binding ATPase"
			},
			{
				"name":"SPy_0334 conserved hypothetical protein\tK07040 yceD; DUF177 domain-containing protein"
			}
			]
		}
		]
	},
	{
		"name":"Related small nucleolar RNAs",
		"children":[
		{
			"name":"Box C\/D snoRNAs",
			"children":[
			{
				"name":"SnoRNAs involved in processing reactions"
			},
			{
				"name":"SnoRNAs act as guides for 2'-O-ribose methylation"
			}
			]
		},
		{
			"name":"Box H\/ACA snoRNAs",
			"children":[
			{
				"name":"SnoRNAs involved in processing reactions"
			},
			{
				"name":"SnoRNAs act as guides for pseudouridynation"
			}
			]
		},
		{
			"name":"Other snoRNA"
		}
		]
	}
	]
}