{
	"name":"sro01008",
	"children":[
	{
		"name":"Polyketide synthase (PKS)",
		"children":[
		{
			"name":"Modular type I PKS",
			"children":[
			{
				"name":"cis-AT PKS",
				"children":[
				{
					"name":"Erythronolide PKS"
				},
				{
					"name":"Oleandomycin synthase"
				},
				{
					"name":"Pikromycin PKS"
				},
				{
					"name":"Avermectin PKS"
				},
				{
					"name":"Tylactone synthase"
				},
				{
					"name":"Protomycinolide IV synthase"
				},
				{
					"name":"Niddamycin PKS"
				},
				{
					"name":"Rapamycin PKS"
				},
				{
					"name":"Immunomycin PKS"
				},
				{
					"name":"Ansamitocin PKS"
				},
				{
					"name":"Rifamycin PKS"
				},
				{
					"name":"Polyene macrolide PKS"
				},
				{
					"name":"Pimaricinolide synthase"
				},
				{
					"name":"Candicidin PKS"
				},
				{
					"name":"Soraphen PKS"
				},
				{
					"name":"Stigmatellin PKS"
				},
				{
					"name":"Mycolactone PKS"
				},
				{
					"name":"Coelimycin PKS"
				},
				{
					"name":"Aureothin PKS"
				},
				{
					"name":"Spectinabilin PKS"
				},
				{
					"name":"Phthiocerol \/ Phenolphthiocerol PKS",
					"children":[
					{
						"name":"Sros_8815 Polyketide synthase modules and related protein-like protein\tK12443 ppsD; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]"
					}
					]
				}
				]
			},
			{
				"name":"trans-AT PKS",
				"children":[
				{
					"name":"Bacillanene hybrid PKS-NRPS"
				},
				{
					"name":"Macrolactin PKS"
				},
				{
					"name":"Difficidin PKS"
				},
				{
					"name":"Rhizoxin hybrid PKS-NRPS"
				},
				{
					"name":"Albicidin synthase, hybrid PKS-NRPS"
				}
				]
			}
			]
		},
		{
			"name":"Iterative type I PKS",
			"children":[
			{
				"name":"Fungal nonreducing PKS (NR-PKS)"
			},
			{
				"name":"Fungal partially reducing PKS (PR-PKS)"
			},
			{
				"name":"Fungal highly reducing PKS (HR-PKS)"
			},
			{
				"name":"Fungal hybrid type",
				"children":[
				{
					"name":"Zearalenone synthase"
				}
				]
			},
			{
				"name":"Bacterial type",
				"children":[
				{
					"name":"Sros_6999 Polyketide synthase modules and related protein-like protein\tK15314 sgcE; enediyne polyketide synthase"
				},
				{
					"name":"Sros_8249 Polyketide synthase modules and related protein-like protein\tK15314 sgcE; enediyne polyketide synthase"
				}
				]
			}
			]
		},
		{
			"name":"Type II PKS",
			"children":[
			{
				"name":"C9-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Spore pigment PKS",
					"children":[
					{
						"name":"Sros_4153 hypothetical protein\tK14670 whiEVI; aromatase"
					},
					{
						"name":"Sros_4148 hypothetical protein\tK14671 whiEVII; cyclase"
					}
					]
				}
				]
			},
			{
				"name":"C7-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Octaketide PKS",
					"children":[
					{
						"name":"Sros_4150 3-oxoacyl-(acyl-carrier-protein) synthase II\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"Sros_4151 3-oxoacyl-(acyl-carrier-protein) synthase II\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"Sros_4152 conserved hypothetical protein\tK05553 actI3; minimal PKS acyl carrier protein"
					},
					{
						"name":"Sros_6284 beta-lactamase domain-containing protein\tK05555 actIV; cyclase [EC:4.-.-.-]"
					}
					]
				},
				{
					"name":"Nonaketide PKS",
					"children":[
					{
						"name":"Sros_4150 3-oxoacyl-(acyl-carrier-protein) synthase II\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"Sros_4151 3-oxoacyl-(acyl-carrier-protein) synthase II\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"Sros_4152 conserved hypothetical protein\tK05553 actI3; minimal PKS acyl carrier protein"
					}
					]
				},
				{
					"name":"Decaketide PKS",
					"children":[
					{
						"name":"Sros_4150 3-oxoacyl-(acyl-carrier-protein) synthase II\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"Sros_4151 3-oxoacyl-(acyl-carrier-protein) synthase II\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"Sros_4152 conserved hypothetical protein\tK05553 actI3; minimal PKS acyl carrier protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"Type III PKS",
			"children":[
			{
				"name":"Plant type"
			},
			{
				"name":"Fungal type"
			},
			{
				"name":"Bacterial type",
				"children":[
				{
					"name":"Sros_5949 3-oxoacyl-(ACP) synthase III\tK16167 bpsA; alkylresorcinol\/alkylpyrone synthase"
				}
				]
			}
			]
		},
		{
			"name":"PKS-NRPS hybrid",
			"children":[
			{
				"name":"Bacterial type (modular)",
				"children":[
				{
					"name":"Myxalamid hybrid PKS-NRPS"
				},
				{
					"name":"Coronatine hybrid PKS-NRPS"
				},
				{
					"name":"Microcystin synthetase"
				},
				{
					"name":"Epothilone synthetase"
				},
				{
					"name":"Bleomycin synthetase"
				},
				{
					"name":"Colibactin synthetase"
				},
				{
					"name":"Myxothiazol hybrid PKS-NRPS"
				}
				]
			},
			{
				"name":"Fungal type (trans-ER, iterative)",
				"children":[
				{
					"name":"Aspyridone synthetase"
				}
				]
			},
			{
				"name":"Fungal type (iterative)"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide synthetase (NRPS)",
		"children":[
		{
			"name":"Linear NRPS",
			"children":[
			{
				"name":"Emericellamide synthetase"
			},
			{
				"name":"Cyanopeptolin synthetase"
			},
			{
				"name":"ACV synthetase"
			},
			{
				"name":"Bacitracin synthetase"
			},
			{
				"name":"Viomycin synthetase"
			},
			{
				"name":"Pristinamycin I synthetase"
			},
			{
				"name":"Tyrocidine synthetase"
			},
			{
				"name":"Surfactin family lipopeptide synthetase"
			},
			{
				"name":"Iturin family lipopeptide synthetase"
			},
			{
				"name":"Fengycin family lipopeptide synthetase"
			},
			{
				"name":"Arthrofactin type cyclic lipopeptide synthetase"
			},
			{
				"name":"Vancomycin synthetase"
			},
			{
				"name":"Nocardicin synthetase",
				"children":[
				{
					"name":"Sros_2200 conserved hypothetical protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"Sros_2422 conserved hypothetical protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"Sros_3469 conserved hypothetical protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"Sros_5581 conserved hypothetical protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"Sros_6555 conserved hypothetical protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"Sros_6841 MbtH domain-containing protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"Sros_6969 conserved hypothetical protein\tK05375 mbtH; MbtH protein"
				}
				]
			},
			{
				"name":"Bialaphos synthetase"
			},
			{
				"name":"L-2-amino-4-methoxy-trans-3-butenoic acid synthetase"
			},
			{
				"name":"Anabaenopeptin synthetase"
			},
			{
				"name":"Linear gramicidin synthetase"
			}
			]
		},
		{
			"name":"Iterative NRPS",
			"children":[
			{
				"name":"Enterobactin synthetase",
				"children":[
				{
					"name":"Sros_3805 putative phosphopantetheinyl transferase\tK02362 entD; enterobactin synthetase component D \/ holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]"
				},
				{
					"name":"Sros_3774 (2,3-dihydroxybenzoyl)adenylate synthase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Bacillibactin synthetase",
				"children":[
				{
					"name":"Sros_3774 (2,3-dihydroxybenzoyl)adenylate synthase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Gramicidin synthetase"
			}
			]
		},
		{
			"name":"Nonlinear NRPS",
			"children":[
			{
				"name":"Yersiniabactin synthetase"
			},
			{
				"name":"Pyochelin synthetase",
				"children":[
				{
					"name":"Sros_3767 pyochelin synthetase F\tK12240 pchF; L-cysteine---[L-cysteinyl-carrier protein] ligase PchF [EC:6.2.1.69]"
				}
				]
			},
			{
				"name":"Mycobactin synthetase"
			},
			{
				"name":"Vibriobactin synthetase",
				"children":[
				{
					"name":"Sros_3774 (2,3-dihydroxybenzoyl)adenylate synthase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Myxochelin synthetase",
				"children":[
				{
					"name":"Sros_3774 (2,3-dihydroxybenzoyl)adenylate synthase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Petrobacin synthetase"
			},
			{
				"name":"Syringomycin synthetase"
			},
			{
				"name":"Vanchrobactin synthetase",
				"children":[
				{
					"name":"Sros_3774 (2,3-dihydroxybenzoyl)adenylate synthase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Isonitrile lipopeptide synthase"
			}
			]
		}
		]
	},
	{
		"name":"Polyketide tailoring proteins",
		"children":[
		{
			"name":"Hydrolase",
			"children":[
			{
				"name":"Sros_6998 hypothetical protein\tK15315 sgcE10; enediyne core biosynthesis thioesterase"
			}
			]
		},
		{
			"name":"Ketoreductase"
		},
		{
			"name":"Oxygenase",
			"children":[
			{
				"name":"Sros_4752 hypothetical protein\tK14632 actVA6; C-6 monooxygenase"
			},
			{
				"name":"Sros_6983 cytochrome P450-family protein\tK20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]"
			},
			{
				"name":"Sros_8715 cytochrome P450-family protein\tK20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]"
			},
			{
				"name":"Sros_6973 4-hydroxyphenylacetate 3-monooxygenase oxygenase component\tK21184 sgcC; two-component FAD-dependent monooxygenase [EC:1.14.14.15 1.14.14.-]"
			},
			{
				"name":"Sros_0451 Microsomal epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"Sros_1214 putative hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"Sros_2973 Microsomal epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"Sros_4599 putative hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"Sros_4618 putative epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"Sros_5100 putative hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"Sros_5218 putative hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"Sros_9243 putative hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"Sros_4149 hypothetical protein\tK14673 whiEII; putative monooxygenase"
			},
			{
				"name":"Sros_4156 PheA\/TfdB family FAD-binding monooxygenase\tK14672 whiEVIII; putative polyketide hydroxylase"
			},
			{
				"name":"Sros_4181 PheA\/TfdB family FAD-binding monooxygenase\tK14672 whiEVIII; putative polyketide hydroxylase"
			}
			]
		},
		{
			"name":"Methylase",
			"children":[
			{
				"name":"Sros_6962 hydroxyneurosporene-O-methyltransferase\tK21178 sgcD4; O-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"Sros_6986 hydroxyneurosporene-O-methyltransferase\tK21178 sgcD4; O-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"Sros_5950 conserved hypothetical protein\tK16168 bpsB; methyltransferase"
			}
			]
		},
		{
			"name":"Glycosyltransferase"
		},
		{
			"name":"Halogenase"
		},
		{
			"name":"beta-Branched incorporating proteins"
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"Sros_7003 hypothetical protein\tK21160 sgcE2; enediyne biosynthesis protein E2"
			},
			{
				"name":"Sros_7002 hypothetical protein\tK21161 sgcE3; enediyne biosynthesis protein E3"
			},
			{
				"name":"Sros_8246 hypothetical protein\tK21161 sgcE3; enediyne biosynthesis protein E3"
			},
			{
				"name":"Sros_7001 hypothetical protein\tK21162 sgcE4; enediyne biosynthesis protein E4"
			},
			{
				"name":"Sros_8247 hypothetical protein\tK21162 sgcE4; enediyne biosynthesis protein E4"
			},
			{
				"name":"Sros_7000 hypothetical protein\tK21163 sgcE5; enediyne biosynthesis protein E5"
			},
			{
				"name":"Sros_8248 hypothetical protein\tK21163 sgcE5; enediyne biosynthesis protein E5"
			},
			{
				"name":"Sros_6996 cytochrome P450 family protein\tK21164 sgcE7; enediyne biosynthesis protein E7"
			},
			{
				"name":"Sros_6993 hypothetical protein\tK21165 sgcE8; enediyne biosynthesis protein E8"
			},
			{
				"name":"Sros_6992 Choline dehydrogenase and related flavoprotein-like protein\tK21166 sgcE9; enediyne biosynthesis protein E9"
			},
			{
				"name":"Sros_6990 wyosine base formation\tK21167 sgcE11; enediyne biosynthesis protein E11"
			},
			{
				"name":"Sros_6976 Non-ribosomal peptide synthetase modules and related protein-like protein\tK21186 sgcC5; condensation enzyme"
			},
			{
				"name":"Sros_6997 flavin reductase-like, FMN-binding protein\tK21185 sgcE6; flavin reductase"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide tailoring proteins",
		"children":[
		{
			"name":"Reductase",
			"children":[
			{
				"name":"Sros_3769 conserved hypothetical protein\tK12241 pchG; pyochelin biosynthesis protein PchG"
			}
			]
		},
		{
			"name":"Thioesterase",
			"children":[
			{
				"name":"Sros_6554 Oleoyl-(acyl-carrier-protein) hydrolase\tK12242 pchC; pyochelin biosynthesis protein PchC"
			}
			]
		},
		{
			"name":"Oxygenase"
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"Sros_5179 glycosyl transferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]"
			}
			]
		},
		{
			"name":"Aminotransferase"
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"Sros_3487 selenocysteine lyase \/ isopenicillin N epimerase\tK04127 cefD; isopenicillin-N epimerase [EC:5.1.1.17]"
			},
			{
				"name":"Sros_6970 4-hydroxyphenylpyruvate dioxygenase\tK16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46]"
			},
			{
				"name":"Sros_4590 aspartate racemase\tK01779 racD; aspartate racemase [EC:5.1.1.13]"
			}
			]
		}
		]
	}
	]
}