{
	"name":"ssck03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"SPSK_04600 methylated-DNA-protein-cysteine S-methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"SPSK_06116 deoxyribodipyrimidine photo-lyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"SPSK_05302 uracil-DNA glucosyllase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"SPSK_00047 TDG\/mug DNA glucosyllase family protein\tK20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]"
					},
					{
						"name":"SPSK_08707 A\/G-specific adenine glucosyllase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"SPSK_00804 N-glucosyllase\/DNA lyase\tK03660 OGG1; N-glycosylase\/DNA lyase [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"SPSK_05083 endonuclease III\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"SPSK_03279 AP endonuclease 1\tK10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]"
					},
					{
						"name":"SPSK_05918 AP endonuclease 2\tK10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex",
						"children":[
						{
							"name":"SPSK_05870 DNA polymerase delta subunit 1\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"SPSK_05144 DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
						},
						{
							"name":"SPSK_01261 DNA polymerase delta subunit 4\tK03505 POLD4; DNA polymerase delta subunit 4"
						}
						]
					},
					{
						"name":"DNA polymerase epsilon complex",
						"children":[
						{
							"name":"SPSK_03840 DNA polymerase epsilon subunit 1\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"SPSK_10334 DNA polymerase epsilon subunit 2\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
						}
						]
					},
					{
						"name":"SPSK_09621 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"SPSK_04302 flap endonuclease-1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"SPSK_01443 DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				},
				{
					"name":"Short Patch-BER factors"
				},
				{
					"name":"Other BER factors",
					"children":[
					{
						"name":"SPSK_01080 tyrosyl-DNA phosphodiesterase 1\tK10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]"
					},
					{
						"name":"SPSK_09595 histidine triad nucleotide-binding protein\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"SPSK_04209 bifunctional polynucleotide phosphatase\/kinase\tK08073 PNKP; bifunctional polynucleotide phosphatase\/kinase [EC:3.1.3.32 2.7.1.78]"
					},
					{
						"name":"SPSK_07148 poly [ADP-ribose] polymerase\tK28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex",
						"children":[
						{
							"name":"SPSK_04902 xeroderma pigmentosum group C-complementing protein\tK10838 XPC; xeroderma pigmentosum group C-complementing protein"
						},
						{
							"name":"SPSK_08436 xeroderma pigmentosum group C-complementing protein\tK10838 XPC; xeroderma pigmentosum group C-complementing protein"
						},
						{
							"name":"SPSK_05132 UV excision repair protein RAD23\tK10839 RAD23; UV excision repair protein RAD23"
						}
						]
					},
					{
						"name":"Cul4-DDB2 complex",
						"children":[
						{
							"name":"SPSK_02774 RING-box protein 1\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"SPSK_04945 cullin 4\tK10609 CUL4; cullin 4"
						},
						{
							"name":"SPSK_08361 DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
						}
						]
					},
					{
						"name":"NER4 complex",
						"children":[
						{
							"name":"SPSK_05034 DNA repair protein RAD7\tK15082 RAD7; DNA repair protein RAD7"
						},
						{
							"name":"SPSK_04885 DNA repair protein RAD16\tK15083 RAD16; DNA repair protein RAD16"
						}
						]
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex",
						"children":[
						{
							"name":"SPSK_04798 DNA-directed RNA polymerase II subunit RPB1\tK03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]"
						},
						{
							"name":"SPSK_10960 DNA-directed RNA polymerase II subunit RPB2\tK03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]"
						},
						{
							"name":"SPSK_01794 DNA-directed RNA polymerase II subunit RPB3\tK03011 RPB3; DNA-directed RNA polymerase II subunit RPB3"
						},
						{
							"name":"SPSK_08051 DNA-directed RNA polymerase II subunit RPB4\tK03012 RPB4; DNA-directed RNA polymerase II subunit RPB4"
						},
						{
							"name":"SPSK_01895 DNA-directed RNA polymerases I, II, and III subunit RPABC1\tK03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1"
						},
						{
							"name":"SPSK_02760 DNA-directed RNA polymerases I, II, and III subunit RPABC2\tK03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2"
						},
						{
							"name":"SPSK_02509 hypothetical protein\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
						},
						{
							"name":"SPSK_08032 DNA-directed RNA polymerases I, II, and III subunit RPABC3\tK03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3"
						},
						{
							"name":"SPSK_07979 DNA-directed RNA polymerase II subunit RPB9\tK03017 RPB9; DNA-directed RNA polymerase II subunit RPB9"
						},
						{
							"name":"SPSK_10002 DNA-directed RNA polymerases I, II, and III subunit RPABC5\tK03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5"
						},
						{
							"name":"SPSK_05588 DNA-directed RNA polymerase II subunit RPB11\tK03008 RPB11; DNA-directed RNA polymerase II subunit RPB11"
						},
						{
							"name":"SPSK_10938 DNA-directed RNA polymerases I, II, and III subunit RPABC4\tK03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4"
						}
						]
					},
					{
						"name":"Cul4-CSA complex",
						"children":[
						{
							"name":"SPSK_02774 RING-box protein 1\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"SPSK_04945 cullin 4\tK10609 CUL4; cullin 4"
						},
						{
							"name":"SPSK_08361 DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
						},
						{
							"name":"SPSK_00744 DNA excision repair protein ERCC-8\tK10570 ERCC8; DNA excision repair protein ERCC-8"
						}
						]
					},
					{
						"name":"Other TCR factor",
						"children":[
						{
							"name":"SPSK_02168 DNA excision repair protein ERCC-6\tK10841 ERCC6; DNA excision repair protein ERCC-6"
						},
						{
							"name":"SPSK_05575 transcription elongation factor\tK25829 ELOF1; transcription elongation factor 1"
						}
						]
					}
					]
				},
				{
					"name":"TFIIH complex",
					"children":[
					{
						"name":"SPSK_08566 DNA excision repair protein ERCC-3\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					},
					{
						"name":"SPSK_00280 DNA excision repair protein ERCC-2\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					},
					{
						"name":"SPSK_00301 hypothetical protein\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					},
					{
						"name":"SPSK_01543 transcription initiation factor TFIIH subunit 1\tK03141 TFIIH1; transcription initiation factor TFIIH subunit 1"
					},
					{
						"name":"SPSK_01566 transcription initiation factor TFIIH subunit 2\tK03142 TFIIH2; transcription initiation factor TFIIH subunit 2"
					},
					{
						"name":"SPSK_01146 transcription initiation factor TFIIH subunit 3\tK03143 TFIIH3; transcription initiation factor TFIIH subunit 3"
					},
					{
						"name":"SPSK_02439 transcription initiation factor TFIIH subunit 4\tK03144 TFIIH4; transcription initiation factor TFIIH subunit 4"
					},
					{
						"name":"SPSK_05738 TFIIH basal transcription factor complex TTD-A subunit\tK10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit"
					},
					{
						"name":"SPSK_09298 cyclin-dependent kinase 7\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"SPSK_09275 cyclin H\tK06634 CCNH; cyclin H"
					},
					{
						"name":"SPSK_05383 CDK-activating kinase assembly factor MAT1\tK10842 MNAT1; CDK-activating kinase assembly factor MAT1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"SPSK_07207 replication factor A1\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"SPSK_03513 replication factor A2\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"SPSK_04623 replication factor A3\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Other NER factors",
					"children":[
					{
						"name":"SPSK_02531 DNA-repair protein complementing XP-A cell\tK10847 XPA; DNA-repair protein complementing XP-A cells"
					},
					{
						"name":"SPSK_06311 DNA excision repair protein ERCC-1\tK10849 ERCC1; DNA excision repair protein ERCC-1"
					},
					{
						"name":"SPSK_08455 DNA excision repair protein ERCC-4\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
					},
					{
						"name":"SPSK_08333 DNA excision repair protein ERCC-5\tK10846 ERCC5; DNA excision repair protein ERCC-5"
					},
					{
						"name":"SPSK_01443 DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"SPSK_08341 DNA repair\/transcription protein MET18\/MMS19\tK15075 MET18; DNA repair\/transcription protein MET18\/MMS19"
					},
					{
						"name":"SPSK_01645 cytosolic iron-sulfur protein assembly protein 1\tK24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1"
					},
					{
						"name":"SPSK_05404 cytoplasmic protein required for cell viability\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"SPSK_03967 cullin 3\tK03869 CUL3; cullin 3"
					},
					{
						"name":"SPSK_00326 transcription elongation factor B, polypeptide 1\tK03872 ELOC; elongin-C"
					},
					{
						"name":"SPSK_09164 hypothetical protein\tK15077 ELA1; elongin-A"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"SPSK_00411 DNA mismatch repair protein MSH2\tK08735 MSH2; DNA mismatch repair protein MSH2"
					},
					{
						"name":"SPSK_00073 DNA mismatch repair protein MSH3\tK08736 MSH3; DNA mismatch repair protein MSH3"
					},
					{
						"name":"SPSK_02949 DNA mismatch repair protein MSH6\tK08737 MSH6; DNA mismatch repair protein MSH6"
					}
					]
				},
				{
					"name":"MutL homologs",
					"children":[
					{
						"name":"SPSK_03079 DNA mismatch repair protein MLH1\tK08734 MLH1; DNA mismatch repair protein MLH1"
					},
					{
						"name":"SPSK_08387 DNA mismatch repair protein PMS2\tK10858 PMS2; DNA mismatch repair protein PMS2"
					},
					{
						"name":"SPSK_10291 DNA mismatch repair protein MLH3\tK08739 MLH3; DNA mismatch repair protein MLH3"
					}
					]
				},
				{
					"name":"DNA polymerase delta complex",
					"children":[
					{
						"name":"SPSK_05870 DNA polymerase delta subunit 1\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
					},
					{
						"name":"SPSK_05144 DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
					},
					{
						"name":"SPSK_01261 DNA polymerase delta subunit 4\tK03505 POLD4; DNA polymerase delta subunit 4"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"SPSK_07207 replication factor A1\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"SPSK_03513 replication factor A2\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"SPSK_04623 replication factor A3\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"RFC (replication factor C)",
					"children":[
					{
						"name":"SPSK_01394 replication factor C subunit 1\tK10754 RFC1; replication factor C subunit 1"
					},
					{
						"name":"SPSK_04381 replication factor C subunit 2\/4\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"SPSK_06294 replication factor C subunit 2\/4\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"SPSK_01787 replication factor C subunit 3\/5\tK10756 RFC3_5; replication factor C subunit 3\/5"
					},
					{
						"name":"SPSK_09352 replication factor C subunit 3\/5\tK10756 RFC3_5; replication factor C subunit 3\/5"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"SPSK_09621 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"SPSK_01479 exonuclease 1\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
					},
					{
						"name":"SPSK_01443 DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"SPSK_01829 WD domain protein\tK24755 WDR76; WD repeat-containing protein 76"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex",
					"children":[
					{
						"name":"SPSK_03072 double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"SPSK_00983 DNA repair protein RAD50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex"
				},
				{
					"name":"BRCA1-C complex",
					"children":[
					{
						"name":"SPSK_03072 double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"SPSK_00983 DNA repair protein RAD50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"BRCA complex",
					"children":[
					{
						"name":"SPSK_00830 DNA repair protein RAD51\tK04482 RAD51; DNA repair protein RAD51"
					}
					]
				},
				{
					"name":"RecA family proteins",
					"children":[
					{
						"name":"SPSK_00830 DNA repair protein RAD51\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"SPSK_01570 DNA repair protein RAD57\tK10958 RAD57; DNA repair protein RAD57"
					}
					]
				},
				{
					"name":"Rad52 family proteins",
					"children":[
					{
						"name":"SPSK_08796 DNA repair and recombination protein RAD52\tK10873 RAD52; DNA repair and recombination protein RAD52"
					}
					]
				},
				{
					"name":"Rad54 family proteins",
					"children":[
					{
						"name":"SPSK_00436 DNA repair and recombination protein RAD54 and RAD54-like protein\tK10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]"
					}
					]
				},
				{
					"name":"RecQ family DNA helicases",
					"children":[
					{
						"name":"SPSK_02920 bloom syndrome protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"SPSK_02920 bloom syndrome protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"SPSK_07113 DNA topoisomerase III\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"SPSK_00587 RecQ-mediated genome instability protein 1\tK15364 NCE4; RecQ-mediated genome instability protein 1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"SPSK_07207 replication factor A1\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"SPSK_03513 replication factor A2\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"SPSK_04623 replication factor A3\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Protein phosphatase 4",
					"children":[
					{
						"name":"SPSK_03083 hypothetical protein\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					}
					]
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex",
					"children":[
					{
						"name":"SPSK_08376 SMC5 protein\tK22803 SMC5; structural maintenance of chromosomes protein 5"
					},
					{
						"name":"SPSK_00385 SMC6 protein\tK22804 SMC6; structural maintenance of chromosomes protein 6"
					},
					{
						"name":"SPSK_00518 DNA repair protein Nse1\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
					},
					{
						"name":"SPSK_05250 hypothetical protein\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
					},
					{
						"name":"SPSK_06141 hypothetical protein\tK22825 NSMCE4; non-structural maintenance of chromosomes element 4"
					}
					]
				},
				{
					"name":"Other HR factors",
					"children":[
					{
						"name":"SPSK_02241 crossover junction endonuclease EME1\tK10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]"
					},
					{
						"name":"SPSK_06137 crossover junction endonuclease MUS81\tK08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]"
					},
					{
						"name":"SPSK_06751 26 proteasome complex subunit DSS1\tK10881 SHFM1; 26 proteasome complex subunit DSS1"
					},
					{
						"name":"SPSK_09188 structure-specific endonuclease subunit SLX1\tK15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]"
					},
					{
						"name":"SPSK_08490 holliday junction resolvase YEN1\tK15338 GEN1; holliday junction resolvase GEN1\/YEN1 [EC:3.1.-.-]"
					},
					{
						"name":"SPSK_04173 mortality factor 4-like protein 1\tK11339 MORF4L1; mortality factor 4-like protein 1"
					},
					{
						"name":"SPSK_00410 hypothetical protein\tK22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]"
					},
					{
						"name":"SPSK_01076 hypothetical protein\tK22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]"
					},
					{
						"name":"SPSK_08289 ATP-dependent DNA helicase MPH1\tK14635 MPH1; ATP-dependent DNA helicase MPH1 [EC:5.6.2.4]"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex",
					"children":[
					{
						"name":"SPSK_08665 ATP-dependent DNA helicase 2 subunit 1\tK10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1"
					},
					{
						"name":"SPSK_07043 ATP-dependent DNA helicase 2 subunit 2\tK10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2"
					}
					]
				},
				{
					"name":"MRX complex",
					"children":[
					{
						"name":"SPSK_03072 double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"SPSK_00983 DNA repair protein RAD50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"DNA Ligase 4 complex",
					"children":[
					{
						"name":"SPSK_05890 DNA ligase 4\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					},
					{
						"name":"SPSK_08421 hypothetical protein\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					}
					]
				},
				{
					"name":"X-family DNA polymerases",
					"children":[
					{
						"name":"SPSK_04106 DNA polymerase lambda subunit\tK10981 POL4; DNA polymerase IV [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"Other NHEJ factors",
					"children":[
					{
						"name":"SPSK_09595 histidine triad nucleotide-binding protein\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"SPSK_07126 DNA repair protein\tK10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]"
					},
					{
						"name":"SPSK_10452 Endonuclease\/Exonuclease\/phosphatase family protein\tK19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]"
					}
					]
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex"
				},
				{
					"name":"FA core complex binding factors",
					"children":[
					{
						"name":"SPSK_05663 apoptosis-inducing TAF9-like domain 1 family protein\tK11511 APITD1; centromere protein S"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"SPSK_02920 bloom syndrome protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"SPSK_07113 DNA topoisomerase III\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"SPSK_00587 RecQ-mediated genome instability protein 1\tK15364 NCE4; RecQ-mediated genome instability protein 1"
					}
					]
				},
				{
					"name":"FANCD2-I complex"
				},
				{
					"name":"Downstream FA components"
				},
				{
					"name":"Other FA pathway factors",
					"children":[
					{
						"name":"SPSK_00696 fanconi-associated nuclease 1\tK15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]"
					},
					{
						"name":"SPSK_00830 DNA repair protein RAD51\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"SPSK_04884 telomere length regulation protein\tK11137 TELO2; telomere length regulation protein"
					},
					{
						"name":"SPSK_08375 WD repeat-containing protein 48\tK15361 WDR48; WD repeat-containing protein 48"
					}
					]
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6"
				},
				{
					"name":"Ubiquitin ligases"
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"SPSK_05197 WD repeat-containing protein\tK23314 WRAP53; telomerase Cajal body protein 1"
					},
					{
						"name":"SPSK_08948 hypothetical protein\tK24752 WDR70; WD repeat-containing protein 70"
					},
					{
						"name":"SPSK_01829 WD domain protein\tK24755 WDR76; WD repeat-containing protein 76"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"SPSK_05931 DNA polymerase eta subunit\tK03509 POLH; DNA polymerase eta [EC:2.7.7.7]"
				},
				{
					"name":"SPSK_00239 DNA polymerase iota subunit\tK03510 POLI; DNA polymerase iota [EC:2.7.7.7]"
				},
				{
					"name":"SPSK_03129 DNA polymerase kappa subunit\tK03511 POLK; DNA polymerase kappa [EC:2.7.7.7]"
				},
				{
					"name":"SPSK_02160 DNA repair protein REV1\tK03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"B-family DNA polymerases",
				"children":[
				{
					"name":"SPSK_05815 DNA polymerase zeta subunit\tK02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group",
				"children":[
				{
					"name":"SPSK_00906 ubiquitin-conjugating enzyme E2 A\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
				},
				{
					"name":"SPSK_07447 E3 ubiquitin-protein ligase RAD18\tK10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]"
				},
				{
					"name":"SPSK_10447 DNA repair protein RAD5\tK15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]"
				},
				{
					"name":"SPSK_01946 ubiquitin-conjugating enzyme E2 variant\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"SPSK_06576 ubiquitin-conjugating enzyme E2 N\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				}
				]
			},
			{
				"name":"Other TLS factors",
				"children":[
				{
					"name":"SPSK_09621 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"SPSK_01498 hypothetical protein\tK26957 GCNA; germ cell nuclear acidic protein"
				}
				]
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex",
				"children":[
				{
					"name":"SPSK_07314 cell cycle checkpoint control protein RAD9A\tK10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]"
				},
				{
					"name":"SPSK_02527 HUS1 checkpoint protein\tK10903 HUS1; HUS1 checkpoint protein"
				},
				{
					"name":"SPSK_03407 cell cycle checkpoint protein\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"HRAD17(Rad24)-RFC complex",
				"children":[
				{
					"name":"SPSK_00674 cell cycle checkpoint protein\tK06662 HRAD17; cell cycle checkpoint protein"
				},
				{
					"name":"SPSK_04381 replication factor C subunit 2\/4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"SPSK_06294 replication factor C subunit 2\/4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"SPSK_01787 replication factor C subunit 3\/5\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"SPSK_09352 replication factor C subunit 3\/5\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex",
				"children":[
				{
					"name":"SPSK_03407 cell cycle checkpoint protein\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"FPC (fork protection complex)",
				"children":[
				{
					"name":"SPSK_03890 replication fork protection complex subunit Tof1\/Swi1\tK10997 TIMELESS; replication fork protection complex subunit TIMELESS\/Tof1\/Swi1"
				},
				{
					"name":"SPSK_04441 replication fork protection complex subunit Csm3\/Swi3\tK10998 TIPIN; replication fork protection complex subunit TIPIN\/Csm3\/Swi3"
				},
				{
					"name":"SPSK_00656 mediator of replication checkpoint protein 1\tK11272 MRC1; mediator of replication checkpoint protein 1"
				}
				]
			},
			{
				"name":"Triple T complex",
				"children":[
				{
					"name":"SPSK_04884 telomere length regulation protein\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"SPSK_03889 heat repeat protein\tK20403 TTI1; TELO2-interacting protein 1"
				}
				]
			},
			{
				"name":"BAG6-UBL4A-GET4 complex",
				"children":[
				{
					"name":"SPSK_01936 hypothetical protein\tK23388 UBL4; ubiquitin-like protein 4"
				},
				{
					"name":"SPSK_06426 hypothetical protein\tK23387 GET4; golgi to ER traffic protein 4"
				}
				]
			},
			{
				"name":"SOSS complex"
			},
			{
				"name":"Other check point factors",
				"children":[
				{
					"name":"SPSK_02913 serine\/threonineeeee-protein kinase ATR\tK06640 ATR; serine\/threonine-protein kinase ATR [EC:2.7.11.1]"
				},
				{
					"name":"SPSK_04788 ataxia telangectasia mutated family protein\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"SPSK_04135 serine\/threonineeeee-protein kinase Chk1\tK02216 CHEK1; serine\/threonine-protein kinase CHEK1 [EC:2.7.11.1]"
				},
				{
					"name":"SPSK_05999 serine\/threonineeeee-protein kinase Chk2\tK06641 CHEK2; serine\/threonine-protein kinase CHEK2 [EC:2.7.11.1]"
				},
				{
					"name":"SPSK_04062 M-phase inducer tyrosine phosphatase\tK02555 MIH1; M-phase inducer tyrosine phosphatase [EC:3.1.3.48]"
				},
				{
					"name":"SPSK_05465 tyrosine 3-monooxygenase\/tryptophan 5-monooxygenase activation protein\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"SPSK_06387 tyrosine 3-monooxygenase\/tryptophan 5-monooxygenase activation protein\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"SPSK_00667 mitosis inhibitor protein kinase SWE1\tK03114 SWE1; mitosis inhibitor protein kinase SWE1 [EC:2.7.11.1]"
				},
				{
					"name":"SPSK_08564 hypothetical protein\tK24664 FKH; forkhead protein FKH"
				},
				{
					"name":"SPSK_04312 vacuolar protein-sorting-associated protein 4\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				},
				{
					"name":"SPSK_00312 hypothetical protein\tK25059 SDE2; replication stress response regulator SDE2"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases",
				"children":[
				{
					"name":"SPSK_05856 DNA polymerase phi subunit\tK02331 POL5; DNA polymerase phi [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"Nucleases",
				"children":[
				{
					"name":"SPSK_00692 DNA cross-link repair 1A protein\tK15340 DCLRE1A; DNA cross-link repair 1A protein"
				},
				{
					"name":"SPSK_08871 hypothetical protein\tK17815 EXO5; exonuclease V [EC:3.1.-.-]"
				},
				{
					"name":"SPSK_03447 hypothetical protein\tK05986 NUCS; nuclease S1 [EC:3.1.30.1]"
				},
				{
					"name":"SPSK_03497 nuclease S1\tK05986 NUCS; nuclease S1 [EC:3.1.30.1]"
				}
				]
			},
			{
				"name":"Helicases",
				"children":[
				{
					"name":"SPSK_05829 hypothetical protein\tK20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]"
				}
				]
			},
			{
				"name":"PSO4 complex",
				"children":[
				{
					"name":"SPSK_03335 pre-mRNA-processing factor 19\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
				},
				{
					"name":"SPSK_00435 pre-mRNA-splicing factor CDC5\/CEF1\tK12860 CDC5L; pre-mRNA-splicing factor CDC5\/CEF1"
				},
				{
					"name":"SPSK_05541 pre-mRNA-splicing factor SPF27\tK12861 BCAS2; pre-mRNA-splicing factor SPF27"
				},
				{
					"name":"SPSK_03309 pleiotropic regulator 1\tK12862 PLRG1; pleiotropic regulator 1"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"SPSK_08033 hypothetical protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"SPSK_09806 dUTP pyrophosphatase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"SPSK_03956 ribonucleoside-diphosphate reductase subunit M1\tK10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]"
				},
				{
					"name":"SPSK_02467 ribonucleoside-diphosphate reductase subunit M2\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"SPSK_04600 methylated-DNA-protein-cysteine S-methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"SPSK_06116 deoxyribodipyrimidine photo-lyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"SPSK_05302 uracil-DNA glucosyllase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"SPSK_05349 DNA-3-methyladenine glucosyllase II\tK01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]"
					},
					{
						"name":"SPSK_08707 A\/G-specific adenine glucosyllase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"SPSK_05286 formamidopyrimidine-DNA glucosyllase\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]"
					},
					{
						"name":"SPSK_05083 endonuclease III\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"RecJ"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"DNA polymerase I"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"SPSK_08337 DNA helicase II\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)"
					},
					{
						"name":"TRCF (transcription-repair coupling factor)"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"Molecular matchmaker"
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases"
				},
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"SPSK_08337 DNA helicase II\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins"
				},
				{
					"name":"RecFOR pathway proteins"
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway"
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"SPSK_08033 hypothetical protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"SPSK_09806 dUTP pyrophosphatase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}