{
	"name":"strf01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases",
				"children":[
				{
					"name":"ASR50_18410 hydroxyurea phosphotransferase\tK04343 strB; streptomycin 6-kinase [EC:2.7.1.72]"
				},
				{
					"name":"ASR50_25770 kinase\tK04343 strB; streptomycin 6-kinase [EC:2.7.1.72]"
				}
				]
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"ASR50_10950 ABC transporter\tK18233 oleC5; oleandomycin transport system permease protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters",
				"children":[
				{
					"name":"ASR50_33915 tylosin resistance protein TlrC\tK18230 tylC; macrolide transport system ATP-binding\/permease protein"
				},
				{
					"name":"ASR50_33970 ABC transporter ATP-binding protein\tK18230 tylC; macrolide transport system ATP-binding\/permease protein"
				},
				{
					"name":"ASR50_10945 ABC transporter\tK18232 oleC4; oleandomycin transport system ATP-binding protein"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"ASR50_18585 virginiamycin B lyase\tK18235 vgb; virginiamycin B lyase [EC:4.2.99.-]"
				},
				{
					"name":"ASR50_27810 glycosyl transferase\tK21251 mgt; macrolide glycosyltransferase"
				}
				]
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"ASR50_33230 chemotaxis protein\tK18553 cmlR; MFS transporter, DHA1 family, chloramphenicol resistance protein"
				}
				]
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase",
				"children":[
				{
					"name":"ASR50_29350 chloramphenicol phosphotransferase\tK18554 cpt; chloramphenicol 3-O phosphotransferase [EC:2.7.1.-]"
				}
				]
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter",
				"children":[
				{
					"name":"ASR50_07450 MFS transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				},
				{
					"name":"ASR50_08385 transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"ASR50_05495 hypothetical protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"ASR50_21000 hypothetical protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"ASR50_16190 class A beta-lactamase\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				},
				{
					"name":"ASR50_16205 serine hydrolase\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]"
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"ASR50_10925 hypothetical protein\tK18353 vanJ; vancomycin resistance protein VanJ"
				},
				{
					"name":"ASR50_30740 endonuclease\tK18353 vanJ; vancomycin resistance protein VanJ"
				},
				{
					"name":"ASR50_06595 D-alanyl-D-alanine dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]",
				"children":[
				{
					"name":"ASR50_07455 TetR family transcriptional regulator\tK18294 nfxB; TetR\/AcrR family transcriptional regulator, mexCD-oprJ operon repressor"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]"
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]"
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]"
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]",
				"children":[
				{
					"name":"ASR50_07450 MFS transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				},
				{
					"name":"ASR50_08385 transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}