{
	"name":"swo02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"Swol_0480 CRISPR-associated protein, Cas1 family\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Swol_1749 CRISPR-associated protein, Cas1 family\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Swol_1803 CRISPR-associated protein, Cas1 family\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Swol_2516 CRISPR-associated protein, Cas1 family\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Swol_0481 CRISPR-associated protein, Cas2 family\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"Swol_1748 CRISPR-associated protein, Cas2 family\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"Swol_1802 CRISPR-associated protein, Cas2 family\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"Swol_2515 CRISPR-associated protein, Cas2 family\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"Swol_0475 CRISPR-associated helicase, Cas3 family\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				},
				{
					"name":"Swol_1805 CRISPR-associated helicase, Cas3 family\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				},
				{
					"name":"Swol_2518 helicases-like protein\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"Swol_0479 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_1804 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_2517 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_1809 hypothetical protein\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"Swol_1808 hypothetical protein\tK19114 csh1; CRISPR-associated protein Csh1"
				},
				{
					"name":"Swol_2522 CRISPR-associated protein, Csh1 family\tK19114 csh1; CRISPR-associated protein Csh1"
				},
				{
					"name":"Swol_1807 conserved hypothetical protein\tK19115 csh2; CRISPR-associated protein Csh2"
				},
				{
					"name":"Swol_2520 CRISPR-associated protein, Csh2 family\tK19115 csh2; CRISPR-associated protein Csh2"
				},
				{
					"name":"Swol_0479 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_1804 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_2517 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_1806 CRISPR-associated protein, Cas5h family\tK19116 cas5h; CRISPR-associated protein Cas5h"
				},
				{
					"name":"Swol_2519 CRISPR-associated protein, Cas5h family\tK19116 cas5h; CRISPR-associated protein Cas5h"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"Swol_0477 CRISPR-associated protein, Csd1 family\tK19117 csd1; CRISPR-associated protein Csd1"
				},
				{
					"name":"Swol_0478 CRISPR-associated protein, Csd2 family\tK19118 csd2; CRISPR-associated protein Csd2"
				},
				{
					"name":"Swol_0479 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_1804 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_2517 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_0476 CRISPR-associated protein, Csd5d family\tK19119 cas5d; CRISPR-associated protein Cas5d"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"Swol_0479 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_1804 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_2517 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_1809 hypothetical protein\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors",
				"children":[
				{
					"name":"Swol_2527 hypothetical protein\tK19134 csx10; CRISPR-associated protein Csx10"
				}
				]
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"Swol_0479 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_1804 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Swol_2517 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins",
				"children":[
				{
					"name":"Swol_1756 CRISPR-associated protein, Csm1 family\tK07016 csm1; CRISPR-associated protein Csm1"
				}
				]
			},
			{
				"name":"Subtype III-A factors",
				"children":[
				{
					"name":"Swol_1755 hypothetical protein\tK19138 csm2; CRISPR-associated protein Csm2"
				},
				{
					"name":"Swol_1754 CRISPR-associated protein, Csm3 family\tK09002 csm3; CRISPR-associated protein Csm3"
				},
				{
					"name":"Swol_1753 CRISPR-associated protein, Csm4 family\tK19139 csm4; CRISPR-associated protein Csm4"
				},
				{
					"name":"Swol_1752 CRISPR-associated protein, Csm5 family\tK19140 csm5; CRISPR-associated protein Csm5"
				}
				]
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"Swol_0516 type I restriction-modification system R subunit (endonuclease)\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Swol_2256 type I restriction-modification system, R subunit\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Swol_0515 type I restriction-modification system (specificity subunit)\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Swol_2257 Restriction endonuclease S subunits-like protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Swol_0512 type I restriction modification system M subunit (site-specific DNA-methyltransferase subunit)\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"Swol_2258 type I restriction-modification system, M subunit\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"Swol_0503 Site-specific DNA methylase-like protein\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"Swol_0838 Site-specific DNA-methyltransferase (adenine-specific)\tK00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system",
			"children":[
			{
				"name":"Swol_1462 DNA or RNA helicases of superfamily II-like protein\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"Swol_1547 type III restriction system endonuclease\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"Swol_1463 Adenine specific DNA methylase Mod-like protein\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			},
			{
				"name":"Swol_1548 site-specific DNA-methyltransferase (adenine-specific)\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"Swol_2196 Hnh endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"Swol_0993 Restriction endonuclease-like protein\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"Swol_1876 transcriptional modulator of MazE\/toxin, MazF\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"Swol_1879 transcriptional modulator of MazE\/toxin, MazF\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"Swol_1877 transcriptional regulator\/antitoxin, MazE\tK07172 mazE; antitoxin MazE"
				},
				{
					"name":"Swol_1880 putative transcriptional regulator, CopG family\tK07723 ndoAI; CopG family transcriptional regulator \/ antitoxin EndoAI"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"Swol_0286 hypothetical protein\tK06218 relE; mRNA interferase RelE\/StbE"
				}
				]
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"Swol_1075 conserved hypothetical protein\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"Swol_0393 conserved hypothetical protein\tK07473 dinJ; DNA-damage-inducible protein J"
				},
				{
					"name":"Swol_1074 putative DNA-damage-inducibile protein\tK07473 dinJ; DNA-damage-inducible protein J"
				}
				]
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"Swol_0392 conserved hypothetical protein\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"Swol_0432 conserved hypothetical protein\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"Swol_0433 prevent-host-death protein\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"Swol_2275 death-on-curing protein\tK07341 doc; death on curing protein"
				}
				]
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"Swol_0482 hypothetical protein\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"Swol_0483 putative plasmid maintenance system antidote protein, XRE family\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"Swol_0833 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"Swol_1641 rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"Swol_2374 rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"Swol_0930 glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA",
				"children":[
				{
					"name":"Swol_0216 conserved hypothetical protein\tK28186 hepT; HepT family RNase toxin"
				}
				]
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"Swol_0746 conserved hypothetical protein\tK19169 dndB; DNA sulfur modification protein DndB"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}