{
	"name":"syp02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"SYNPCC7002_A1777 cas; putative CRISPR-associated protein\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"SYNPCC7002_D0019 cas1; CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"SYNPCC7002_F0054 cas1; CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"SYNPCC7002_A1778 cas2; CRISPR-associated protein\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"SYNPCC7002_D0018 cas2; CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"SYNPCC7002_A1771 cas3; CRISPR-associated helicase\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				},
				{
					"name":"SYNPCC7002_D0025 conserved hypothetical protein, helicase domain\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"SYNPCC7002_A1773 CRISPR-associated regulatory protein, DevR family\tK19075 cst2; CRISPR-associated protein Cst2"
				},
				{
					"name":"SYNPCC7002_D0020 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"SYNPCC7002_A1776 conserved hypothetical protein\tK19090 cas5t; CRISPR-associated protein Cas5t"
				},
				{
					"name":"SYNPCC7002_D0021 CRISPR-associated protein, TM1814 family\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"SYNPCC7002_D0020 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"SYNPCC7002_D0020 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"SYNPCC7002_D0022 conserved hypothetical protein\tK19120 csc1; CRISPR-associated protein Csc1"
				},
				{
					"name":"SYNPCC7002_D0023 conserved hypothetical protein\tK19121 csc2; CRISPR-associated protein Csc2"
				},
				{
					"name":"SYNPCC7002_D0024 conserved hypothetical protein\tK19122 csc3; CRISPR-associated protein Csc3"
				},
				{
					"name":"SYNPCC7002_D0020 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"SYNPCC7002_D0021 CRISPR-associated protein, TM1814 family\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"SYNPCC7002_D0020 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors",
				"children":[
				{
					"name":"SYNPCC7002_F0048 conserved hypothetical protein\tK19076 cmr2; CRISPR-associated protein Cmr2"
				},
				{
					"name":"SYNPCC7002_F0047 conserved hypothetical protein\tK09127 cmr3; CRISPR-associated protein Cmr3"
				},
				{
					"name":"SYNPCC7002_F0046 conserved hypothetical protein\tK09000 cmr4; CRISPR-associated protein Cmr4"
				},
				{
					"name":"SYNPCC7002_F0044 Protein of unknown function (DUF324)\tK19142 cmr6; CRISPR-associated protein Cmr6"
				}
				]
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"SYNPCC7002_C0006 type I site-specific restriction-modification system, R (restriction) subunit\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"SYNPCC7002_C0004 type 1 restriction-modification system specificity subunit\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"SYNPCC7002_C0003 Type I N6 DNA Methyltransferase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"SYNPCC7002_F0089 Type I restriction modification system, N-6 DNA Methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases",
				"children":[
				{
					"name":"SYNPCC7002_A1189 type II site-specific deoxyribonuclease\tK01155 E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]"
				}
				]
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"SYNPCC7002_A1620 dam; adenine-specific DNA methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"SYNPCC7002_A0849 site-specific DNA-methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"SYNPCC7002_A1188 dcm; DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"SYNPCC7002_E0012 Cytosine-specific methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system",
			"children":[
			{
				"name":"SYNPCC7002_E0035 type III restriction-modification enzyme, R\/helicase subunit\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"SYNPCC7002_E0038 DNA methylase\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"SYNPCC7002_A1072 GTPase subunit of Type II restriction endonuclease\tK07452 mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]"
			},
			{
				"name":"SYNPCC7002_A1001 restriction endonuclease, similarity to Mrr\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"SYNPCC7002_F0009 transcriptional regulator, PemK family\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"SYNPCC7002_G0085 PemK-like protein\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"SYNPCC7002_F0010 PemI-like protein 2; suppressor of ppGpp-regulated growth inhibitor (ChpA\/MazF)\tK07172 mazE; antitoxin MazE"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"SYNPCC7002_A2640 addiction module toxin, RelE\/StbE family subfamily\tK06218 relE; mRNA interferase RelE\/StbE"
				}
				]
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"SYNPCC7002_A0836 addiction module toxin, Txe\/YoeB family\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"SYNPCC7002_A0837 probable antitoxin of toxin-antitoxin stability system\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"SYNPCC7002_F0075 death-on-curing protein\tK07341 doc; death on curing protein"
				}
				]
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"SYNPCC7002_F0023 conserved hypothetical protein\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"SYNPCC7002_D0015 conserved hypothetical protein containing helix turn helix domain\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"SYNPCC7002_F0024 conserved hypothetical protein with helix-turn-helix domain\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"SYNPCC7002_F0029 conserved hypothetical protein, PIN domain\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"SYNPCC7002_F0030 conserved hypothetical protein\tK18829 mvpT; antitoxin VapB"
				},
				{
					"name":"SYNPCC7002_A0409 conserved hypothetical protein, PIN domain\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"SYNPCC7002_A1775 PIN domain protein\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"SYNPCC7002_C0012 conserved hypothetical protein, PIN domain\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"SYNPCC7002_F0079 conserved hypothetical protein, PIN domain\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"SYNPCC7002_A2315 conserved hypothetical protein\tK28280 vapB22; antitoxin VapB22"
				},
				{
					"name":"SYNPCC7002_C0013 conserved hypothetical protein\tK28280 vapB22; antitoxin VapB22"
				},
				{
					"name":"SYNPCC7002_F0080 prevent-host-death family protein\tK28280 vapB22; antitoxin VapB22"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA",
				"children":[
				{
					"name":"SYNPCC7002_A0055 PIN domain protein\tK07062 fitB; toxin FitB [EC:3.1.-.-]"
				},
				{
					"name":"SYNPCC7002_A0056 conserved hypothetical protein\tK21495 fitA; antitoxin FitA"
				}
				]
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"SYNPCC7002_A0024 ftsZ; cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"SYNPCC7002_A1525 cell shape determining protein, MreB\/Mrl family subfamily\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"SYNPCC7002_A1394 gltX; glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"SYNPCC7002_A0787 nifS; Cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"SYNPCC7002_A0921 nifS; cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}