{
	"name":"thd03000",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Basic leucine zipper (bZIP)",
			"children":[
			{
				"name":"AP-1(-like) components, Jun"
			},
			{
				"name":"AP-1(-like) components, Fos"
			},
			{
				"name":"AP-1(-like) components, Maf"
			},
			{
				"name":"AP-1(-like) components, NF-E2"
			},
			{
				"name":"AP-1(-like) components, Fungal regulators"
			},
			{
				"name":"AP-1(-like) components, CRE-BP\/ATF"
			},
			{
				"name":"CREB"
			},
			{
				"name":"C\/EBP-like factors"
			},
			{
				"name":"bZIP\/PAR"
			},
			{
				"name":"Plant bZIP factors"
			},
			{
				"name":"ZIP only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix (bHLH)",
			"children":[
			{
				"name":"Ubiquitous (class A) factors"
			},
			{
				"name":"Myogenic transcription factors"
			},
			{
				"name":"Achaete-Scute"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Lymphoid factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesodermal Twist-like factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, HEN"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesp"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Atonal"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Pancreatic factors"
			},
			{
				"name":"Hairy, Hairy\/E(SPL)"
			},
			{
				"name":"Hairy, Fungal regulators"
			},
			{
				"name":"Factors with PAS domain"
			},
			{
				"name":"Yabby"
			},
			{
				"name":"INO"
			},
			{
				"name":"HLH domain only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix\/leucine zipper (bHLH-ZIP)",
			"children":[
			{
				"name":"Ubiquitous bHLH-ZIP factors"
			},
			{
				"name":"Cell cycle controlling factors, Myc"
			},
			{
				"name":"Cell cycle controlling factors, Mad\/Max"
			},
			{
				"name":"Other bHLH-ZIP factors"
			}
			]
		},
		{
			"name":"Other basic domains",
			"children":[
			{
				"name":"NF-1"
			},
			{
				"name":"RF-X"
			},
			{
				"name":"AP-2 (bHSH)"
			}
			]
		},
		{
			"name":"Zinc finger",
			"children":[
			{
				"name":"Cys4 thyroid hormone receptor-like"
			},
			{
				"name":"Cys4 hepatocyte nuclear factor 4-like"
			},
			{
				"name":"Cys4 estrogen receptor-like"
			},
			{
				"name":"Cys4 nerve growth factor IB-like"
			},
			{
				"name":"Cys4 Fushi tarazu-F1-like"
			},
			{
				"name":"Cys4 germ cell nuclear factor"
			},
			{
				"name":"Cys4 Knirps\/DAX1-like"
			},
			{
				"name":"Cys4 GATA-factors"
			},
			{
				"name":"Cys2His2 SP\/KLF family and related proteins"
			},
			{
				"name":"Cys2His2 GLI-like"
			},
			{
				"name":"Cys2His2 Snail"
			},
			{
				"name":"Cys2His2 BTB-ZF factors"
			},
			{
				"name":"Cys2His2 BED"
			},
			{
				"name":"Cys2His2 PRDM"
			},
			{
				"name":"Cys2His2 metabolic regulators in fungi"
			},
			{
				"name":"Cys2His2 others"
			},
			{
				"name":"Cys2HisCys zinc factors"
			},
			{
				"name":"Cys3His zinc factors"
			},
			{
				"name":"Cys2CysHis zinc factors"
			},
			{
				"name":"CXXC CpG-binding proteins"
			},
			{
				"name":"Cys6 metabolic regulators in fungi"
			},
			{
				"name":"Other zinc fingers"
			}
			]
		},
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"Homeo domain ANTP: HOXL"
			},
			{
				"name":"Homeo domain ANTP: NKL"
			},
			{
				"name":"Homeo domain Paired-related"
			},
			{
				"name":"Homeo domain LIM"
			},
			{
				"name":"Homeo domain POU"
			},
			{
				"name":"Homeo domain SINE"
			},
			{
				"name":"Homeo domain ZF"
			},
			{
				"name":"Homeo domain CUT"
			},
			{
				"name":"Homeo domain PROS"
			},
			{
				"name":"Homeo domain TALE"
			},
			{
				"name":"Homeo domain other"
			},
			{
				"name":"Fork head\/winged helix developmental regulators"
			},
			{
				"name":"Fork head\/winged helix tissue-specific regulators"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, E2F"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, DP"
			},
			{
				"name":"Fork head\/winged helix other regulators"
			},
			{
				"name":"Stork head\/winged helix factors"
			},
			{
				"name":"Heat shock factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-like factors"
			},
			{
				"name":"Tryptophan clusters Ets-type"
			},
			{
				"name":"Tryptophan clusters interferon-regulating factors"
			},
			{
				"name":"TEA domain"
			},
			{
				"name":"ARID"
			}
			]
		},
		{
			"name":"beta-Scaffold factors with minor groove contacts",
			"children":[
			{
				"name":"RHR (Rel homology region) Rel\/Ankyrin"
			},
			{
				"name":"RHR (Rel homology region) Ankyrin only"
			},
			{
				"name":"RHR (Rel homology region) NF-AT"
			},
			{
				"name":"STAT"
			},
			{
				"name":"p53"
			},
			{
				"name":"MADS-box regulators of differentiation, MEF-2"
			},
			{
				"name":"MADS-box regulators of differentiation, Homeotic genes"
			},
			{
				"name":"MADS-box regulators of differentiation, Yeast regulators"
			},
			{
				"name":"MADS-box responders to external signals"
			},
			{
				"name":"SAND domain-containing proteins"
			},
			{
				"name":"TATA-binding proteins"
			},
			{
				"name":"HMG SOX"
			},
			{
				"name":"HMG TCF-1"
			},
			{
				"name":"HMG TOX"
			},
			{
				"name":"HMG2-related"
			},
			{
				"name":"UBF"
			},
			{
				"name":"Other HMG box factors"
			},
			{
				"name":"Heteromeric CCAAT factors"
			},
			{
				"name":"Grainyhead"
			},
			{
				"name":"Cold-shock domain factors, DbpA-like"
			},
			{
				"name":"Cold-shock domain factors, YB-1\/DbpB-like"
			},
			{
				"name":"Cold-shock domain factors, FRG Y2-like"
			},
			{
				"name":"Runt"
			},
			{
				"name":"MYRF"
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"HMGI(Y)"
			},
			{
				"name":"NUPR"
			},
			{
				"name":"Pocket domain Rb"
			},
			{
				"name":"Pocket domain CBP"
			},
			{
				"name":"T-box"
			},
			{
				"name":"DMRT"
			},
			{
				"name":"LRRFIP"
			},
			{
				"name":"TCP"
			},
			{
				"name":"AP2\/ERF"
			},
			{
				"name":"WRKY"
			},
			{
				"name":"LOB"
			},
			{
				"name":"GRAS"
			},
			{
				"name":"NAC"
			},
			{
				"name":"Copper-fist proteins fungal regulators"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"AraC family",
				"children":[
				{
					"name":"BHV28_00650 ada; 6-O-methylguanine DNA methyltransferase\tK10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response \/ methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]"
				}
				]
			},
			{
				"name":"LysR family",
				"children":[
				{
					"name":"BHV28_11550 MerR family transcriptional regulator\tK11921 cynR; LysR family transcriptional regulator, cyn operon transcriptional activator"
				}
				]
			},
			{
				"name":"DeoR family"
			},
			{
				"name":"LacI family"
			},
			{
				"name":"GntR family",
				"children":[
				{
					"name":"BHV28_12960 hutC; Histidine utilization repressor, GntR family\tK05836 hutC; GntR family transcriptional regulator, histidine utilization repressor"
				}
				]
			},
			{
				"name":"TetR\/AcrR family",
				"children":[
				{
					"name":"BHV28_01380 betI; HTH-type transcriptional regulator BetI\tK02167 betI; TetR\/AcrR family transcriptional regulator, transcriptional repressor of bet genes"
				}
				]
			},
			{
				"name":"Lrp\/AsnC family",
				"children":[
				{
					"name":"BHV28_10880 ArsR family transcriptional regulator\tK05800 decR; Lrp\/AsnC family transcriptional regulator, cysteine-sensing transcriptional activator"
				}
				]
			},
			{
				"name":"LuxR family"
			},
			{
				"name":"MarR family"
			},
			{
				"name":"MerR family"
			},
			{
				"name":"Fur family",
				"children":[
				{
					"name":"BHV28_02560 fur; Ferric uptake regulation protein\tK03711 fur; Fur family transcriptional regulator, ferric uptake regulator"
				},
				{
					"name":"BHV28_08380 Ferric uptake regulator Fur family protein\tK09823 zur; Fur family transcriptional regulator, zinc uptake regulator"
				},
				{
					"name":"BHV28_14770 Ferric uptake regulator family protein\tK09826 irr; Fur family transcriptional regulator, iron response regulator"
				}
				]
			},
			{
				"name":"IclR family"
			},
			{
				"name":"CRP\/FNR family",
				"children":[
				{
					"name":"BHV28_12550 Crp\/Fnr family transcriptional regulator\tK01420 fnr; CRP\/FNR family transcriptional regulator, anaerobic regulatory protein"
				}
				]
			},
			{
				"name":"Rrf2 family",
				"children":[
				{
					"name":"BHV28_07310 Rrf2 family protein\tK13772 rirA; Rrf2 family transcriptional regulator, iron-responsive regulator"
				}
				]
			},
			{
				"name":"ArsR family",
				"children":[
				{
					"name":"BHV28_04720 Putative DNA-binding protein\tK22042 hlyU; ArsR family transcriptional regulator, virulence genes transcriptional regulator"
				}
				]
			},
			{
				"name":"XRE family"
			},
			{
				"name":"PadR family"
			},
			{
				"name":"Other families",
				"children":[
				{
					"name":"BHV28_06310 Biotin--acetyl-CoA-carboxylase ligase\tK03524 birA; BirA family transcriptional regulator, biotin operon repressor \/ biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]"
				},
				{
					"name":"BHV28_16660 Putative DNA-binding protein\tK07726 K07726; putative transcriptional regulator"
				}
				]
			}
			]
		},
		{
			"name":"Ribbon-helix-helix",
			"children":[
			{
				"name":"CopG family"
			},
			{
				"name":"Other families",
				"children":[
				{
					"name":"BHV28_01280 putA; Bifunctional proline dehydrogenase\/delta-1-pyrroline-5-carboxylatedehydrogenase\tK13821 putA; RHH-type transcriptional regulator, proline utilization regulon repressor \/ proline dehydrogenase \/ delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]"
				}
				]
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"BglG family"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"BHV28_15800 BolA-like protein family\tK05527 bolA; BolA family transcriptional regulator, general stress-responsive regulator"
				},
				{
					"name":"BHV28_00100 parB; Chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"BHV28_15560 CarD-like\/TRCF domain-containing protein\tK07736 carD; CarD family transcriptional regulator, regulator of rRNA transcription"
				},
				{
					"name":"BHV28_17000 hrcA; Heat-inducible transcription repressor HrcA\tK03705 hrcA; heat-inducible transcriptional repressor"
				},
				{
					"name":"BHV28_14060 Putative transcriptional regulator\tK07735 algH; putative transcriptional regulator"
				},
				{
					"name":"BHV28_10730 dksA; RNA polymerase-binding transcription factor DksA\tK06204 dksA; RNA polymerase-binding transcription factor"
				},
				{
					"name":"BHV28_07710 nrdR; Transcriptional repressor NrdR\tK07738 nrdR; transcriptional repressor NrdR"
				},
				{
					"name":"BHV28_05280 Sel1 repeat-containing protein\tK25885 exoR; exopolysaccharide production negative regulator"
				}
				]
			}
			]
		}
		]
	}
	]
}