{
	"name":"thi03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)"
			},
			{
				"name":"CDK (cyclin dependent kinase)"
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)"
			},
			{
				"name":"GINS complex"
			},
			{
				"name":"Other initiation factors"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex"
			},
			{
				"name":"DNA polymerase epsilon complex"
			},
			{
				"name":"DNA polymerase delta complex"
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)"
			},
			{
				"name":"RPA (replication protein A)"
			},
			{
				"name":"RFC (replication factor C)"
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"THI_2428 rnhA; Ribonuclease HI (RNase HI) (Ribonuclease H) (RNase H)\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				}
				]
			},
			{
				"name":"Other elongation factors"
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"THI_p0025 putative C-5 cytosine-specific DNA methylase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors"
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex"
				},
				{
					"name":"TERB1-TERB2-MAJIN complex"
				},
				{
					"name":"CST complex (animals)"
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins"
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"Dyskerin complex"
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"Sm core complex"
				}
				]
			},
			{
				"name":"ELG1-RFC complex"
			},
			{
				"name":"MRN complex"
			},
			{
				"name":"Other termination factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases"
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)",
				"children":[
				{
					"name":"THI_1423 hupB; DNA-binding protein HU-beta (NS1) (HU-1)\tK03530 hupB; DNA-binding protein HU-beta"
				},
				{
					"name":"THI_1705 ihfA; integration host factor (IHF), alpha subunit\tK04764 ihfA; integration host factor subunit alpha"
				},
				{
					"name":"THI_2300 himD; Integration host factor subunit beta (IHF-beta)\tK05788 ihfB; integration host factor subunit beta"
				},
				{
					"name":"THI_2373 putative Integration host factor (IHF)\tK05788 ihfB; integration host factor subunit beta"
				},
				{
					"name":"THI_0001 dnaA; Chromosomal replication initiator protein dnaA\tK02313 dnaA; chromosomal replication initiator protein"
				},
				{
					"name":"THI_2447 dnaB; Replicative DNA helicase\tK02314 dnaB; replicative DNA helicase [EC:5.6.2.3]"
				},
				{
					"name":"THI_2093 putative DNA primase\tK02316 dnaG; DNA primase [EC:2.7.7.101]"
				},
				{
					"name":"THI_0087 ssb; Single-stranded DNA-binding protein (SSB) (Helix-destabilizing protein)\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"THI_p0033 ssb; Single-stranded DNA-binding protein (SSB) (Helix-destabilizing protein)\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme",
					"children":[
					{
						"name":"THI_2829 dnaE; DNA polymerase III subunit alpha\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]"
					},
					{
						"name":"THI_0002 dnaN; DNA polymerase III, beta subunit\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]"
					},
					{
						"name":"THI_2980 putative DNA polymerase III chi subunit, HolC\tK02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]"
					},
					{
						"name":"THI_0168 putative DNA polymerase III, delta subunit\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]"
					},
					{
						"name":"THI_1879 putative DNA-directed DNA polymerase\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]"
					},
					{
						"name":"THI_1346 putative protein fusion of DNA polymerase III, epsilon subunit and Excinuclease ABC, C subunit\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"THI_1689 dnaQ; DNA polymerase III subunit epsilon\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"THI_2291 putative DNA polymerase III subunit tau [Contains: DNA polymerase III subunit gamma] (DnaX)\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"THI_2428 rnhA; Ribonuclease HI (RNase HI) (Ribonuclease H) (RNase H)\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"THI_2458 rnhB; Ribonuclease HII (RNase HII)\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"THI_1572 polA; DNA polymerase I (POL I)\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					},
					{
						"name":"THI_1898 ligA; DNA ligase (Polydeoxyribonucleotide synthase [NAD+])\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"THI_2428 rnhA; Ribonuclease HI (RNase HI) (Ribonuclease H) (RNase H)\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"THI_2458 rnhB; Ribonuclease HII (RNase HII)\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"THI_0080 ecoRVM; Modification methylase EcoRV (Adenine-specific methyltransferase EcoRV) (M.EcoRV)\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors",
				"children":[
				{
					"name":"THI_1285 putative ATPase involved in DNA replication initiation\tK10763 hda; DnaA-homolog protein"
				}
				]
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"THI_2307 gyrA; DNA gyrase subunit A\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]"
			},
			{
				"name":"THI_0003 gyrB; DNA gyrase subunit B\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]"
			},
			{
				"name":"THI_0549 parC; DNA topoisomerase 4 subunit A (Topoisomerase IV subunit A)\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
			},
			{
				"name":"THI_0550 parE; DNA topoisomerase 4 subunit B (Topoisomerase IV subunit B)\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
			},
			{
				"name":"THI_0757 putative DNA topoisomerase III, bacterial-type\tK03169 topB; DNA topoisomerase III [EC:5.6.2.1]"
			},
			{
				"name":"THI_2315 putative DNA topoisomerase III (TopB)\tK03169 topB; DNA topoisomerase III [EC:5.6.2.1]"
			}
			]
		}
		]
	}
	]
}