{
	"name":"tht03009",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Sno RNPs",
			"children":[
			{
				"name":"Box C\/D snoRNPs"
			},
			{
				"name":"Box H\/ACA snoRNPs"
			}
			]
		},
		{
			"name":"90S particles",
			"children":[
			{
				"name":"U3 small nucleolar RNA-associated proteins"
			},
			{
				"name":"Helicases"
			},
			{
				"name":"GTPase"
			},
			{
				"name":"RNase",
				"children":[
				{
					"name":"E2K93_12060 ribonuclease III\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
				}
				]
			},
			{
				"name":"Kinase"
			},
			{
				"name":"Other 90S particles"
			}
			]
		},
		{
			"name":"Pre-40S particles",
			"children":[
			{
				"name":"Kinases"
			},
			{
				"name":"Export and cytoplasmic maturation factors"
			},
			{
				"name":"Other pre-40S particles"
			}
			]
		},
		{
			"name":"Pre-60S particles",
			"children":[
			{
				"name":"Helicases"
			},
			{
				"name":"GTPases"
			},
			{
				"name":"RNases",
				"children":[
				{
					"name":"E2K93_09705 oligoribonuclease\tK13288 orn; oligoribonuclease [EC:3.1.-.-]"
				},
				{
					"name":"RNase MRP"
				}
				]
			},
			{
				"name":"Kinases"
			},
			{
				"name":"Export and cytoplasmic maturation factors"
			},
			{
				"name":"55LCC heterohexameric ATPase complex"
			},
			{
				"name":"5-FMC complex"
			},
			{
				"name":"Ribosome quality control proteins"
			},
			{
				"name":"Other pre-60S particles"
			}
			]
		},
		{
			"name":"Other ribosome biogenesis factors",
			"children":[
			{
				"name":"E2K93_12065 GTPase Era\tK03595 era; GTPase"
			},
			{
				"name":"E2K93_11485 cgtA; Obg family GTPase CgtA\tK03979 obgE; GTPase [EC:3.6.5.-]"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Sno RNPs",
			"children":[
			{
				"name":"Box C\/D snoRNPs"
			},
			{
				"name":"Box H\/ACA snoRNPs"
			}
			]
		},
		{
			"name":"rRNA transcription factors",
			"children":[
			{
				"name":"E2K93_07770 TraR\/DksA family transcriptional regulator\tK06204 dksA; RNA polymerase-binding transcription factor"
			},
			{
				"name":"E2K93_08635 TraR\/DksA family transcriptional regulator\tK06204 dksA; RNA polymerase-binding transcription factor"
			},
			{
				"name":"E2K93_10220 dksA; RNA polymerase-binding protein DksA\tK06204 dksA; RNA polymerase-binding transcription factor"
			},
			{
				"name":"E2K93_00395 nusA; transcription termination\/antitermination protein NusA\tK02600 nusA; transcription termination\/antitermination protein NusA"
			},
			{
				"name":"E2K93_02885 nusB; transcription antitermination factor NusB\tK03625 nusB; transcription antitermination protein NusB"
			},
			{
				"name":"E2K93_06150 nusG; transcription termination\/antitermination protein NusG\tK02601 nusG; transcription termination\/antitermination protein NusG"
			}
			]
		},
		{
			"name":"rRNA modification factors",
			"children":[
			{
				"name":"16S rRNA modification factors",
				"children":[
				{
					"name":"E2K93_01760 rsuA; 16S rRNA pseudouridine(516) synthase RsuA\tK06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]"
				},
				{
					"name":"E2K93_10960 rsmA; 16S rRNA (adenine(1518)-N(6)\/adenine(1519)-N(6))-dimethyltransferase RsmA\tK02528 ksgA; 16S rRNA (adenine1518-N6\/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]"
				},
				{
					"name":"E2K93_08500 rsmB; 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB\tK03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]"
				},
				{
					"name":"E2K93_11425 16S rRNA methyltransferase\tK00564 rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172]"
				},
				{
					"name":"E2K93_07805 rsmD; 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD\tK08316 rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171]"
				},
				{
					"name":"E2K93_11990 rsmE; 16S rRNA (uracil(1498)-N(3))-methyltransferase\tK09761 rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]"
				},
				{
					"name":"E2K93_08400 rsmG; 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG\tK03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]"
				},
				{
					"name":"E2K93_10675 rsmH; 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH\tK03438 mraW; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]"
				},
				{
					"name":"E2K93_10605 rsmI; 16S rRNA (cytidine(1402)-2'-O)-methyltransferase\tK07056 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198]"
				},
				{
					"name":"E2K93_08725 16S rRNA methyltransferase\tK15984 rsmJ; 16S rRNA (guanine1516-N2)-methyltransferase [EC:2.1.1.242]"
				}
				]
			},
			{
				"name":"23S rRNA modification factors",
				"children":[
				{
					"name":"E2K93_00920 rlmA; 23S rRNA (guanine(745)-N(1))-methyltransferase\tK00563 rlmA1; 23S rRNA (guanine745-N1)-methyltransferase [EC:2.1.1.187]"
				},
				{
					"name":"E2K93_10325 rlmB; 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB\tK03218 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185]"
				},
				{
					"name":"E2K93_00535 rlmE; 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE\tK02427 rlmE; 23S rRNA (uridine2552-2'-O)-methyltransferase [EC:2.1.1.166]"
				},
				{
					"name":"E2K93_03575 rlmF; 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF\tK06970 rlmF; 23S rRNA (adenine1618-N6)-methyltransferase [EC:2.1.1.181]"
				},
				{
					"name":"E2K93_12310 methyltransferase domain-containing protein\tK11391 rlmG; 23S rRNA (guanine1835-N2)-methyltransferase [EC:2.1.1.174]"
				},
				{
					"name":"E2K93_14420 rlmH; 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH\tK00783 rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177]"
				},
				{
					"name":"E2K93_00160 methyltransferase domain-containing protein\tK06969 rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]"
				},
				{
					"name":"E2K93_04875 methyltransferase domain-containing protein\tK06969 rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]"
				},
				{
					"name":"E2K93_00100 rlmKL; bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK\/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL\tK12297 rlmKL; 23S rRNA (guanine2069-N7)-methyltransferase \/ 23S rRNA (guanine2445-N2)-methyltransferase [EC:2.1.1.264 2.1.1.173]"
				},
				{
					"name":"E2K93_01950 rlmM; 23S rRNA (cytidine(2498)-2'-O)-methyltransferase RlmM\tK06968 rlmM; 23S rRNA (cytidine2498-2'-O)-methyltransferase [EC:2.1.1.186]"
				},
				{
					"name":"E2K93_11560 trmG_rlmN; bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG\/ribosomal RNA large subunit methyltransferase RlmN\tK06941 rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]"
				},
				{
					"name":"E2K93_12090 rlmD; 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD\tK03215 rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]"
				},
				{
					"name":"E2K93_10995 rluA; bifunctional tRNA pseudouridine(32) synthase\/23S rRNA pseudouridine(746) synthase RluA\tK06177 rluA; tRNA pseudouridine32 synthase \/ 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]"
				},
				{
					"name":"E2K93_12870 TIGR01621 family pseudouridine synthase\tK06177 rluA; tRNA pseudouridine32 synthase \/ 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]"
				},
				{
					"name":"E2K93_13045 RluA family pseudouridine synthase\tK06177 rluA; tRNA pseudouridine32 synthase \/ 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]"
				},
				{
					"name":"E2K93_16295 RluA family pseudouridine synthase\tK06177 rluA; tRNA pseudouridine32 synthase \/ 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]"
				},
				{
					"name":"E2K93_13560 rluB; 23S rRNA pseudouridine(2605) synthase RluB\tK06178 rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]"
				},
				{
					"name":"E2K93_16075 rluC; 23S rRNA pseudouridine(955\/2504\/2580) synthase RluC\tK06179 rluC; 23S rRNA pseudouridine955\/2504\/2580 synthase [EC:5.4.99.24]"
				},
				{
					"name":"E2K93_13190 rluD; 23S rRNA pseudouridine(1911\/1915\/1917) synthase RluD\tK06180 rluD; 23S rRNA pseudouridine1911\/1915\/1917 synthase [EC:5.4.99.23]"
				},
				{
					"name":"E2K93_16975 pseudouridine synthase\tK06181 rluE; 23S rRNA pseudouridine2457 synthase [EC:5.4.99.20]"
				},
				{
					"name":"E2K93_07050 rluF; 23S rRNA pseudouridine(2604) synthase RluF\tK06182 rluF; 23S rRNA pseudouridine2604 synthase [EC:5.4.99.21]"
				}
				]
			}
			]
		},
		{
			"name":"ribosomal protein modification factors",
			"children":[
			{
				"name":"E2K93_12565 rimI; ribosomal-protein-alanine N-acetyltransferase\tK03789 rimI; [ribosomal protein S18]-alanine N-acetyltransferase \/ [ribosomal protein L31]-L-lysine N-acetyltransferase [EC:2.3.1.266 2.3.1.338]"
			},
			{
				"name":"E2K93_08660 rimK; 30S ribosomal protein S6--L-glutamate ligase\tK05844 rimK; ribosomal protein S6--L-glutamate ligase [EC:6.3.2.-]"
			},
			{
				"name":"E2K93_12935 rimM; ribosome maturation factor RimM\tK02860 rimM; 16S rRNA processing protein RimM"
			},
			{
				"name":"E2K93_09250 OsmC domain\/YcaO domain-containing protein\tK09136 ycaO; ribosomal protein S12 methylthiotransferase accessory factor"
			},
			{
				"name":"E2K93_10050 prmA; 50S ribosomal protein L11 methyltransferase\tK02687 prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"E2K93_02610 prmB; 50S ribosomal protein L3 N(5)-glutamine methyltransferase\tK07320 prmB; ribosomal protein L3 glutamine methyltransferase [EC:2.1.1.298]"
			},
			{
				"name":"E2K93_16950 cupin domain-containing protein\tK18850 ycfD; 50S ribosomal protein L16 3-hydroxylase [EC:1.14.11.47]"
			}
			]
		},
		{
			"name":"rRNA processing factors",
			"children":[
			{
				"name":"E2K93_12060 ribonuclease III\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
			},
			{
				"name":"E2K93_16070 ribonuclease E\tK08300 rne; ribonuclease E [EC:3.1.26.12]"
			},
			{
				"name":"E2K93_10385 ribonuclease G\tK08301 rng; ribonuclease G [EC:3.1.26.-]"
			},
			{
				"name":"E2K93_04015 ruvX; Holliday junction resolvase RuvX\tK07447 ruvX; putative pre-16S rRNA nuclease [EC:3.1.-.-]"
			}
			]
		},
		{
			"name":"rRNA helicases",
			"children":[
			{
				"name":"E2K93_15960 dbpA; ATP-dependent RNA helicase DbpA\tK05591 dbpA; ATP-dependent RNA helicase DbpA [EC:5.6.2.6]"
			},
			{
				"name":"E2K93_14585 DEAD\/DEAH box helicase\tK05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]"
			},
			{
				"name":"E2K93_04045 srmB; ATP-dependent RNA helicase SrmB\tK05590 srmB; ATP-dependent RNA helicase SrmB [EC:5.6.2.7]"
			}
			]
		},
		{
			"name":"GTPases",
			"children":[
			{
				"name":"E2K93_12065 GTPase Era\tK03595 era; GTPase"
			},
			{
				"name":"E2K93_09700 rsgA; small ribosomal subunit biogenesis GTPase RsgA\tK06949 rsgA; ribosome biogenesis GTPase \/ thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]"
			},
			{
				"name":"E2K93_11595 der; ribosome biogenesis GTPase Der\tK03977 engA; GTPase"
			},
			{
				"name":"E2K93_11485 cgtA; Obg family GTPase CgtA\tK03979 obgE; GTPase [EC:3.6.5.-]"
			},
			{
				"name":"E2K93_13260 ylqF; ribosome biogenesis GTPase YlqF\tK14540 rbgA; ribosome biogenesis GTPase A"
			},
			{
				"name":"E2K93_09760 hflX; GTPase HflX\tK03665 hflX; GTPase"
			}
			]
		},
		{
			"name":"Other maturation factors",
			"children":[
			{
				"name":"E2K93_08545 threonylcarbamoyl-AMP synthase\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
			},
			{
				"name":"E2K93_06955 spoT; bifunctional GTP diphosphokinase\/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase\tK01139 spoT; GTP diphosphokinase \/ guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]"
			},
			{
				"name":"E2K93_00385 rbfA; 30S ribosome-binding factor RbfA\tK02834 rbfA; ribosome-binding factor A"
			},
			{
				"name":"E2K93_00400 rimP; ribosome maturation factor RimP\tK09748 rimP; ribosome maturation factor RimP"
			},
			{
				"name":"E2K93_02405 RNA-binding S4 domain-containing protein\tK14761 rlbA; ribosome-associated protein"
			},
			{
				"name":"E2K93_14425 rsfS; ribosome silencing factor\tK09710 ybeB; ribosome-associated protein"
			},
			{
				"name":"E2K93_13820 ybeY; rRNA maturation RNase YbeY\tK07042 ybeY; probable rRNA maturation factor"
			},
			{
				"name":"E2K93_00540 yhbY; ribosome assembly RNA-binding protein YhbY\tK07574 yhbY; RNA-binding protein"
			},
			{
				"name":"E2K93_10405 DUF615 domain-containing protein\tK09889 yjgA; ribosome-associated protein"
			},
			{
				"name":"E2K93_04195 ribosome modulation factor\tK03812 rmf; ribosome modulation factor"
			},
			{
				"name":"E2K93_10435 ribosome hibernation promoting factor\tK05808 hpf; ribosome hibernation promoting factor"
			},
			{
				"name":"E2K93_02355 raiA; ribosome-associated translation inhibitor RaiA\tK05809 raiA; ribosome-associated inhibitor A"
			},
			{
				"name":"E2K93_02060 ychF; redox-regulated ATPase YchF\tK06942 ychF; ribosome-binding ATPase"
			},
			{
				"name":"E2K93_16095 yceD; 23S rRNA accumulation protein YceD\tK07040 yceD; DUF177 domain-containing protein"
			}
			]
		}
		]
	},
	{
		"name":"Related small nucleolar RNAs",
		"children":[
		{
			"name":"Box C\/D snoRNAs",
			"children":[
			{
				"name":"SnoRNAs involved in processing reactions"
			},
			{
				"name":"SnoRNAs act as guides for 2'-O-ribose methylation"
			}
			]
		},
		{
			"name":"Box H\/ACA snoRNAs",
			"children":[
			{
				"name":"SnoRNAs involved in processing reactions"
			},
			{
				"name":"SnoRNAs act as guides for pseudouridynation"
			}
			]
		},
		{
			"name":"Other snoRNA"
		}
		]
	}
	]
}