{
	"name":"tlr03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)"
			},
			{
				"name":"CDK (cyclin dependent kinase)"
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)"
			},
			{
				"name":"GINS complex"
			},
			{
				"name":"Other initiation factors"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex"
			},
			{
				"name":"DNA polymerase epsilon complex"
			},
			{
				"name":"DNA polymerase delta complex"
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)"
			},
			{
				"name":"RPA (replication protein A)"
			},
			{
				"name":"RFC (replication factor C)"
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"Thiosp_02831 rnhA; Ribonuclease HI\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				}
				]
			},
			{
				"name":"Other elongation factors"
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex"
				},
				{
					"name":"TERB1-TERB2-MAJIN complex"
				},
				{
					"name":"CST complex (animals)"
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins"
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"Dyskerin complex"
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"Sm core complex"
				}
				]
			},
			{
				"name":"ELG1-RFC complex"
			},
			{
				"name":"MRN complex"
			},
			{
				"name":"Other termination factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases"
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)",
				"children":[
				{
					"name":"Thiosp_04422 hupB; DNA-binding protein HU-beta\tK03530 hupB; DNA-binding protein HU-beta"
				},
				{
					"name":"Thiosp_03503 ihfA; Integration host factor subunit alpha\tK04764 ihfA; integration host factor subunit alpha"
				},
				{
					"name":"Thiosp_01540 ihfB; Integration host factor subunit beta\tK05788 ihfB; integration host factor subunit beta"
				},
				{
					"name":"Thiosp_00001 dnaA; Chromosomal replication initiator protein DnaA\tK02313 dnaA; chromosomal replication initiator protein"
				},
				{
					"name":"Thiosp_01974 dnaC; DNA replication protein DnaC\tK02315 dnaC; DNA replication protein DnaC"
				},
				{
					"name":"Thiosp_02644 dnaG_2; DNA primase\tK02316 dnaG; DNA primase [EC:2.7.7.101]"
				},
				{
					"name":"Thiosp_01895 ssb_1; Helix-destabilizing protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"Thiosp_01992 ssb_2; Helix-destabilizing protein\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme",
					"children":[
					{
						"name":"Thiosp_01104 dnaE; DNA polymerase III subunit alpha\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]"
					},
					{
						"name":"Thiosp_00002 dnaN; DNA polymerase III subunit beta\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]"
					},
					{
						"name":"Thiosp_04658 holC; DNA polymerase III subunit chi\tK02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]"
					},
					{
						"name":"Thiosp_02958 holA; DNA polymerase III subunit delta\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]"
					},
					{
						"name":"Thiosp_03757 holB; DNA polymerase III subunit delta'\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]"
					},
					{
						"name":"Thiosp_02393 polC_1; DNA polymerase III PolC-type\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"Thiosp_02830 dnaQ; DNA polymerase III subunit epsilon\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"Thiosp_03559 polC_2; DNA polymerase III PolC-type\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"Thiosp_00789 dnaX; DNA polymerase III subunit tau\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"Thiosp_02831 rnhA; Ribonuclease HI\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"Thiosp_00663 rnhB; Ribonuclease HII\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"Thiosp_04317 polA_2; DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					},
					{
						"name":"Thiosp_04230 ligA_2; DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"Thiosp_02831 rnhA; Ribonuclease HI\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"Thiosp_00663 rnhB; Ribonuclease HII\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors",
				"children":[
				{
					"name":"Thiosp_04312 hda; DnaA regulatory inactivator Hda\tK10763 hda; DnaA-homolog protein"
				}
				]
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"Thiosp_02610 gyrA; DNA gyrase subunit A\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]"
			},
			{
				"name":"Thiosp_00004 gyrB; DNA gyrase subunit B\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]"
			},
			{
				"name":"Thiosp_00005 parC; DNA topoisomerase 4 subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
			},
			{
				"name":"Thiosp_00210 parE; DNA topoisomerase 4 subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
			},
			{
				"name":"Thiosp_03604 topA; DNA topoisomerase 1\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
			},
			{
				"name":"Thiosp_00492 topB; DNA topoisomerase 3\tK03169 topB; DNA topoisomerase III [EC:5.6.2.1]"
			}
			]
		}
		]
	}
	]
}