{
	"name":"tra02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"Trad_0429 CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Trad_1672 CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Trad_2305 CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Trad_0428 CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"Trad_1673 CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"Trad_2304 CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"Trad_1659 CRISPR-associated helicase Cas3\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				},
				{
					"name":"Trad_2312 CRISPR-associated helicase Cas3\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"Trad_1671 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Trad_0432 CRISPR-associated protein Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"Trad_1671 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"Trad_1661 CRISPR-associated protein, Csd1 family\tK19117 csd1; CRISPR-associated protein Csd1"
				},
				{
					"name":"Trad_1662 CRISPR-associated protein, Csd2 family\tK19118 csd2; CRISPR-associated protein Csd2"
				},
				{
					"name":"Trad_1671 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Trad_1660 CRISPR-associated protein Cas5 family\tK19119 cas5d; CRISPR-associated protein Cas5d"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"Trad_1671 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Trad_0432 CRISPR-associated protein Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-E factors",
				"children":[
				{
					"name":"Trad_2310 CRISPR-associated protein, Cse1 family\tK19123 casA; CRISPR system Cascade subunit CasA"
				},
				{
					"name":"Trad_2309 CRISPR-associated protein, Cse2 family\tK19046 casB; CRISPR system Cascade subunit CasB"
				},
				{
					"name":"Trad_2308 CRISPR-associated protein, Cse4 family\tK19124 casC; CRISPR system Cascade subunit CasC"
				},
				{
					"name":"Trad_2307 CRISPR-associated protein Cas5 family\tK19125 casD; CRISPR system Cascade subunit CasD"
				},
				{
					"name":"Trad_2306 CRISPR-associated protein, Cse3 family\tK19126 casE; CRISPR system Cascade subunit CasE"
				}
				]
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"Trad_1671 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors",
				"children":[
				{
					"name":"Trad_1447 CRISPR-associated RAMP protein, Cmr1 family\tK07061 cmr1; CRISPR-associated protein Cmr1"
				},
				{
					"name":"Trad_1663 CRISPR-associated RAMP protein, Cmr1 family\tK07061 cmr1; CRISPR-associated protein Cmr1"
				},
				{
					"name":"Trad_1448 CRISPR-associated protein, Crm2 family\tK19076 cmr2; CRISPR-associated protein Cmr2"
				},
				{
					"name":"Trad_1664 CRISPR-associated protein, Crm2 family\tK19076 cmr2; CRISPR-associated protein Cmr2"
				},
				{
					"name":"Trad_1449 CRISPR-associated protein, Cmr3 family\tK09127 cmr3; CRISPR-associated protein Cmr3"
				},
				{
					"name":"Trad_1665 CRISPR-associated protein, Cmr3 family\tK09127 cmr3; CRISPR-associated protein Cmr3"
				},
				{
					"name":"Trad_1450 CRISPR-associated RAMP protein, Cmr4 family\tK09000 cmr4; CRISPR-associated protein Cmr4"
				},
				{
					"name":"Trad_1666 CRISPR-associated RAMP protein, Cmr4 family\tK09000 cmr4; CRISPR-associated protein Cmr4"
				},
				{
					"name":"Trad_1451 CRISPR-associated protein, Cmr5 family\tK19141 cmr5; CRISPR-associated protein Cmr5"
				},
				{
					"name":"Trad_1667 CRISPR-associated protein, Cmr5 family\tK19141 cmr5; CRISPR-associated protein Cmr5"
				},
				{
					"name":"Trad_1452 CRISPR-associated RAMP protein, Cmr6 family\tK19142 cmr6; CRISPR-associated protein Cmr6"
				},
				{
					"name":"Trad_1668 CRISPR-associated RAMP protein, Cmr6 family\tK19142 cmr6; CRISPR-associated protein Cmr6"
				}
				]
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system"
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases"
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"Trad_1508 HNH endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"Trad_0999 transcriptional modulator of MazE\/toxin, MazF\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"Trad_0998 conserved hypothetical protein\tK26989 mazE9; antitoxin MazE9"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"Trad_0423 plasmid stabilization system\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"Trad_2110 plasmid stabilization system\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"Trad_2656 plasmid stabilization system\tK06218 relE; mRNA interferase RelE\/StbE"
				}
				]
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"Trad_1431 plasmid maintenance system killer\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"Trad_0928 transcriptional regulator, XRE family\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"Trad_1432 plasmid maintenance system antidote protein, XRE family\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"Trad_2819 PilT protein domain protein\tK28141 vapC1S; ribonuclease VapC1\/3\/9\/12 [EC:3.1.-.-]"
				},
				{
					"name":"Trad_2820 conserved hypothetical protein\tK28257 vapB12; antitoxin VapB12"
				},
				{
					"name":"Trad_1778 PilT protein domain protein\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"Trad_2454 PilT protein domain protein\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"Trad_1777 prevent-host-death family protein\tK28280 vapB22; antitoxin VapB22"
				},
				{
					"name":"Trad_1393 PIN domain protein family protein\tK28143 vapC24S; ribonuclease VapC24\/25\/29\/31\/33\/37\/38\/39\/41\/43\/44\/48 [EC:3.1.-.-]"
				},
				{
					"name":"Trad_1402 PIN domain protein family protein\tK28143 vapC24S; ribonuclease VapC24\/25\/29\/31\/33\/37\/38\/39\/41\/43\/44\/48 [EC:3.1.-.-]"
				},
				{
					"name":"Trad_1394 transcriptional regulator, CopG family\tK28144 vapB24S; antitoxin VapB24\/25\/29\/31\/33\/37\/38\/39\/41\/43\/44\/48"
				},
				{
					"name":"Trad_1403 conserved hypothetical protein\tK28144 vapB24S; antitoxin VapB24\/25\/29\/31\/33\/37\/38\/39\/41\/43\/44\/48"
				},
				{
					"name":"Trad_1398 PilT protein domain protein\tK28282 vapC26; ribonuclease VapC26 [EC:3.1.-.-]"
				},
				{
					"name":"Trad_0957 CopG domain protein DNA-binding domain protein\tK28283 vapB26; antitoxin VapB26"
				},
				{
					"name":"Trad_1397 CopG domain protein DNA-binding domain protein\tK28283 vapB26; antitoxin VapB26"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"Trad_1611 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"Trad_0317 cell shape determining protein MreB\/Mrl\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"Trad_1283 glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"Trad_1999 Glutamyl\/glutaminyl-tRNA synthetase, class Ic, catalytic domain protein\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"Trad_1802 Cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}