{
	"name":"tsu02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"Tresu_2180 CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Tresu_2178 CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"Tresu_2179 CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins"
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins",
				"children":[
				{
					"name":"Tresu_2191 CRISPR-associated protein, Csm1 family\tK07016 csm1; CRISPR-associated protein Csm1"
				}
				]
			},
			{
				"name":"Subtype III-A factors",
				"children":[
				{
					"name":"Tresu_2190 CRISPR-associated protein TM1810 domain protein\tK19138 csm2; CRISPR-associated protein Csm2"
				},
				{
					"name":"Tresu_2189 CRISPR-associated RAMP protein, Csm3 family\tK09002 csm3; CRISPR-associated protein Csm3"
				},
				{
					"name":"Tresu_2188 hypothetical protein\tK19139 csm4; CRISPR-associated protein Csm4"
				},
				{
					"name":"Tresu_2187 CRISPR-associated RAMP protein, Csm5 family\tK19140 csm5; CRISPR-associated protein Csm5"
				}
				]
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"Tresu_0201 type I site-specific deoxyribonuclease, HsdR family\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Tresu_0519 type I site-specific deoxyribonuclease, HsdR family\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Tresu_0583 Type I site-specific deoxyribonuclease\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Tresu_1090 Type I site-specific deoxyribonuclease\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Tresu_1115 Type I site-specific deoxyribonuclease\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Tresu_0196 restriction modification system DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Tresu_0516 restriction modification system DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Tresu_0517 restriction modification system DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Tresu_0584 restriction modification system DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Tresu_0589 restriction modification system DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Tresu_1097 restriction modification system DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Tresu_1106 restriction modification system DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Tresu_1113 restriction modification system DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Tresu_0193 Site-specific DNA-methyltransferase (adenine-specific)\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"Tresu_0513 type I restriction-modification system, M subunit\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"Tresu_0585 N-6 DNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"Tresu_1099 N-6 DNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"Tresu_1114 Site-specific DNA-methyltransferase (adenine-specific)\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases",
				"children":[
				{
					"name":"Tresu_1694 Type II site-specific deoxyribonuclease\tK01155 E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]"
				}
				]
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"Tresu_0668 DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"Tresu_1696 DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"Tresu_0669 Site-specific DNA-methyltransferase (adenine-specific)\tK07318 K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"Tresu_2158 Site-specific DNA-methyltransferase (adenine-specific)\tK07318 K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"Tresu_1691 DNA methylase N-4\/N-6 domain protein\tK00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]"
				},
				{
					"name":"Tresu_2145 DNA methylase N-4\/N-6 domain protein\tK00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]"
				},
				{
					"name":"Tresu_0110 DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"Tresu_0530 DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"Tresu_0540 DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"Tresu_0695 DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"Tresu_0703 DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"Tresu_0713 DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"Tresu_1682 DNA (cytosine-5-)-methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"Tresu_1987 DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system",
			"children":[
			{
				"name":"Tresu_0646 type III restriction protein res subunit\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"Tresu_1193 type III restriction protein res subunit\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"Tresu_0645 DNA methylase N-4\/N-6 domain protein\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			},
			{
				"name":"Tresu_1687 DNA methylase N-4\/N-6 domain protein\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type IV R-M system"
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"Tresu_0747 transcriptional modulator of MazE\/toxin, MazF\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"Tresu_0746 transcriptional regulator\/antitoxin, MazE\tK07172 mazE; antitoxin MazE"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"Tresu_1505 CopG-like DNA-binding protein\tK18918 relB; RHH-type transcriptional regulator, rel operon repressor \/ antitoxin RelB"
				}
				]
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"Tresu_1777 addiction module toxin, RelE\/StbE family\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"Tresu_1962 addiction module toxin, RelE\/StbE family\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"Tresu_2228 addiction module toxin, RelE\/StbE family\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"Tresu_1778 addiction module antitoxin, RelB\/DinJ family\tK07473 dinJ; DNA-damage-inducible protein J"
				},
				{
					"name":"Tresu_2227 addiction module antitoxin, RelB\/DinJ family\tK07473 dinJ; DNA-damage-inducible protein J"
				}
				]
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB",
				"children":[
				{
					"name":"Tresu_0218 HipA N-terminal domain protein\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				}
				]
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"Tresu_0707 plasmid maintenance system killer\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"Tresu_0925 plasmid maintenance system killer\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"Tresu_2690 plasmid maintenance system killer\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"Tresu_0924 plasmid maintenance system antidote protein, XRE family\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"Tresu_0708 plasmid maintenance system antidote protein, XRE family\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"Tresu_1381 plasmid maintenance system antidote protein, XRE family\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"Tresu_2689 plasmid maintenance system antidote protein, XRE family\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"Tresu_0146 PilT protein domain protein\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"Tresu_0665 PilT protein domain protein\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"Tresu_0682 PilT protein domain protein\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"PezT-PezA",
				"children":[
				{
					"name":"Tresu_0877 Zeta toxin family protein\tK16214 pezT; UDP-N-acetylglucosamine kinase [EC:2.7.1.176]"
				}
				]
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"Tresu_1592 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"Tresu_1246 cell shape determining protein, MreB\/Mrl family\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"Tresu_0355 DNA topoisomerase (ATP-hydrolyzing)\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"Tresu_0354 DNA topoisomerase type IIA subunit B region 2 domain protein\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"Tresu_1378 glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system",
				"children":[
				{
					"name":"Tresu_0689 hypothetical protein\tK19167 abiQ; protein AbiQ"
				}
				]
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"Tresu_1863 Cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"Tresu_1638 hypothetical protein\tK19171 dndD; DNA sulfur modification protein DndD"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}