{
	"name":"twg03036",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Sister chromatid cohesion proteins",
			"children":[
			{
				"name":"Cohesin complex"
			},
			{
				"name":"Adherin complex"
			},
			{
				"name":"CTF18-RFC complex"
			},
			{
				"name":"Fork protection complex"
			},
			{
				"name":"55LCC heterohexameric ATPase complex"
			},
			{
				"name":"Other sister chromatid cohesion factors"
			}
			]
		},
		{
			"name":"Meiosis-specific proteins",
			"children":[
			{
				"name":"Cohesin complex and associated proteins"
			},
			{
				"name":"Synaptonemal complex"
			},
			{
				"name":"DSB formation-related proteins"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Nucleosome assembly factors",
			"children":[
			{
				"name":"Histones"
			},
			{
				"name":"Histone chaperones",
				"children":[
				{
					"name":"Nucleoplasmins"
				},
				{
					"name":"NAPs (Nucleosome assembly proteins)"
				},
				{
					"name":"CAF-1"
				},
				{
					"name":"FACT complex"
				},
				{
					"name":"Other Histone chaperones and regulators"
				}
				]
			},
			{
				"name":"HMG (high mobility group) proteins"
			}
			]
		},
		{
			"name":"Histone modification proteins",
			"children":[
			{
				"name":"HATs (histone acetyltransferases)"
			},
			{
				"name":"HAT complexes",
				"children":[
				{
					"name":"PCAF complex"
				},
				{
					"name":"STAGA complex"
				},
				{
					"name":"TFTC complex"
				},
				{
					"name":"TIP60 complex"
				},
				{
					"name":"HBO1 complex"
				},
				{
					"name":"MOZ\/MORF complex"
				},
				{
					"name":"SAGA complex"
				},
				{
					"name":"SLIK complex"
				},
				{
					"name":"ADA-HAT complex"
				},
				{
					"name":"HAT-A2 complex"
				},
				{
					"name":"ATAC complex"
				},
				{
					"name":"HATB complex"
				},
				{
					"name":"NSL complex"
				},
				{
					"name":"MSL complex"
				},
				{
					"name":"NuA3 complex"
				},
				{
					"name":"NuA4 complex"
				},
				{
					"name":"SAS complex"
				}
				]
			},
			{
				"name":"HDACs (histone deacetylases)",
				"children":[
				{
					"name":"Class I HDACs"
				},
				{
					"name":"Class II HDACs"
				},
				{
					"name":"SIRTs (sirtuins, class III HDACs)"
				},
				{
					"name":"Class IV HDACs"
				}
				]
			},
			{
				"name":"HDAC complexes",
				"children":[
				{
					"name":"Sin3A-HDAC complex"
				},
				{
					"name":"BRAF-HDAC complex"
				},
				{
					"name":"REST complex"
				},
				{
					"name":"SHIP complex"
				},
				{
					"name":"MiDAC complex"
				},
				{
					"name":"SMART complex"
				},
				{
					"name":"Other HDAC associated proteins"
				}
				]
			},
			{
				"name":"HMTs (histone methyltransferases)",
				"children":[
				{
					"name":"HKMTs (histone lysine methyltransferases)"
				},
				{
					"name":"PRMTs (protein arginine metyltransferases)"
				}
				]
			},
			{
				"name":"HMT complexes",
				"children":[
				{
					"name":"COMPASS\/SET1 complex"
				},
				{
					"name":"COMPASS\/SET1 complex (yeast)"
				},
				{
					"name":"MLL-HCF complex"
				},
				{
					"name":"MLL3\/MLL4 complex"
				},
				{
					"name":"Dot1-containing complex"
				},
				{
					"name":"CHTOP-methylosome complex"
				}
				]
			},
			{
				"name":"Histone demethylases"
			},
			{
				"name":"Polycomb repressive complex (PRC) and associated proteins",
				"children":[
				{
					"name":"Canonical PRC1 (PRC1.2\/1.4)",
					"children":[
					{
						"name":"PRC1.4 specific proteins"
					}
					]
				},
				{
					"name":"Noncanonical PRC1 (PRC1.1)"
				},
				{
					"name":"Noncanonical PRC1 (PRC1.3\/1.5)"
				},
				{
					"name":"Noncanonical PRC1 (PRC1.6)"
				},
				{
					"name":"PRC2.1"
				},
				{
					"name":"PRC2.2"
				},
				{
					"name":"PR-DUB complex"
				},
				{
					"name":"Other PRC associated proteins"
				}
				]
			},
			{
				"name":"Sir proteins"
			},
			{
				"name":"Other histone modification proteins"
			}
			]
		},
		{
			"name":"Chromosome condensation proteins",
			"children":[
			{
				"name":"Condensin I"
			},
			{
				"name":"Condensin II"
			},
			{
				"name":"Other regulators of chromosome condensation"
			}
			]
		},
		{
			"name":"Centromeric chromatin formation proteins",
			"children":[
			{
				"name":"Kinetochore proteins",
				"children":[
				{
					"name":"Centromere proteins"
				},
				{
					"name":"CPC (chromosomal passenger complex)"
				},
				{
					"name":"KMN network proteins",
					"children":[
					{
						"name":"MIS12 complex"
					},
					{
						"name":"NDC80 complex"
					}
					]
				},
				{
					"name":"Mis6 complex"
				},
				{
					"name":"COMA complex"
				},
				{
					"name":"NMS complex",
					"children":[
					{
						"name":"NDC80 complex"
					},
					{
						"name":"MIND kinetochore complex"
					}
					]
				},
				{
					"name":"MIS16-MIS18 complex"
				},
				{
					"name":"DASH complex"
				},
				{
					"name":"CBF3 complex"
				},
				{
					"name":"Others"
				}
				]
			},
			{
				"name":"SAC (spindle assembly checkpoint) factors",
				"children":[
				{
					"name":"Core SAC proteins"
				},
				{
					"name":"Motor proteins",
					"children":[
					{
						"name":"RZZ complex"
					},
					{
						"name":"Dynein complex"
					}
					]
				},
				{
					"name":"Protein kinases"
				},
				{
					"name":"Others"
				}
				]
			},
			{
				"name":"Other centromeric chromatin formation proteins",
				"children":[
				{
					"name":"Shugoshin"
				},
				{
					"name":"PP2A (protein phosphatase 2A)"
				}
				]
			}
			]
		},
		{
			"name":"Heterochromatin formation proteins",
			"children":[
			{
				"name":"HP1 (heterochromatin protein 1)"
			},
			{
				"name":"MBPs (metylated DNA binding proteins)"
			},
			{
				"name":"Other heterochromatin formation proteins",
				"children":[
				{
					"name":"Thiowin_03426 haeIIIM; Modification methylase HaeIII\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Gene silencing",
			"children":[
			{
				"name":"RISC (RNA-induced silencing complex)"
			},
			{
				"name":"piRNA pathway"
			},
			{
				"name":"RNA interference (RNAi) pathway",
				"children":[
				{
					"name":"RITS (RNA-induced transcriptional silencing) complex"
				},
				{
					"name":"RDRC (RNA-directed RNA polymerase complex)"
				},
				{
					"name":"Other RNAi proteins"
				}
				]
			},
			{
				"name":"microRNA pathway",
				"children":[
				{
					"name":"Microprocessor complex",
					"children":[
					{
						"name":"Thiowin_02226 rnc; Ribonuclease 3\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
					}
					]
				},
				{
					"name":"RISC loading complex"
				},
				{
					"name":"Other miRNA pathway proteins"
				}
				]
			},
			{
				"name":"Transposable elements"
			}
			]
		},
		{
			"name":"Centrosome formation proteins",
			"children":[
			{
				"name":"Centriole proteins"
			},
			{
				"name":"Pericentriolar materials (PCM)",
				"children":[
				{
					"name":"Centriolar satellite"
				},
				{
					"name":"Other PCM proteins"
				}
				]
			},
			{
				"name":"Cyclins"
			},
			{
				"name":"Kinases and associated factors",
				"children":[
				{
					"name":"Kinase associated protein"
				}
				]
			},
			{
				"name":"Microtubules and associated factors",
				"children":[
				{
					"name":"gamma-tubulin ring complex"
				},
				{
					"name":"Other tubulins"
				},
				{
					"name":"Dynactin complex"
				},
				{
					"name":"BRISC complex"
				},
				{
					"name":"Microtubule-associated proteins"
				}
				]
			},
			{
				"name":"Augmin complex"
			},
			{
				"name":"Centrosome duplication proteins",
				"children":[
				{
					"name":"Centriole replication proteins"
				},
				{
					"name":"Regulators of centriole replication"
				},
				{
					"name":"Other centrosome duplication proteins"
				}
				]
			},
			{
				"name":"Nde1-Su48 complex"
			},
			{
				"name":"LINC complex"
			},
			{
				"name":"3M complex"
			},
			{
				"name":"Gypsy chromatin insulator complex"
			},
			{
				"name":"Other centrosome associated proteins"
			},
			{
				"name":"Spindle formation proteins"
			}
			]
		},
		{
			"name":"Sister chromatid separation proteins",
			"children":[
			{
				"name":"Securin and associated proteins"
			},
			{
				"name":"Separase"
			},
			{
				"name":"APC\/C complex"
			},
			{
				"name":"Aurora kinases",
				"children":[
				{
					"name":"Regulators of Aurora kinases"
				}
				]
			},
			{
				"name":"TACC proteins"
			},
			{
				"name":"Polo kinases"
			},
			{
				"name":"Early mitotic inhibitors"
			}
			]
		},
		{
			"name":"Chromatin remodeling factors",
			"children":[
			{
				"name":"BAF complex"
			},
			{
				"name":"PBAF complex"
			},
			{
				"name":"GBAF(ncBAF) complex"
			},
			{
				"name":"CHRAC complex"
			},
			{
				"name":"RSF complex"
			},
			{
				"name":"WICH complex"
			},
			{
				"name":"B-WICH complex"
			},
			{
				"name":"NORC complex"
			},
			{
				"name":"BRF complex"
			},
			{
				"name":"NuRD complex"
			},
			{
				"name":"NuRF complex"
			},
			{
				"name":"NuRF complex (fruit fly)"
			},
			{
				"name":"CERF complex"
			},
			{
				"name":"SRCAP complex"
			},
			{
				"name":"INO80 complex"
			},
			{
				"name":"INO80 complex (yeast)"
			},
			{
				"name":"RSC complex"
			},
			{
				"name":"SWI\/SNF complex"
			},
			{
				"name":"SWR1 complex"
			},
			{
				"name":"ASTRA complex"
			},
			{
				"name":"Other chromatin remodeling factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Nucleoid associated proteins",
			"children":[
			{
				"name":"HNS (histone-like nucleoid structuring protein)",
				"children":[
				{
					"name":"Thiowin_04762 H-NS histone family protein\tK03746 hns; DNA-binding protein H-NS"
				}
				]
			},
			{
				"name":"HU (heat unstable protein)",
				"children":[
				{
					"name":"Thiowin_00574 hupB; DNA-binding protein HU-beta\tK03530 hupB; DNA-binding protein HU-beta"
				}
				]
			},
			{
				"name":"IHF (integration host factor)",
				"children":[
				{
					"name":"Thiowin_03160 ihfA; Integration host factor subunit alpha\tK04764 ihfA; integration host factor subunit alpha"
				},
				{
					"name":"Thiowin_02852 ihfB; Integration host factor subunit beta\tK05788 ihfB; integration host factor subunit beta"
				}
				]
			},
			{
				"name":"Other nucleoid associated proteins",
				"children":[
				{
					"name":"Thiowin_03691 cbpA; Curved DNA-binding protein\tK05516 cbpA; curved DNA-binding protein"
				},
				{
					"name":"Thiowin_03692 cbpM; Chaperone modulatory protein CbpM\tK18997 cbpM; chaperone modulatory protein CbpM"
				},
				{
					"name":"Thiowin_00001 dnaA_1; Chromosomal replication initiator protein DnaA\tK02313 dnaA; chromosomal replication initiator protein"
				},
				{
					"name":"Thiowin_01624 fis; Hin recombinational enhancer-binding protein\tK03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein"
				},
				{
					"name":"Thiowin_00398 hfq; Host factor-I protein\tK03666 hfq; host factor-I protein"
				},
				{
					"name":"Thiowin_04961 lrp; Leucine-responsive regulatory protein\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				}
				]
			}
			]
		},
		{
			"name":"Chromosome partitioning proteins",
			"children":[
			{
				"name":"MukBEF complex"
			},
			{
				"name":"Condensin-like complex",
				"children":[
				{
					"name":"Thiowin_04437 smc; Chromosome partition protein Smc\tK03529 smc; chromosome segregation protein"
				},
				{
					"name":"Thiowin_00970 scpA; Segregation and condensation protein A\tK05896 scpA; segregation and condensation protein A"
				},
				{
					"name":"Thiowin_00971 scpB; Segregation and condensation protein B\tK06024 scpB; segregation and condensation protein B"
				}
				]
			},
			{
				"name":"Divisome proteins",
				"children":[
				{
					"name":"Thiowin_00992 ftsA; Cell division protein FtsA\tK03590 ftsA; cell division protein FtsA"
				},
				{
					"name":"Thiowin_01248 ftsB; Cell division protein FtsB\tK05589 ftsB; cell division protein FtsB"
				},
				{
					"name":"Thiowin_04594 ftsE; Cell division ATP-binding protein FtsE\tK09812 ftsE; cell division transport system ATP-binding protein"
				},
				{
					"name":"Thiowin_00981 ftsI; Peptidoglycan synthase FtsI precursor\tK03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]"
				},
				{
					"name":"Thiowin_01741 ftsK; DNA translocase FtsK\tK03466 ftsK; DNA segregation ATPase FtsK\/SpoIIIE, S-DNA-T family"
				},
				{
					"name":"Thiowin_00980 ftsL; Cell division protein FtsL\tK03586 ftsL; cell division protein FtsL"
				},
				{
					"name":"Thiowin_00991 ftsQ; Cell division protein FtsQ\tK03589 ftsQ; cell division protein FtsQ"
				},
				{
					"name":"Thiowin_00335 ftsW_1; Cell division protein FtsW\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
				},
				{
					"name":"Thiowin_00986 ftsW_2; Cell division protein FtsW\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
				},
				{
					"name":"Thiowin_04593 ftsX; Cell division protein FtsX\tK09811 ftsX; cell division transport system permease protein"
				},
				{
					"name":"Thiowin_00993 ftsZ; Cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"Thiowin_04438 zipA; Cell division protein ZipA\tK03528 zipA; cell division protein ZipA"
				},
				{
					"name":"Thiowin_00337 zapA; Z ring-associated protein ZapA\tK09888 zapA; cell division protein ZapA"
				},
				{
					"name":"Thiowin_00338 hypothetical protein\tK09892 zapB; cell division protein ZapB"
				},
				{
					"name":"Thiowin_04894 zapD; Z ring-associated protein D\tK18778 zapD; cell division protein ZapD"
				},
				{
					"name":"Thiowin_04014 amiC; N-acetylmuramoyl-L-alanine amidase AmiC precursor\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]"
				},
				{
					"name":"Thiowin_00277 bepF_1; Efflux pump periplasmic linker BepF\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"Thiowin_00599 mdtE_1; Multidrug resistance protein MdtE precursor\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"Thiowin_00693 bepF_2; Efflux pump periplasmic linker BepF\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"Thiowin_02175 mdtE_2; Multidrug resistance protein MdtE precursor\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"Thiowin_03417 srpA; Solvent efflux pump periplasmic linker SrpA precursor\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"Thiowin_05098 mdtA_2; Multidrug transporter MdtA\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Inhibitors of FtsZ assembly",
				"children":[
				{
					"name":"Thiowin_04841 minC; Septum site-determining protein MinC\tK03610 minC; septum site-determining protein MinC"
				},
				{
					"name":"Thiowin_04840 minD; Cell division inhibitor MinD\tK03609 minD; septum site-determining protein MinD"
				},
				{
					"name":"Thiowin_04839 minE; Cell division topological specificity factor\tK03608 minE; cell division topological specificity factor"
				}
				]
			},
			{
				"name":"Other chromosome partitioning proteins",
				"children":[
				{
					"name":"Thiowin_05082 mreB; Rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"Thiowin_05081 mreC; Rod shape-determining protein MreC\tK03570 mreC; rod shape-determining protein MreC"
				},
				{
					"name":"Thiowin_05080 mreD; Rod shape-determining protein MreD\tK03571 mreD; rod shape-determining protein MreD"
				},
				{
					"name":"Thiowin_05078 mrdB; Rod shape-determining protein RodA\tK05837 rodA; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
				},
				{
					"name":"Thiowin_00490 ParA-like protein\tK03496 parA; chromosome partitioning protein"
				},
				{
					"name":"Thiowin_00602 ParA-like protein\tK03496 parA; chromosome partitioning protein"
				},
				{
					"name":"Thiowin_03902 soj_2; Sporulation initiation inhibitor protein soj\tK03496 parA; chromosome partitioning protein"
				},
				{
					"name":"Thiowin_04168 soj_3; Sporulation initiation inhibitor protein soj\tK03496 parA; chromosome partitioning protein"
				},
				{
					"name":"Thiowin_03903 parB; putative chromosome-partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"Thiowin_00005 parC; DNA topoisomerase 4 subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"Thiowin_05088 parE; DNA topoisomerase 4 subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"Thiowin_03900 mnmG; Glucose-inhibited division protein A\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				},
				{
					"name":"Thiowin_03901 rsmG; Ribosomal RNA small subunit methyltransferase G\tK03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]"
				},
				{
					"name":"Thiowin_02899 xerC_3; Tyrosine recombinase XerC\tK03733 xerC; integrase\/recombinase XerC"
				},
				{
					"name":"Thiowin_01859 xerD_5; Tyrosine recombinase XerD\tK04763 xerD; integrase\/recombinase XerD"
				},
				{
					"name":"Thiowin_04712 ylxH_1; Flagellum site-determining protein YlxH\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				},
				{
					"name":"Thiowin_01023 Adenosine monophosphate-protein transferase SoFic\tK04095 fic; cell filamentation protein, protein adenylyltransferase [EC:2.7.7.108]"
				},
				{
					"name":"Thiowin_03521 Adenosine monophosphate-protein transferase SoFic\tK04095 fic; cell filamentation protein, protein adenylyltransferase [EC:2.7.7.108]"
				},
				{
					"name":"Thiowin_00349 engB; putative GTP-binding protein EngB\tK03978 engB; GTP-binding protein"
				}
				]
			}
			]
		}
		]
	}
	]
}