{
	"name":"xcu02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"J159_03993 CRISPR-associated protein, Cas1 family\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"J159_03994 CRISPR-associated protein, Cas2 family\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"J159_03987 CRISPR-associated helicase, Cas3 family\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"J159_03992 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"J159_03992 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"J159_03989 CRISPR-associated protein (Cas_Csd1)\tK19117 csd1; CRISPR-associated protein Csd1"
				},
				{
					"name":"J159_03990 CRISPR-associated protein Cas8c\/Csd1, subtype I-C\/DVULG\tK19117 csd1; CRISPR-associated protein Csd1"
				},
				{
					"name":"J159_03991 CRISPR-associated protein, Csd2 family\tK19118 csd2; CRISPR-associated protein Csd2"
				},
				{
					"name":"J159_03992 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"J159_03988 CRISPR-associated protein, Cas5d family\tK19119 cas5d; CRISPR-associated protein Cas5d"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"J159_03992 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"J159_03992 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system"
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"J159_02808 DNA modification methylase\tK00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]"
				},
				{
					"name":"J159_02364 Site-specific DNA methylase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system"
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR",
				"children":[
				{
					"name":"J159_02059 Toxin SymE, type I toxin-antitoxin system\tK19048 symE; toxic protein SymE"
				},
				{
					"name":"J159_03029 Toxin SymE, type I toxin-antitoxin system\tK19048 symE; toxic protein SymE"
				},
				{
					"name":"J159_03410 Toxin SymE, type I toxin-antitoxin system\tK19048 symE; toxic protein SymE"
				}
				]
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"J159_00074 Growth inhibitor\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"J159_02338 transcriptional regulator\/antitoxin, MazE\tK07172 mazE; antitoxin MazE"
				}
				]
			},
			{
				"name":"ChpB-ChpS",
				"children":[
				{
					"name":"J159_00027 Growth inhibitor\tK18841 chpB; mRNA interferase ChpB [EC:3.1.-.-]"
				},
				{
					"name":"J159_00028 Growth regulator\tK18842 chpS; antitoxin ChpS"
				}
				]
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD"
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB",
				"children":[
				{
					"name":"J159_00301 HipA N-terminal domain\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				},
				{
					"name":"J159_00302 transcriptional regulator\tK15773 hipB; HTH-type transcriptional regulator \/ antitoxin HipB"
				}
				]
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA",
				"children":[
				{
					"name":"J159_00891 Post-segregation antitoxin CcdA\tK19164 ccdA; antitoxin CcdA"
				}
				]
			},
			{
				"name":"ParE-ParD",
				"children":[
				{
					"name":"J159_01272 Plasmid stabilization system protein\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"J159_01271 putative addiction module antidote protein, CC2985 family\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				}
				]
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"J159_01328 death-on-curing family protein\tK07341 doc; death on curing protein"
				}
				]
			},
			{
				"name":"HigB-HigA"
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"J159_00101 putative nucleic acid-binding protein, contains PIN domain\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"J159_00102 Virulence-associated protein\tK18829 mvpT; antitoxin VapB"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA",
				"children":[
				{
					"name":"J159_04447 putative nucleic acid-binding protein, contains PIN domain\tK07062 fitB; toxin FitB [EC:3.1.-.-]"
				},
				{
					"name":"J159_04446 Plasmid stability protein\tK21495 fitA; antitoxin FitA"
				}
				]
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"J159_00906 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"J159_00774 rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"J159_01584 DNA topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"J159_01856 DNA topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"J159_03013 glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"J159_02228 hypothetical protein\tK19168 cptA; toxin CptA"
				},
				{
					"name":"J159_02227 hypothetical protein\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins"
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}