{
	"name":"xdi03016",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P"
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"EZH22_14830 ribonuclease T\tK01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"EZH22_10020 tRNA nucleotidyltransferase\tK00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonuclease complex"
			},
			{
				"name":"tRNA splicing ligase complex"
			},
			{
				"name":"Other tRNA splicing factors"
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors"
			},
			{
				"name":"tRNA import factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"EZH22_20795 glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"EZH22_18445 proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				},
				{
					"name":"EZH22_08685 isoleucine--tRNA ligase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"EZH22_26530 leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"EZH22_21005 methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"EZH22_19675 arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"EZH22_23085 alaS; alanine--tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"EZH22_27340 thrS; threonine--tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"EZH22_18735 serS; serine--tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"EZH22_17605 cysteine--tRNA ligase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"EZH22_22740 valine--tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"EZH22_13045 histidine--tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"EZH22_04910 pheS; phenylalanine--tRNA ligase subunit alpha\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"EZH22_04915 phenylalanine--tRNA ligase subunit beta\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"EZH22_18385 tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"EZH22_27260 trpS; tryptophan--tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				}
				]
			},
			{
				"name":"Trans-editing factors"
			},
			{
				"name":"AARS associated factors",
				"children":[
				{
					"name":"EZH22_18285 HIT family protein\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferase",
				"children":[
				{
					"name":"EZH22_07610 miaB; tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB\tK06168 CDK5RAP1; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]"
				},
				{
					"name":"EZH22_13515 mtaB; tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase MtaB\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"EZH22_07645 trmB; tRNA (guanosine(46)-N7)-methyltransferase TrmB\tK03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"EZH22_10840 truA; tRNA pseudouridine(38-40) synthase TruA\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"EZH22_06760 truB; tRNA pseudouridine(55) synthase TruB\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"EZH22_04115 nifS; cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"EZH22_18400 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Elongator complex"
			},
			{
				"name":"Elongator related proteins"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"EZH22_26245 threonylcarbamoyl-AMP synthase\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"EZH22_17735 miaA; tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]"
				},
				{
					"name":"EZH22_07725 mnmE; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				},
				{
					"name":"EZH22_07730 mnmG; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				},
				{
					"name":"EZH22_15000 selD; selenide, water dikinase SelD\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"TRAMP complex"
			},
			{
				"name":"Rapid tRNA decay (RTD) pathway factors",
				"children":[
				{
					"name":"EZH22_17450 cysQ; 3'(2'),5'-bisphosphate nucleotidase CysQ\tK01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]"
				}
				]
			},
			{
				"name":"Other tRNA degradation factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"EZH22_05460 rnpA; ribonuclease P protein component\tK03536 rnpA; ribonuclease P protein component [EC:3.1.26.5]"
				},
				{
					"name":"EZH22_07945 rnpB; RNase P RNA component class A\tK01978 rnpB; RNase P catalytic RNA component"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"EZH22_09935 rph; ribonuclease PH\tK00989 rph; ribonuclease PH [EC:2.7.7.56]"
				},
				{
					"name":"EZH22_04310 ribonuclease D\tK03684 rnd; ribonuclease D [EC:3.1.13.5]"
				},
				{
					"name":"EZH22_26030 rnd; ribonuclease D\tK03684 rnd; ribonuclease D [EC:3.1.13.5]"
				},
				{
					"name":"EZH22_14830 ribonuclease T\tK01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"EZH22_10020 tRNA nucleotidyltransferase\tK00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonucleases"
			},
			{
				"name":"tRNA splicing ligases"
			},
			{
				"name":"Other tRNA splicing factors",
				"children":[
				{
					"name":"EZH22_13495 thpR; RNA 2',3'-cyclic phosphodiesterase\tK01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors",
				"children":[
				{
					"name":"EZH22_01415 ettA; energy-dependent translational throttle protein EttA\tK06020 ettA; energy-dependent translational throttle protein EttA"
				}
				]
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"EZH22_26530 leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"EZH22_18445 proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"EZH22_18385 tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"EZH22_27260 trpS; tryptophan--tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"EZH22_27340 thrS; threonine--tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"EZH22_08685 isoleucine--tRNA ligase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"EZH22_23085 alaS; alanine--tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"EZH22_22740 valine--tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"EZH22_21005 methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"EZH22_18735 serS; serine--tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"EZH22_03765 glycine--tRNA ligase subunit alpha\tK01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]"
				},
				{
					"name":"EZH22_03755 glycine--tRNA ligase subunit beta\tK01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]"
				},
				{
					"name":"EZH22_17605 cysteine--tRNA ligase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"EZH22_20795 glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"EZH22_19675 arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"EZH22_04910 pheS; phenylalanine--tRNA ligase subunit alpha\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"EZH22_04915 phenylalanine--tRNA ligase subunit beta\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"EZH22_13045 histidine--tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"EZH22_11060 gluQRS; tRNA glutamyl-Q(34) synthetase GluQRS\tK01894 gluQ; glutamyl-Q tRNA(Asp) synthetase [EC:6.1.1.-]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"EZH22_15200 ybaK; Cys-tRNA(Pro) deacylase\tK03976 ybaK; Cys-tRNA(Pro)\/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]"
				},
				{
					"name":"EZH22_06650 prolyl-tRNA synthetase associated domain-containing protein\tK19055 prdX; Ala-tRNA(Pro) deacylase [EC:3.1.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases",
				"children":[
				{
					"name":"EZH22_26690 nucleoside deaminase\tK11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]"
				}
				]
			},
			{
				"name":"Dihydorouridine synthases",
				"children":[
				{
					"name":"EZH22_19700 dusA; tRNA dihydrouridine(20\/20a) synthase DusA\tK05539 dusA; tRNA-dihydrouridine synthase A [EC:1.-.-.-]"
				},
				{
					"name":"EZH22_19015 dusB; tRNA dihydrouridine synthase DusB\tK05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-]"
				}
				]
			},
			{
				"name":"Methylthiotransferases",
				"children":[
				{
					"name":"EZH22_07610 miaB; tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB\tK06168 CDK5RAP1; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]"
				},
				{
					"name":"EZH22_13515 mtaB; tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase MtaB\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"EZH22_18775 trmFO; methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO\tK04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]"
				},
				{
					"name":"EZH22_07645 trmB; tRNA (guanosine(46)-N7)-methyltransferase TrmB\tK03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]"
				},
				{
					"name":"EZH22_09810 trmD; tRNA (guanosine(37)-N1)-methyltransferase TrmD\tK00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]"
				},
				{
					"name":"EZH22_07725 mnmE; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				},
				{
					"name":"EZH22_11440 tRNA (cytidine(34)-2'-O)-methyltransferase\tK03216 trmL; tRNA (cytidine\/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"EZH22_10840 truA; tRNA pseudouridine(38-40) synthase TruA\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"EZH22_06760 truB; tRNA pseudouridine(55) synthase TruB\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"EZH22_07885 RNA pseudouridine synthase\tK06177 rluA; tRNA pseudouridine32 synthase \/ 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"EZH22_06315 mnmA; tRNA 2-thiouridine(34) synthase MnmA\tK00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]"
				},
				{
					"name":"EZH22_20800 sulfurtransferase TusA family protein\tK04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]"
				},
				{
					"name":"EZH22_23725 iron-sulfur cluster assembly accessory protein\tK13628 iscA; iron-sulfur cluster assembly protein"
				},
				{
					"name":"EZH22_04115 nifS; cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"EZH22_18400 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"EZH22_11130 folate-binding protein YgfZ\tK06980 ygfZ; tRNA-modifying protein YgfZ"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex",
				"children":[
				{
					"name":"EZH22_31240 hypothetical protein\tK09119 cgi121; KEOPS complex subunit Cgi121"
				}
				]
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"EZH22_07730 mnmG; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				},
				{
					"name":"EZH22_17735 miaA; tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]"
				},
				{
					"name":"EZH22_20290 queA; tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA\tK07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]"
				},
				{
					"name":"EZH22_07935 queC; 7-cyano-7-deazaguanine synthase QueC\tK06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]"
				},
				{
					"name":"EZH22_12010 7-cyano-7-deazaguanine synthase\tK06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]"
				},
				{
					"name":"EZH22_17090 queD; 6-carboxytetrahydropterin synthase QueD\tK01737 queD; 6-pyruvoyltetrahydropterin\/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]"
				},
				{
					"name":"EZH22_17085 queE; 7-carboxy-7-deazaguanine synthase\tK10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]"
				},
				{
					"name":"EZH22_20150 queF; NADPH-dependent 7-cyano-7-deazaguanine reductase QueF\tK09457 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]"
				},
				{
					"name":"EZH22_07605 queG; tRNA epoxyqueuosine(34) reductase QueG\tK18979 queG; epoxyqueuosine reductase [EC:1.17.99.6]"
				},
				{
					"name":"EZH22_15000 selD; selenide, water dikinase SelD\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]"
				},
				{
					"name":"EZH22_20295 tgt; tRNA guanosine(34) transglycosylase Tgt\tK00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]"
				},
				{
					"name":"EZH22_03000 tilS; tRNA lysidine(34) synthetase TilS\tK04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]"
				},
				{
					"name":"EZH22_07670 tsaB; tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB\tK14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB"
				},
				{
					"name":"EZH22_26245 threonylcarbamoyl-AMP synthase\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"EZH22_26765 tsaD; tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD\tK25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"EZH22_19235 rnr; ribonuclease R\tK12573 rnr; ribonuclease R [EC:3.1.13.1]"
			},
			{
				"name":"EZH22_06770 pnp; polyribonucleotide nucleotidyltransferase\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
			}
			]
		}
		]
	}
	]
}