{
	"name":"ypo02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"BZ17_4127 cas1; CRISPR-associated endonuclease Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"BZ17_4128 cas3f; CRISPR-associated helicase Cas3, subtype I-F\/YPEST\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors",
				"children":[
				{
					"name":"BZ17_4129 csy1; CRISPR type I-F\/YPEST-associated protein Csy1\tK19127 csy1; CRISPR-associated protein Csy1"
				},
				{
					"name":"BZ17_4130 csy2; CRISPR type I-F\/YPEST-associated protein Csy2\tK19128 csy2; CRISPR-associated protein Csy2"
				},
				{
					"name":"BZ17_4131 csy3; CRISPR type I-F\/YPEST-associated protein Csy3\tK19129 csy3; CRISPR-associated protein Csy3"
				},
				{
					"name":"BZ17_4132 cas6f; CRISPR-associated endoribonuclease Cas6\/Csy4, subtype I-F\/YPEST\tK19130 csy4; CRISPR-associated endonuclease Csy4 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"BZ17_2024 hsdR; type I site-specific deoxyribonuclease, HsdR family protein\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"BZ17_2702 hsdR; type I site-specific deoxyribonuclease, HsdR family protein\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"BZ17_2023 type I restriction modification DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"BZ17_2700 type I restriction modification DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"BZ17_2022 hsdM; type I restriction-modification system, M subunit\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"BZ17_2699 hsdM; type I restriction-modification system, M subunit\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"BZ17_2839 dam; DNA adenine methylase family protein\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"BZ17_613 dam; DNA adenine methylase family protein\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"BZ17_686 C-5 cytosine-specific DNA methylase family protein\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"BZ17_2707 restriction endonuclease family protein\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR",
				"children":[
				{
					"name":"BZ17_2980 toxin SymE, type I toxin-antitoxin system family protein\tK19048 symE; toxic protein SymE"
				}
				]
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE"
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD"
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"BZ17_2999 relB antitoxin family protein\tK07473 dinJ; DNA-damage-inducible protein J"
				}
				]
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"BZ17_4293 addiction module toxin, Txe\/YoeB family\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"BZ17_4292 yefM; antitoxin YefM\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB",
				"children":[
				{
					"name":"BZ17_3941 hypothetical protein\tK18843 hicB; antitoxin HicB"
				}
				]
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB",
				"children":[
				{
					"name":"BZ17_193 pspC; phage shock protein C\tK03973 pspC; phage shock protein C"
				},
				{
					"name":"BZ17_192 pspB; phage shock protein B\tK03970 pspB; phage shock protein B"
				}
				]
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD",
				"children":[
				{
					"name":"BZ17_4208 plasmid stabilization system family protein\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"BZ17_4207 hypothetical protein\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				}
				]
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"BZ17_794 death-on-curing family protein\tK07341 doc; death on curing protein"
				}
				]
			},
			{
				"name":"HigB-HigA"
			},
			{
				"name":"MqsR-MqsA",
				"children":[
				{
					"name":"BZ17_3493 mqsR; mRNA interferase MqsR\tK13651 mqsR; motility quorum-sensing regulator \/ GCU-specific mRNA interferase toxin"
				},
				{
					"name":"BZ17_3494 mqsA; antitoxin MqsA\tK13655 mqsA; HTH-type transcriptional regulator \/ antitoxin MqsA"
				}
				]
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6",
				"children":[
				{
					"name":"BZ17_2790 toxin 61 family protein\tK28299 tse6; NAD(P)(+) glycohydrolase toxin Tse6 [EC:3.2.2.5]"
				},
				{
					"name":"BZ17_2791 hypothetical protein\tK28300 tsi6; immune protein Tsi6"
				},
				{
					"name":"BZ17_2792 hypothetical protein\tK28300 tsi6; immune protein Tsi6"
				}
				]
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"BZ17_2037 hypothetical protein\tK19334 tabA; biofilm protein TabA"
				},
				{
					"name":"BZ17_4153 bssS family protein\tK12148 bssS; biofilm regulator BssS"
				},
				{
					"name":"BZ17_1862 ftsZ; cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"BZ17_3036 mreB; rod shape-determining protein mreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"BZ17_3217 parC; DNA topoisomerase IV, A subunit\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"BZ17_3214 parE; DNA topoisomerase IV, B subunit\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"BZ17_3926 gltX; glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU",
				"children":[
				{
					"name":"BZ17_2715 putative toxin YpjF\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"BZ17_2714 putative structural protein\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				}
				]
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"BZ17_3438 flavinator of succinate dehydrogenase family protein\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB",
				"children":[
				{
					"name":"BZ17_1569 hha; hemolysin expression-modulating protein\tK05839 hha; haemolysin expression modulating protein"
				},
				{
					"name":"BZ17_1568 biofilm formation regulator YbaJ family protein\tK19162 tomB; hha toxicity modulator TomB"
				}
				]
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"BZ17_3772 iscS; cysteine desulfurase IscS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"BZ17_397 beta-eliminating lyase family protein\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}