{
	"name":"aam03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)",
				"children":[
				{
					"name":"106491085 ORC1; origin recognition complex subunit 1\tK02603 ORC1; origin recognition complex subunit 1"
				},
				{
					"name":"106492459 ORC2; origin recognition complex subunit 2\tK02604 ORC2; origin recognition complex subunit 2"
				},
				{
					"name":"106489666 ORC3; origin recognition complex subunit 3\tK02605 ORC3; origin recognition complex subunit 3"
				},
				{
					"name":"106498517 ORC4; origin recognition complex subunit 4\tK02606 ORC4; origin recognition complex subunit 4"
				},
				{
					"name":"106485867 ORC5; origin recognition complex subunit 5\tK02607 ORC5; origin recognition complex subunit 5"
				},
				{
					"name":"106483218 ORC6; origin recognition complex subunit 6\tK02608 ORC6; origin recognition complex subunit 6"
				},
				{
					"name":"106491420 CDT1; chromatin licensing and DNA replication factor 1\tK10727 CDT1; chromatin licensing and DNA replication factor 1"
				},
				{
					"name":"106494356 DNA replication factor Cdt1-like\tK10727 CDT1; chromatin licensing and DNA replication factor 1"
				},
				{
					"name":"106486420 CDC6; cell division cycle 6\tK02213 CDC6; cell division control protein 6"
				},
				{
					"name":"106482774 MCM2; minichromosome maintenance complex component 2\tK02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]"
				},
				{
					"name":"106500523 MCM3; minichromosome maintenance complex component 3\tK02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]"
				},
				{
					"name":"106494391 MCM4; minichromosome maintenance complex component 4\tK02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]"
				},
				{
					"name":"106488827 MCM5; minichromosome maintenance complex component 5\tK02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]"
				},
				{
					"name":"106498425 MCM6; minichromosome maintenance complex component 6\tK02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]"
				},
				{
					"name":"106484790 MCM7; minichromosome maintenance complex component 7\tK02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]"
				}
				]
			},
			{
				"name":"CDK (cyclin dependent kinase)",
				"children":[
				{
					"name":"106492064 CCNA2; cyclin A2\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"106500420 CCNA1; cyclin A1\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"106483300 CCNE1; cyclin E1\tK06626 CCNE; G1\/S-specific cyclin-E1"
				},
				{
					"name":"106483881 CCNE2; cyclin E2\tK06626 CCNE; G1\/S-specific cyclin-E1"
				},
				{
					"name":"106482119 CDK2; cyclin dependent kinase 2\tK02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]"
				}
				]
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)",
				"children":[
				{
					"name":"106499794 CDC7; cell division cycle 7\tK02214 CDC7; cell division control protein 7 [EC:2.7.11.1]"
				},
				{
					"name":"106483609 DBF4; DBF4 zinc finger\tK06629 DBF4; protein DBF4"
				},
				{
					"name":"106496690 DBF4B; DBF4 zinc finger B\tK06629 DBF4; protein DBF4"
				}
				]
			},
			{
				"name":"GINS complex",
				"children":[
				{
					"name":"106495089 GINS1; GINS complex subunit 1\tK10732 GINS1; GINS complex subunit 1"
				},
				{
					"name":"106492249 GINS2; GINS complex subunit 2\tK10733 GINS2; GINS complex subunit 2"
				},
				{
					"name":"106485791 GINS3; GINS complex subunit 3\tK10734 GINS3; GINS complex subunit 3"
				}
				]
			},
			{
				"name":"Other initiation factors",
				"children":[
				{
					"name":"106491223 TOPBP1; topoisomerase (DNA) II binding protein 1\tK10728 TOPBP1; topoisomerase (DNA) II binding protein 1"
				},
				{
					"name":"106486533 RECQL4; RecQ like helicase 4\tK10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]"
				},
				{
					"name":"106486844 CDC45; cell division cycle 45\tK06628 CDC45; cell division control protein 45"
				},
				{
					"name":"106499837 MCM8; minichromosome maintenance 8 homologous recombination repair factor\tK10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]"
				},
				{
					"name":"106497961 MCM9; minichromosome maintenance 9 homologous recombination repair factor\tK10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]"
				},
				{
					"name":"106485467 MCM10; minichromosome maintenance 10 replication initiation factor\tK10736 MCM10; minichromosome maintenance protein 10"
				},
				{
					"name":"106499014 MCMBP; minichromosome maintenance complex binding protein\tK28390 MCMBP; minichromosome maintenance complex-binding protein"
				},
				{
					"name":"106488149 HELB; DNA helicase B\tK15254 HELB; DNA helicase B [EC:5.6.2.3]"
				},
				{
					"name":"106483132 CINP; cyclin dependent kinase 2 interacting protein\tK26052 CINP; cyclin-dependent kinase 2-interacting protein"
				},
				{
					"name":"106496213 MTBP; MDM2 binding protein\tK26116 MTBP; Mdm2-binding protein"
				},
				{
					"name":"106497299 TICRR; TOPBP1 interacting checkpoint and replication regulator\tK26117 TICRR; Treslin"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex",
				"children":[
				{
					"name":"106492264 POLA1; DNA polymerase alpha 1, catalytic subunit\tK02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]"
				},
				{
					"name":"106494367 POLA2; DNA polymerase alpha 2, accessory subunit\tK02321 POLA2; DNA polymerase alpha subunit B"
				},
				{
					"name":"106492497 PRIM2; primase (DNA) subunit 2\tK02685 PRI2; DNA primase large subunit"
				}
				]
			},
			{
				"name":"DNA polymerase epsilon complex",
				"children":[
				{
					"name":"106487395 POLE; DNA polymerase epsilon, catalytic subunit\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"106487022 POLE2; DNA polymerase epsilon 2, accessory subunit\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
				},
				{
					"name":"106487017 POLE3; DNA polymerase epsilon 3, accessory subunit\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"DNA polymerase delta complex",
				"children":[
				{
					"name":"106483931 DNA polymerase delta subunit 2-like\tK02328 POLD2; DNA polymerase delta subunit 2"
				},
				{
					"name":"106484160 POLD3; DNA polymerase delta 3, accessory subunit\tK03504 POLD3; DNA polymerase delta subunit 3"
				}
				]
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)",
				"children":[
				{
					"name":"106497322 POLG; DNA polymerase gamma, catalytic subunit\tK02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]"
				},
				{
					"name":"106493152 POLG2; DNA polymerase gamma 2, accessory subunit\tK02333 POLG2; DNA polymerase gamma 2"
				}
				]
			},
			{
				"name":"RPA (replication protein A)",
				"children":[
				{
					"name":"106487714 RPA1; replication protein A1\tK07466 RFA1; replication factor A1"
				},
				{
					"name":"106484718 RPA2; replication protein A2\tK10739 RFA2; replication factor A2"
				},
				{
					"name":"106483524 RPA3; replication protein A3\tK10740 RPA3; replication factor A3"
				}
				]
			},
			{
				"name":"RFC (replication factor C)",
				"children":[
				{
					"name":"106490105 RFC1; replication factor C subunit 1\tK10754 RFC1; replication factor C subunit 1"
				},
				{
					"name":"106482224 RFC4; replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"106493865 replication factor C subunit 2-like\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"106497608 replication factor C subunit 2-like\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"106497611 RFC2; replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"106497470 RFC5; replication factor C subunit 5\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"106500451 RFC3; replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"106492989 RNASEH1; ribonuclease H1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				},
				{
					"name":"106489164 RNASEH2B; ribonuclease H2 subunit B\tK10744 RNASEH2B; ribonuclease H2 subunit B"
				}
				]
			},
			{
				"name":"Other elongation factors",
				"children":[
				{
					"name":"106486972 DNA2; DNA replication helicase\/nuclease 2\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
				},
				{
					"name":"106484371 FEN1; flap structure-specific endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
				},
				{
					"name":"106485527 EXO1; exonuclease 1\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
				},
				{
					"name":"106498481 ZRANB3; zinc finger RANBP2-type containing 3\tK25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]"
				},
				{
					"name":"106482030 LIG1; DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
				},
				{
					"name":"106493097 ATAD5; ATPase family, AAA domain containing 5\tK26118 ATAD5; ATPase family AAA domain-containing protein 5"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"106500205 DNMT1; DNA methyltransferase 1\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors",
				"children":[
				{
					"name":"106482402 GMNN; geminin, DNA replication inhibitor\tK10749 GMNN; geminin"
				},
				{
					"name":"106484407 G2\/mitotic-specific cyclin-B1-like\tK05868 CCNB1; G2\/mitotic-specific cyclin-B1"
				},
				{
					"name":"106497404 CCNB3; cyclin B3\tK21771 CCNB3; G2\/mitotic-specific cyclin-B3"
				},
				{
					"name":"106486975 CDK1; cyclin dependent kinase 1\tK02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]"
				}
				]
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex",
					"children":[
					{
						"name":"106495929 POT1; protection of telomeres 1\tK11109 POT1; protection of telomeres protein 1"
					},
					{
						"name":"106484635 TERF1; telomeric repeat binding factor 1\tK11110 TERF1; telomeric repeat-binding factor 1"
					},
					{
						"name":"106494586 TERF2; telomeric repeat binding factor 2\tK11111 TERF2; telomeric repeat-binding factor 2"
					},
					{
						"name":"106484525 ACD; ACD, shelterin complex subunit and telomerase recruitment factor\tK11114 ACD; adrenocortical dysplasia protein"
					}
					]
				},
				{
					"name":"TERB1-TERB2-MAJIN complex",
					"children":[
					{
						"name":"106483245 TERB1; telomere repeat binding bouquet formation protein 1\tK25749 TERB1; telomere repeats-binding bouquet formation protein 1"
					},
					{
						"name":"106495674 TERB2; telomere repeat binding bouquet formation protein 2\tK25750 TERB2; telomere repeats-binding bouquet formation protein 2"
					},
					{
						"name":"106485351 MAJIN; membrane anchored junction protein\tK25751 MAJIN; membrane-anchored junction protein"
					}
					]
				},
				{
					"name":"CST complex (animals)",
					"children":[
					{
						"name":"106497254 CTC1; CST telomere replication complex component 1\tK23311 CTC1; CST complex subunit CTC1"
					},
					{
						"name":"106498547 STN1; STN1, CST complex subunit\tK23312 STN1; CST complex subunit STN1"
					},
					{
						"name":"106483829 CST complex subunit TEN1-like\tK23313 TEN1; CST complex subunit TEN1"
					},
					{
						"name":"106483851 TEN1; TEN1, CST complex subunit\tK23313 TEN1; CST complex subunit TEN1"
					}
					]
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins"
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"106484302 telomerase-binding protein EST1A-like\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]"
				},
				{
					"name":"106484304 telomerase-binding protein EST1A-like\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]"
				},
				{
					"name":"106492309 SMG5; SMG5, nonsense mediated mRNA decay factor\tK11125 SMG5; protein SMG5"
				},
				{
					"name":"106492846 TERT; telomerase reverse transcriptase\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"Dyskerin complex",
					"children":[
					{
						"name":"106492119 GAR1; GAR1 ribonucleoprotein\tK11128 GAR1; H\/ACA ribonucleoprotein complex subunit 1"
					},
					{
						"name":"106489847 NHP2; NHP2 ribonucleoprotein\tK11129 NHP2; H\/ACA ribonucleoprotein complex subunit 2"
					},
					{
						"name":"106482685 H\/ACA ribonucleoprotein complex subunit 4-like\tK11131 DKC1; H\/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"106492846 TERT; telomerase reverse transcriptase\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"Sm core complex",
					"children":[
					{
						"name":"106497591 SNRPB; small nuclear ribonucleoprotein polypeptides B and B1\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"106491231 SNRPD1; small nuclear ribonucleoprotein D1 polypeptide\tK11087 SNRPD1; small nuclear ribonucleoprotein D1"
					},
					{
						"name":"106489920 SNRPD2; small nuclear ribonucleoprotein D2 polypeptide\tK11096 SNRPD2; small nuclear ribonucleoprotein D2"
					},
					{
						"name":"106486334 SNRPD3; small nuclear ribonucleoprotein D3 polypeptide\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"106484866 SNRPE; small nuclear ribonucleoprotein polypeptide E\tK11097 SNRPE; small nuclear ribonucleoprotein E"
					},
					{
						"name":"106488188 SNRPF; small nuclear ribonucleoprotein polypeptide F\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"106490254 SNRPG; small nuclear ribonucleoprotein polypeptide G\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					}
					]
				}
				]
			},
			{
				"name":"ELG1-RFC complex",
				"children":[
				{
					"name":"106482224 RFC4; replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"106493865 replication factor C subunit 2-like\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"106497608 replication factor C subunit 2-like\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"106497611 RFC2; replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"106497470 RFC5; replication factor C subunit 5\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"106500451 RFC3; replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"MRN complex",
				"children":[
				{
					"name":"106495525 MRE11; MRE11 homolog, double strand break repair nuclease\tK10865 MRE11; double-strand break repair protein MRE11"
				},
				{
					"name":"106487246 RAD50; RAD50 double strand break repair protein\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
				},
				{
					"name":"106496199 NBN; nibrin\tK10867 NBN; nibrin"
				}
				]
			},
			{
				"name":"Other termination factors",
				"children":[
				{
					"name":"106493490 ATM; ATM serine\/threonine kinase\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"106494833 WRN; Werner syndrome RecQ like helicase\tK10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]"
				},
				{
					"name":"106487040 BLM; Bloom syndrome RecQ like helicase\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
				},
				{
					"name":"106494392 PRKDC; protein kinase, DNA-activated, catalytic polypeptide\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]"
				},
				{
					"name":"106482627 ERCC4; ERCC excision repair 4, endonuclease catalytic subunit\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
				},
				{
					"name":"106482730 PARP1; poly(ADP-ribose) polymerase 1\tK24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]"
				},
				{
					"name":"106494109 TNKS2; tankyrase 2\tK10799 TNKS; tankyrase [EC:2.4.2.30]"
				},
				{
					"name":"106495836 TNKS; tankyrase\tK10799 TNKS; tankyrase [EC:2.4.2.30]"
				},
				{
					"name":"106496028 PINX1; PIN2\/TERF1 interacting, telomerase inhibitor 1\tK11135 PINX1; Pin2-interacting protein X1"
				},
				{
					"name":"106493212 RTEL1; regulator of telomere elongation helicase 1\tK11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]"
				},
				{
					"name":"106482368 TELO2; telomere maintenance 2\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"106482295 RIF1; replication timing regulatory factor 1\tK11138 RIF1; telomere-associated protein RIF1"
				},
				{
					"name":"106499445 PIF1; PIF1 5'-to-3' DNA helicase\tK15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]"
				},
				{
					"name":"106494294 PURA; purine rich element binding protein A\tK21772 PURA; transcriptional activator protein Pur-alpha"
				},
				{
					"name":"106494813 purine-rich element-binding protein gamma-like\tK21800 PURG; purine-rich element-binding protein gamma"
				},
				{
					"name":"106494839 purine-rich element-binding protein gamma-like\tK21800 PURG; purine-rich element-binding protein gamma"
				},
				{
					"name":"106482728 SDE2; SDE2 telomere maintenance homolog\tK25059 SDE2; replication stress response regulator SDE2"
				},
				{
					"name":"106491734 RTFDC1; replication termination factor 2 domain containing 1\tK25186 RTF2; replication termination factor 2"
				}
				]
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"106488294 TOP1; topoisomerase (DNA) I\tK03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]"
			},
			{
				"name":"106483492 TOP2B; topoisomerase (DNA) II beta\tK03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]"
			},
			{
				"name":"106486418 TOP2A; topoisomerase (DNA) II alpha\tK03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]"
			},
			{
				"name":"106486872 TOP3B; topoisomerase (DNA) III beta\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			},
			{
				"name":"106492933 TOP3A; topoisomerase (DNA) III alpha\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)"
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"106492989 RNASEH1; ribonuclease H1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors"
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"106492989 RNASEH1; ribonuclease H1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"106486972 DNA2; DNA replication helicase\/nuclease 2\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
					},
					{
						"name":"106484371 FEN1; flap structure-specific endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"106482030 LIG1; DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases"
		}
		]
	}
	]
}