{
	"name":"bapi04131",
	"children":[
	{
		"name":"Exocytosis",
		"children":[
		{
			"name":"Calcium ion-dependent exocytosis",
			"children":[
			{
				"name":"Synaptotagmins"
			},
			{
				"name":"Septins"
			},
			{
				"name":"DOC-2 proteins"
			},
			{
				"name":"Acrosomal exocytosis proteins"
			},
			{
				"name":"Phospholipases"
			},
			{
				"name":"Kinases and associated proteins",
				"children":[
				{
					"name":"BBC0122_008880 nucleoside diphosphate kinase\tK00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Small GTPases and associated proteins",
			"children":[
			{
				"name":"Rab GTPases"
			},
			{
				"name":"Rab associated proteins"
			},
			{
				"name":"Rho GTPases"
			},
			{
				"name":"Other small GTPases and associated proteins"
			}
			]
		},
		{
			"name":"Tethering complex",
			"children":[
			{
				"name":"Exocyst complex"
			},
			{
				"name":"Exocyst complex assembly proteins"
			}
			]
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"Exomer complex"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"SNARE",
		"children":[
		{
			"name":"Syntaxin (Qa)",
			"children":[
			{
				"name":"Stx-PM"
			},
			{
				"name":"Stx-Endo"
			},
			{
				"name":"Stx-TGN \/ EE"
			},
			{
				"name":"Stx-cisGolgi"
			},
			{
				"name":"Stx-sER"
			},
			{
				"name":"Stx-rER"
			}
			]
		},
		{
			"name":"SNAP-25[N] (Qb)",
			"children":[
			{
				"name":"Vti1"
			},
			{
				"name":"NPSN"
			},
			{
				"name":"Gos1 (Gos28)"
			},
			{
				"name":"Bos1 \/ Membrin"
			},
			{
				"name":"Sec20"
			}
			]
		},
		{
			"name":"SNAP-25[C] (Qc)",
			"children":[
			{
				"name":"STX6"
			},
			{
				"name":"STX8"
			},
			{
				"name":"STX10"
			},
			{
				"name":"Bet1"
			},
			{
				"name":"Sft1"
			},
			{
				"name":"Syp7"
			},
			{
				"name":"Use1"
			}
			]
		},
		{
			"name":"SNAP-25 (Qb,c)",
			"children":[
			{
				"name":"SNAP-23"
			},
			{
				"name":"SNAP-25"
			},
			{
				"name":"SNAP-29"
			},
			{
				"name":"SNAP-47"
			}
			]
		},
		{
			"name":"VAMP, Ykt6, Sec22 (R)",
			"children":[
			{
				"name":"VAMP"
			},
			{
				"name":"Ykt6"
			},
			{
				"name":"Sec22"
			},
			{
				"name":"Tomosyn"
			},
			{
				"name":"Putative SNAREs"
			}
			]
		},
		{
			"name":"SNARE associated proteins",
			"children":[
			{
				"name":"Syntaxin-binding proteins"
			},
			{
				"name":"Palmitoyltransferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Endocytosis",
		"children":[
		{
			"name":"Clathrin-mediated endocytosis",
			"children":[
			{
				"name":"Clathrin"
			},
			{
				"name":"Dynamin"
			},
			{
				"name":"AP-2 complex"
			},
			{
				"name":"Other core components"
			},
			{
				"name":"Low-density lipoprotein receptor (LDLR) family proteins"
			},
			{
				"name":"LDLR adaptor proteins"
			},
			{
				"name":"GPCR adaptor proteins"
			},
			{
				"name":"Receptor tyrosine kinase (RTK) adaptor proteins"
			},
			{
				"name":"Inositol 5-phosphatases"
			},
			{
				"name":"Kinases"
			},
			{
				"name":"Ubiquitin E3 ligases"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Lipid raft mediated endocytosis",
			"children":[
			{
				"name":"Caveolin-mediated endocytosis"
			},
			{
				"name":"Flotillin-dependent endocytosis"
			},
			{
				"name":"GRAF1-dependent endocytosis"
			},
			{
				"name":"Arf6-dependent endocytosis"
			},
			{
				"name":"RhoA-dependent endocytosis"
			}
			]
		},
		{
			"name":"Phagocytosis",
			"children":[
			{
				"name":"Fc receptors"
			},
			{
				"name":"Integrins (complement receptors)"
			},
			{
				"name":"Opsonins"
			},
			{
				"name":"Toll-like receptors"
			},
			{
				"name":"C-lectin receptors"
			},
			{
				"name":"Scavenger receptors"
			},
			{
				"name":"Coronins"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macropinocytosis",
			"children":[
			{
				"name":"Ras GTPases"
			},
			{
				"name":"Kinases"
			},
			{
				"name":"Phospholipase C"
			},
			{
				"name":"Sorting nexins"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Bin\/Amphiphysin\/Rvs (BAR) family proteins",
			"children":[
			{
				"name":"N-BAR proteins"
			},
			{
				"name":"F-BAR proteins"
			},
			{
				"name":"I-BAR proteins"
			}
			]
		},
		{
			"name":"Rab GTPases and associated proteins",
			"children":[
			{
				"name":"Rab GTPases"
			},
			{
				"name":"Rab associated proteins"
			}
			]
		},
		{
			"name":"Arf GTPases and associated proteins",
			"children":[
			{
				"name":"Arf GTPases"
			},
			{
				"name":"Arf associated proteins"
			}
			]
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"Fucosyltransferase"
			},
			{
				"name":"EFR3-PI4KIII alpha complex and associated proteins"
			},
			{
				"name":"Insulin-like growth factor-binding proteins"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Endosome - Lysosome transport",
		"children":[
		{
			"name":"Rab GTPases and associated proteins",
			"children":[
			{
				"name":"Rab GTPases"
			},
			{
				"name":"FTS\/Hook\/FHIP (FHF) complex"
			},
			{
				"name":"FERRY complex"
			},
			{
				"name":"Rab associated proteins"
			}
			]
		},
		{
			"name":"Arf GTPases and associated proteins",
			"children":[
			{
				"name":"Arf GTPases"
			},
			{
				"name":"BLOC-one-related complex (BORC)"
			},
			{
				"name":"N-acetyl transferase complex C (NatC)"
			},
			{
				"name":"Other Arf associated proteins"
			}
			]
		},
		{
			"name":"Endosomal sorting complexes required for transport (ESCRT)",
			"children":[
			{
				"name":"ESCRT-0 complex"
			},
			{
				"name":"ESCRT-I complex"
			},
			{
				"name":"ESCRT-II complex"
			},
			{
				"name":"ESCRT-III complex"
			},
			{
				"name":"ESCRT associated proteins"
			}
			]
		},
		{
			"name":"Tethering complex",
			"children":[
			{
				"name":"CORVET complex"
			},
			{
				"name":"Hops complex"
			}
			]
		},
		{
			"name":"Acidification regulators",
			"children":[
			{
				"name":"Rabconnectin-3 complex"
			},
			{
				"name":"RAVE complex"
			}
			]
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"AP-3 complex"
			},
			{
				"name":"BLOC-1 complex"
			},
			{
				"name":"BLOC-1 complex (yeast)"
			},
			{
				"name":"BLOC-2 complex"
			},
			{
				"name":"BLOC-3 complex"
			},
			{
				"name":"Ferlins"
			},
			{
				"name":"Lysosomal membrane proteins"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Protein recycling",
		"children":[
		{
			"name":"Rab GTPases and associated proteins",
			"children":[
			{
				"name":"Rab GTPases"
			},
			{
				"name":"Rab4 associated proteins"
			},
			{
				"name":"Rab11 associated proteins"
			},
			{
				"name":"Other Rab GTPase associated proteins"
			}
			]
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"Glutamate receptor-interacting proteins (GRIPs)"
			},
			{
				"name":"GRIP associated proteins"
			},
			{
				"name":"EARP complex"
			},
			{
				"name":"WASH complex"
			},
			{
				"name":"Retriever complex"
			},
			{
				"name":"CCC complex"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Endosome - Golgi transport",
		"children":[
		{
			"name":"Rab GTPases and associated proteins",
			"children":[
			{
				"name":"Rab GTPases"
			},
			{
				"name":"Retromer subcomplex"
			},
			{
				"name":"Rab associated proteins"
			}
			]
		},
		{
			"name":"Arf GTPases and associated proteins",
			"children":[
			{
				"name":"Arf GTPases"
			},
			{
				"name":"Arf GTPase associated proteins"
			}
			]
		},
		{
			"name":"Tethering complex",
			"children":[
			{
				"name":"Conserved oligomeric Golgi (COG) complex"
			},
			{
				"name":"GARP complex"
			},
			{
				"name":"TRAPP complex II"
			}
			]
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"AP-1 complex"
			},
			{
				"name":"AP-3 complex"
			},
			{
				"name":"AP-4 complex"
			},
			{
				"name":"GGA"
			},
			{
				"name":"Aftiphilin\/p200\/gamma-synergin complex"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Endoplasmic reticulum (ER) - Golgi transport",
		"children":[
		{
			"name":"Forward pathways",
			"children":[
			{
				"name":"Coat protein complex II (COP-II)"
			},
			{
				"name":"TRAPP complex I"
			},
			{
				"name":"p24 family proteins"
			},
			{
				"name":"PDI family proteins"
			},
			{
				"name":"Rab GTPases"
			},
			{
				"name":"Rab associated proteins"
			},
			{
				"name":"ER-Golgi intermediate compartment (ERGIC) proteins"
			}
			]
		},
		{
			"name":"Retrieval pathways",
			"children":[
			{
				"name":"Coat protein complex I (COP-I)"
			},
			{
				"name":"NRZ (DSL1) complex"
			},
			{
				"name":"Golgi to ER traffic proteins (GET)"
			},
			{
				"name":"Rab GTPases"
			},
			{
				"name":"Rab associated proteins"
			}
			]
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"Oxysterol-binding proteins"
			},
			{
				"name":"FXYD proteins"
			},
			{
				"name":"YIPF proteins"
			},
			{
				"name":"ER membrane protein complex"
			},
			{
				"name":"SEC61 complex"
			},
			{
				"name":"TRAP complex"
			},
			{
				"name":"Multi-pass translocon (MPT) complex"
			},
			{
				"name":"Post-GPI attachment to proteins factors (PGAP)"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Autophagy",
		"children":[
		{
			"name":"Autophagosome formation proteins",
			"children":[
			{
				"name":"ULK complex"
			},
			{
				"name":"Atg1 complex"
			},
			{
				"name":"PI3K complex"
			},
			{
				"name":"ATG9 transmembrane protein"
			},
			{
				"name":"Atg18-Atg2 complex"
			},
			{
				"name":"Atg12 conjugation proteins"
			},
			{
				"name":"Atg8 conjugation proteins"
			}
			]
		},
		{
			"name":"Cytoplasm to vacuolar targeting (CVT) pathway",
			"children":[
			{
				"name":"Selective cargos"
			},
			{
				"name":"Cargo receptors"
			},
			{
				"name":"Scaffold protein"
			},
			{
				"name":"Other Cvt associated proteins"
			}
			]
		},
		{
			"name":"Mitophagy",
			"children":[
			{
				"name":"Cargo receptors"
			},
			{
				"name":"Scaffold proteins"
			},
			{
				"name":"PINK1-Parkin associated proteins"
			},
			{
				"name":"Other mitophagy associated  proteins"
			}
			]
		},
		{
			"name":"Pexophagy",
			"children":[
			{
				"name":"Selective cargos"
			},
			{
				"name":"Cargo receptors"
			},
			{
				"name":"Other pexophagy associated proteins"
			}
			]
		},
		{
			"name":"Aggrephagy",
			"children":[
			{
				"name":"Cargo receptors"
			},
			{
				"name":"Scaffold proteins"
			},
			{
				"name":"Other aggrephagy associated proteins"
			}
			]
		},
		{
			"name":"Xenophagy",
			"children":[
			{
				"name":"Cargo receptors"
			},
			{
				"name":"Other xenophagy associated proteins"
			}
			]
		},
		{
			"name":"ER-phagy",
			"children":[
			{
				"name":"ER-phagy recepters"
			},
			{
				"name":"Other ER-phagy associated proteins"
			},
			{
				"name":"ER stress-related proteins"
			}
			]
		},
		{
			"name":"Chaperone mediated autophagy (CMA)",
			"children":[
			{
				"name":"Selective cargos",
				"children":[
				{
					"name":"BBC0122_022770 fructose-bisphosphate aldolase, class I\tK01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]"
				},
				{
					"name":"BBC0122_022790 glyceraldehyde-3-phosphate dehydrogenase (NAD+)\tK00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]"
				},
				{
					"name":"BBC0122_018330 phosphoglycerate mutase\tK01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"
				},
				{
					"name":"BBC0122_022830 pyruvate kinase\tK00873 PK; pyruvate kinase [EC:2.7.1.40]"
				}
				]
			},
			{
				"name":"Cargo receptors"
			},
			{
				"name":"Chaperones"
			},
			{
				"name":"Co-chaperones"
			},
			{
				"name":"Other CMA associated proteins"
			}
			]
		},
		{
			"name":"Other autophagy associated proteins",
			"children":[
			{
				"name":"RNautophagy\/DNautophagy"
			},
			{
				"name":"Micronucleophagy"
			},
			{
				"name":"Midbophagy"
			},
			{
				"name":"Glycophagy"
			},
			{
				"name":"TRIM-directed selective autophagy"
			},
			{
				"name":"ER-mitochondria tethering complex"
			},
			{
				"name":"mTORC1 complex"
			},
			{
				"name":"mTORC2 complex"
			},
			{
				"name":"SEACIT\/GATOR1 complex"
			},
			{
				"name":"SEACAT\/GATOR2 complex"
			},
			{
				"name":"KICSTOR complex"
			},
			{
				"name":"Rab GTPases"
			},
			{
				"name":"Rab associated proteins"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Others",
		"children":[
		{
			"name":"NADPH oxidases (Nox) and associated proteins",
			"children":[
			{
				"name":"NADPH oxidases"
			},
			{
				"name":"Nox associated proteins"
			}
			]
		},
		{
			"name":"Actin-binding proteins",
			"children":[
			{
				"name":"Myosins"
			},
			{
				"name":"Arp2\/3 complex"
			},
			{
				"name":"Nucleation-promoting factors (NPFs)"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Mucins",
			"children":[
			{
				"name":"Membrane bound mucins"
			},
			{
				"name":"Secretory mucins"
			}
			]
		},
		{
			"name":"MARVEL domain-containing proteins"
		},
		{
			"name":"Specific organelles associated proteins",
			"children":[
			{
				"name":"Melanosome"
			},
			{
				"name":"Auto phagosome"
			},
			{
				"name":"Lipid droplets"
			},
			{
				"name":"Mitochondrion"
			}
			]
		},
		{
			"name":"Rho GTPase associated proteins",
			"children":[
			{
				"name":"Rho GTPase-activating proteins"
			},
			{
				"name":"Rho guanine nucleotide exchange factors (GEFs)"
			}
			]
		}
		]
	}
	]
}