{
	"name":"ccae03016",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"111924514 POP1; ribonucleases P\/MRP protein subunit POP1\tK01164 POP1; ribonuclease P\/MRP protein subunit POP1 [EC:3.1.26.5]"
				},
				{
					"name":"111934654 POP4; ribonuclease P protein subunit p29\tK03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]"
				},
				{
					"name":"111936602 POP5; ribonuclease P\/MRP protein subunit POP5\tK03537 POP5; ribonuclease P\/MRP protein subunit POP5 [EC:3.1.26.5]"
				},
				{
					"name":"111931177 RPP30; ribonuclease P protein subunit p30\tK03539 RPP1; ribonuclease P\/MRP protein subunit RPP1 [EC:3.1.26.5]"
				},
				{
					"name":"111935292 RPP14; ribonuclease P protein subunit p14\tK14529 RPP14; ribonuclease P protein subunit RPP14 [EC:3.1.26.5]"
				},
				{
					"name":"111934271 RPP25; ribonuclease P protein subunit p25\tK14525 RPP25; ribonucleases P\/MRP protein subunit RPP25 [EC:3.1.26.5]"
				},
				{
					"name":"111941044 RPP25L; ribonuclease P protein subunit p25-like protein\tK14525 RPP25; ribonucleases P\/MRP protein subunit RPP25 [EC:3.1.26.5]"
				},
				{
					"name":"111924180 RPP38; ribonuclease P protein subunit p38\tK14523 RPP38; ribonucleases P\/MRP protein subunit RPP38 [EC:3.1.26.5]"
				},
				{
					"name":"111923818 RPP40; ribonuclease P protein subunit p40\tK14530 RPP40; ribonucleases P\/MRP protein subunit RPP40 [EC:3.1.26.5]"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"111940944 ELAC1; zinc phosphodiesterase ELAC protein 1 isoform X1\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				},
				{
					"name":"111942395 ELAC2; zinc phosphodiesterase ELAC protein 2\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				},
				{
					"name":"111926928 RNASET2; ribonuclease T2\tK01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]"
				},
				{
					"name":"111936122 PTCD1; pentatricopeptide repeat-containing protein 1, mitochondrial\tK17710 PTCD1; pentatricopeptide repeat domain-containing protein 1"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"111934938 TRNT1; CCA tRNA nucleotidyltransferase 1, mitochondrial\tK00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonuclease complex",
				"children":[
				{
					"name":"111935236 TSEN2; tRNA-splicing endonuclease subunit Sen2 isoform X1\tK15322 TSEN2; tRNA-splicing endonuclease subunit Sen2 [EC:4.6.1.16]"
				},
				{
					"name":"111932543 TSEN15; tRNA-splicing endonuclease subunit Sen15 isoform X1\tK15324 TSEN15; tRNA-splicing endonuclease subunit Sen15"
				},
				{
					"name":"111942931 TSEN54; tRNA-splicing endonuclease subunit Sen54\tK15326 TSEN54; tRNA-splicing endonuclease subunit Sen54"
				}
				]
			},
			{
				"name":"tRNA splicing ligase complex",
				"children":[
				{
					"name":"111931292 RTCB; tRNA-splicing ligase RtcB homolog\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				},
				{
					"name":"111922677 C1H2orf49; ashwin\tK15432 ASW; ashwin"
				},
				{
					"name":"111929521 RTRAF; RNA transcription, translation and transport factor protein\tK15433 CGI99; RLL motif containing protein 1"
				},
				{
					"name":"111942150 FAM98B; protein FAM98B\tK15434 FAM98B; protein FAM98B"
				},
				{
					"name":"111926783 DDX1; ATP-dependent RNA helicase DDX1\tK13177 DDX1; ATP-dependent RNA helicase DDX1 [EC:5.6.2.7]"
				},
				{
					"name":"111939152 ZBTB8OS; protein archease isoform X1\tK24956 ZBTB8OS; protein archease"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors"
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors",
				"children":[
				{
					"name":"111936334 RAN; GTP-binding nuclear protein Ran\tK07936 RAN; GTP-binding nuclear protein Ran"
				},
				{
					"name":"111932448 XPOT; exportin-T\tK14288 XPOT; exportin-T"
				},
				{
					"name":"111926443 XPO1; exportin-1\tK14290 XPO1; exportin-1"
				},
				{
					"name":"111927086 XPO5; exportin-5\tK14289 XPO5; exportin-5"
				},
				{
					"name":"111925807 EEF1A1; elongation factor 1-alpha 1\tK03231 EEF1A; elongation factor 1-alpha"
				},
				{
					"name":"111938093 EEF1A2; elongation factor 1-alpha 2\tK03231 EEF1A; elongation factor 1-alpha"
				},
				{
					"name":"111934976 GTPBP1; GTP-binding protein 1 isoform X1\tK24887 GTPBP1; GTP-binding protein 1"
				}
				]
			},
			{
				"name":"tRNA import factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"111926217 EPRS; bifunctional glutamate\/proline--tRNA ligase isoform X1\tK14163 EPRS; bifunctional glutamyl\/prolyl-tRNA synthetase [EC:6.1.1.17 6.1.1.15]"
				},
				{
					"name":"111922602 EARS2; probable glutamate--tRNA ligase, mitochondrial\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"111942731 PARS2; probable proline--tRNA ligase, mitochondrial\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				},
				{
					"name":"111926589 IARS2; isoleucine--tRNA ligase, mitochondrial\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"111935220 IARS; isoleucine--tRNA ligase, cytoplasmic isoform X1\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"111923589 LARS2; probable leucine--tRNA ligase, mitochondrial isoform X1\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"111935431 LARS; leucine--tRNA ligase, cytoplasmic\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"111929278 MARS2; methionine--tRNA ligase, mitochondrial isoform X1\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"111940543 MARS; methionine--tRNA ligase, cytoplasmic\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"111944665 QARS; glutamine--tRNA ligase\tK01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]"
				},
				{
					"name":"111925748 RARS2; probable arginine--tRNA ligase, mitochondrial isoform X1\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"111935739 RARS; arginine--tRNA ligase, cytoplasmic\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"111934371 KARS; lysine--tRNA ligase isoform X1\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]"
				},
				{
					"name":"111932320 DARS; aspartate--tRNA ligase, cytoplasmic\tK22503 DARS1; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"111932489 DARS2; aspartate--tRNA ligase, mitochondrial\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"111927760 AIMP1; aminoacyl tRNA synthase complex-interacting multifunctional protein 1\tK15437 AIMP1; aminoacyl tRNA synthase complex-interacting multifunctional protein 1"
				},
				{
					"name":"111922581 AIMP2; aminoacyl tRNA synthase complex-interacting multifunctional protein 2\tK15438 AIMP2; aminoacyl tRNA synthase complex-interacting multifunctional protein 2"
				},
				{
					"name":"111923934 EEF1E1; eukaryotic translation elongation factor 1 epsilon-1\tK15439 EEF1E1; eukaryotic translation elongation factor 1 epsilon-1"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"111941933 AARS; alanine--tRNA ligase, cytoplasmic\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"111945617 AARS2; alanine--tRNA ligase, mitochondrial\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"111925396 NARS2; probable asparagine--tRNA ligase, mitochondrial\tK01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]"
				},
				{
					"name":"111941057 NARS; asparagine--tRNA ligase, cytoplasmic\tK01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]"
				},
				{
					"name":"111925457 GARS; glycine--tRNA ligase\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]"
				},
				{
					"name":"111922432 threonine--tRNA ligase, mitochondrial-like\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"111933893 probable threonine--tRNA ligase 2, cytoplasmic\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"111941136 TARS; threonine--tRNA ligase, cytoplasmic\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"111922400 SARS2; serine--tRNA ligase, mitochondrial\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"111939725 SARS; serine--tRNA ligase, cytoplasmic\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"111922728 CARS2; probable cysteine--tRNA ligase, mitochondrial\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"111930786 CARS; LOW QUALITY PROTEIN: cysteine--tRNA ligase, cytoplasmic\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"111942764 HARS; histidine--tRNA ligase, cytoplasmic\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"111944412 histidine--tRNA ligase, cytoplasmic-like\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"111924022 FARS2; phenylalanine--tRNA ligase, mitochondrial isoform X1\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"111933629 FARSB; phenylalanine--tRNA ligase beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"111936587 YARS2; tyrosine--tRNA ligase, mitochondrial\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"111939139 YARS; tyrosine--tRNA ligase, cytoplasmic\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"111929816 WARS; tryptophan--tRNA ligase, cytoplasmic\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"111938603 WARS2; tryptophan--tRNA ligase, mitochondrial isoform X1\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"111926603 DTD1; D-aminoacyl-tRNA deacylase 1\tK07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				},
				{
					"name":"111930871 DTD2; putative D-tyrosyl-tRNA(Tyr) deacylase 2\tK07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				},
				{
					"name":"111940134 AARSD1; alanyl-tRNA editing protein Aarsd1 isoform X1\tK07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]"
				}
				]
			},
			{
				"name":"AARS associated factors",
				"children":[
				{
					"name":"111939052 TRNAU1AP; tRNA selenocysteine 1-associated protein 1 isoform X1\tK25102 TRNAU1AP; tRNA selenocysteine 1-associated protein 1"
				},
				{
					"name":"111941725 HINT1; histidine triad nucleotide-binding protein 1\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
				},
				{
					"name":"111946000 HINT2; histidine triad nucleotide-binding protein 2, mitochondrial\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
				},
				{
					"name":"111927228 HINT3; histidine triad nucleotide-binding protein 3\tK12150 HINT3; adenosine 5'-monophosphoramidase HINT3 [EC:3.9.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases",
				"children":[
				{
					"name":"111934369 ADAT1; tRNA-specific adenosine deaminase 1 isoform X1\tK15440 TAD1; tRNA-specific adenosine deaminase 1 [EC:3.5.4.34]"
				},
				{
					"name":"111926767 ADAT2; tRNA-specific adenosine deaminase 2\tK15441 TAD2; tRNA-specific adenosine deaminase 2 [EC:3.5.4.-]"
				},
				{
					"name":"111944932 ADAT3; probable inactive tRNA-specific adenosine deaminase-like protein 3\tK15442 TAD3; tRNA-specific adenosine deaminase 3"
				}
				]
			},
			{
				"name":"Dihydorouridine synthases",
				"children":[
				{
					"name":"111937510 DUS1L; tRNA-dihydrouridine(16\/17) synthase [NAD(P)(+)]-like\tK05542 DUS1; tRNA-dihydrouridine synthase 1 [EC:1.3.1.88]"
				},
				{
					"name":"111934575 DUS2; tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1\tK05543 DUS2; tRNA-dihydrouridine synthase 2 [EC:1.3.1.91]"
				},
				{
					"name":"111940296 DUS3L; tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like\tK05544 DUS3; tRNA-dihydrouridine synthase 3 [EC:1.3.1.89]"
				},
				{
					"name":"111922999 DUS4L; tRNA-dihydrouridine(20a\/20b) synthase [NAD(P)+]-like\tK05545 DUS4; tRNA-dihydrouridine synthase 4 [EC:1.3.1.90]"
				}
				]
			},
			{
				"name":"Methylthiotransferase",
				"children":[
				{
					"name":"111938151 CDK5RAP1; CDK5 regulatory subunit-associated protein 1\tK06168 CDK5RAP1; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]"
				},
				{
					"name":"111923736 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"111936510 TRMT2A; tRNA (uracil-5-)-methyltransferase homolog A\tK15332 TRMT2A; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"111929389 TRMT2B; tRNA (uracil(54)-C(5))-methyltransferase homolog\tK15331 TRMT2B; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35]"
				},
				{
					"name":"111922607 probable methyltransferase TARBP1\tK15333 TRM3; tRNA guanosine-2'-O-methyltransferase [EC:2.1.1.34]"
				},
				{
					"name":"111926865 TARBP1; LOW QUALITY PROTEIN: probable methyltransferase TARBP1\tK15333 TRM3; tRNA guanosine-2'-O-methyltransferase [EC:2.1.1.34]"
				},
				{
					"name":"111925368 NSUN2; tRNA (cytosine(34)-C(5))-methyltransferase\tK15335 NSUN2; tRNA (cytosine34-C5)-methyltransferase [EC:2.1.1.203]"
				},
				{
					"name":"111943650 NSUN3; tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial\tK21969 NSUN3; tRNA (cytosine34-C5)-methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"111924155 NSUN6; putative methyltransferase NSUN6 isoform X1\tK21971 NSUN6; methyltransferase NSUN6 [EC:2.1.1.-]"
				},
				{
					"name":"111929713 TRMT5; tRNA (guanine(37)-N1)-methyltransferase\tK15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]"
				},
				{
					"name":"111926599 TRMT61B; tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial\tK07442 TRM61; tRNA (adenine57-N1\/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]"
				},
				{
					"name":"111929779 TRMT61A; tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A\tK07442 TRM61; tRNA (adenine57-N1\/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]"
				},
				{
					"name":"111921980 TRMT6; tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X1\tK03256 TRM6; tRNA (adenine58-N1)-methyltransferase non-catalytic subunit"
				},
				{
					"name":"111944225 putative tRNA (cytidine(32)\/guanosine(34)-2'-O)-methyltransferase\tK14864 FTSJ1; tRNA (cytidine32\/guanosine34-2'-O)-methyltransferase [EC:2.1.1.205]"
				},
				{
					"name":"111944442 putative tRNA (cytidine(32)\/guanosine(34)-2'-O)-methyltransferase\tK14864 FTSJ1; tRNA (cytidine32\/guanosine34-2'-O)-methyltransferase [EC:2.1.1.205]"
				},
				{
					"name":"111939932 METTL2A; methyltransferase-like protein 2A\tK24974 METTL2; tRNA N(3)-methylcytidine methyltransferase METTL2 [EC:2.1.1.-]"
				},
				{
					"name":"111923534 METTL6; methyltransferase-like protein 6\tK00599 METTL6; tRNA N(3)-methylcytidine methyltransferase METTL6 [EC:2.1.1.-]"
				},
				{
					"name":"111924140 ALKBH8; alkylated DNA repair protein alkB homolog 8\tK10770 ALKBH8; alkylated DNA repair protein alkB homolog 8 [EC:1.14.11.- 2.1.1.229]"
				},
				{
					"name":"111928004 TRMT9B; LOW QUALITY PROTEIN: probable tRNA methyltransferase 9-like protein\tK28867 TRMT9B; tRNA methyltransferase 9B [EC:2.1.1.-]"
				},
				{
					"name":"111929436 TRMT10A; tRNA methyltransferase 10 homolog A\tK15445 TRMT10; tRNA (guanine9-N1)-methyltransferase [EC:2.1.1.221]"
				},
				{
					"name":"111941583 TRMT10B; tRNA methyltransferase 10 homolog B\tK15445 TRMT10; tRNA (guanine9-N1)-methyltransferase [EC:2.1.1.221]"
				},
				{
					"name":"111927226 TRMT11; tRNA (guanine(10)-N2)-methyltransferase homolog\tK15430 TRM11; tRNA (guanine10-N2)-methyltransferase [EC:2.1.1.214]"
				},
				{
					"name":"111932562 TRMT13; tRNA:m(4)X modification enzyme TRM13 homolog\tK15446 TRM13; tRNA:m4X modification enzyme [EC:2.1.1.225]"
				},
				{
					"name":"111928223 TRMT44; probable tRNA (uracil-O(2)-)-methyltransferase\tK15447 TRM44; tRNASer (uridine44-2'-O)-methyltransferase [EC:2.1.1.211]"
				},
				{
					"name":"111926744 WDR4; tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4\tK15443 TRM82; tRNA (guanine-N(7)-)-methyltransferase subunit TRM82"
				},
				{
					"name":"111935275 THUMPD3; THUMP domain-containing protein 3\tK28362 THUMPD3; tRNA (guanine(6\/7)-N(2))-methyltransferase [EC:2.1.1.256 2.1.1.-]"
				},
				{
					"name":"111924171 TRDMT1; tRNA (cytosine(38)-C(5))-methyltransferase isoform X1\tK15336 TRDMT1; tRNA (cytosine38-C5)-methyltransferase [EC:2.1.1.204]"
				},
				{
					"name":"111937628 TYW1; S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase isoform X1\tK15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]"
				},
				{
					"name":"111928720 TRMT12; tRNA wybutosine-synthesizing protein 2 homolog\tK07055 TRM12; tRNA wybutosine-synthesizing protein 2 [EC:2.5.1.114]"
				},
				{
					"name":"111944641 TYW3; tRNA wybutosine-synthesizing protein 3 homolog\tK15450 TYW3; tRNA wybutosine-synthesizing protein 3 [EC:2.1.1.282]"
				},
				{
					"name":"111942741 LCMT2; tRNA wybutosine-synthesizing protein 4 isoform X1\tK15451 PPM2; tRNA wybutosine-synthesizing protein 4 [EC:2.1.1.290 2.3.1.231]"
				},
				{
					"name":"111931974 TYW5; tRNA wybutosine-synthesizing protein 5\tK18066 TYW5; tRNA wybutosine-synthesizing protein 5 [EC:1.14.11.42]"
				},
				{
					"name":"111940472 BCDIN3D; pre-miRNA 5'-monophosphate methyltransferase\tK25191 BCDIN3D; RNA 5'-monophosphate methyltransferase [EC:2.1.1.-]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"111936487 PUS1; tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"111939361 PUS3; tRNA pseudouridine(38\/39) synthase\tK01855 PUS3; tRNA pseudouridine38\/39 synthase [EC:5.4.99.45]"
				},
				{
					"name":"111930960 TRUB1; probable tRNA pseudouridine synthase 1\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"111923250 PUS7; pseudouridylate synthase 7 homolog isoform X1\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"111932038 PUS7L; pseudouridylate synthase 7 homolog-like protein isoform X1\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"111926440 PUS10; putative tRNA pseudouridine synthase Pus10\tK07583 PUS10; tRNA pseudouridine synthase 10 [EC:5.4.99.25]"
				},
				{
					"name":"111939360 RPUSD4; mitochondrial RNA pseudouridine synthase RPUSD4\tK22538 RPUSD4; mitochondrial RNA pseudouridine synthase RPUSD4 [EC:5.4.99.-]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"111923024 TRMU; mitochondrial tRNA-specific 2-thiouridylase 1\tK21027 TRMU; tRNA-5-taurinomethyluridine 2-sulfurtransferase [EC:2.8.1.14]"
				},
				{
					"name":"111925707 CTU2; cytoplasmic tRNA 2-thiolation protein 2\tK14169 CTU2; cytoplasmic tRNA 2-thiolation protein 2"
				},
				{
					"name":"111938366 NFS1; cysteine desulfurase, mitochondrial\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"111922333 URM1; ubiquitin-related modifier 1\tK12161 URM1; ubiquitin related modifier 1"
				},
				{
					"name":"111938395 MOCS3; adenylyltransferase and sulfurtransferase MOCS3\tK11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex",
				"children":[
				{
					"name":"111938289 TP53RK; TP53-regulating kinase\tK08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]"
				},
				{
					"name":"111931920 OSGEPL1; probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial\tK01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]"
				},
				{
					"name":"111942843 OSGEP; probable tRNA N6-adenosine threonylcarbamoyltransferase\tK01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]"
				},
				{
					"name":"111923023 TPRKB; EKC\/KEOPS complex subunit TPRKB\tK15901 TPRKB; EKC\/KEOPS complex subunit TPRKB\/CGI121"
				}
				]
			},
			{
				"name":"Elongator complex",
				"children":[
				{
					"name":"111941319 ELP1; elongator complex protein 1\tK11373 ELP1; elongator complex protein 1"
				},
				{
					"name":"111925316 ELP2; elongator complex protein 2\tK11374 ELP2; elongator complex protein 2"
				},
				{
					"name":"111927348 ELP3; elongator complex protein 3\tK07739 ELP3; elongator complex protein 3 (tRNA carboxymethyluridine synthase) [EC:2.3.1.311]"
				},
				{
					"name":"111930359 ELP4; elongator complex protein 4\tK11375 ELP4; elongator complex protein 4"
				},
				{
					"name":"111925495 ELP6; elongator complex protein 6\tK11377 ELP6; elongator complex protein 6"
				}
				]
			},
			{
				"name":"Elongator related proteins",
				"children":[
				{
					"name":"111923446 DPH3; DPH3 homolog\tK15455 DPH3; diphthamide biosynthesis protein 3"
				}
				]
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"111938940 YRDC; yrdC domain-containing protein, mitochondrial\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"111939132 TRIT1; tRNA dimethylallyltransferase\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]"
				},
				{
					"name":"111940260 GTPBP3; tRNA modification GTPase GTPBP3, mitochondrial\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				},
				{
					"name":"111925808 MTO1; protein MTO1 homolog, mitochondrial\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				},
				{
					"name":"111939309 QTRT2; queuine tRNA-ribosyltransferase accessory subunit 2\tK15407 QTRT2; queuine tRNA-ribosyltransferase accessory subunit"
				},
				{
					"name":"111923109 SEPHS1; selenide, water dikinase 1\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]"
				},
				{
					"name":"111941899 selenide, water dikinase 1-like\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]"
				},
				{
					"name":"111936266 THUMPD1; THUMP domain-containing protein 1\tK06963 TAN1; tRNA acetyltransferase TAN1"
				},
				{
					"name":"111935491 THG1L; probable tRNA(His) guanylyltransferase isoform X1\tK10761 THG1; tRNA(His) guanylyltransferase [EC:2.7.7.79]"
				},
				{
					"name":"111931375 ATE1; arginyl-tRNA--protein transferase 1 isoform X1\tK00685 ATE1; arginyl-tRNA---protein transferase [EC:2.3.2.8]"
				},
				{
					"name":"111935298 DALRD3; DALR anticodon-binding domain-containing protein 3\tK24973 DALRD3; DALR anticodon-binding domain-containing protein 3"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"TRAMP complex",
				"children":[
				{
					"name":"111925393 PAPD7; non-canonical poly(A) RNA polymerase PAPD7 isoform X1\tK03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5\/7 [EC:2.7.7.19]"
				},
				{
					"name":"111934616 PAPD5; non-canonical poly(A) RNA polymerase PAPD5\tK03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5\/7 [EC:2.7.7.19]"
				},
				{
					"name":"111941623 ZCCHC7; zinc finger CCHC domain-containing protein 7\tK12597 AIR1_2; protein AIR1\/2"
				},
				{
					"name":"111941442 MTREX; exosome RNA helicase MTR4 isoform X1\tK12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]"
				}
				]
			},
			{
				"name":"Rapid tRNA decay (RTD) pathway factors",
				"children":[
				{
					"name":"111933509 XRN1; 5'-3' exoribonuclease 1 isoform X1\tK12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]"
				},
				{
					"name":"111926373 XRN2; 5'-3' exoribonuclease 2\tK12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]"
				},
				{
					"name":"111942003 BPNT1; 3'(2'),5'-bisphosphate nucleotidase 1\tK01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]"
				}
				]
			},
			{
				"name":"Other tRNA degradation factors",
				"children":[
				{
					"name":"111931169 interferon-induced protein with tetratricopeptide repeats 5-like\tK24850 IFIT5; interferon-induced protein with tetratricopeptide repeats 5"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P"
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"111940944 ELAC1; zinc phosphodiesterase ELAC protein 1 isoform X1\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				},
				{
					"name":"111942395 ELAC2; zinc phosphodiesterase ELAC protein 2\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				},
				{
					"name":"111926928 RNASET2; ribonuclease T2\tK01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"111934938 TRNT1; CCA tRNA nucleotidyltransferase 1, mitochondrial\tK00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonucleases"
			},
			{
				"name":"tRNA splicing ligases",
				"children":[
				{
					"name":"111931292 RTCB; tRNA-splicing ligase RtcB homolog\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors"
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"111923589 LARS2; probable leucine--tRNA ligase, mitochondrial isoform X1\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"111935431 LARS; leucine--tRNA ligase, cytoplasmic\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"111942731 PARS2; probable proline--tRNA ligase, mitochondrial\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"111936587 YARS2; tyrosine--tRNA ligase, mitochondrial\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"111939139 YARS; tyrosine--tRNA ligase, cytoplasmic\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"111929816 WARS; tryptophan--tRNA ligase, cytoplasmic\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"111938603 WARS2; tryptophan--tRNA ligase, mitochondrial isoform X1\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"111922432 threonine--tRNA ligase, mitochondrial-like\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"111933893 probable threonine--tRNA ligase 2, cytoplasmic\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"111941136 TARS; threonine--tRNA ligase, cytoplasmic\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"111926589 IARS2; isoleucine--tRNA ligase, mitochondrial\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"111935220 IARS; isoleucine--tRNA ligase, cytoplasmic isoform X1\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"111934371 KARS; lysine--tRNA ligase isoform X1\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]"
				},
				{
					"name":"111941933 AARS; alanine--tRNA ligase, cytoplasmic\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"111945617 AARS2; alanine--tRNA ligase, mitochondrial\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"111929278 MARS2; methionine--tRNA ligase, mitochondrial isoform X1\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"111940543 MARS; methionine--tRNA ligase, cytoplasmic\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"111922400 SARS2; serine--tRNA ligase, mitochondrial\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"111939725 SARS; serine--tRNA ligase, cytoplasmic\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"111932489 DARS2; aspartate--tRNA ligase, mitochondrial\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"111922728 CARS2; probable cysteine--tRNA ligase, mitochondrial\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"111930786 CARS; LOW QUALITY PROTEIN: cysteine--tRNA ligase, cytoplasmic\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"111922602 EARS2; probable glutamate--tRNA ligase, mitochondrial\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"111944665 QARS; glutamine--tRNA ligase\tK01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]"
				},
				{
					"name":"111925748 RARS2; probable arginine--tRNA ligase, mitochondrial isoform X1\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"111935739 RARS; arginine--tRNA ligase, cytoplasmic\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"111924022 FARS2; phenylalanine--tRNA ligase, mitochondrial isoform X1\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"111933629 FARSB; phenylalanine--tRNA ligase beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"111942764 HARS; histidine--tRNA ligase, cytoplasmic\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"111944412 histidine--tRNA ligase, cytoplasmic-like\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"111925396 NARS2; probable asparagine--tRNA ligase, mitochondrial\tK01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]"
				},
				{
					"name":"111941057 NARS; asparagine--tRNA ligase, cytoplasmic\tK01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"111926603 DTD1; D-aminoacyl-tRNA deacylase 1\tK07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				},
				{
					"name":"111930871 DTD2; putative D-tyrosyl-tRNA(Tyr) deacylase 2\tK07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				},
				{
					"name":"111940134 AARSD1; alanyl-tRNA editing protein Aarsd1 isoform X1\tK07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferases",
				"children":[
				{
					"name":"111938151 CDK5RAP1; CDK5 regulatory subunit-associated protein 1\tK06168 CDK5RAP1; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]"
				},
				{
					"name":"111923736 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"111940260 GTPBP3; tRNA modification GTPase GTPBP3, mitochondrial\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"111936487 PUS1; tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"111930960 TRUB1; probable tRNA pseudouridine synthase 1\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"111923250 PUS7; pseudouridylate synthase 7 homolog isoform X1\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"111932038 PUS7L; pseudouridylate synthase 7 homolog-like protein isoform X1\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"111938366 NFS1; cysteine desulfurase, mitochondrial\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex",
				"children":[
				{
					"name":"111938289 TP53RK; TP53-regulating kinase\tK08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]"
				},
				{
					"name":"111931920 OSGEPL1; probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial\tK01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]"
				},
				{
					"name":"111942843 OSGEP; probable tRNA N6-adenosine threonylcarbamoyltransferase\tK01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]"
				}
				]
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"111925808 MTO1; protein MTO1 homolog, mitochondrial\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				},
				{
					"name":"111939132 TRIT1; tRNA dimethylallyltransferase\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]"
				},
				{
					"name":"111939278 PTS; 6-pyruvoyl tetrahydrobiopterin synthase\tK01737 queD; 6-pyruvoyltetrahydropterin\/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]"
				},
				{
					"name":"111923109 SEPHS1; selenide, water dikinase 1\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]"
				},
				{
					"name":"111941899 selenide, water dikinase 1-like\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]"
				},
				{
					"name":"111938940 YRDC; yrdC domain-containing protein, mitochondrial\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"111926406 PNPT1; polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
			}
			]
		}
		]
	}
	]
}