{
	"name":"cck02022",
	"children":[
	{
		"name":"OmpR family",
		"children":[
		{
			"name":"PhoR-PhoB (phosphate starvation response)",
			"children":[
			{
				"name":"Ccar_00500 histidine kinase\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_10305 histidine kinase\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_12325 histidine kinase\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_00495 ArsR family transcriptional regulator\tK07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP"
			},
			{
				"name":"Ccar_05215 response regulator\tK07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP"
			},
			{
				"name":"Ccar_12320 ArsR family transcriptional regulator\tK07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP"
			},
			{
				"name":"Ccar_22980 XRE family transcriptional regulator\tK07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP"
			}
			]
		},
		{
			"name":"SenX3-RegX3 (phosphate starvation response)"
		},
		{
			"name":"PhoQ-PhoP (magnesium transport)"
		},
		{
			"name":"EnvZ-OmpR (osmotic stress response)"
		},
		{
			"name":"RstB-RstA"
		},
		{
			"name":"CpxA-CpxR (envelope stress response)"
		},
		{
			"name":"CssS-CssR (secretion stress response)",
			"children":[
			{
				"name":"Ccar_23350 histidine kinase\tK07650 cssS; two-component system, OmpR family, sensor histidine kinase CssS [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"CreC-CreB (phosphate regulation)"
		},
		{
			"name":"BaeS-BaeR (envelope stress response)"
		},
		{
			"name":"BasS-BasR (antimicrobial peptide resistance)"
		},
		{
			"name":"CusS-CusR (copper tolerance)"
		},
		{
			"name":"QseC-QseB (quorum sensing)"
		},
		{
			"name":"KdpD-KdpE (potassium transport)"
		},
		{
			"name":"TorS-TorR (TMAO respiration)"
		},
		{
			"name":"ArcB-ArcA (anoxic redox control)"
		},
		{
			"name":"TctE-TctD (tricarboxylic acid transport)"
		},
		{
			"name":"ResE-ResD (aerobic and anaerobic respiration)",
			"children":[
			{
				"name":"Ccar_12100 transcriptional regulator\tK07775 resD; two-component system, OmpR family, response regulator ResD"
			},
			{
				"name":"Ccar_12900 transcriptional regulator\tK07775 resD; two-component system, OmpR family, response regulator ResD"
			},
			{
				"name":"Ccar_20180 transcriptional regulator\tK07775 resD; two-component system, OmpR family, response regulator ResD"
			},
			{
				"name":"Ccar_23180 PhoB family transcriptional regulator\tK07775 resD; two-component system, OmpR family, response regulator ResD"
			}
			]
		},
		{
			"name":"VicK-VicR (cell wall metabolism)",
			"children":[
			{
				"name":"Ccar_12105 histidine kinase\tK07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"MprB-MprA (maintenance of persistent infection)"
		},
		{
			"name":"MtrB-MtrA (osmotic stress response)"
		},
		{
			"name":"PrrB-PrrA (intracellular multiplication)"
		},
		{
			"name":"TrcS-TrcR"
		},
		{
			"name":"NrsS-NrsR (nickel tolerance)"
		},
		{
			"name":"ManS-ManR (manganese homeostasis)"
		},
		{
			"name":"NblS-NblR (photosynthesis)"
		},
		{
			"name":"SasA-RpaAB (circadian timing mediating)"
		},
		{
			"name":"SaeS-SaeR (staphylococcal virulence regulation)"
		},
		{
			"name":"BceS-BceR (bacitracin transport)"
		},
		{
			"name":"BraS-BraR (bacitracin transport)",
			"children":[
			{
				"name":"Ccar_03200 membrane protein\tK19081 braS; two-component system, OmpR family, sensor histidine kinase BraS\/BceS [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_03440 histidine kinase\tK19081 braS; two-component system, OmpR family, sensor histidine kinase BraS\/BceS [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_04990 histidine kinase\tK19081 braS; two-component system, OmpR family, sensor histidine kinase BraS\/BceS [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_03195 PhoB family transcriptional regulator\tK19082 braR; two-component system, OmpR family, response regulator protein BraR\/BceR"
			},
			{
				"name":"Ccar_03435 transcriptional regulator\tK19082 braR; two-component system, OmpR family, response regulator protein BraR\/BceR"
			},
			{
				"name":"Ccar_04985 PhoB family transcriptional regulator\tK19082 braR; two-component system, OmpR family, response regulator protein BraR\/BceR"
			}
			]
		},
		{
			"name":"GraS-GraR (cationic antimicrobial peptide transport)"
		},
		{
			"name":"YxdK-YxdJ (antimicrobial peptide response)",
			"children":[
			{
				"name":"Ccar_22380 membrane protein\tK11633 yxdK; two-component system, OmpR family, sensor histidine kinase YxdK [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_22375 transcriptional regulator\tK11634 yxdJ; two-component system, OmpR family, response regulator YxdJ"
			}
			]
		},
		{
			"name":"ChvG-ChvI (acidity sensing)"
		},
		{
			"name":"CiaH-CiaR",
			"children":[
			{
				"name":"Ccar_05470 histidine kinase\tK14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"ParS-ParR (polymyxin-adaptive resistance)"
		},
		{
			"name":"AdeS-AdeR"
		},
		{
			"name":"VanS-VanR (VanB type vancomycin resistance)",
			"children":[
			{
				"name":"Ccar_09990 histidine kinase\tK18345 vanSB; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_12895 histidine kinase\tK18345 vanSB; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_12970 histidine kinase\tK18345 vanSB; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_23185 histidine kinase\tK18345 vanSB; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_09995 transcriptional regulator\tK18344 vanRB; two-component system, OmpR family, response regulator VanR"
			}
			]
		},
		{
			"name":"VanS-VanR (VanE type vancomycin resistance)",
			"children":[
			{
				"name":"Ccar_09805 PhoB family transcriptional regulator\tK18349 vanRC; two-component system, OmpR family, response regulator VanR"
			},
			{
				"name":"Ccar_18540 transcriptional regulator\tK18349 vanRC; two-component system, OmpR family, response regulator VanR"
			}
			]
		},
		{
			"name":"VanS-VanR (actinomycete type vancomycin resistance)"
		},
		{
			"name":"ArlS-ArlR (virulence regulation)"
		},
		{
			"name":"Ihk-Irr (virulence regulation)"
		},
		{
			"name":"PfeS-PfeR (enterobactin-dependent iron acquisition)"
		},
		{
			"name":"NisK-NisR (lantibiotic biosynthesis)",
			"children":[
			{
				"name":"Ccar_06850 histidine kinase\tK20487 nisK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK\/SpaK [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_07175 multidrug ABC transporter\tK20487 nisK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK\/SpaK [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_09220 subtilin biosynthesis sensor protein SpaK\tK20487 nisK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK\/SpaK [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_06825 chemotaxis protein CheY\tK20488 nisR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR\/SpaR"
			},
			{
				"name":"Ccar_07170 multidrug ABC transporter\tK20488 nisR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR\/SpaR"
			},
			{
				"name":"Ccar_09215 transcriptional regulatory protein SpaR\tK20488 nisR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR\/SpaR"
			}
			]
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"Ccar_13670 histidine kinase\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_11390 PhoB family transcriptional regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"Ccar_13665 transcriptional regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"Ccar_23355 regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NarL family",
		"children":[
		{
			"name":"NarX-NarL (nitrate respiration)"
		},
		{
			"name":"NarQ-NarP (nitrate respiration)"
		},
		{
			"name":"UhpB-UhpA (hexose phosphates uptake)"
		},
		{
			"name":"FusK-FusR (virulence regulation)"
		},
		{
			"name":"RcsC-RcsD-RcsB (capsule synthesis)"
		},
		{
			"name":"BarA-UvrY (central carbon metabolism)"
		},
		{
			"name":"ComP-ComA (competence)"
		},
		{
			"name":"EvgS-EvgA (acid and drug tolerance)"
		},
		{
			"name":"DegS-DegU (multicellular behavior control)"
		},
		{
			"name":"DesK-DesR (membrane lipid fluidity regulation)"
		},
		{
			"name":"VraS-VraR (cell-wall peptidoglycan synthesis)"
		},
		{
			"name":"LiaS-LiaR (cell wall stress response)"
		},
		{
			"name":"DevS-DevR (redox response)"
		},
		{
			"name":"NreB-NreC (dissimilatory nitrate\/nitrite reduction)"
		},
		{
			"name":"YdfH-YdfI"
		},
		{
			"name":"SalK-SalR"
		},
		{
			"name":"PprA–PprB (biofilm formation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"Spo family",
		"children":[
		{
			"name":"KinABCDE-Spo0FA (sporulation control)",
			"children":[
			{
				"name":"Ccar_25675 chemotaxis protein CheY\tK07699 spo0A; two-component system, response regulator, stage 0 sporulation protein A"
			}
			]
		}
		]
	},
	{
		"name":"CitB family",
		"children":[
		{
			"name":"CitA-CitB (citrate fermentation)"
		},
		{
			"name":"CitS-CitT (magnesium-citrate transport)"
		},
		{
			"name":"DcuS-DcuR (C4-dicarboxylate metabolism)"
		},
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"MalK-MalR (malate transport)",
			"children":[
			{
				"name":"Ccar_14790 histidine kinase\tK11614 yufL; two-component system, CitB family, sensor histidine kinase MalK [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_14785 transcriptional regulator\tK11615 malR; two-component system, CitB family, response regulator MalR"
			}
			]
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"LytTR family",
		"children":[
		{
			"name":"LysS-LysR",
			"children":[
			{
				"name":"Ccar_18675 histidine kinase\tK07704 lytS; two-component system, LytTR family, sensor histidine kinase LytS [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_18670 transcriptional regulator\tK07705 lytT; two-component system, LytTR family, response regulator LytT"
			}
			]
		},
		{
			"name":"AlgZ-AlgR (alginate production)"
		},
		{
			"name":"NatK-NatR (sodium extrusion)"
		},
		{
			"name":"AgrC-AgrA (exoprotein synthesis)",
			"children":[
			{
				"name":"Ccar_24170 histidine kinase\tK07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_03780 histidine kinase\tK07707 agrA; two-component system, LytTR family, response regulator AgrA"
			},
			{
				"name":"Ccar_24165 LytTR family transcriptional regulator\tK07707 agrA; two-component system, LytTR family, response regulator AgrA"
			}
			]
		},
		{
			"name":"AgrC2-AgrA2 (virulence regulation)"
		},
		{
			"name":"ComD-ComE (competence)"
		},
		{
			"name":"BtsS-BtsR (pyruvate reutilization)"
		},
		{
			"name":"PyrS-PyrR (pyruvate reutilization)",
			"children":[
			{
				"name":"Ccar_06670 membrane protein\tK27884 pyrS; two-component system, LytTR family, high-concentration pyruvate sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_06675 LytTR family transcriptional regulator\tK27885 pyrR; two-component system, LytTR family, high-concentration pyruvate response regulator"
			}
			]
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"Ccar_13175 LytTR family transcriptional regulator\tK02477 K02477; two-component system, LytTR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NtrC family",
		"children":[
		{
			"name":"GlnL-GlnG (nitrogen regulation)"
		},
		{
			"name":"NtrY-NtrX (nitrogen regulation)"
		},
		{
			"name":"HydH-HydG (metal tolerance)"
		},
		{
			"name":"AtoS-AtoC (cPHB biosynthesis)"
		},
		{
			"name":"PilS-PilR (type 4 fimbriae synthesis)"
		},
		{
			"name":"GlrK-GlrR (amino sugar metabolism)"
		},
		{
			"name":"PgtB-PgtA (phosphoglycerate transport)"
		},
		{
			"name":"DctB-DctD (C4-dicarboxylate transport)"
		},
		{
			"name":"KinB-AlgB (alginate production)"
		},
		{
			"name":"HupT-HupR (hydrogenase synthesis regulation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"CheA family",
		"children":[
		{
			"name":"CheA-CheYBV (chemotaxis)",
			"children":[
			{
				"name":"Ccar_13750 chemotaxis protein CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_24965 chemotaxis protein CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_02655 histidine kinase\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"Ccar_05770 histidine kinase\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"Ccar_08395 histidine kinase\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"Ccar_08400 histidine kinase\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"Ccar_09735 chemotaxis protein CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"Ccar_11660 histidine kinase\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"Ccar_24770 chemotaxis protein CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"Ccar_24975 chemotaxis protein CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"Ccar_13730 chemotaxis protein\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"Ccar_24955 chemotaxis protein CheY\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"Ccar_08060 chemotaxis protein CheV\tK03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV"
			}
			]
		},
		{
			"name":"ChpA-ChpB\/PilGH (chemosensory)"
		},
		{
			"name":"PixL-PixGH (positive phototaxis)"
		},
		{
			"name":"WspE-WspRF (chemosensory)"
		},
		{
			"name":"Cph1-Rcp1 (light response)"
		}
		]
	},
	{
		"name":"Cell cycle family",
		"children":[
		{
			"name":"PleC-PleD (cell fate control)"
		},
		{
			"name":"CckA-CtrA\/CpdR (cell cycle control)"
		},
		{
			"name":"Hk1-Rrp1 (glycerol uptake and utilization)"
		}
		]
	},
	{
		"name":"Lux family",
		"children":[
		{
			"name":"LuxQN\/CqsS-LuxU-LuxO (quorum sensing)"
		}
		]
	},
	{
		"name":"LuxR family",
		"children":[
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"TtrS-TtrR (tetrathionate respiration)"
		},
		{
			"name":"FixL-FixJ (nitrogen fixation)"
		},
		{
			"name":"SsrA-SsrB"
		}
		]
	},
	{
		"name":"Other families",
		"children":[
		{
			"name":"FlrB-FlrC (polar flagellar synthesis)"
		},
		{
			"name":"AauS-AauR (acidic amino acids utilization)"
		},
		{
			"name":"SLN1-YPD1-SSK1\/SKN7 (osmosensing)"
		},
		{
			"name":"RpfC-RpfG (cell-to-cell signaling)"
		},
		{
			"name":"GlnK-GlnL (glutamine utilization)",
			"children":[
			{
				"name":"Ccar_12850 histidine kinase\tK07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_19380 histidine kinase\tK07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_12855 transcriptional regulator\tK07719 glnL; two-component system, response regulator GlnL"
			},
			{
				"name":"Ccar_19375 chemotaxis protein CheY\tK07719 glnL; two-component system, response regulator GlnL"
			}
			]
		},
		{
			"name":"HspS-HspR (hexose phosphates uptake)"
		},
		{
			"name":"YesM-YesN",
			"children":[
			{
				"name":"Ccar_08330 histidine kinase\tK07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]"
			},
			{
				"name":"Ccar_03015 histidine kinase\tK07720 yesN; two-component system, response regulator YesN"
			},
			{
				"name":"Ccar_08360 histidine kinase\tK07720 yesN; two-component system, response regulator YesN"
			}
			]
		},
		{
			"name":"CikA"
		},
		{
			"name":"RegB-RegA (redox response)"
		},
		{
			"name":"FitF-FitH (insecticidal toxin regulation)"
		},
		{
			"name":"PhcS-PhcRQ"
		},
		{
			"name":"SagS-HptB-HsbR (swarming activity and biofilm formation)"
		},
		{
			"name":"PdtaS-PdtaR",
			"children":[
			{
				"name":"Ccar_09930 response regulator receiver protein\tK22010 pdtaR; two-component system, response regulator PdtaR"
			}
			]
		},
		{
			"name":"NasS-NasT"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"Ccar_20860 histidine kinase\tK11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]"
			}
			]
		}
		]
	}
	]
}