{
	"name":"cow03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)"
			},
			{
				"name":"CDK (cyclin dependent kinase)"
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)"
			},
			{
				"name":"GINS complex"
			},
			{
				"name":"Other initiation factors"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex"
			},
			{
				"name":"DNA polymerase epsilon complex"
			},
			{
				"name":"DNA polymerase delta complex"
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)"
			},
			{
				"name":"RPA (replication protein A)"
			},
			{
				"name":"RFC (replication factor C)"
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"Calow_1132 Ribonuclease H\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				}
				]
			},
			{
				"name":"Other elongation factors"
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex"
				},
				{
					"name":"TERB1-TERB2-MAJIN complex"
				},
				{
					"name":"CST complex (animals)"
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins"
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"Dyskerin complex"
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"Sm core complex"
				}
				]
			},
			{
				"name":"ELG1-RFC complex"
			},
			{
				"name":"MRN complex"
			},
			{
				"name":"Other termination factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases"
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)",
				"children":[
				{
					"name":"Calow_0524 histone family protein DNA-binding protein\tK03530 hupB; DNA-binding protein HU-beta"
				},
				{
					"name":"Calow_0001 chromosomal replication initiator protein DnaA\tK02313 dnaA; chromosomal replication initiator protein"
				},
				{
					"name":"Calow_0722 replicative DNA helicase\tK02314 dnaB; replicative DNA helicase [EC:5.6.2.3]"
				},
				{
					"name":"Calow_0819 AAA ATPase\tK02315 dnaC; DNA replication protein DnaC"
				},
				{
					"name":"Calow_1732 AAA ATPase\tK02315 dnaC; DNA replication protein DnaC"
				},
				{
					"name":"Calow_0581 DNA primase\tK02316 dnaG; DNA primase [EC:2.7.7.101]"
				},
				{
					"name":"Calow_2040 TOPRIM domain-containing protein\tK02316 dnaG; DNA primase [EC:2.7.7.101]"
				},
				{
					"name":"Calow_1782 single-strand binding protein\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme",
					"children":[
					{
						"name":"Calow_1053 DNA polymerase III, alpha subunit\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]"
					},
					{
						"name":"Calow_1551 DNA polymerase III, alpha subunit\tK03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]"
					},
					{
						"name":"Calow_0002 DNA polymerase III, beta subunit\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]"
					},
					{
						"name":"Calow_1636 DNA polymerase III, delta subunit\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]"
					},
					{
						"name":"Calow_0371 DNA-directed DNA polymerase\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]"
					},
					{
						"name":"Calow_1793 DNA polymerase III, subunits gamma and tau\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"Calow_1132 Ribonuclease H\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"Calow_0758 Ribonuclease H\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"Calow_1220 DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					},
					{
						"name":"Calow_1362 DNA ligase, NAD-dependent\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"Calow_1132 Ribonuclease H\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"Calow_0758 Ribonuclease H\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"Calow_1355 DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"Calow_0007 DNA gyrase, A subunit\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]"
			},
			{
				"name":"Calow_0005 DNA gyrase, B subunit\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]"
			},
			{
				"name":"Calow_1871 DNA topoisomerase I\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
			},
			{
				"name":"Calow_0945 reverse gyrase\tK03170 topG; reverse gyrase [EC:5.6.2.2 5.6.2.-]"
			}
			]
		}
		]
	}
	]
}