{
	"name":"esj02022",
	"children":[
	{
		"name":"OmpR family",
		"children":[
		{
			"name":"PhoR-PhoB (phosphate starvation response)",
			"children":[
			{
				"name":"SJ05684_c01160 Phosphate regulon sensor protein PhoR (SphS)\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_c01230 Phosphate regulon transcriptional regulatory protein PhoB (SphR)\tK07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB"
			}
			]
		},
		{
			"name":"SenX3-RegX3 (phosphate starvation response)"
		},
		{
			"name":"PhoQ-PhoP (magnesium transport)"
		},
		{
			"name":"EnvZ-OmpR (osmotic stress response)",
			"children":[
			{
				"name":"SJ05684_c23760 Osmolarity sensor protein EnvZ\tK07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_b51130 two component response regulator\tK07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR"
			},
			{
				"name":"SJ05684_c23750 DNA-binding response regulator PetR\tK07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR"
			}
			]
		},
		{
			"name":"RstB-RstA"
		},
		{
			"name":"CpxA-CpxR (envelope stress response)"
		},
		{
			"name":"CssS-CssR (secretion stress response)"
		},
		{
			"name":"CreC-CreB (phosphate regulation)"
		},
		{
			"name":"BaeS-BaeR (envelope stress response)"
		},
		{
			"name":"BasS-BasR (antimicrobial peptide resistance)"
		},
		{
			"name":"CusS-CusR (copper tolerance)"
		},
		{
			"name":"QseC-QseB (quorum sensing)"
		},
		{
			"name":"KdpD-KdpE (potassium transport)"
		},
		{
			"name":"TorS-TorR (TMAO respiration)"
		},
		{
			"name":"ArcB-ArcA (anoxic redox control)"
		},
		{
			"name":"TctE-TctD (tricarboxylic acid transport)",
			"children":[
			{
				"name":"SJ05684_b44370 Tricarboxylate transport sensor protein TctE\tK07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_b57520 Tricarboxylate transport sensor protein TctE\tK07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_b44360 Tricarboxylate transport transcriptional regulator TctD\tK07774 tctD; two-component system, OmpR family, response regulator TctD"
			},
			{
				"name":"SJ05684_b57510 Tricarboxylate transport transcriptional regulator TctD\tK07774 tctD; two-component system, OmpR family, response regulator TctD"
			}
			]
		},
		{
			"name":"ResE-ResD (aerobic and anaerobic respiration)"
		},
		{
			"name":"VicK-VicR (cell wall metabolism)"
		},
		{
			"name":"MprB-MprA (maintenance of persistent infection)"
		},
		{
			"name":"MtrB-MtrA (osmotic stress response)"
		},
		{
			"name":"PrrB-PrrA (intracellular multiplication)"
		},
		{
			"name":"TrcS-TrcR"
		},
		{
			"name":"NrsS-NrsR (nickel tolerance)"
		},
		{
			"name":"ManS-ManR (manganese homeostasis)"
		},
		{
			"name":"NblS-NblR (photosynthesis)"
		},
		{
			"name":"SasA-RpaAB (circadian timing mediating)"
		},
		{
			"name":"SaeS-SaeR (staphylococcal virulence regulation)"
		},
		{
			"name":"BceS-BceR (bacitracin transport)"
		},
		{
			"name":"BraS-BraR (bacitracin transport)"
		},
		{
			"name":"GraS-GraR (cationic antimicrobial peptide transport)"
		},
		{
			"name":"YxdK-YxdJ (antimicrobial peptide response)"
		},
		{
			"name":"ChvG-ChvI (acidity sensing)",
			"children":[
			{
				"name":"SJ05684_c34120 Sensor histidine kinase ChvG\tK14980 chvG; two-component system, OmpR family, sensor histidine kinase ChvG [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_c34130 DNA-binding response regulator ChvI\tK14981 chvI; two-component system, OmpR family, response regulator ChvI"
			}
			]
		},
		{
			"name":"CiaH-CiaR"
		},
		{
			"name":"ParS-ParR (polymyxin-adaptive resistance)"
		},
		{
			"name":"AdeS-AdeR"
		},
		{
			"name":"VanS-VanR (VanB type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (VanE type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (actinomycete type vancomycin resistance)"
		},
		{
			"name":"ArlS-ArlR (virulence regulation)"
		},
		{
			"name":"Ihk-Irr (virulence regulation)"
		},
		{
			"name":"PfeS-PfeR (enterobactin-dependent iron acquisition)"
		},
		{
			"name":"NisK-NisR (lantibiotic biosynthesis)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"SJ05684_c02700 Transcriptional regulator\tK21603 ftcR; two-component system, OmpR family, flagellar system response regulator FtcR"
			},
			{
				"name":"SJ05684_a37390 hypothetical protein\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"SJ05684_b48030 DNA-binding response regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"SJ05684_b51700 hypothetical protein\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"SJ05684_b59080 two-component response regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"SJ05684_c06440 Two-component system response regulator QseB\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"SJ05684_c06540 response regulator in two-component regulatory system with PhoQ\tK02483 K02483; two-component system, OmpR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NarL family",
		"children":[
		{
			"name":"NarX-NarL (nitrate respiration)",
			"children":[
			{
				"name":"SJ05684_b42450 two-component response regulator\tK07684 narL; two-component system, NarL family, nitrate\/nitrite response regulator NarL"
			},
			{
				"name":"SJ05684_b51450 DNA-binding response regulator, LuxR family\tK07684 narL; two-component system, NarL family, nitrate\/nitrite response regulator NarL"
			},
			{
				"name":"SJ05684_b58030 two-component response regulator\tK07684 narL; two-component system, NarL family, nitrate\/nitrite response regulator NarL"
			}
			]
		},
		{
			"name":"NarQ-NarP (nitrate respiration)",
			"children":[
			{
				"name":"SJ05684_b48750 DNA-binding response regulator, LuxR family\tK07685 narP; two-component system, NarL family, nitrate\/nitrite response regulator NarP"
			}
			]
		},
		{
			"name":"UhpB-UhpA (hexose phosphates uptake)"
		},
		{
			"name":"FusK-FusR (virulence regulation)"
		},
		{
			"name":"RcsC-RcsD-RcsB (capsule synthesis)"
		},
		{
			"name":"BarA-UvrY (central carbon metabolism)"
		},
		{
			"name":"ComP-ComA (competence)"
		},
		{
			"name":"EvgS-EvgA (acid and drug tolerance)"
		},
		{
			"name":"DegS-DegU (multicellular behavior control)"
		},
		{
			"name":"DesK-DesR (membrane lipid fluidity regulation)"
		},
		{
			"name":"VraS-VraR (cell-wall peptidoglycan synthesis)"
		},
		{
			"name":"LiaS-LiaR (cell wall stress response)"
		},
		{
			"name":"DevS-DevR (redox response)"
		},
		{
			"name":"NreB-NreC (dissimilatory nitrate\/nitrite reduction)"
		},
		{
			"name":"YdfH-YdfI"
		},
		{
			"name":"SalK-SalR"
		},
		{
			"name":"PprA–PprB (biofilm formation)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"SJ05684_b51440 Sensor histidine kinase\tK02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"Spo family",
		"children":[
		{
			"name":"KinABCDE-Spo0FA (sporulation control)"
		}
		]
	},
	{
		"name":"CitB family",
		"children":[
		{
			"name":"CitA-CitB (citrate fermentation)"
		},
		{
			"name":"CitS-CitT (magnesium-citrate transport)"
		},
		{
			"name":"DcuS-DcuR (C4-dicarboxylate metabolism)"
		},
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"MalK-MalR (malate transport)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"LytTR family",
		"children":[
		{
			"name":"LysS-LysR"
		},
		{
			"name":"AlgZ-AlgR (alginate production)"
		},
		{
			"name":"NatK-NatR (sodium extrusion)"
		},
		{
			"name":"AgrC-AgrA (exoprotein synthesis)"
		},
		{
			"name":"AgrC2-AgrA2 (virulence regulation)"
		},
		{
			"name":"ComD-ComE (competence)"
		},
		{
			"name":"BtsS-BtsR (pyruvate reutilization)"
		},
		{
			"name":"PyrS-PyrR (pyruvate reutilization)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"NtrC family",
		"children":[
		{
			"name":"GlnL-GlnG (nitrogen regulation)",
			"children":[
			{
				"name":"SJ05684_c13030 Nitrogen regulation protein NtrB\tK07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_c13040 Nitrogen regulation protein NR(I)\tK07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG"
			}
			]
		},
		{
			"name":"NtrY-NtrX (nitrogen regulation)",
			"children":[
			{
				"name":"SJ05684_c13050 Nitrogen regulation protein NtrY\tK13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_c13060 Nitrogen regulation protein NR(I)\tK13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX"
			}
			]
		},
		{
			"name":"HydH-HydG (metal tolerance)"
		},
		{
			"name":"AtoS-AtoC (cPHB biosynthesis)"
		},
		{
			"name":"PilS-PilR (type 4 fimbriae synthesis)"
		},
		{
			"name":"GlrK-GlrR (amino sugar metabolism)"
		},
		{
			"name":"PgtB-PgtA (phosphoglycerate transport)"
		},
		{
			"name":"DctB-DctD (C4-dicarboxylate transport)",
			"children":[
			{
				"name":"SJ05684_b42720 Signal transduction histidine kinase regulating C4-dicarboxylate transport system\tK10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_b57140 Sensory box histidine kinase\tK10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_b42710 C4-dicarboxylate transport transcriptional regulatory protein dctD\tK10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD"
			},
			{
				"name":"SJ05684_b57130 C4-dicarboxylate transport transcriptional regulatory protein\tK10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD"
			}
			]
		},
		{
			"name":"KinB-AlgB (alginate production)"
		},
		{
			"name":"HupT-HupR (hydrogenase synthesis regulation)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"SJ05684_b52970 Signal transduction histidine kinase\tK02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"CheA family",
		"children":[
		{
			"name":"CheA-CheYBV (chemotaxis)",
			"children":[
			{
				"name":"SJ05684_b45190 Signal transduction histidine kinase CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_c02310 Signal transduction histidine kinase CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_c02300 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"SJ05684_c02350 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"SJ05684_c27310 hypothetical protein\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"SJ05684_b45180 Chemotaxis response regulator protein-glutamate methylesterase CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"SJ05684_c02340 Chemotaxis response regulator protein-glutamate methylesterase CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"SJ05684_b56290 Chemotaxis protein methyltransferase CheR\tK13924 cheBR; two-component system, chemotaxis family, CheB\/CheR fusion protein [EC:2.1.1.80 3.1.1.61]"
			},
			{
				"name":"SJ05684_c06950 Chemotaxis protein methyltransferase CheR\tK13924 cheBR; two-component system, chemotaxis family, CheB\/CheR fusion protein [EC:2.1.1.80 3.1.1.61]"
			}
			]
		},
		{
			"name":"ChpA-ChpB\/PilGH (chemosensory)"
		},
		{
			"name":"PixL-PixGH (positive phototaxis)"
		},
		{
			"name":"WspE-WspRF (chemosensory)"
		},
		{
			"name":"Cph1-Rcp1 (light response)"
		}
		]
	},
	{
		"name":"Cell cycle family",
		"children":[
		{
			"name":"PleC-PleD (cell fate control)",
			"children":[
			{
				"name":"SJ05684_c06570 Two-component sensor histidine kinase PleC\tK07716 pleC; two-component system, cell cycle sensor histidine kinase PleC [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_c18230 Sensor histidine kinase\tK07716 pleC; two-component system, cell cycle sensor histidine kinase PleC [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_c06290 Signal transduction histidine kinase\tK11357 divJ; two-component system, cell cycle sensor histidine kinase DivJ [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_c09600 Pole remodelling regulatory diguanylate cyclase\tK02488 pleD; two-component system, cell cycle response regulator [EC:2.7.7.65]"
			},
			{
				"name":"SJ05684_c09590 two component response regulator\tK11443 divK; two-component system, cell cycle response regulator DivK"
			}
			]
		},
		{
			"name":"CckA-CtrA\/CpdR (cell cycle control)",
			"children":[
			{
				"name":"SJ05684_c17060 sensory box histidine kinase\/response regulator\tK13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_c27300 Two-component cell cycle transcriptional regulator ctrA, winged helix family\tK13584 ctrA; two-component system, cell cycle response regulator CtrA"
			},
			{
				"name":"SJ05684_c28430 Response regulator\tK13589 cpdR; two-component system, cell cycle response regulator CpdR"
			}
			]
		},
		{
			"name":"Hk1-Rrp1 (glycerol uptake and utilization)"
		}
		]
	},
	{
		"name":"Lux family",
		"children":[
		{
			"name":"LuxQN\/CqsS-LuxU-LuxO (quorum sensing)"
		}
		]
	},
	{
		"name":"LuxR family",
		"children":[
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)",
			"children":[
			{
				"name":"SJ05684_c08910 putative two-component transmembrane sensor histidine kinase transcription regulator protein\tK11711 dctS; two-component system, LuxR family, sensor histidine kinase DctS [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_c08900 Response regulator\tK11712 dctR; two-component system, LuxR family, response regulator DctR"
			}
			]
		},
		{
			"name":"TtrS-TtrR (tetrathionate respiration)"
		},
		{
			"name":"FixL-FixJ (nitrogen fixation)"
		},
		{
			"name":"SsrA-SsrB"
		}
		]
	},
	{
		"name":"Other families",
		"children":[
		{
			"name":"FlrB-FlrC (polar flagellar synthesis)"
		},
		{
			"name":"AauS-AauR (acidic amino acids utilization)"
		},
		{
			"name":"SLN1-YPD1-SSK1\/SKN7 (osmosensing)"
		},
		{
			"name":"RpfC-RpfG (cell-to-cell signaling)"
		},
		{
			"name":"GlnK-GlnL (glutamine utilization)"
		},
		{
			"name":"HspS-HspR (hexose phosphates uptake)"
		},
		{
			"name":"YesM-YesN"
		},
		{
			"name":"CikA"
		},
		{
			"name":"RegB-RegA (redox response)",
			"children":[
			{
				"name":"SJ05684_c34340 Sensor histidine kinase PrrB (RegB)\tK15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]"
			},
			{
				"name":"SJ05684_c34330 Dna binding response regulator PrrA (RegA)\tK15012 regA; two-component system, response regulator RegA"
			}
			]
		},
		{
			"name":"FitF-FitH (insecticidal toxin regulation)"
		},
		{
			"name":"PhcS-PhcRQ"
		},
		{
			"name":"SagS-HptB-HsbR (swarming activity and biofilm formation)",
			"children":[
			{
				"name":"SJ05684_b59020 Signal transduction histidine kinase\tK20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"PdtaS-PdtaR"
		},
		{
			"name":"NasS-NasT",
			"children":[
			{
				"name":"SJ05684_b46030 Nitrate ABC transporter, nitrate-binding protein\tK22067 nasS; two-component system, oxyanion-binding sensor"
			},
			{
				"name":"SJ05684_b46040 Response regulator NasT\tK07183 nasT; two-component system, response regulator \/ RNA-binding antiterminator"
			}
			]
		},
		{
			"name":"Unclassified"
		}
		]
	}
	]
}