{
	"name":"ko00003",
	"children":[
	{
		"name":"Reaction modules",
		"children":[
		{
			"name":"Carboxylic acid metabolism",
			"children":[
			{
				"name":"2-Oxocarboxylic acid chain extension",
				"children":[
				{
					"name":"RM001  2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway",
					"children":[
					{
						"name":"M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate"
					},
					{
						"name":"M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate"
					},
					{
						"name":"M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate"
					},
					{
						"name":"M00535  Isoleucine biosynthesis, pyruvate => 2-oxobutanoate"
					},
					{
						"name":"M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate"
					}
					]
				}
				]
			},
			{
				"name":"2-Oxocarboxylic acid chain modification",
				"children":[
				{
					"name":"RM002  Carboxyl to amino conversion using protective N-acetyl group (basic amino acid synthesis)",
					"children":[
					{
						"name":"M00028  Ornithine biosynthesis, glutamate => ornithine"
					},
					{
						"name":"M00763  Ornithine biosynthesis, mediated by LysW, glutamate => ornithine"
					},
					{
						"name":"M00031  Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine"
					}
					]
				},
				{
					"name":"RM032  Carboxyl to amino conversion without using protective group",
					"children":[
					{
						"name":"M00033  Ectoine biosynthesis, aspartate => ectoine"
					}
					]
				},
				{
					"name":"RM033  Branched-chain addition (branched-chain amino acid synthesis)",
					"children":[
					{
						"name":"M00019  Valine\/isoleucine biosynthesis, pyruvate => valine \/ 2-oxobutanoate => isoleucine"
					}
					]
				},
				{
					"name":"RM030  Glucosinolate synthesis",
					"children":[
					{
						"name":"M00370  Glucosinolate biosynthesis, tryptophan => glucobrassicin"
					}
					]
				},
				{
					"name":"RM044  2-Oxocarboxylic acid conversion to its CoA derivative",
					"children":[
					{
						"name":"M00307  Pyruvate oxidation, pyruvate => acetyl-CoA"
					},
					{
						"name":"M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate"
					},
					{
						"name":"M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA"
					}
					]
				},
				{
					"name":"RM901  Reductive amination of 2-oxocarboxylic acid (aminotransferase reaction)"
				},
				{
					"name":"RM903  Oxidative decarboxylation of 2-oxoacid to form its CoA derivative"
				}
				]
			},
			{
				"name":"Fatty acid synthesis and degradation",
				"children":[
				{
					"name":"RM018  Beta oxidation in acyl-CoA degradation",
					"children":[
					{
						"name":"M00087  beta-Oxidation"
					},
					{
						"name":"M00861  beta-Oxidation, peroxisome, VLCFA"
					},
					{
						"name":"M00862  beta-Oxidation, peroxisome, tri\/dihydroxycholestanoyl-CoA => choloyl\/chenodeoxycholoyl-CoA"
					}
					]
				},
				{
					"name":"RM020  Fatty acid synthesis using acetyl-CoA (reversal of RM018)",
					"children":[
					{
						"name":"M00085  Fatty acid elongation in mitochondria"
					}
					]
				},
				{
					"name":"RM021  Fatty acid synthesis using malonyl-CoA",
					"children":[
					{
						"name":"M00083  Fatty acid biosynthesis, elongation"
					},
					{
						"name":"M00572  Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP"
					},
					{
						"name":"M00885  Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)"
					},
					{
						"name":"M00886  Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)"
					},
					{
						"name":"M00415  Fatty acid elongation in endoplasmic reticulum"
					}
					]
				}
				]
			},
			{
				"name":"Acyl-CoA metabolism",
				"children":[
				{
					"name":"RM019  Acyl-CoA conversion via dicarboxylate semialdehyde",
					"children":[
					{
						"name":"M00013  Malonate semialdehyde pathway, propanoyl-CoA => Acetyl-CoA"
					},
					{
						"name":"M00375  Hydroxypropionate-hydroxybutylate cycle"
					},
					{
						"name":"M00376  3-Hydroxypropionate bi-cycle"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"Nucleotide sugar metabolism",
			"children":[
			{
				"name":"Nucleotide sugar biosynthesis",
				"children":[
				{
					"name":"RM022  Nucleotide sugar biosynthesis, type 1"
				},
				{
					"name":"RM023  Nucleotide sugar biosynthesis, type 2"
				},
				{
					"name":"RM039  Nucleotide sugar biosynthesis, type 3"
				},
				{
					"name":"RM042  Nucleotide sugar biosynthesis, type 4",
					"children":[
					{
						"name":"M00955  CMP-Neu5Ac\/Neu5Gc biosynthesis, animals, UDP-GlcNAc => CMP-Neu5Ac => CMP-Neu5Gc"
					},
					{
						"name":"M00954  CMP-KDN biosynthesis, Man-6P => CMP-KDN"
					},
					{
						"name":"M00063  CMP-KDO biosynthesis, ribulose-5P => CMP-KDO"
					},
					{
						"name":"M00922  CMP-Neu5Ac biosynthesis, bacteria, UDP-GlcNAc => CMP-Neu5Ac"
					},
					{
						"name":"M01011  CMP-Leg5Ac7Ac biosynthesis, UDP-BacNAc4NAc => CMP-Leg5Ac7Ac"
					},
					{
						"name":"M01012  CMP-Leg5Ac7Ala biosynthesis, UDP-GlcNAc => CMP-Leg5Ac7Ala"
					},
					{
						"name":"M01008  CMP-8eLeg5Ac7Ac biosynthesis, UDP-GlcNAc => CMP-8eLeg5Ac7Ac"
					},
					{
						"name":"M01007  CMP-Pse5Ac7Ac biosynthesis, UDP-GlcNAc => CMP-Pse5Ac7Ac"
					}
					]
				}
				]
			},
			{
				"name":"Deoxy sugar metabolism",
				"children":[
				{
					"name":"RM035  Transamination and N,N-dimethylation in polyketide biosynthesis",
					"children":[
					{
						"name":"M00796  dTDP-D-mycaminose biosynthesis"
					},
					{
						"name":"M00797  dTDP-D-desosamine biosynthesis"
					},
					{
						"name":"M00802  dTDP-D-forosamine biosynthesis"
					},
					{
						"name":"M00803  dTDP-D-angolosamine biosynthesis"
					},
					{
						"name":"M00800  dTDP-L-megosamine biosynthesis"
					},
					{
						"name":"M00780  Tetracycline\/oxytetracycline biosynthesis, pretetramide => tetracycline\/oxytetracycline"
					},
					{
						"name":"M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline"
					}
					]
				},
				{
					"name":"RM043  Transamination and N-acetylation in deoxysugar biosynthesis",
					"children":[
					{
						"name":"M01024  dTDP-Qui3NAc biosynthesis, Glc-1P => dTDP-Qui3NAc"
					},
					{
						"name":"M01023  dTDP-D-Fuc3NAc biosynthesis, Glc-1P => dTDP-D-Fuc3NAc"
					},
					{
						"name":"M01026  dTDP-Qui4NAc biosynthesis, Glc-1P => dTDP-Qui4NAc"
					},
					{
						"name":"M01025  dTDP-D-Fuc4NAc biosynthesis, Glc-1P => dTDP-D-Fuc4NAc"
					},
					{
						"name":"M01020  GDP-D-Rha4NAc biosynthesis, GDP-Man => GDP-D-Rha4N => GDP-D-Rha4NAc"
					},
					{
						"name":"M01010  UDP-BacNAc4NAc biosynthesis, UDP-GlcNAc => UDP-BacNAc4NAc"
					},
					{
						"name":"M01012  CMP-Leg5Ac7Ala biosynthesis, UDP-GlcNAc => CMP-Leg5Ac7Ala"
					},
					{
						"name":"M01033  UDP-yelosamine biosynthesis, UDP-GlcNAc => UDP-yelosamine"
					},
					{
						"name":"M01008  CMP-8eLeg5Ac7Ac biosynthesis, UDP-GlcNAc => CMP-8eLeg5Ac7Ac"
					},
					{
						"name":"M01007  CMP-Pse5Ac7Ac biosynthesis, UDP-GlcNAc => CMP-Pse5Ac7Ac"
					},
					{
						"name":"M01035  UDP-ManNAc3NAcA biosynthesis, UDP-GlcNAc => UDP-ManNAc3NAcA"
					}
					]
				},
				{
					"name":"RM036  Epimerization and reduction in deoxysugar biosynthesis",
					"children":[
					{
						"name":"M00793  dTDP-L-rhamnose biosynthesis"
					},
					{
						"name":"M00801  dTDP-L-olivose biosynthesis"
					},
					{
						"name":"M00794  dTDP-6-deoxy-D-allose biosynthesis"
					},
					{
						"name":"M00800  dTDP-L-megosamine biosynthesis"
					},
					{
						"name":"M00798  dTDP-L-mycarose biosynthesis"
					}
					]
				},
				{
					"name":"RM037  Deoxygenation (transamination and deamination) in deoxysugar biosynthesis",
					"children":[
					{
						"name":"M00797  dTDP-D-desosamine biosynthesis"
					}
					]
				},
				{
					"name":"RM038  Deoxygenation (dehydration and reduction) in deoxysugar biosynthesis",
					"children":[
					{
						"name":"M00798  dTDP-L-mycarose biosynthesis"
					},
					{
						"name":"M00799  dTDP-L-oleandrose biosynthesis"
					},
					{
						"name":"M00801  dTDP-L-olivose biosynthesis"
					},
					{
						"name":"M00802  dTDP-D-forosamine biosynthesis"
					}
					]
				}
				]
			},
			{
				"name":"Sugar conversion",
				"children":[
				{
					"name":"RM040  Sugar activation and nucleotide sugar interconversion"
				},
				{
					"name":"RM041  Inversion of the carbon chain"
				}
				]
			}
			]
		},
		{
			"name":"Aromatics degradation",
			"children":[
			{
				"name":"Methyl to carboxyl conversion on aromatic ring",
				"children":[
				{
					"name":"RM003  Methyl to carboxyl conversion on aromatic ring",
					"children":[
					{
						"name":"M00538  Toluene degradation, toluene => benzoate"
					},
					{
						"name":"M00537  Xylene degradation, xylene => methylbenzoate"
					},
					{
						"name":"M00419  Cymene degradation, p-cymene => p-cumate"
					}
					]
				},
				{
					"name":"RM015  Methyl to carboxyl conversion on aromatic ring, anaerobic",
					"children":[
					{
						"name":"M00418  Toluene degradation, anaerobic, toluene => benzoyl-CoA"
					}
					]
				}
				]
			},
			{
				"name":"Dihydroxylation of aromatic ring",
				"children":[
				{
					"name":"RM004  Dihydroxylation of aromatic ring, type 1 (dioxygenase and dehydrogenase reactions)",
					"children":[
					{
						"name":"M00547  Benzene\/toluene degradation, benzene => catechol \/ toluene => 3-methylcatechol"
					}
					]
				},
				{
					"name":"RM005  Dihydroxylation of aromatic ring, type 1a (dioxygenase and decarboxylating dehydrogenase reactions)",
					"children":[
					{
						"name":"M00551  Benzoate degradation, benzoate => catechol"
					}
					]
				},
				{
					"name":"RM902  Dihydroxylation of aromatic ring, type 1b (single dioxygenase reaction)"
				},
				{
					"name":"RM006  Dihydroxylation of aromatic ring, type 2 (two monooxygenase reactions)",
					"children":[
					{
						"name":"M00548  Benzene degradation, benzene => catechol"
					}
					]
				},
				{
					"name":"RM007  Dihydroxylation of aromatic ring, type 3 (dealkylation and monooxygenase reactions)"
				}
				]
			},
			{
				"name":"Cleavage of aromatic ring",
				"children":[
				{
					"name":"RM008  Ortho-cleavage of dihydroxylated aromatic ring",
					"children":[
					{
						"name":"M00568  Catechol ortho-cleavage, catechol => 3-oxoadipate"
					}
					]
				},
				{
					"name":"RM009  Meta-cleavage of dihydroxylated aromatic ring",
					"children":[
					{
						"name":"M00569  Catechol meta-cleavage, catechol => acetyl-CoA \/ 4-methylcatechol => propanoyl-CoA"
					},
					{
						"name":"M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA"
					}
					]
				},
				{
					"name":"RM013  Ortho-cleavage of halogenated aromatic ring"
				},
				{
					"name":"RM016  Ring cleavage via beta oxidation, anaerobic",
					"children":[
					{
						"name":"M00540  Benzoate degradation, cyclohexanecarboxylic acid =>pimeloyl-CoA"
					}
					]
				},
				{
					"name":"RM017  Ring cleavage via Baeyer-Villiger oxidation"
				}
				]
			},
			{
				"name":"Dihydroxylation and cleavage of aromatic ring",
				"children":[
				{
					"name":"RM010  Dihydroxylation and meta-cleavage of aromatic ring, type 1",
					"children":[
					{
						"name":"M00539  Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate"
					},
					{
						"name":"M00545  Trans-cinnamate degradation, trans-cinnamate => 2-oxopent-4-enoate + fumarate"
					},
					{
						"name":"M00543  Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate"
					}
					]
				},
				{
					"name":"RM011  Dihydroxylation and meta-cleavage of aromatic ring, type 1b",
					"children":[
					{
						"name":"M00544  Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate"
					}
					]
				},
				{
					"name":"RM012  Dihydroxylation and meta-cleavage of aromatic ring, type 3a",
					"children":[
					{
						"name":"M00533  Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate"
					}
					]
				},
				{
					"name":"RM014  Ring removal from polycyclic aromatic ring",
					"children":[
					{
						"name":"M00534  Naphthalene degradation, naphthalene => salicylate"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"Other",
			"children":[
			{
				"name":"Amino acid metabolism",
				"children":[
				{
					"name":"RM025  Conversion of amino acid moiety to carboxyl group (biogenic amine metabolism)"
				}
				]
			},
			{
				"name":"Nucleotide metabolism",
				"children":[
				{
					"name":"RM045  Conversion of base \/ nucleoside \/ nucleotide"
				},
				{
					"name":"RM024  Pyrimidine degradation",
					"children":[
					{
						"name":"M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate"
					}
					]
				}
				]
			},
			{
				"name":"Sugar metabolism",
				"children":[
				{
					"name":"RM034  Sugar degradation to aldehyde and pyruvate",
					"children":[
					{
						"name":"M00008  Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate"
					}
					]
				}
				]
			},
			{
				"name":"Aromatics metabolism",
				"children":[
				{
					"name":"RM027  Hydroxylation and methylation motif"
				},
				{
					"name":"RM026  Hydroxylation and decarboxylation motif"
				},
				{
					"name":"RM028  Flavonoid synthesis"
				},
				{
					"name":"RM029  Pterocarpan synthesis"
				},
				{
					"name":"RM031  Oxime to acetate conversion"
				}
				]
			}
			]
		}
		]
	}
	]
}