{
	"name":"ko00536",
	"children":[
	{
		"name":"Heparan sulfate \/ Heparin",
		"children":[
		{
			"name":"Cytokines",
			"children":[
			{
				"name":"K04519  IL1B; interleukin 1 beta"
			},
			{
				"name":"K05429  IL2; interleukin 2"
			},
			{
				"name":"K04736  IL3; interleukin 3"
			},
			{
				"name":"K05430  IL4; interleukin 4"
			},
			{
				"name":"K05428  IL5; interleukin 5"
			},
			{
				"name":"K05431  IL7; interleukin 7"
			},
			{
				"name":"K05443  IL10, CSIF; interleukin 10"
			},
			{
				"name":"K05406  IL12A; interleukin 12A"
			},
			{
				"name":"K05425  IL12B; interleukin 12B"
			},
			{
				"name":"K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor"
			},
			{
				"name":"K04687  IFNG; interferon gamma"
			},
			{
				"name":"K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2"
			}
			]
		},
		{
			"name":"Chemokines",
			"children":[
			{
				"name":"K14624  CCL2, MCP1; C-C motif chemokine 2"
			},
			{
				"name":"K05408  CCL3; C-C motif chemokine 3"
			},
			{
				"name":"K12499  CCL5; C-C motif chemokine 5"
			},
			{
				"name":"------  CCL12; C-C motif chemokine 12 [MMU:20293] [KO:K14624]"
			},
			{
				"name":"K16595  CCL13; C-C motif chemokine 13"
			},
			{
				"name":"K05407  PF4, CXCL4; platelet factor 4"
			},
			{
				"name":"K10030  IL8, CXCL8; interleukin 8"
			},
			{
				"name":"K12671  CXCL10, IP10; C-X-C motif chemokine 10"
			},
			{
				"name":"K10031  CXCL12; C-X-C motif chemokine 12"
			}
			]
		},
		{
			"name":"Adhesion molecules of cell surface",
			"children":[
			{
				"name":"K06495  SELL, CD62L; selectin, lymphocyte"
			},
			{
				"name":"K06496  SELP, CD62P; selectin, platelet"
			},
			{
				"name":"K06461  ITGAM, CD11b; integrin alpha M"
			},
			{
				"name":"K06491  NCAM, CD56; neural cell adhesion molecule"
			},
			{
				"name":"K06471  PECAM1, CD31; platelet\/endothelial cell adhesion molecule"
			}
			]
		},
		{
			"name":"Morphogens",
			"children":[
			{
				"name":"K21283  BMP2; bone morphogenetic protein 2"
			},
			{
				"name":"K04662  BMP4; bone morphogenetic protein 4"
			},
			{
				"name":"K16621  BMP7; bone morphogenetic protein 7"
			},
			{
				"name":"K06224  HH; hedgehog"
			},
			{
				"name":"K11988  SHH; sonic hedgehog"
			},
			{
				"name":"K03209  WNT1; wingless-type MMTV integration site family, member 1"
			},
			{
				"name":"K00182  WNT2; wingless-type MMTV integration site family, member 2"
			},
			{
				"name":"K00312  WNT3; wingless-type MMTV integration site family, member 3"
			},
			{
				"name":"K00408  WNT4; wingless-type MMTV integration site family, member 4"
			},
			{
				"name":"K00444  WNT5; wingless-type MMTV integration site family, member 5"
			},
			{
				"name":"K00445  WNT6; wingless-type MMTV integration site family, member 6"
			},
			{
				"name":"K00572  WNT7; wingless-type MMTV integration site family, member 7"
			},
			{
				"name":"K00714  WNT8; wingless-type MMTV integration site family, member 8"
			},
			{
				"name":"K01064  WNT9; wingless-type MMTV integration site family, member 9"
			},
			{
				"name":"K01357  WNT10; wingless-type MMTV integration site family, member 10"
			},
			{
				"name":"K01384  WNT11; wingless-type MMTV integration site family, member 11"
			},
			{
				"name":"K01558  WNT16; wingless-type MMTV integration site family, member 16"
			}
			]
		},
		{
			"name":"Growth factors\/receptors",
			"children":[
			{
				"name":"K09782  AREG; amphiregulin"
			},
			{
				"name":"K09783  BTC; betacellulin"
			},
			{
				"name":"K18496  FGF1; fibroblast growth factor 1"
			},
			{
				"name":"K18497  FGF2; fibroblast growth factor 2"
			},
			{
				"name":"K04358  FGF; fibroblast growth factor"
			},
			{
				"name":"K22413  FGF11_12_13, FHF3_1_2; fibroblast growth factor 11\/12\/13"
			},
			{
				"name":"K23920  FGF14, FHF4; fibroblast growth factor 14"
			},
			{
				"name":"K22603  FGF19; fibroblast growth factor 19"
			},
			{
				"name":"K22429  FGF21; fibroblast growth factor 21"
			},
			{
				"name":"K22428  FGF23; fibroblast growth factor 23"
			},
			{
				"name":"K04362  FGFR1, CD331; fibroblast growth factor receptor 1 [EC:2.7.10.1]"
			},
			{
				"name":"K05093  FGFR2, CD332; fibroblast growth factor receptor 2 [EC:2.7.10.1]"
			},
			{
				"name":"K08523  HBEGF; heparin-binding EGF-like growth factor"
			},
			{
				"name":"K05460  HGF; hepatocyte growth factor"
			},
			{
				"name":"K06828  MDK; midkine"
			},
			{
				"name":"K13769  IGF2; insulin-like growth factor 2"
			},
			{
				"name":"K05455  NRG1; neuregulin 1"
			},
			{
				"name":"K16641  HDGF; hepatoma-derived growth factor"
			},
			{
				"name":"K04359  PDGFA; platelet-derived growth factor subunit A"
			},
			{
				"name":"K17386  PDGFB; platelet-derived growth factor subunit B"
			},
			{
				"name":"K13375  TGFB1; transforming growth factor beta-1"
			},
			{
				"name":"K13376  TGFB2; transforming growth factor beta-2"
			},
			{
				"name":"K16642  PTN; pleiotrophin"
			},
			{
				"name":"K05448  VEGFA; vascular endothelial growth factor A"
			},
			{
				"name":"K25640  MPIG6B; megakaryocyte and platelet inhibitory receptor G6b"
			}
			]
		},
		{
			"name":"Extracellular matrix molecules",
			"children":[
			{
				"name":"K03903  FGA; fibrinogen alpha chain"
			},
			{
				"name":"K03904  FGB; fibrinogen beta chain"
			},
			{
				"name":"K03905  FGG; fibrinogen gamma chain"
			},
			{
				"name":"K05717  FN1; fibronectin 1"
			},
			{
				"name":"K06825  FBN1; fibrillin 1"
			},
			{
				"name":"K23342  FBN2_3; fibrillin 2\/3"
			},
			{
				"name":"------  LAMA5; laminin, alpha 5 [HSA:3911] [KO:K06240]"
			},
			{
				"name":"K06252  TN; tenascin"
			},
			{
				"name":"K24354  SMOC; SPARC-related modular calcium-binding protein"
			},
			{
				"name":"K16857  THBS1; thrombospondin 1"
			},
			{
				"name":"K04659  THBS2S; thrombospondin 2\/3\/4\/5"
			},
			{
				"name":"K06251  VTN; vitronectin"
			},
			{
				"name":"K06236  COL1A; collagen type I alpha"
			},
			{
				"name":"K19719  COL2A; collagen type II alpha"
			},
			{
				"name":"K19720  COL3A; collagen type III alpha"
			},
			{
				"name":"K06237  COL4A; collagen type IV alpha"
			},
			{
				"name":"K19721  COL5AS; collagen type V\/XI\/XXIV\/XXVII, alpha"
			},
			{
				"name":"K06238  COL6A; collagen type VI alpha"
			},
			{
				"name":"K16617  COL13A; collagen type XIII alpha"
			},
			{
				"name":"K06823  COL18A; collagen type XVIII alpha"
			},
			{
				"name":"K24340  COL19A; collagen type XIX alpha"
			},
			{
				"name":"K24355  COL23A; collagen type XXIII alpha"
			},
			{
				"name":"K24356  COL25A; collagen type XXV alpha"
			},
			{
				"name":"K26586  COLQ; acetylcholinesterase collagenic tail peptide"
			}
			]
		},
		{
			"name":"Axon guidance molecules",
			"children":[
			{
				"name":"K05462  EFNA; ephrin-A"
			},
			{
				"name":"K06843  NTN1; netrin 1"
			},
			{
				"name":"K06838  SLIT1; slit 1"
			},
			{
				"name":"K06839  SLIT2; slit 2"
			},
			{
				"name":"K06850  SLIT3; slit 3"
			},
			{
				"name":"------  SEMA5A; semaphorin 5A [HSA:9037] [KO:K06841]"
			}
			]
		},
		{
			"name":"Coagulation and fibrinolysis",
			"children":[
			{
				"name":"K01313  F2; coagulation factor II (thrombin) [EC:3.4.21.5]"
			},
			{
				"name":"K01314  F10; coagulation factor X [EC:3.4.21.6]"
			},
			{
				"name":"K03913  SERPINA5, PCI; protein C inhibitor"
			},
			{
				"name":"K03911  SERPINC1, AT3; antithrombin III"
			},
			{
				"name":"K03912  SERPIND1, HCF2; heparin cofactor II"
			},
			{
				"name":"K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1"
			},
			{
				"name":"K16643  SERPINE2; glia-derived nexin"
			},
			{
				"name":"K01343  PLAT; tissue plasminogen activator [EC:3.4.21.68]"
			},
			{
				"name":"K01348  PLAU; urokinase plasminogen activator [EC:3.4.21.73]"
			},
			{
				"name":"K03909  TFPI; tissue factor pathway inhibitor"
			}
			]
		},
		{
			"name":"Enzymes",
			"children":[
			{
				"name":"K01327  ELANE; leukocyte elastase [EC:3.4.21.37]"
			},
			{
				"name":"K07964  HPSE; heparanase [EC:3.2.1.166]"
			},
			{
				"name":"K07965  HPSE2; heparanase 2 [EC:3.2.1.-]"
			},
			{
				"name":"K01197  hya; hyaluronoglucosaminidase [EC:3.2.1.35]"
			},
			{
				"name":"K01059  LPL; lipoprotein lipase [EC:3.1.1.34]"
			},
			{
				"name":"K16627  SOD3; superoxide dismutase, Cu-Zn family [EC:1.15.1.1]"
			}
			]
		},
		{
			"name":"Microbial pathogens",
			"children":[
			{
				"name":"K19252  VP1; Dependoparvovirus capsid protein VP1\/VP2\/VP3"
			},
			{
				"name":"K19255  gB; Herpesviridae envelope glycoprotein B"
			},
			{
				"name":"K19256  gC; Simplexvirus envelope glycoprotein C"
			},
			{
				"name":"K19264  gD; Simplexvirus envelope glycoprotein D"
			},
			{
				"name":"K19257  gM, UL10; Herpesviridae envelope glycoprotein M"
			},
			{
				"name":"K22773  gB, UL55; Betaherpesvirinae envelope glycoprotein B"
			},
			{
				"name":"K19287  env, gp160; HIV envelope glycoprotein gp160"
			},
			{
				"name":"K24266  gp120; HIV envelope glycoprotein gp120"
			},
			{
				"name":"K19258  tat; HIV protein Tat"
			},
			{
				"name":"K19259  env; Deltaretrovirus envelope glycoprotein gp62"
			},
			{
				"name":"K24862  gp46; HTLV envelope surface glycoprotein gp46"
			},
			{
				"name":"K19288  p130; Alphavirus structral polyprotein"
			},
			{
				"name":"------  Dengue virus, envelope protein"
			},
			{
				"name":"------  Foot-and-mouth disease virus - type O, VP3"
			},
			{
				"name":"K19260  L1; Papillomaviridae major capsid protein L1"
			},
			{
				"name":"K19261  F; Pneumoviridae fusion glycoprotein F0"
			},
			{
				"name":"K19262  L5; Mastadenovirus fiber protein"
			},
			{
				"name":"K19263  A27L; Orthopoxvirus protein A27"
			},
			{
				"name":"K13836  CSP; circumsporozoite protein"
			},
			{
				"name":"K15125  fhaB; filamentous hemagglutinin"
			},
			{
				"name":"K16644  actA; actin-assembly inducing protein"
			},
			{
				"name":"K16645  hbhA; heparin binding hemagglutinin HbhA"
			},
			{
				"name":"------  penetrin"
			},
			{
				"name":"------  Borrelia burgdorferi"
			},
			{
				"name":"------  Chlamydia trachomatis"
			},
			{
				"name":"------  Neisseria gonorrhoeae"
			},
			{
				"name":"------  Leishmania amazonensis"
			}
			]
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"K16631  ANG, RNASE5; angiogenin [EC:3.1.27.-]"
			},
			{
				"name":"K16646  ANXA5; annexin A5"
			},
			{
				"name":"K09025  APOA5; apolipoprotein A-V"
			},
			{
				"name":"K14462  APOB; apolipoprotein B"
			},
			{
				"name":"K04524  APOE; apolipoprotein E"
			},
			{
				"name":"K04520  APP; amyloid beta A4 protein"
			},
			{
				"name":"K01363  CTSB; cathepsin B [EC:3.4.22.1]"
			},
			{
				"name":"K01319  CTSG; cathepsin G [EC:3.4.21.20]"
			},
			{
				"name":"K05634  PRNP, PrP, CD230; prion protein"
			},
			{
				"name":"K05849  SLC8A, NCX; solute carrier family 8 (sodium\/calcium exchanger)"
			}
			]
		}
		]
	},
	{
		"name":"Hyaluronan",
		"children":[
		{
			"name":"Cell surface receptors",
			"children":[
			{
				"name":"K01242  CD38; ADP-ribosyl cyclase 1 [EC:3.2.2.6 2.4.99.20]"
			},
			{
				"name":"K06256  CD44; CD44 antigen"
			},
			{
				"name":"K06267  HMMR, RHAMM, CD168; hyaluronan-mediated motility receptor"
			},
			{
				"name":"K06490  ICAM1, CD54; intercellular adhesion molecule 1"
			},
			{
				"name":"K10159  TLR2, CD282; toll-like receptor 2"
			},
			{
				"name":"K10160  TLR4, CD284; toll-like receptor 4"
			},
			{
				"name":"K10077  LAYN; layilin"
			},
			{
				"name":"K19012  LYVE1; lymphatic vessel endothelial hyaluronan receptor 1"
			},
			{
				"name":"K19020  STAB1; stabilin-1"
			},
			{
				"name":"K19013  STAB2, HARE; stabilin-2"
			},
			{
				"name":"K19031  CEMIP, KIAA1199; cell migration-inducing and hyaluronan-binding protein [EC:3.2.1.35]"
			},
			{
				"name":"K22144  TEME2; cell surface hyaluronidase [EC:3.2.1.35]"
			}
			]
		},
		{
			"name":"Extracellular matrix or blood plasma proteins",
			"children":[
			{
				"name":"K06792  AGC1, CSPG1; aggrecan 1"
			},
			{
				"name":"K06795  BCAN; brevican"
			},
			{
				"name":"K15414  C1QBP; complement component 1 Q subcomponent-binding protein, mitochondrial"
			},
			{
				"name":"K06238  COL6A; collagen type VI alpha"
			},
			{
				"name":"K03903  FGA; fibrinogen alpha chain"
			},
			{
				"name":"K03904  FGB; fibrinogen beta chain"
			},
			{
				"name":"K03905  FGG; fibrinogen gamma chain"
			},
			{
				"name":"K08648  HABP2; hyaluronan binding protein 2 [EC:3.4.21.-]"
			},
			{
				"name":"K06848  HAPLN1, CRTL1; hyaluronan and proteoglycan link protein 1"
			},
			{
				"name":"K06851  HAPLN2; hyaluronan and proteoglycan link protein 2"
			},
			{
				"name":"K06853  HAPLN4; hyaluronan and proteoglycan link protein 4"
			},
			{
				"name":"K18977  HPX; hemopexin"
			},
			{
				"name":"K19014  ITIH1, SHAP; inter-alpha-trypsin inhibitor heavy chain H1"
			},
			{
				"name":"K19015  ITIH2, SHAP; inter-alpha-trypsin inhibitor heavy chain H2"
			},
			{
				"name":"K24513  ITIH3, SHAP; inter-alpha-trypsin inhibitor heavy chain H3"
			},
			{
				"name":"K06794  NCAN, CSPG3; neurocan core protein"
			},
			{
				"name":"K19016  IMPG1, SPACR; interphotoreceptor matrix proteoglycan 1"
			},
			{
				"name":"K19017  IMPG2, SPACRCAN; interphotoreceptor matrix proteoglycan 2"
			},
			{
				"name":"K19018  TNFAIP6, TSG6; tumor necrosis factor-inducible gene 6 protein"
			},
			{
				"name":"K06793  VCAN, CSPG2; versican core protein"
			}
			]
		},
		{
			"name":"Intracellular proteins",
			"children":[
			{
				"name":"K09554  CDC37; cell division cycle protein 37"
			},
			{
				"name":"K19019  HABP4; intracellular hyaluronan-binding protein 4"
			}
			]
		}
		]
	}
	]
}