{
	"name":"ko01008",
	"children":[
	{
		"name":"Polyketide synthase (PKS)",
		"children":[
		{
			"name":"Modular type I PKS",
			"children":[
			{
				"name":"cis-AT PKS",
				"children":[
				{
					"name":"Erythronolide PKS",
					"children":[
					{
						"name":"K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94]"
					},
					{
						"name":"K24563  eryAII; 6-deoxyerythronolide B synthase EryAII [EC:2.3.1.94]"
					},
					{
						"name":"K24564  eryAIII; 6-deoxyerythronolide B synthase EryAIII [EC:2.3.1.94]"
					}
					]
				},
				{
					"name":"Oleandomycin synthase",
					"children":[
					{
						"name":"K16007  oleAI; 8,8a-deoxyoleandolide synthase 1"
					},
					{
						"name":"K24565  oleAII; 8,8a-deoxyoleandolide synthase 2"
					},
					{
						"name":"K24566  oleAIII; 8,8a-deoxyoleandolide synthase 3"
					}
					]
				},
				{
					"name":"Pikromycin PKS",
					"children":[
					{
						"name":"K16000  pikAI; narbonolide\/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]"
					},
					{
						"name":"K16001  pikAII; narbonolide\/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]"
					},
					{
						"name":"K16002  pikAIII; narbonolide\/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]"
					},
					{
						"name":"K16003  pikAIV; narbonolide synthase [EC:2.3.1.240]"
					}
					]
				},
				{
					"name":"Avermectin PKS",
					"children":[
					{
						"name":"K14371  aveA1; avermectin polyketide synthase AveA1"
					},
					{
						"name":"K24567  aveA2; avermectin polyketide synthase AveA2"
					},
					{
						"name":"K24568  aveA3; avermectin polyketide synthase AveA3"
					},
					{
						"name":"K24569  aveA4; avermectin polyketide synthase AveA4"
					}
					]
				},
				{
					"name":"Tylactone synthase",
					"children":[
					{
						"name":"K15988  tylG1; tylactone synthase 1"
					},
					{
						"name":"K24555  tylG2; tylactone synthase 2"
					},
					{
						"name":"K24556  tylG3; tylactone synthase 3"
					},
					{
						"name":"K24557  tylG4; tylactone synthase 4"
					},
					{
						"name":"K24558  tylG5; tylactone synthase 5"
					}
					]
				},
				{
					"name":"Protomycinolide IV synthase",
					"children":[
					{
						"name":"K24528  mycAI; protomycinolide IV synthase 1"
					},
					{
						"name":"K24559  mycAII; protomycinolide IV synthase 2"
					},
					{
						"name":"K24560  mycAIII; protomycinolide IV synthase 3"
					},
					{
						"name":"K24561  mycAIV; protomycinolide IV synthase 4"
					},
					{
						"name":"K24562  mycAV; protomycinolide IV synthase 5"
					}
					]
				},
				{
					"name":"Niddamycin PKS",
					"children":[
					{
						"name":"K16372  nidA1; niddamycin polyketide synthase 1"
					},
					{
						"name":"K20786  nidA2; niddamycin polyketide synthase 2"
					},
					{
						"name":"K16373  nidA3; niddamycin polyketide synthase 3"
					},
					{
						"name":"K16374  nidA4_5; niddamycin polyketide synthase 4\/5"
					}
					]
				},
				{
					"name":"Rapamycin PKS",
					"children":[
					{
						"name":"K16420  rapA_B_C; rapamycin polyketide synthase A\/B\/C"
					}
					]
				},
				{
					"name":"Immunomycin PKS",
					"children":[
					{
						"name":"K16377  fkbA; polyketide synthase FkbA"
					},
					{
						"name":"K16375  fkbB; polyketide synthase FkbB"
					},
					{
						"name":"K16376  fkbC; polyketide synthase FkbC"
					}
					]
				},
				{
					"name":"Ansamitocin PKS",
					"children":[
					{
						"name":"K16029  asmA; ansamitocin polyketide synthase A"
					},
					{
						"name":"K16030  asmB; ansamitocin polyketide synthase B"
					},
					{
						"name":"K16031  asmC; ansamitocin polyketide synthase C"
					},
					{
						"name":"K16032  asmD; ansamitocin polyketide synthase D"
					}
					]
				},
				{
					"name":"Rifamycin PKS",
					"children":[
					{
						"name":"K15670  rifA; rifamycin polyketide synthase modules 1, 2 and 3 [EC:6.2.1.74]"
					},
					{
						"name":"K15671  rifB; rifamycin polyketide synthase modules 4, 5 and 6"
					},
					{
						"name":"K15672  rifC_D; rifamycin polyketide synthase modules 7 and 8"
					},
					{
						"name":"K15673  rifE; rifamycin polyketide synthase modules 9 and 10"
					}
					]
				},
				{
					"name":"Polyene macrolide PKS",
					"children":[
					{
						"name":"K16382  amphA, nysA; polyene macrolide polyketide synthase, loading module"
					},
					{
						"name":"K16383  amphB, nysB; polyene macrolide polyketide synthase, A-type KR domains"
					},
					{
						"name":"K16384  amphC, nysC; polyene macrolide polyketide synthase"
					},
					{
						"name":"K16385  amphI, nysI; polyene macrolide polyketide synthase, KS-AT-KR-ACP domains"
					},
					{
						"name":"K16386  amphJ, nysJ; polyene macrolide polyketide synthase"
					},
					{
						"name":"K16387  amphK, nysK; polyene macrolide polyketide synthase"
					}
					]
				},
				{
					"name":"Pimaricinolide synthase",
					"children":[
					{
						"name":"K16391  pimS0; pimaricinolide synthase, loading module"
					},
					{
						"name":"K19203  pimS1; pimaricinolide synthase PimS1"
					},
					{
						"name":"K19204  pimS2; pimaricinolide synthase PimS2"
					},
					{
						"name":"K19205  pimS3; pimaricinolide synthase PimS3"
					},
					{
						"name":"K19206  pimS4; pimaricinolide synthase PimS4"
					}
					]
				},
				{
					"name":"Candicidin PKS",
					"children":[
					{
						"name":"K16392  fscA; candicidin polyketide synthase FscA"
					},
					{
						"name":"K16393  fscB; candicidin polyketide synthase FscB"
					},
					{
						"name":"K20787  fscC; candicidin polyketide synthase FscC"
					},
					{
						"name":"K19207  fscD; candicidin polyketide synthase FscD"
					},
					{
						"name":"K19208  fscE; candicidin polyketide synthase FscE"
					},
					{
						"name":"K25145  fscF; candicidin polyketide synthase FscF"
					}
					]
				},
				{
					"name":"Soraphen PKS",
					"children":[
					{
						"name":"K16401  sorA; soraphen polyketide synthase A"
					},
					{
						"name":"K16402  sorB; soraphen polyketide synthase B"
					}
					]
				},
				{
					"name":"Stigmatellin PKS",
					"children":[
					{
						"name":"K16405  stiA; stigmatellin polyketide synthase StiA"
					},
					{
						"name":"K16406  stiB; stigmatellin polyketide synthase StiB"
					},
					{
						"name":"K16407  stiC; stigmatellin polyketide synthase StiC"
					},
					{
						"name":"K16408  stiD; stigmatellin polyketide synthase StiD"
					},
					{
						"name":"K16409  stiE; stigmatellin polyketide synthase StiE"
					},
					{
						"name":"K16410  stiF; stigmatellin polyketide synthase StiF"
					},
					{
						"name":"K16411  stiG; stigmatellin polyketide synthase StiG"
					},
					{
						"name":"K16412  stiH; stigmatellin polyketide synthase StiH"
					},
					{
						"name":"K16413  stiJ; stigmatellin polyketide synthase StiJ"
					}
					]
				},
				{
					"name":"Mycolactone PKS",
					"children":[
					{
						"name":"K16418  mlsA1; mycolactone core lactone polyketide synthase MlsA1"
					},
					{
						"name":"K16450  mlsA2; mycolactone core lactone polyketide synthase MlsA2"
					},
					{
						"name":"K16419  mlsB; mycolactone side chain polyketide synthase"
					}
					]
				},
				{
					"name":"Coelimycin PKS",
					"children":[
					{
						"name":"K23365  cpkA; 5-hydroxydodecatetraenal polyketide synthase CpkA [EC:2.3.1.281]"
					},
					{
						"name":"K23366  cpkB; 5-hydroxydodecatetraenal polyketide synthase CpkB [EC:2.3.1.281]"
					},
					{
						"name":"K23367  cpkC; 5-hydroxydodecatetraenal polyketide synthase CpkC [EC:2.3.1.281]"
					}
					]
				},
				{
					"name":"Aureothin PKS",
					"children":[
					{
						"name":"K23744  aurA; aureothin polyketide synthase system AurA [EC:2.3.1.289]"
					},
					{
						"name":"K23745  aurB; aureothin polyketide synthase system AurB [EC:2.3.1.289]"
					},
					{
						"name":"K23746  aurC; aureothin polyketide synthase system AurC [EC:2.3.1.289]"
					}
					]
				},
				{
					"name":"Spectinabilin PKS",
					"children":[
					{
						"name":"K23747  norA; spectinabilin polyketide synthase system NorA [EC:2.3.1.290]"
					},
					{
						"name":"K23748  norB; spectinabilin polyketide synthase system NorB [EC:2.3.1.290]"
					},
					{
						"name":"K23749  norC; spectinabilin polyketide synthase system NorC [EC:2.3.1.290]"
					}
					]
				},
				{
					"name":"Phthiocerol \/ Phenolphthiocerol PKS",
					"children":[
					{
						"name":"K12440  ppsA; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase A [EC:2.3.1.292]"
					},
					{
						"name":"K12441  ppsB; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase B [EC:2.3.1.292]"
					},
					{
						"name":"K12442  ppsC; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase C [EC:2.3.1.292]"
					},
					{
						"name":"K12443  ppsD; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]"
					},
					{
						"name":"K12444  ppsE; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase E [EC:2.3.1.292]"
					}
					]
				}
				]
			},
			{
				"name":"trans-AT PKS",
				"children":[
				{
					"name":"Bacillanene hybrid PKS-NRPS",
					"children":[
					{
						"name":"K15329  pksE, baeE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"K15328  pksD, baeD; bacillaene synthase trans-acting acyltransferase"
					},
					{
						"name":"K13611  pksJ, baeJ; bacillaene biosynthesis, polyketide synthase \/ nonribosomal peptide synthetase PksJ\/BaeJ"
					},
					{
						"name":"K13612  pksL, baeL; bacillaene polyketide synthase PksL\/BaeL"
					},
					{
						"name":"K13613  pksM, baeM; bacillaene polyketide synthase PksM\/BaeM"
					},
					{
						"name":"K13614  pksN, baeN; bacillaene biosynthesis, polyketide synthase \/ nonribosomal peptide synthetase PksN\/BaeN"
					},
					{
						"name":"K13615  pksR, baeR; bacillaene polyketide synthase PksR\/BaeR"
					}
					]
				},
				{
					"name":"Macrolactin PKS",
					"children":[
					{
						"name":"K15329  pksE, baeE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"K25842  mlnB; macrolactin polyketide synthase MlnB"
					},
					{
						"name":"K25843  mlnC; macrolactin polyketide synthase MlnC"
					},
					{
						"name":"K25844  mlnD; macrolactin polyketide synthase MlnD"
					},
					{
						"name":"K25845  mlnE; macrolactin polyketide synthase MlnE"
					},
					{
						"name":"K25846  mlnF; macrolactin polyketide synthase MlnF"
					},
					{
						"name":"K25847  mlnG; macrolactin polyketide synthase MlnG"
					},
					{
						"name":"K25848  mlnH; macrolactin polyketide synthase MlnH"
					}
					]
				},
				{
					"name":"Difficidin PKS",
					"children":[
					{
						"name":"K15329  pksE, baeE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"K25849  dfnD; difficidin synthase DfnD"
					},
					{
						"name":"K25850  dfnE; difficidin synthase DfnE"
					},
					{
						"name":"K25851  dfnF; difficidin synthase DfnF"
					},
					{
						"name":"K25852  dfnG; difficidin synthase DfnG"
					},
					{
						"name":"K25853  dfnH; difficidin synthase DfnH"
					},
					{
						"name":"K25854  dfnI; difficidin synthase DfnI"
					},
					{
						"name":"K25855  dfnJ; difficidin synthase DfnJ"
					}
					]
				},
				{
					"name":"Rhizoxin hybrid PKS-NRPS",
					"children":[
					{
						"name":"K15469  rhiG; rhizoxin biosynthesis acyltransferase"
					},
					{
						"name":"K15674  rhiA; rhizoxin biosynthesis, polyketide synthase \/ nonribosomal peptide synthetase RhiA"
					},
					{
						"name":"K15675  rhiB; rhizoxin biosynthesis, polyketide synthase \/ nonribosomal peptide synthetase RhiB"
					},
					{
						"name":"K15676  rhiC; rhizoxin biosynthesis, polyketide synthase RhiC"
					},
					{
						"name":"K15677  rhiD; rhizoxin biosynthesis, polyketide synthase RhiD"
					},
					{
						"name":"K15678  rhiE; rhizoxin biosynthesis, polyketide synthase RhiE"
					},
					{
						"name":"K15679  rhiF; rhizoxin biosynthesis, polyketide synthase RhiF"
					}
					]
				},
				{
					"name":"Albicidin synthase, hybrid PKS-NRPS",
					"children":[
					{
						"name":"K28567  albXIII; albicidin biosynthesis acyltransferase"
					},
					{
						"name":"K28568  albI; albicidin biosynthesis, polyketide synthase \/ nonribosomal peptide synthetase AlbI"
					},
					{
						"name":"K28569  albIV; albicidin biosynthesis, nonribosomal peptide synthetase AlbIV"
					},
					{
						"name":"K28570  albIX; albicidin biosynthesis, nonribosomal peptide synthetase AlbIX"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"Iterative type I PKS",
			"children":[
			{
				"name":"Fungal nonreducing PKS (NR-PKS)",
				"children":[
				{
					"name":"K15316  PKSA; noranthrone synthase [EC:2.3.1.221]"
				},
				{
					"name":"K15321  WA; naphtho-gamma-pyrone polyketide synthase"
				},
				{
					"name":"K15317  APTA; asperthecin polyketide synthase"
				},
				{
					"name":"K15416  ORSA; orsellinic acid synthase"
				},
				{
					"name":"K20984  LOVF; 2-methylbutanoate polyketide synthase [EC:2.3.1.244]"
				},
				{
					"name":"K15415  TPCC, MDPG, GEDC, ACAS; atrochrysone-2-carbonyl-[acyl-carrier protein] synthase [EC:2.3.1.336]"
				},
				{
					"name":"K28740  CoPKS, CrPKS; 6-hydroxymusizin-2-carbonyl-ACP\/atrochrysone-2-carbonyl-ACP synthase\/thioesterase [EC:2.3.1.335 2.3.1.336 3.1.2.35 3.1.2.34]"
				},
				{
					"name":"K28741  SPOP; 6-hydroxymusizin-2-carbonyl-[acyl-carrier protein] synthase [EC:2.3.1.335]"
				}
				]
			},
			{
				"name":"Fungal partially reducing PKS (PR-PKS)",
				"children":[
				{
					"name":"K15320  ATX, chlB1, mdpB; 6-methylsalicylic acid synthase [EC:2.3.1.165]"
				}
				]
			},
			{
				"name":"Fungal highly reducing PKS (HR-PKS)",
				"children":[
				{
					"name":"K15419  EASB; emericellamide biosynthesis, highly reducing iterative type I polyketide synthase"
				},
				{
					"name":"K20981  LOVB; lovastatin nonaketide synthase [EC:2.3.1.161]"
				}
				]
			},
			{
				"name":"Fungal hybrid type",
				"children":[
				{
					"name":"Zearalenone synthase",
					"children":[
					{
						"name":"K15417  ZEA1; zearalenone synthase, nonreducing iterative type I polyketide synthase"
					},
					{
						"name":"K15418  ZEA2; zearalenone synthase, highly reducing iterative type I polyketide synthase"
					}
					]
				}
				]
			},
			{
				"name":"Bacterial type",
				"children":[
				{
					"name":"K15314  sgcE, mdpE, ncsE, kedE, calE8, pksE; enediyne polyketide synthase"
				},
				{
					"name":"K21254  calO5; orsellinic acid synthase [EC:2.3.1.-]"
				},
				{
					"name":"K20422  ncsB; neocarzinostatin naphthoate synthase [EC:2.3.1.237]"
				},
				{
					"name":"K21221  kedU38; iterative type I polyketide synthase KedU38"
				},
				{
					"name":"K12436  pks12; mycoketide-CoA synthase [EC:2.3.1.295]"
				}
				]
			}
			]
		},
		{
			"name":"Type II PKS",
			"children":[
			{
				"name":"C9-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Spore pigment PKS",
					"children":[
					{
						"name":"K14667  whiEIII; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.-]"
					},
					{
						"name":"K14668  whiEIV; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.-]"
					},
					{
						"name":"K14669  whiEV; minimal PKS acyl carrier protein"
					},
					{
						"name":"K14670  whiEVI; aromatase"
					},
					{
						"name":"K14671  whiEVII; cyclase"
					}
					]
				}
				]
			},
			{
				"name":"C7-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Octaketide PKS",
					"children":[
					{
						"name":"K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein"
					},
					{
						"name":"K12420  actIII, oxyJ, snoaD, aknA; ketoreductase [EC:1.1.1.-]"
					},
					{
						"name":"K05554  actVII; aromatase [EC:4.2.1.-]"
					},
					{
						"name":"K05555  actIV; cyclase [EC:4.-.-.-]"
					}
					]
				},
				{
					"name":"Nonaketide PKS",
					"children":[
					{
						"name":"K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein"
					},
					{
						"name":"K12420  actIII, oxyJ, snoaD, aknA; ketoreductase [EC:1.1.1.-]"
					},
					{
						"name":"K14249  oxyK; bifunctional cyclase\/aromatase [EC:4.2.1.-]"
					},
					{
						"name":"K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase"
					},
					{
						"name":"K15926  jadI; cyclase"
					}
					]
				},
				{
					"name":"Decaketide PKS",
					"children":[
					{
						"name":"K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"K05553  actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein"
					},
					{
						"name":"K12420  actIII, oxyJ, snoaD, aknA; ketoreductase [EC:1.1.1.-]"
					},
					{
						"name":"K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase"
					},
					{
						"name":"K15884  snoaE, aknE1; bifunctional aromatase (cyclase\/dehydratase) [EC:4.2.1.-]"
					},
					{
						"name":"K15886  tcmN; multifunctional cyclase \/ dehydratase \/ O-methyltransferase [EC:2.3.1.235]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"Type III PKS",
			"children":[
			{
				"name":"Plant type",
				"children":[
				{
					"name":"K00660  CHS; chalcone synthase [EC:2.3.1.74]"
				},
				{
					"name":"K13232  ST; stilbene synthase [EC:2.3.1.95]"
				},
				{
					"name":"K17212  CUS; bisdemethoxycurcumin synthase [EC:2.3.1.211]"
				},
				{
					"name":"K13231  STS; pinosylvin synthase [EC:2.3.1.146]"
				},
				{
					"name":"K13233  DCS; phenylpropanoylacetyl-CoA synthase [EC:2.3.1.218]"
				},
				{
					"name":"K13234  CURS1_2; curcumin synthase [EC:2.3.1.217]"
				},
				{
					"name":"K17211  CURS3; curcumin\/demethoxycurcumin synthase [EC:2.3.1.217 2.3.1.219]"
				},
				{
					"name":"K21384  BIS; 3,5-dihydroxybiphenyl\/4-hydroxycoumarin synthase [EC:2.3.1.177 2.3.1.208]"
				},
				{
					"name":"K21385  PCS; 5,7-dihydroxy-2-methylchromone synthase [EC:2.3.1.216]"
				},
				{
					"name":"K21386  BPS; 2,4,6-trihydroxybenzophenone synthase [EC:2.3.1.220]"
				}
				]
			},
			{
				"name":"Fungal type",
				"children":[
				{
					"name":"K16231  csyA; fungal type III polyketide synthase"
				}
				]
			},
			{
				"name":"Bacterial type",
				"children":[
				{
					"name":"K16424  dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246]"
				},
				{
					"name":"K15431  phlD; phloroglucinol synthase [EC:2.3.1.253]"
				},
				{
					"name":"K19580  rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233]"
				},
				{
					"name":"K16232  gcs; germicidin synthase"
				},
				{
					"name":"K16167  bpsA, srsA, pks11, pks10; alkylresorcinol\/alkylpyrone synthase"
				},
				{
					"name":"K16233  pks18; alpha-pyrone synthase"
				},
				{
					"name":"K28571  arsB; alkylresorcinol synthase"
				},
				{
					"name":"K28572  arsC; alkylpyrone synthase"
				}
				]
			}
			]
		},
		{
			"name":"PKS-NRPS hybrid",
			"children":[
			{
				"name":"Bacterial type (modular)",
				"children":[
				{
					"name":"Myxalamid hybrid PKS-NRPS",
					"children":[
					{
						"name":"K16416  mxaA; myxalamid-type nonribosomal peptide synthetase MxaA"
					},
					{
						"name":"K15643  mxaB; myxalamid-type polyketide synthase MxaB"
					},
					{
						"name":"K16417  mxaC; myxalamid-type polyketide synthase MxaC"
					},
					{
						"name":"K15642  mxaD; myxalamid-type polyketide synthase MxaD"
					},
					{
						"name":"K20788  mxaE; myxalamid-type polyketide synthase MxaE"
					},
					{
						"name":"K15641  mxaF; myxalamid-type polyketide synthase MxaF"
					}
					]
				},
				{
					"name":"Coronatine hybrid PKS-NRPS",
					"children":[
					{
						"name":"K15644  cfa6; coronafacic acid polyketide synthase Cfa6"
					},
					{
						"name":"K15645  cfa7; coronafacic acid polyketide synthase Cfa7"
					},
					{
						"name":"K15646  cmaA; coronamic acid synthetase CmaA, adenylation and thiolation didomain protein [EC:6.2.1.46]"
					},
					{
						"name":"K15648  cmaD; coronamic acid synthetase CmaD, carrier protein"
					},
					{
						"name":"K15647  cmaE; coronamic acid synthetase CmaE, aminoacyltransferase [EC:2.3.2.28]"
					},
					{
						"name":"K15649  cmaT; coronamic acid synthetase CmaT, thioesterase component"
					}
					]
				},
				{
					"name":"Microcystin synthetase",
					"children":[
					{
						"name":"K16130  mcyA; microcystin synthetase protein McyA"
					},
					{
						"name":"K16131  mcyB; microcystin synthetase protein McyB"
					},
					{
						"name":"K16132  mcyC; microcystin synthetase protein McyC"
					},
					{
						"name":"K16128  mcyD; microcystin synthetase protein McyD"
					},
					{
						"name":"K16129  mcyE; microcystin synthetase protein McyE"
					},
					{
						"name":"K16127  mcyG; microcystin synthetase protein McyG"
					}
					]
				},
				{
					"name":"Epothilone synthetase",
					"children":[
					{
						"name":"K16394  epoA; epothilone polyketide synthase A"
					},
					{
						"name":"K16395  epoB; epothilone synthetase B"
					},
					{
						"name":"K16396  epoC; epothilone polyketide synthase C"
					},
					{
						"name":"K16397  epoD; epothilone polyketide synthase D"
					},
					{
						"name":"K16398  epoE; epothilone polyketide synthase E"
					},
					{
						"name":"K16399  epoF; epothilone polyketide synthase F"
					}
					]
				},
				{
					"name":"Bleomycin synthetase",
					"children":[
					{
						"name":"K16113  blmIII; nonribosomal peptide synthetase protein BlmIII"
					},
					{
						"name":"K16112  blmIV; nonribosomal peptide synthetase protein BlmIV"
					},
					{
						"name":"K16107  blmV; nonribosomal peptide synthetase protein BlmV"
					},
					{
						"name":"K16106  blmVI; nonribosomal peptide synthetase protein BlmVI"
					},
					{
						"name":"K16111  blmVII; nonribosomal peptide synthetase protein BlmVII"
					},
					{
						"name":"K16110  blmVIII; nonribosomal peptide synthetase protein BlmVIII"
					},
					{
						"name":"K16109  blmIX; nonribosomal peptide synthetase protein BlmIX"
					},
					{
						"name":"K16108  blmX; nonribosomal peptide synthetase protein BlmX"
					}
					]
				},
				{
					"name":"Colibactin synthetase",
					"children":[
					{
						"name":"K26572  clbN; colibactin biosynthesis nonribosomal peptide synthase"
					},
					{
						"name":"K26573  clbB; colibactin biosynthesis hybrid nonribosomal peptide\/polyketide synthase"
					},
					{
						"name":"K26574  clbC; colibactin biosynthesis polyketide synthase"
					},
					{
						"name":"K26565  clbH; colibactin biosynthesis nonribosomal peptide synthase"
					},
					{
						"name":"K26575  clbI; colibactin biosynthesis polyketide synthase"
					},
					{
						"name":"K26578  clbJ; colibactin biosynthesis nonribosomal peptide synthase"
					},
					{
						"name":"K26577  clbK; colibactin biosynthesis hybrid nonribosomal peptide\/polyketide synthase"
					},
					{
						"name":"K26576  clbO; colibactin biosynthesis polyketide synthase"
					}
					]
				},
				{
					"name":"Myxothiazol hybrid PKS-NRPS",
					"children":[
					{
						"name":"K28573  mtaB; myxothiazol biosynthesis polyketide synthase MtaB"
					},
					{
						"name":"K28574  mtaC; myxothiazol nonribosomal peptide synthase MtaC"
					},
					{
						"name":"K28575  mtaD; myxothiazol biosynthesis hybrid nonribosomal peptide\/polyketide synthetase MtaD"
					},
					{
						"name":"K28576  mtaE; myxothiazol biosynthesis polyketide synthase MtaE"
					},
					{
						"name":"K28577  mtaF; myxothiazol biosynthesis polyketide synthase MtaF"
					},
					{
						"name":"K28578  mtaG; myxothiazol nonribosomal peptide synthase MtaG"
					}
					]
				}
				]
			},
			{
				"name":"Fungal type (trans-ER, iterative)",
				"children":[
				{
					"name":"Aspyridone synthetase",
					"children":[
					{
						"name":"K15384  APDA; aspyridone synthetase, hybrid polyketide synthase \/ nonribosomal peptide synthetase"
					},
					{
						"name":"K15385  APDC; aspyridone synthetase trans-acting enoyl reductase"
					}
					]
				}
				]
			},
			{
				"name":"Fungal type (iterative)",
				"children":[
				{
					"name":"K15390  PSOA; pseurotin A synthetase, hybrid polyketide synthase \/ nonribosomal peptide synthetase"
				},
				{
					"name":"K15391  CPAA; cyclopiazonic acid synthetase, hybrid polyketide synthase \/ nonribosomal peptide synthetase"
				},
				{
					"name":"K01043  SWNK; swainsonine synthetase, hybrid polyketide synthase \/ nonribosomal peptide synthetase"
				},
				{
					"name":"K15394  ACE1; hybrid polyketide synthase \/ nonribosomal peptide synthetase ACE1"
				},
				{
					"name":"K15395  ftdB; hybrid polyketide synthase \/ nonribosomal peptide synthetase FtdB"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide synthetase (NRPS)",
		"children":[
		{
			"name":"Linear NRPS",
			"children":[
			{
				"name":"Emericellamide synthetase",
				"children":[
				{
					"name":"K28585  EASA; emericellamide biosynthesis, nonribosomal peptide synthetase [EC:6.3.2.-]"
				}
				]
			},
			{
				"name":"Cyanopeptolin synthetase",
				"children":[
				{
					"name":"K28588  mcnA; cyanopeptolin synthetase 1"
				},
				{
					"name":"K28589  mcnB; cyanopeptolin synthetase 2"
				},
				{
					"name":"K28590  mcnC; cyanopeptolin synthetase 3,4,5,6"
				},
				{
					"name":"K28591  mcnE; cyanopeptolin synthetase 7"
				}
				]
			},
			{
				"name":"ACV synthetase",
				"children":[
				{
					"name":"K12743  PCBAB; N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase [EC:6.3.2.26]"
				}
				]
			},
			{
				"name":"Bacitracin synthetase",
				"children":[
				{
					"name":"K16093  bacA; bacitracin synthase 1"
				},
				{
					"name":"K16094  bacB; bacitracin synthase 2"
				},
				{
					"name":"K16095  bacC; bacitracin synthase 3"
				}
				]
			},
			{
				"name":"Viomycin synthetase",
				"children":[
				{
					"name":"K16099  vioA; nonribosomal peptide synthetase protein VioA"
				},
				{
					"name":"K16098  vioF; nonribosomal peptide synthetase protein VioF"
				},
				{
					"name":"K16101  vioG; nonribosomal peptide synthetase protein VioG"
				},
				{
					"name":"K16100  vioI; nonribosomal peptide synthetase protein VioI"
				},
				{
					"name":"K16103  vioM; nonribosomal peptide synthetase protein VioM"
				},
				{
					"name":"K16102  vioO; nonribosomal peptide synthetase protein VioO"
				}
				]
			},
			{
				"name":"Pristinamycin I synthetase",
				"children":[
				{
					"name":"K16116  snbA; pristinamycin I synthetase 1"
				},
				{
					"name":"K16117  snbC; pristinamycin I synthase 2"
				},
				{
					"name":"K16118  snbDE; pristinamycin I synthase 3 and 4"
				}
				]
			},
			{
				"name":"Tyrocidine synthetase",
				"children":[
				{
					"name":"K16122  tycA; tyrocidine synthetase I"
				},
				{
					"name":"K16123  tycB; tyrocidine synthetase II"
				},
				{
					"name":"K16124  tycC; tyrocidine synthetase III"
				}
				]
			},
			{
				"name":"Surfactin family lipopeptide synthetase",
				"children":[
				{
					"name":"K15654  srfAA, licA, lchAA; surfactin\/lichenysin synthetase A"
				},
				{
					"name":"K15655  srfAB, licB, lchAB; surfactin\/lichenysin synthetase B"
				},
				{
					"name":"K15656  srfAC, licC, lchAC; surfactin\/lichenysin synthetase C"
				}
				]
			},
			{
				"name":"Iturin family lipopeptide synthetase",
				"children":[
				{
					"name":"K15661  ituA, mycA, bmyA; iturin family lipopeptide synthetase A"
				},
				{
					"name":"K15662  ituB, mycB, bmyB; iturin family lipopeptide synthetase B"
				},
				{
					"name":"K15663  ituC, mycC, bmyC; iturin family lipopeptide synthetase C"
				}
				]
			},
			{
				"name":"Fengycin family lipopeptide synthetase",
				"children":[
				{
					"name":"K15664  ppsA, fenC; plipastatin\/fengycin lipopeptide synthetase A"
				},
				{
					"name":"K15665  ppsB, fenD; plipastatin\/fengycin lipopeptide synthetase B"
				},
				{
					"name":"K15666  ppsC, fenE; plipastatin\/fengycin lipopeptide synthetase C"
				},
				{
					"name":"K15667  ppsD, fenA; plipastatin\/fengycin lipopeptide synthetase D"
				},
				{
					"name":"K15668  ppsE, fenB; plipastatin\/fengycin lipopeptide synthetase E"
				}
				]
			},
			{
				"name":"Arthrofactin type cyclic lipopeptide synthetase",
				"children":[
				{
					"name":"K15658  ofaA, arfA; arthrofactin-type cyclic lipopeptide synthetase A"
				},
				{
					"name":"K15659  ofaB, arfB; arthrofactin-type cyclic lipopeptide synthetase B"
				},
				{
					"name":"K15660  ofaC, arfC; arthrofactin-type cyclic lipopeptide synthetase C"
				}
				]
			},
			{
				"name":"Vancomycin synthetase",
				"children":[
				{
					"name":"K16428  cepA; nonribosomal peptide synthetase CepA"
				},
				{
					"name":"K16429  cepB; nonribosomal peptide synthetase CepB"
				},
				{
					"name":"K16430  cepC; nonribosomal peptide synthetase CepC"
				},
				{
					"name":"K16432  cepK; nonribosomal peptide synthetase CepK"
				}
				]
			},
			{
				"name":"Nocardicin synthetase",
				"children":[
				{
					"name":"K19102  nocA; nocardicin nonribosomal peptide synthetase NocA"
				},
				{
					"name":"K19103  nocB; nocardicin nonribosomal peptide synthetase NocB"
				},
				{
					"name":"K05375  mbtH, nocI; MbtH protein"
				}
				]
			},
			{
				"name":"Bialaphos synthetase",
				"children":[
				{
					"name":"K12911  phsA; phosphinothricin tripeptide synthetase PhsA"
				},
				{
					"name":"K12912  phsB; phosphinothricin tripeptide synthetase phsB [EC:6.2.1.67]"
				},
				{
					"name":"K12913  phsC; phosphinothricin tripeptide synthetase PhsC"
				}
				]
			},
			{
				"name":"L-2-amino-4-methoxy-trans-3-butenoic acid synthetase",
				"children":[
				{
					"name":"K25233  ambB; L-alanine---[L-alanyl-carrier protein] ligase [EC:6.2.1.67]"
				},
				{
					"name":"K25234  ambE; L-glutamate---[L-glutamyl-carrier protein] ligase [EC:6.2.1.68]"
				}
				]
			},
			{
				"name":"Anabaenopeptin synthetase",
				"children":[
				{
					"name":"K28594  aptA; anabaenopeptin synthetase AptA"
				},
				{
					"name":"K28595  aptB; anabaenopeptin synthetase AptB"
				},
				{
					"name":"K28596  aptC; anabaenopeptin synthetase AptC"
				},
				{
					"name":"K28597  aptD; anabaenopeptin synthetase AptD"
				}
				]
			},
			{
				"name":"Linear gramicidin synthetase",
				"children":[
				{
					"name":"K28600  lgrA; linear gramicidin synthase LgrA"
				},
				{
					"name":"K28601  lgrB; linear gramicidin synthase LgrB"
				},
				{
					"name":"K28602  lgrC; linear gramicidin synthase LgrC"
				},
				{
					"name":"K28603  lgrD; linear gramicidin synthase LgrD"
				}
				]
			}
			]
		},
		{
			"name":"Iterative NRPS",
			"children":[
			{
				"name":"Enterobactin synthetase",
				"children":[
				{
					"name":"K01252  entB, dhbB, vibB, mxcF; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"K02362  entD, pptT; enterobactin synthetase component D \/ holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]"
				},
				{
					"name":"K02363  entE, dhbE, vibE, mxcE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"K02364  entF; L-serine---[L-seryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.72]"
				},
				{
					"name":"K24147  entH; proofreading thioesterase EntH"
				}
				]
			},
			{
				"name":"Bacillibactin synthetase",
				"children":[
				{
					"name":"K01252  entB, dhbB, vibB, mxcF; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"K02363  entE, dhbE, vibE, mxcE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"K04780  dhbF; glyine---[glycyl-carrier protein] ligase [EC:6.2.1.66]"
				}
				]
			},
			{
				"name":"Gramicidin synthetase",
				"children":[
				{
					"name":"K16096  grsA; gramicidin S synthase 1"
				},
				{
					"name":"K16097  grsB; gramicidin S synthase 2"
				}
				]
			}
			]
		},
		{
			"name":"Nonlinear NRPS",
			"children":[
			{
				"name":"Yersiniabactin synthetase",
				"children":[
				{
					"name":"K04786  irp1, HMWP1; yersiniabactin nonribosomal peptide\/polyketide synthase"
				},
				{
					"name":"K04784  irp2, HMWP2; yersiniabactin nonribosomal peptide synthetase"
				},
				{
					"name":"K04783  irp5, ybtE; yersiniabactin salicyl-AMP ligase [EC:6.3.2.-]"
				}
				]
			},
			{
				"name":"Pyochelin synthetase",
				"children":[
				{
					"name":"K12238  pchD; salicylate---[aryl-carrier protein] ligase [EC:6.2.1.61]"
				},
				{
					"name":"K12239  pchE; L-cysteine---[L-cysteinyl-carrier protein] ligase PchE [EC:6.2.1.69]"
				},
				{
					"name":"K12240  pchF; L-cysteine---[L-cysteinyl-carrier protein] ligase PchF [EC:6.2.1.69]"
				}
				]
			},
			{
				"name":"Mycobactin synthetase",
				"children":[
				{
					"name":"K04787  mbtA; mycobactin salicyl-AMP ligase [EC:6.3.2.-]"
				},
				{
					"name":"K04788  mbtB; mycobactin phenyloxazoline synthetase"
				},
				{
					"name":"K04790  mbtC; mycobactin polyketide synthetase MbtC"
				},
				{
					"name":"K04791  mbtD; mycobactin polyketide synthetase MbtD"
				},
				{
					"name":"K04789  mbtE; mycobactin peptide synthetase MbtE"
				},
				{
					"name":"K04792  mbtF; mycobactin peptide synthetase MbtF"
				}
				]
			},
			{
				"name":"Vibriobactin synthetase",
				"children":[
				{
					"name":"K01252  entB, dhbB, vibB, mxcF; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"K02363  entE, dhbE, vibE, mxcE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"K12237  vibF; nonribosomal peptide synthetase VibF"
				},
				{
					"name":"K04778  vibH; vibriobactin synthetase"
				}
				]
			},
			{
				"name":"Myxochelin synthetase",
				"children":[
				{
					"name":"K02363  entE, dhbE, vibE, mxcE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"K01252  entB, dhbB, vibB, mxcF; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"K15653  mxcG; nonribosomal peptide synthetase MxcG"
				}
				]
			},
			{
				"name":"Petrobacin synthetase",
				"children":[
				{
					"name":"K24110  asbC; 3,4-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.2.1.62]"
				},
				{
					"name":"K24111  asbD; aryl carrier protein AsbD"
				},
				{
					"name":"K24112  asbE; petrobactin synthase [EC:2.-.-.-]"
				}
				]
			},
			{
				"name":"Syringomycin synthetase",
				"children":[
				{
					"name":"K16126  syrB1; L-threonine---[L-threonyl-carrier protein] ligase [EC:6.2.1.70]"
				},
				{
					"name":"K16125  syrE; syringomycin synthetase protein SyrE"
				}
				]
			},
			{
				"name":"Vanchrobactin synthetase",
				"children":[
				{
					"name":"K01252  entB, dhbB, vibB, mxcF; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"K02363  entE, dhbE, vibE, mxcE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"K24101  vabF; L-arginine---[L-arginyl-carrier protein] ligase [EC:6.2.1.63]"
				}
				]
			},
			{
				"name":"Isonitrile lipopeptide synthase",
				"children":[
				{
					"name":"K28321  scoA; isonitrile lipopeptide synthase \/ L-lysine---[L-lysyl-carrier protein] ligase [EC:2.3.1.329 6.2.1.77]"
				},
				{
					"name":"K28320  mmaA; isonitrile lipopeptide synthase [EC:2.3.1.329]"
				},
				{
					"name":"K28329  mmaB; acyl carrier protein"
				},
				{
					"name":"K12422  fadD10; medium\/long-chain-fatty-acid---[acyl-carrier-protein] ligase FadD10 [EC:6.2.1.-]"
				},
				{
					"name":"K26055  scoD, mmaD; (3R)-3-[(carboxylmethyl)amino]fatty acid synthase [EC:4.3.2.11]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Polyketide tailoring proteins",
		"children":[
		{
			"name":"Hydrolase",
			"children":[
			{
				"name":"K15318  APTB; hydrolase"
			},
			{
				"name":"K15315  sgcE10, mdpE10, ncsE10, kedE10, calE7, pksE10; enediyne core biosynthesis thioesterase"
			}
			]
		},
		{
			"name":"Ketoreductase",
			"children":[
			{
				"name":"K14373  aveF; C-5 ketoreductase"
			},
			{
				"name":"K05556  actVI1, RED1; ketoreductase RED1 [EC:1.1.1.-]"
			},
			{
				"name":"K14633  gra6, RED2; ketoreductase RED2 [EC:1.1.1.-]"
			}
			]
		},
		{
			"name":"Oxygenase",
			"children":[
			{
				"name":"K14366  eryF, CYP107A; 6-deoxyerythronolide B hydroxylase [EC:1.14.15.35]"
			},
			{
				"name":"K14370  eryK, CYP113A; erythromycin 12 hydroxylase [EC:1.14.13.154]"
			},
			{
				"name":"K16008  oleP, CYP107D; cytochrome P450 monooxygenase OleP"
			},
			{
				"name":"K16006  pikC, CYP107L; pikromycin synthase [EC:1.14.15.33]"
			},
			{
				"name":"K14372  aveE, CYP171A; cytochrome P450 hydroxylase [EC:1.14.-.-]"
			},
			{
				"name":"K15992  tylI, CYP113B; cytochrome P450 TylI"
			},
			{
				"name":"K15991  tylHI, CYP105L1; 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase [EC:1.14.15.34]"
			},
			{
				"name":"K16022  rif19; flavoprotein hydroxylase"
			},
			{
				"name":"K20789  CYP140A7; cytochrome P450 hydroxylase [EC:1.14.-.-]"
			},
			{
				"name":"K24292  mycCI, CYP105L2; mycinamicin VIII C21 methyl hydroxylase [EC:1.14.-.-]"
			},
			{
				"name":"K24390  mycG, CYP107E1; mycinamicin IV hydroxylase\/epoxidase [EC:1.14.-.-]"
			},
			{
				"name":"K16379  fkbD, rapJ; cytochrome P450 C-9 hydroxylase"
			},
			{
				"name":"K16380  rapN; cytochrome P450 RapN"
			},
			{
				"name":"K16389  amphN, nysN, fscP, pimG; cytochrome P450 monooxygenase"
			},
			{
				"name":"K16390  amphL, nysL, pimD; cytochrome P450 monooxygenase"
			},
			{
				"name":"K16400  epoK; cytochrome P450 enzyme"
			},
			{
				"name":"K14630  actVA5; two-component flavin-dependent monooxygenase [EC:1.14.14.-]"
			},
			{
				"name":"K14632  actVA6; C-6 monooxygenase"
			},
			{
				"name":"K20420  ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]"
			},
			{
				"name":"K21184  sgcC, mdpC; two-component FAD-dependent monooxygenase [EC:1.14.14.15 1.14.14.-]"
			},
			{
				"name":"K21159  sgcF, ncsF2, kedF; epoxide hydrolase"
			},
			{
				"name":"K21222  kedN3; cytochrome P450 monooxygenase [EC:1.14.-.-]"
			},
			{
				"name":"K21257  calO2; orsellenic acid P450 oxidase [EC:1.14.-.-]"
			},
			{
				"name":"K14253  oxyE; 6-methylpretetramide 4-monooxygenase [EC:1.14.13.232]"
			},
			{
				"name":"K14252  oxyL; 6-methylpretetramide 4-monooxygenase \/ 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233]"
			},
			{
				"name":"K14256  oxyS, cts8; anhydrotetracycline 6-monooxygenase \/ 5a,11a-dehydrotetracycline 5-monooxygenase [EC:1.14.13.38 1.14.13.234]"
			},
			{
				"name":"K15941  snoaB, dnrG, aknX; deoxynogalonate \/ 12-deoxyaklanonic acid monooxygenase [EC:1.13.12.22 1.13.12.-]"
			},
			{
				"name":"K15966  mtmOIV; monooxygenase [EC:1.14.13.-]"
			},
			{
				"name":"K15969  tcmH; tetracenomycin F1 monooxygenase [EC:1.13.12.21]"
			},
			{
				"name":"K15972  tcmG, elmG; tetracenomycin A2 monooxygenase-dioxygenase [EC:1.14.13.200]"
			},
			{
				"name":"K16427  dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]"
			},
			{
				"name":"K14673  whiEII; putative monooxygenase"
			},
			{
				"name":"K14672  whiEVIII; putative polyketide hydroxylase"
			},
			{
				"name":"K15468  pksS, CYP107K1; cytochrome P450 family 107 subfamily K polypeptide 1"
			},
			{
				"name":"K15470  rhiH; cytochrome P450 monooxygenase"
			},
			{
				"name":"K16415  stiL; cytochrome P450 dependent monooxygenase"
			},
			{
				"name":"K15319  APTC; monooxygenase"
			},
			{
				"name":"K15386  APDB, CYP685A1; cytochrome P450 monooxygenase"
			},
			{
				"name":"K15387  APDD; FAD-dependent monooxygenase"
			},
			{
				"name":"K15388  APDE, CYP655; cytochrome P450 monooxygenase"
			}
			]
		},
		{
			"name":"Methylase",
			"children":[
			{
				"name":"K14369  eryG; erythromycin 3''-O-methyltransferase [EC:2.1.1.254]"
			},
			{
				"name":"K14374  aveD; avermectin B 5-O-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K16381  fkbM; 31-O-methyltransferase"
			},
			{
				"name":"K15995  tylE; demethylmacrocin O-methyltransferase [EC:2.1.1.102]"
			},
			{
				"name":"K15996  tylF; macrocin O-methyltransferase [EC:2.1.1.101]"
			},
			{
				"name":"K21540  mycE; mycinamicin VI 2''-O-methyltransferase [EC:2.1.1.238]"
			},
			{
				"name":"K21539  mycF; mycinamicin III 3''-O-methyltransferase [EC:2.1.1.237]"
			},
			{
				"name":"K13320  oleY; L-olivosyl-oleandolide 3-O-methyltransferase [EC:2.1.1.239]"
			},
			{
				"name":"K16034  asm7; 20-O-methyltransferase"
			},
			{
				"name":"K16038  asm10; N-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K16028  asm17; O-methyltransferase"
			},
			{
				"name":"K15467  rif14; 27-O-demethylrifamycin SV methyltransferase [EC:2.1.1.315]"
			},
			{
				"name":"K15471  rhiI; O-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K21192  mdpB1; methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K21189  mdpC6; O-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K20421  ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]"
			},
			{
				"name":"K21215  ncsC5; N-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K21178  sgcD4; O-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K21255  calO6; orsellinic acid C2-O-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K21258  calO1; orsellinic acid C3-O-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K21223  kedN1; O-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K21224  kedN5; radical SAM C-methyltransferase"
			},
			{
				"name":"K14251  oxyF; C-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K14255  oxyT, ctcO, cts6; 4-amino-anhydrotetracycline N4-methyltransferase [EC:2.1.1.335]"
			},
			{
				"name":"K15942  snoaC, dnrC, dauC, aknG; O-methyltransferase \/ aklanonic acid methyltransferase [EC:2.1.1.- 2.1.1.288]"
			},
			{
				"name":"K15959  mtmMI; O-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K15963  mtmMII; C-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K15962  mtmC; D-mycarose 3-C-methyltransferase"
			},
			{
				"name":"K15886  tcmN; multifunctional cyclase \/ dehydratase \/ O-methyltransferase [EC:2.3.1.235]"
			},
			{
				"name":"K15970  tcmO; 8-O-methyltransferase"
			},
			{
				"name":"K15971  tcmP, elmP; O-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K19567  elmMI; 8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase [EC:2.1.1.305]"
			},
			{
				"name":"K19568  elmMII; 8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase [EC:2.1.1.306]"
			},
			{
				"name":"K19569  elmMIII; 8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase [EC:2.1.1.307]"
			},
			{
				"name":"K19570  elmD; 8-demethyl-8-(2,3,4-trimethoxy-alpha-L-rhamnosyl)tetracenomycin-C O-methyltransferase [EC:2.1.1.-]"
			},
			{
				"name":"K16168  bpsB, srsB; methyltransferase"
			},
			{
				"name":"K16403  sorM; O-methyltransferase"
			},
			{
				"name":"K16414  stiK; methyltransferase"
			}
			]
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"K14367  eryBV; erythronolide mycarosyltransferase [EC:2.4.1.328]"
			},
			{
				"name":"K14368  eryCIII; 3-alpha-mycarosylerythronolide B desosaminyl transferase [EC:2.4.1.278]"
			},
			{
				"name":"K15997  eryCII; 3-alpha-mycarosylerythronolide B desosaminyl transferase auxiliary protein"
			},
			{
				"name":"K14375  aveBI; dTDP-L-oleandrosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K16004  desVII; narbonolide\/10-deoxymethynolide desosaminyltransferase [EC:2.4.1.277]"
			},
			{
				"name":"K16005  desVIII; narbonolide\/10-deoxymethynolide desosaminyltransferase auxiliary protein"
			},
			{
				"name":"K15989  tylMII; tylactone mycaminosyltransferase [EC:2.4.1.316]"
			},
			{
				"name":"K15990  tylMIII; tylactone mycaminosyltransferase auxiliary protein"
			},
			{
				"name":"K15993  tylN; O-mycaminosyltylonolide 6-deoxyallosyltransferase [EC:2.4.1.317]"
			},
			{
				"name":"K15994  tylCV; demethyllactenocin mycarosyltransferase [EC:2.4.1.318]"
			},
			{
				"name":"K24529  mycB; protomycinolide IV desosaminyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K24531  mycD; mycinamicin VII 6-deoxyallosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K16009  oleGII; glycosyltransferase OleGII"
			},
			{
				"name":"K16010  oleGI; desosaminyltransferase OleGI"
			},
			{
				"name":"K16388  amphDI, nysDI, fscMI, pimK; polyene glycosyltransferase"
			},
			{
				"name":"K16039  asm25; N-glycosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K21216  ncsC6; glycosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K21187  sgcA6; glycosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K21194  mdpA6; glycosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K21229  kedS6; glycosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K21230  kedS10; glycosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K21259  calG3; calicheamicinone 4-hydroxyamino-4,6-dideoxy-alpha-D-glucosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K21260  calG2; calicheamicin 4-deoxy-4-thio-alpha-D-digitoxosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K21262  calG4; calicheamicin aminopentosyltransferase [EC:2.4.2.-]"
			},
			{
				"name":"K21263  calG1; calicheamicin 3'-O-methyl-rhamnosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K15960  mtmGIV; glycosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K15961  mtmGIII; glycosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K15964  mtmGI; glycosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K15965  mtmGII; glycosyltransferase [EC:2.4.1.-]"
			},
			{
				"name":"K19566  elmGT; 8-demethyltetracenomycin C L-rhamnosyltransferase [EC:2.4.1.331]"
			}
			]
		},
		{
			"name":"Halogenase",
			"children":[
			{
				"name":"K16033  asm12; FADH2-dependent halogenase"
			},
			{
				"name":"K21256  calO3; flavin-dependent halogenase"
			},
			{
				"name":"K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase [EC:1.14.19.-]"
			},
			{
				"name":"K14257  ctcP, cts4, prnC; tetracycline 7-halogenase \/ FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-]"
			},
			{
				"name":"K15650  cmaB; non-haem Fe2+, alpha-ketoglutarate-dependent halogenase"
			},
			{
				"name":"K28679  syrB2; L-threonyl-[L-threonyl-carrier protein] 4-chlorinase [EC:1.14.20.15]"
			}
			]
		},
		{
			"name":"beta-Branched incorporating proteins",
			"children":[
			{
				"name":"K15327  pksC; polyketide biosynthesis malonyl-CoA-[acyl-carrier-protein] transacylase"
			},
			{
				"name":"K00646  pksF, curC, aprD, corD; malonyl-[acp] decarboxylase [EC:4.1.1.124]"
			},
			{
				"name":"K15337  acpK, curB, aprC, corC; polyketide biosynthesis acyl carrier protein"
			},
			{
				"name":"K15311  pksG, curD, aprE, corE; 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase [EC:2.3.3.22]"
			},
			{
				"name":"K15312  pksH, curE, aprF, corF; 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase [EC:4.2.1.181]"
			},
			{
				"name":"K15313  pksI, corG; 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase [EC:4.1.1.125]"
			},
			{
				"name":"K27305  aprG, curF; polyketide synthase \/ 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase [EC:4.1.1.125]"
			}
			]
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"K16037  asm11; 4,5-epoxidase"
			},
			{
				"name":"K16024  asm13; methoxymalonate biosynthesis protein"
			},
			{
				"name":"K16025  asm14; methoxymalonate biosynthesis acyl carrier protein"
			},
			{
				"name":"K16026  asm15, fkbI; 2-hydroxy-3-oxopropanoyl-[acyl-carrier-protein] 3-hydroxylase [EC:1.2.99.11]"
			},
			{
				"name":"K16027  asm16; methoxymalonate biosynthesis protein"
			},
			{
				"name":"K16036  asm19; 3-O-acyltransferase"
			},
			{
				"name":"K16035  asm21; 7-O-carbamoyltransferase [EC:2.1.3.-]"
			},
			{
				"name":"K15466  rifF, asm9; amide synthase"
			},
			{
				"name":"K16023  rif20; acetyltransferase"
			},
			{
				"name":"K14626  actVIA; actinorhodin biosynthesis protein ActVIA"
			},
			{
				"name":"K14627  actVI3; dehydratase [EC:4.2.1.-]"
			},
			{
				"name":"K14628  actVI2; enoyl reductase"
			},
			{
				"name":"K14629  actVI4; enoyl reductase"
			},
			{
				"name":"K14631  actVB; flavin reductase ActVB [EC:1.5.1.-]"
			},
			{
				"name":"K16378  rapP, fkbP; pipecolate-incorporating enzyme"
			},
			{
				"name":"K15389  APDG; acyl-CoA dehydrogenase"
			},
			{
				"name":"K21160  sgcE2, ncsE2, kedE2; enediyne biosynthesis protein E2"
			},
			{
				"name":"K21161  sgcE3, ncsE3, kedE3; enediyne biosynthesis protein E3"
			},
			{
				"name":"K21162  sgcE4, ncsE4, kedE4; enediyne biosynthesis protein E4"
			},
			{
				"name":"K21163  sgcE5, ncsE5, kedE5; enediyne biosynthesis protein E5"
			},
			{
				"name":"K21164  sgcE7, ncsE7, kedE7; enediyne biosynthesis protein E7"
			},
			{
				"name":"K21165  sgcE8, ncsE8, kedE8; enediyne biosynthesis protein E8"
			},
			{
				"name":"K21166  sgcE9, ncsE9, kedE9; enediyne biosynthesis protein E9"
			},
			{
				"name":"K21167  sgcE11, ncsE11, kedE11; enediyne biosynthesis protein E11"
			},
			{
				"name":"K21168  calE1; enediyne biosynthesis protein CalE1"
			},
			{
				"name":"K21169  calE2; enediyne biosynthesis protein CalE2"
			},
			{
				"name":"K21170  calE3; enediyne biosynthesis protein CalE3"
			},
			{
				"name":"K21171  calE4; enediyne biosynthesis protein CalE4"
			},
			{
				"name":"K21172  calE5; enediyne biosynthesis protein CalE5"
			},
			{
				"name":"K21173  calE6; methionine gamma-lyase"
			},
			{
				"name":"K21174  calE9; enediyne biosynthesis protein CalE9"
			},
			{
				"name":"K21186  sgcC5, mdpC5, kedY5; condensation enzyme"
			},
			{
				"name":"K21180  sgcD6; 3-O-acyltransferase"
			},
			{
				"name":"K21185  sgcE6, mdpE6, kedE6; flavin reductase"
			},
			{
				"name":"K21191  mdpB2; CoA ligase [EC:6.2.1.-]"
			},
			{
				"name":"K21193  mdpB3; acetyltransferase\/esterase"
			},
			{
				"name":"K21190  mdpC8; dehydrogenase"
			},
			{
				"name":"K20423  ncsB2; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase [EC:6.2.1.43]"
			},
			{
				"name":"K21209  ncsB4; acyltransferase"
			},
			{
				"name":"K21225  kedN2; acyl-CoA synthetase"
			},
			{
				"name":"K21226  kedN4; acyl-CoA N-acyltransferase"
			},
			{
				"name":"K21261  calO4; acyltransferase"
			},
			{
				"name":"K14254  oxyQ; aminotransferase"
			},
			{
				"name":"K21301  oxyR, ctcR; 5a,11a-dehydrotetracycline reductase [EC:1.3.98.4]"
			},
			{
				"name":"K21297  ctcQ; flavin reductase (NADH) [EC:1.5.1.36]"
			},
			{
				"name":"K15943  snoaL, dnrD, dauD, aknH; nogalonic acid methyl ester cyclase \/ aklanonic acid methyl ester cyclase [EC:5.5.1.26 5.5.1.23]"
			},
			{
				"name":"K15944  snoaF, dnrE, dauE, aknU; nogalaviketone\/aklaviketone reductase [EC:1.1.1.- 1.1.1.362]"
			},
			{
				"name":"K15967  mtmW; ketoreductase"
			},
			{
				"name":"K15968  tcmI; tetracenomycin F2 cyclase [EC:4.2.1.154]"
			},
			{
				"name":"K14244  oxyD; amidotransferase [EC:6.3.5.-]"
			},
			{
				"name":"K15392  CPAD; cyclo-acetoacetyl-L-tryptophan dimethylallyltransferase [EC:2.5.1.-]"
			},
			{
				"name":"K15393  CPAO; beta-cyclopiazonate dehydrogenase [EC:1.21.99.1]"
			},
			{
				"name":"K15651  cmaC; aminocarboxycyclopropane-forming enzyme"
			},
			{
				"name":"K16404  sorR; reductase"
			},
			{
				"name":"K26570  clbQ; colibactin biosynthesis thioesterase"
			},
			{
				"name":"K26571  clbL; colibactin biosynthesis amidase"
			},
			{
				"name":"K26579  clbP; colibactin biosynthesis peptidase"
			},
			{
				"name":"K23875  tmlU; marinolic acid---CoA ligase [EC:6.2.1.60]"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide tailoring proteins",
		"children":[
		{
			"name":"Reductase",
			"children":[
			{
				"name":"K04785  irp3, ybtU; yersiniabactin synthetase, thiazolinyl reductase component"
			},
			{
				"name":"K12241  pchG; pyochelin biosynthesis protein PchG"
			}
			]
		},
		{
			"name":"Thioesterase",
			"children":[
			{
				"name":"K05374  irp4, ybtT; yersiniabactin synthetase, thioesterase component"
			},
			{
				"name":"K12242  pchC; pyochelin biosynthesis protein PchC"
			},
			{
				"name":"K15657  srfATE, srfAD, lchAD; external thioesterase TEII"
			},
			{
				"name":"K16434  cepJ; thioesterase CepJ"
			},
			{
				"name":"K28742  TPCB, ACTE; atrochrysone-2-carbonyl-[acyl-carrier protein] thioesterase [EC:3.1.2.34]"
			},
			{
				"name":"K28743  SPOB; 6-hydroxymusizin-2-carbonyl-[acyl-carrier protein] thioesterase [EC:3.1.2.35]"
			}
			]
		},
		{
			"name":"Oxygenase",
			"children":[
			{
				"name":"K04793  mbtG; mycobactin lysine-N-oxygenase"
			},
			{
				"name":"K16445  cepE, oxyA, CYP165A3; oxidation protein CepE"
			},
			{
				"name":"K16446  cepF, oxyB, CYP165B3; oxidation protein CepF"
			},
			{
				"name":"K16447  cepG, oxyC, CYP165C4; oxidation protein CepG"
			},
			{
				"name":"K19106  nocL; nocardicin C N-oxygenase [EC:1.14.15.43]"
			}
			]
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"K16440  gtfA; chloroorienticin B synthase [EC:2.4.1.311]"
			},
			{
				"name":"K16444  gtfB, gtfE; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]"
			},
			{
				"name":"K16443  gtfD; desvancosaminyl-vancomycin vancosaminetransferase [EC:2.4.1.322]"
			}
			]
		},
		{
			"name":"Aminotransferase",
			"children":[
			{
				"name":"K15681  mxcL; aminotransferase MxcL"
			},
			{
				"name":"K16423  hpgT, nocG; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103]"
			}
			]
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"K28586  EASC; acyltransferase [EC:2.3.1.-]"
			},
			{
				"name":"K28587  EASD; acyl-CoA ligase [EC:6.2.1.-]"
			},
			{
				"name":"K04126  PCBC; isopenicillin-N synthase [EC:1.21.3.1]"
			},
			{
				"name":"K10852  PENDE; isopenicillin-N N-acyltransferase [EC:2.3.1.164]"
			},
			{
				"name":"K04127  cefD; isopenicillin-N epimerase [EC:5.1.1.17]"
			},
			{
				"name":"K12744  cefE; deacetoxycephalosporin-C synthase [EC:1.14.20.1]"
			},
			{
				"name":"K12745  cefF; deacetoxycephalosporin-C hydroxylase [EC:1.14.11.26]"
			},
			{
				"name":"K04128  cmcH; hydroxymethyl cephem carbamoyltransferase [EC:2.1.3.7]"
			},
			{
				"name":"K18062  cmcI; cephamycin C biosynthesis protein"
			},
			{
				"name":"K18063  cmcJ; cephamycin C biosynthesis protein"
			},
			{
				"name":"K16104  vioJ; 2,3-diaminopropionyl alpha,beta-desaturase"
			},
			{
				"name":"K16105  vioL; carbamoyltransferase"
			},
			{
				"name":"K16114  blmE; glycosyl transferase protein BlmE"
			},
			{
				"name":"K16115  blmF; glycosyl transferase \/ beta-hydroxylase protein BlmF"
			},
			{
				"name":"K16433  cepL; hydroxylation protein CepL"
			},
			{
				"name":"K19104  nat; isonocardicin synthase [EC:2.5.1.38]"
			},
			{
				"name":"K19105  nocJ; nocardicin-A epimerase [EC:5.1.1.14]"
			},
			{
				"name":"K16421  hmaS, nocF; 4-hydroxymandelate synthase [EC:1.13.11.46]"
			},
			{
				"name":"K16422  hmo, nocN; 4-hydroxymandelate oxidase [EC:1.1.3.46]"
			},
			{
				"name":"K16425  dpgB; isomerase DpgB"
			},
			{
				"name":"K16427  dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]"
			},
			{
				"name":"K16426  dpgD; dehydration protein DpgD"
			},
			{
				"name":"K16442  gtfC; glycosyltransferase GtfC"
			},
			{
				"name":"K16448  mtfA; methylation protein MtfA"
			},
			{
				"name":"K16133  mcyI; microcystin synthetase protein McyI"
			},
			{
				"name":"K24530  mycCII; ferredoxin"
			},
			{
				"name":"K01779  racD; aspartate racemase [EC:5.1.1.13]"
			},
			{
				"name":"K16134  mcyJ; microcystin synthetase protein McyJ"
			},
			{
				"name":"K28713  OMT1; atrochrysone 6-O-methyltransferase [EC:2.1.1.404]"
			}
			]
		}
		]
	}
	]
}