{
	"name":"ko04031",
	"children":[
	{
		"name":"Heterotrimeric G-proteins",
		"children":[
		{
			"name":"Alpha Subunits",
			"children":[
			{
				"name":"Alpha type 1 (Gi\/o) [OT]",
				"children":[
				{
					"name":"K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha"
				},
				{
					"name":"K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha"
				},
				{
					"name":"K04631  GNAT1_2; guanine nucleotide-binding protein G(t) subunit alpha 1\/2"
				},
				{
					"name":"K19729  GNAT3; guanine nucleotide-binding protein G(t) subunit alpha 3"
				},
				{
					"name":"K04535  GNAZ; guanine nucleotide-binding protein G(z) subunit alpha"
				}
				]
			},
			{
				"name":"Alpha type 2 (Gs)",
				"children":[
				{
					"name":"K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha"
				},
				{
					"name":"K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha"
				}
				]
			},
			{
				"name":"Alpha type 3 (Gq\/11) [OT]",
				"children":[
				{
					"name":"K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha"
				},
				{
					"name":"K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11"
				},
				{
					"name":"K04636  GNA14; guanine nucleotide-binding protein subunit alpha-14"
				},
				{
					"name":"K04637  GNA15; guanine nucleotide-binding protein subunit alpha-15"
				}
				]
			},
			{
				"name":"Alpha type 4 (G12\/13)",
				"children":[
				{
					"name":"K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12"
				},
				{
					"name":"K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13"
				}
				]
			},
			{
				"name":"Alpha others - lower eukaryotes",
				"children":[
				{
					"name":"K19860  GPA1; guanine nucleotide-binding protein alpha-1 subunit"
				},
				{
					"name":"K04640  GNA; guanine nucleotide-binding protein subunit alpha, other"
				}
				]
			}
			]
		},
		{
			"name":"Beta Subunits",
			"children":[
			{
				"name":"Beta [OT]",
				"children":[
				{
					"name":"K04536  GNB1; guanine nucleotide-binding protein G(I)\/G(S)\/G(T) subunit beta-1"
				},
				{
					"name":"K04537  GNB2; guanine nucleotide-binding protein G(I)\/G(S)\/G(T) subunit beta-2"
				},
				{
					"name":"K07825  GNB3; guanine nucleotide-binding protein G(I)\/G(S)\/G(T) subunit beta-3"
				},
				{
					"name":"K04538  GNB4; guanine nucleotide-binding protein subunit beta-4"
				},
				{
					"name":"K04539  GNB5; guanine nucleotide-binding protein subunit beta-5"
				},
				{
					"name":"K07972  GNB; guanine nucleotide-binding protein subunit beta, other"
				}
				]
			}
			]
		},
		{
			"name":"Gamma Subunits",
			"children":[
			{
				"name":"Gamma [OT]",
				"children":[
				{
					"name":"K07826  GNG2; guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-2"
				},
				{
					"name":"K04540  GNG3; guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-3"
				},
				{
					"name":"K04541  GNG4; guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-4"
				},
				{
					"name":"K04542  GNG5; guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-5"
				},
				{
					"name":"K04543  GNG7; guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-7"
				},
				{
					"name":"K04544  GNG8; guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-8"
				},
				{
					"name":"K04545  GNG10; guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-10"
				},
				{
					"name":"K04546  GNG11; guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-11"
				},
				{
					"name":"K04347  GNG12; guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-12"
				},
				{
					"name":"K04547  GNG13; guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-13"
				},
				{
					"name":"K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1"
				},
				{
					"name":"K04549  GNGT2; guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-T2"
				},
				{
					"name":"K24772  GG1_2; guanine nucleotide-binding protein subunit gamma 1\/2, plant"
				},
				{
					"name":"K24773  GG3; guanine nucleotide-binding protein subunit gamma 3, plant"
				},
				{
					"name":"K07973  GNG; guanine nucleotide-binding protein subunit gamma, fungi"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Small (monomeric) G-proteins",
		"children":[
		{
			"name":"Ras Family",
			"children":[
			{
				"name":"Ras [OT]",
				"children":[
				{
					"name":"K02833  HRAS; GTPase HRas"
				},
				{
					"name":"K07827  KRAS, KRAS2; GTPase KRas"
				},
				{
					"name":"K07828  NRAS; GTPase NRas"
				},
				{
					"name":"K17196  ERAS; GTPase Eras"
				},
				{
					"name":"K07829  RRAS; Ras-related protein R-Ras"
				},
				{
					"name":"K07830  RRAS2, TC21; Ras-related protein R-Ras2"
				},
				{
					"name":"K07831  MRAS; Ras-related protein M-Ras"
				}
				]
			},
			{
				"name":"Rit",
				"children":[
				{
					"name":"K07832  RIT1; Ras-like without CAAX 1"
				},
				{
					"name":"K07833  RIT2, RIN; Ras-like without CAAX 2"
				}
				]
			},
			{
				"name":"Ral",
				"children":[
				{
					"name":"K07834  RALA; Ras-related protein Ral-A"
				},
				{
					"name":"K07835  RALB; Ras-related protein Ral-B"
				}
				]
			},
			{
				"name":"Rap [OT]",
				"children":[
				{
					"name":"K04353  RAP1A; Ras-related protein Rap-1A"
				},
				{
					"name":"K07836  RAP1B; Ras-related protein Rap-1B"
				},
				{
					"name":"K07837  RAP2A; Ras-related protein Rap-2A"
				},
				{
					"name":"K07838  RAP2B; Ras-related protein Rap-2B"
				},
				{
					"name":"K07839  RAP2C; Ras-related protein Rap-2C"
				}
				]
			},
			{
				"name":"Di-Ras [OT]",
				"children":[
				{
					"name":"K07840  DIRAS1; DIRAS family, GTP-binding Ras-like 1"
				},
				{
					"name":"K07841  DIRAS2; DIRAS family, GTP-binding Ras-like 2"
				},
				{
					"name":"K07842  DIRAS3, NOEY2; DIRAS family, GTP-binding Ras-like 3"
				}
				]
			},
			{
				"name":"RasD",
				"children":[
				{
					"name":"K07843  RASD1; RAS, dexamethasone-induced Ras-related protein 1"
				},
				{
					"name":"K07844  RASD2; RASD family, member 2"
				}
				]
			},
			{
				"name":"Rad\/Gem\/Kir [OT]",
				"children":[
				{
					"name":"K07845  RRAD, RAD1; Ras-related associated with diabetes"
				},
				{
					"name":"K07846  GEM; GTP binding protein overexpressed in skeletal muscle"
				},
				{
					"name":"K07847  REM1; Rad and Gem related GTP binding protein 1"
				},
				{
					"name":"K07848  REM2; Rad and Gem related GTP binding protein 2"
				}
				]
			},
			{
				"name":"Rheb",
				"children":[
				{
					"name":"K07208  RHEB; Ras homolog enriched in brain"
				},
				{
					"name":"K07849  RHEBL1; Ras homolog enriched in brain like 1"
				}
				]
			},
			{
				"name":"Nki-Ras",
				"children":[
				{
					"name":"K17197  NKIRAS; NF-kappa-B inhibitor-interacting Ras-like protein"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"K07850  RASL10A, RRP22; Ras-like protein family member 10A"
				},
				{
					"name":"K07851  RASL10B; Ras-like protein family member 10B"
				},
				{
					"name":"K07852  RASL11A; Ras-like protein family member 11A"
				},
				{
					"name":"K07853  RASL11B; Ras-like protein family member 11B"
				},
				{
					"name":"K07854  RASL12, RIS; Ras-like protein family member 12"
				},
				{
					"name":"K07855  RERG; Ras-related and estrogen-regulated growth inhibitor"
				},
				{
					"name":"K17198  RERGL; Ras-related and estrogen-regulated growth inhibitor-like protein"
				}
				]
			}
			]
		},
		{
			"name":"Rho Family",
			"children":[
			{
				"name":"RhoA\/B\/C [OT]",
				"children":[
				{
					"name":"K04513  RHOA; Ras homolog gene family, member A"
				},
				{
					"name":"K07856  RHOB; Ras homolog gene family, member B"
				},
				{
					"name":"K07857  RHOC; Ras homolog gene family, member C"
				}
				]
			},
			{
				"name":"Rnd [OT]",
				"children":[
				{
					"name":"K07531  RND1; Rho family GTPase 1"
				},
				{
					"name":"K07858  RND2; Rho family GTPase 2"
				},
				{
					"name":"K07859  RND3; Rho family GTPase 3"
				}
				]
			},
			{
				"name":"Rac\/Cdc42 [OT]",
				"children":[
				{
					"name":"K04392  RAC1; Ras-related C3 botulinum toxin substrate 1"
				},
				{
					"name":"K07860  RAC2; Ras-related C3 botulinum toxin substrate 2"
				},
				{
					"name":"K07861  RAC3; Ras-related C3 botulinum toxin substrate 3"
				},
				{
					"name":"K07863  RHOG; Ras homolog gene family, member G"
				},
				{
					"name":"K04393  CDC42; cell division control protein 42"
				},
				{
					"name":"K07864  RHOJ, TCL; Ras homolog gene family, member J"
				},
				{
					"name":"K07194  RHOQ, TC10; Ras homolog gene family, member Q"
				},
				{
					"name":"K07873  RHOH, TTF; Ras homolog gene family, member H"
				},
				{
					"name":"K07865  RHOU, WRCH1; Ras homolog gene family, member U"
				},
				{
					"name":"K07866  RHOV, WRCH2; Ras homolog gene family, member V"
				}
				]
			},
			{
				"name":"RhoBTB",
				"children":[
				{
					"name":"K07868  RHOBTB1_2; Rho-related BTB domain-containing protein 1\/2"
				}
				]
			},
			{
				"name":"Miro",
				"children":[
				{
					"name":"K07870  RHOT1, ARHT1; mitochondrial Rho GTPase 1 [EC:3.6.5.-]"
				},
				{
					"name":"K07871  RHOT2, ARHT2; mitochondrial Rho GTPase 2 [EC:3.6.5.-]"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"K07530  RHOD; Ras homolog gene family, member D"
				},
				{
					"name":"K07872  RHOF, RIF; Ras homolog gene family, member F"
				},
				{
					"name":"K07934  IFT27, RAYL, RABL4; intraflagellar transport protein 27"
				},
				{
					"name":"K07975  K07975; Rho family, other"
				}
				]
			}
			]
		},
		{
			"name":"Rab Family",
			"children":[
			{
				"name":"Rab1\/35 [OT]",
				"children":[
				{
					"name":"K07874  RAB1A; Ras-related protein Rab-1A"
				},
				{
					"name":"K07875  RAB1B; Ras-related protein Rab-1B"
				},
				{
					"name":"K07876  RAB35, RAB1C; Ras-related protein Rab-35"
				}
				]
			},
			{
				"name":"Rab2\/4\/14 [OT]",
				"children":[
				{
					"name":"K07877  RAB2A; Ras-related protein Rab-2A"
				},
				{
					"name":"K07878  RAB2B; Ras-related protein Rab-2B"
				},
				{
					"name":"K07879  RAB4A, RAB4; Ras-related protein Rab-4A"
				},
				{
					"name":"K07880  RAB4B; Ras-related protein Rab-4B"
				},
				{
					"name":"K07881  RAB14; Ras-related protein Rab-14"
				}
				]
			},
			{
				"name":"Rab3\/27 [OT]",
				"children":[
				{
					"name":"K07882  RAB3A; Ras-related protein Rab-3A"
				},
				{
					"name":"K06108  RAB3B; Ras-related protein Rab-3B"
				},
				{
					"name":"K07883  RAB3C; Ras-related protein Rab-3C"
				},
				{
					"name":"K07884  RAB3D; Ras-related protein Rab-3D"
				},
				{
					"name":"K07885  RAB27A; Ras-related protein Rab-27A"
				},
				{
					"name":"K07886  RAB27B; Ras-related protein Rab-27B"
				}
				]
			},
			{
				"name":"Rab5\/17\/22\/31 [OT]",
				"children":[
				{
					"name":"K07887  RAB5A; Ras-related protein Rab-5A"
				},
				{
					"name":"K07888  RAB5B; Ras-related protein Rab-5B"
				},
				{
					"name":"K07889  RAB5C; Ras-related protein Rab-5C"
				},
				{
					"name":"K07909  RAB17; Ras-related protein Rab-17"
				},
				{
					"name":"K07891  RAB22; Ras-related protein Rab-22"
				}
				]
			},
			{
				"name":"Rab6\/41 [OT]",
				"children":[
				{
					"name":"K07893  RAB6A_C_D; Ras-related protein Rab-6A\/C\/D [EC:3.6.5.2]"
				},
				{
					"name":"K07894  RAB6B; Ras-related protein Rab-6B [EC:3.6.5.2]"
				},
				{
					"name":"K07896  RAB41; Ras-related protein Rab-41"
				}
				]
			},
			{
				"name":"Rab7\/9 [OT]",
				"children":[
				{
					"name":"K07897  RAB7A, YPT7; Ras-related protein Rab-7A [EC:3.6.5.2]"
				},
				{
					"name":"K07898  RAB7B; Ras-related protein Rab-7B"
				},
				{
					"name":"K07899  RAB9A, RAB9; Ras-related protein Rab-9A"
				},
				{
					"name":"K07900  RAB9B; Ras-related protein Rab-9B"
				}
				]
			},
			{
				"name":"Rab8\/10\/13 [OT]",
				"children":[
				{
					"name":"K07901  RAB8A, MEL; Ras-related protein Rab-8A"
				},
				{
					"name":"K07902  RAB8B; Ras-related protein Rab-8B"
				},
				{
					"name":"K07903  RAB10; Ras-related protein Rab-10"
				},
				{
					"name":"K06109  RAB13; Ras-related protein Rab-13"
				}
				]
			},
			{
				"name":"Rab11\/25 [OT]",
				"children":[
				{
					"name":"K07904  RAB11A; Ras-related protein Rab-11A"
				},
				{
					"name":"K07905  RAB11B; Ras-related protein Rab-11B"
				},
				{
					"name":"K07906  RAB25; Ras-related protein Rab-25"
				}
				]
			},
			{
				"name":"Rab12\/18",
				"children":[
				{
					"name":"K07907  RAB12; Ras-related protein Rab-12"
				},
				{
					"name":"K07910  RAB18; Ras-related protein Rab-18"
				}
				]
			},
			{
				"name":"Rab15",
				"children":[
				{
					"name":"K07908  RAB15; Ras-related protein Rab-15"
				}
				]
			},
			{
				"name":"Rab19\/30\/43 [OT]",
				"children":[
				{
					"name":"K17047  RAB19; Ras-related protein Rab-19"
				},
				{
					"name":"K07917  RAB30; Ras-related protein Rab-30"
				},
				{
					"name":"K07930  RAB43; Ras-related protein Rab-43"
				}
				]
			},
			{
				"name":"Rab20\/21\/24 [OT]",
				"children":[
				{
					"name":"K07911  RAB20; Ras-related protein Rab-20"
				},
				{
					"name":"K07890  RAB21; Ras-related protein Rab-21"
				},
				{
					"name":"K07912  RAB24; Ras-related protein Rab-24"
				}
				]
			},
			{
				"name":"Rab23",
				"children":[
				{
					"name":"K06234  RAB23; Ras-related protein Rab-23"
				}
				]
			},
			{
				"name":"Rab26\/37",
				"children":[
				{
					"name":"K07913  RAB26; Ras-related protein Rab-26"
				},
				{
					"name":"K07914  RAB37; Ras-related protein Rab-37"
				}
				]
			},
			{
				"name":"Rab28",
				"children":[
				{
					"name":"K07915  RAB28; Ras-related protein Rab-28"
				}
				]
			},
			{
				"name":"Rab29\/32\/38 [OT]",
				"children":[
				{
					"name":"K07916  RAB7L1, RAB7L; Ras-related protein Rab-7L1"
				},
				{
					"name":"K07918  RAB32; Ras-related protein Rab-32"
				},
				{
					"name":"K07923  RAB38; Ras-related protein Rab-38"
				}
				]
			},
			{
				"name":"Rab33",
				"children":[
				{
					"name":"K07919  RAB33A; Ras-related protein Rab-33A"
				},
				{
					"name":"K07920  RAB33B; Ras-related protein Rab-33B"
				}
				]
			},
			{
				"name":"Rab34\/36",
				"children":[
				{
					"name":"K07921  RAB34; Ras-related protein Rab-34"
				},
				{
					"name":"K07922  RAB36; Ras-related protein Rab-36"
				}
				]
			},
			{
				"name":"Rab39\/42 [OT]",
				"children":[
				{
					"name":"K07924  RAB39A; Ras-related protein Rab-39A"
				},
				{
					"name":"K07925  RAB39B; Ras-related protein Rab-39B"
				},
				{
					"name":"K07929  RAB42; Ras-related protein Rab-42"
				}
				]
			},
			{
				"name":"Rab40",
				"children":[
				{
					"name":"K07928  RAB40; Ras-related protein Rab-40"
				}
				]
			},
			{
				"name":"Rab45",
				"children":[
				{
					"name":"K17199  RASEF, RAB45; Ras and EF-hand domain-containing protein"
				}
				]
			},
			{
				"name":"Rab-like",
				"children":[
				{
					"name":"K07931  RABL2; Rab-like protein 2"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"K07976  RAB; Rab family, other"
				}
				]
			}
			]
		},
		{
			"name":"Ran Family",
			"children":[
			{
				"name":"Ran",
				"children":[
				{
					"name":"K07936  RAN; GTP-binding nuclear protein Ran"
				}
				]
			}
			]
		},
		{
			"name":"Arf\/Sar Family",
			"children":[
			{
				"name":"Arf [OT]",
				"children":[
				{
					"name":"K07937  ARF1_2; ADP-ribosylation factor 1\/2"
				},
				{
					"name":"K07938  ARF3; ADP-ribosylation factor 3"
				},
				{
					"name":"K07939  ARF4; ADP-ribosylation factor 4"
				},
				{
					"name":"K07940  ARF5; ADP-ribosylation factor 5"
				},
				{
					"name":"K07941  ARF6; ADP-ribosylation factor 6"
				}
				]
			},
			{
				"name":"Arl1\/Arl5 [OT]",
				"children":[
				{
					"name":"K07942  ARL1; ADP-ribosylation factor-like protein 1"
				},
				{
					"name":"K07949  ARL5A; ADP-ribosylation factor-like protein 5A"
				},
				{
					"name":"K07950  ARL5B; ADP-ribosylation factor-like protein 5B"
				}
				]
			},
			{
				"name":"Arl2\/Arl3",
				"children":[
				{
					"name":"K07943  ARL2; ADP-ribosylation factor-like protein 2"
				},
				{
					"name":"K07944  ARL3; ADP-ribosylation factor-like protein 3"
				}
				]
			},
			{
				"name":"Arl4\/Arl7",
				"children":[
				{
					"name":"K07945  ARL4; ADP-ribosylation factor-like protein 4"
				}
				]
			},
			{
				"name":"Arl6",
				"children":[
				{
					"name":"K07951  ARL6, BBS3; ADP-ribosylation factor-like protein 6"
				}
				]
			},
			{
				"name":"Arp",
				"children":[
				{
					"name":"K07952  ARFRP1; ADP-ribosylation factor related protein 1"
				}
				]
			},
			{
				"name":"Sar",
				"children":[
				{
					"name":"K07953  SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]"
				}
				]
			},
			{
				"name":"Arl8",
				"children":[
				{
					"name":"K07955  ARL8; ADP-ribosylation factor-like protein 8"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"K07957  ARL9; ADP-ribosylation factor-like protein 9"
				},
				{
					"name":"K07958  ARL10; ADP-ribosylation factor-like protein 10"
				},
				{
					"name":"K07959  ARL11; ADP-ribosylation factor-like protein 11"
				},
				{
					"name":"K07960  ARL12; ADP-ribosylation factor-like protein 12"
				},
				{
					"name":"K07961  ARL13A; ADP-ribosylation factor-like protein 13A"
				},
				{
					"name":"K07962  ARL13B, ARL2L1; ADP-ribosylation factor-like protein 13B"
				},
				{
					"name":"K17200  ARL14, ARF7; ADP-ribosylation factor-like protein 14"
				},
				{
					"name":"K17201  ARL15; ADP-ribosylation factor-like protein 15"
				},
				{
					"name":"K07963  TRIM23, ARFD1; tripartite motif-containing protein 23 [EC:2.3.2.27]"
				}
				]
			}
			]
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"K07933  RABL3; Rab-like protein 3"
			},
			{
				"name":"K07935  IFT22, RABL5; intraflagellar transport protein 22"
			},
			{
				"name":"K12272  SRPRB, SRP102; signal recognition particle receptor subunit beta"
			},
			{
				"name":"K24888  GTPBP2; GTP-binding protein 2"
			}
			]
		}
		]
	}
	]
}