{ "name":"mmu03019", "children":[ { "name":"Eukaryotic type", "children":[ { "name":"mRNA processing factors", "children":[ { "name":"5' end processing", "children":[ { "name":"Capping factors", "children":[ { "name":"67897 Rnmt; mRNA cap guanine-N7 methyltransferase isoform 1\tK00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]" }, { "name":"24018 Rngtt; mRNA-capping enzyme isoform 1\tK13917 RNGTT; mRNA-capping enzyme [EC:2.7.7.50 3.6.1.74]" }, { "name":"12572 Cdk7; cyclin-dependent kinase 7\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]" }, { "name":"74157 Cmtr1; cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1\tK14589 CMTR1; cap1 methyltransferase [EC:2.1.1.57]" }, { "name":"234728 Cmtr2; cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2\tK14590 CMTR2; cap2 methyltransferase [EC:2.1.1.296]" }, { "name":"100038538 Ramacl; RNA guanine-N7 methyltransferase activating subunit-like\tK18708 FAM103A1; RNMT-activating mini protein" }, { "name":"100043059 Gm4199; RNA guanine-N7 methyltransferase activating subunit-like\tK18708 FAM103A1; RNMT-activating mini protein" }, { "name":"67148 Ramac; RNA guanine-N7 methyltransferase activating subunit\tK18708 FAM103A1; RNMT-activating mini protein" } ] }, { "name":"Cap binding complex", "children":[ { "name":"433702 Ncbp1; nuclear cap-binding protein subunit 1 isoform 1\tK12882 NCBP1; nuclear cap-binding protein subunit 1" }, { "name":"68092 Ncbp2; nuclear cap-binding protein subunit 2\tK12883 NCBP2; nuclear cap-binding protein subunit 2" } ] } ] }, { "name":"3' end processing", "children":[ { "name":"Pre-mRNA cleavage factor Im (CFIm)", "children":[ { "name":"68219 Nudt21; cleavage and polyadenylation specificity factor subunit 5\tK14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5" }, { "name":"269061 Cpsf7; cleavage and polyadenylation specificity factor subunit 7 isoform 1\tK14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6\/7" }, { "name":"432508 Cpsf6; cleavage and polyadenylation specificity factor subunit 6 isoform 2\tK14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6\/7" } ] }, { "name":"Pre-mRNA cleavage factor IIm (CFIIm)", "children":[ { "name":"98985 Clp1; polyribonucleotide 5'-hydroxyl-kinase Clp1\tK14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]" }, { "name":"74737 Pcf11; pre-mRNA cleavage complex 2 protein Pcf11\tK14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11" } ] }, { "name":"Cleavage and polyadenylation specificity factor (CPSF) complex", "children":[ { "name":"94230 Cpsf1; cleavage and polyadenylation specificity factor subunit 1 isoform 2\tK14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1" }, { "name":"51786 Cpsf2; cleavage and polyadenylation specificity factor subunit 2\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2" }, { "name":"54451 Cpsf3; cleavage and polyadenylation specificity factor subunit 3 isoform 1\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]" }, { "name":"54188 Cpsf4; cleavage and polyadenylation specificity factor subunit 4 isoform c\tK14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4" }, { "name":"66899 Fip1l1; pre-mRNA 3'-end-processing factor FIP1 isoform 1\tK14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1" }, { "name":"74320 Wdr33; pre-mRNA 3' end processing protein WDR33 isoform 1\tK15542 PFS2; polyadenylation factor subunit 2" }, { "name":"77305 Wdr82; WD repeat-containing protein 82\tK14962 WDR82; COMPASS component SWD2" }, { "name":"19045 Ppp1ca; serine\/threonine-protein phosphatase PP1-alpha catalytic subunit\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]" }, { "name":"19046 Ppp1cb; serine\/threonine-protein phosphatase PP1-beta catalytic subunit\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]" }, { "name":"19047 Ppp1cc; serine\/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]" }, { "name":"434233 Ppp1ccb; protein phosphatase 1 catalytic subunit gamma B\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]" }, { "name":"68991 Ssu72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72\tK15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]" } ] }, { "name":"Cleavage stimulation factor (CSTF) complex", "children":[ { "name":"67337 Cstf1; cleavage stimulation factor subunit 1\tK14406 CSTF1; cleavage stimulation factor subunit 1" }, { "name":"108062 Cstf2; cleavage stimulation factor subunit 2 isoform 1\tK14407 CSTF2; cleavage stimulation factor subunit 2" }, { "name":"83410 Cstf2t; cleavage stimulation factor subunit 2 tau variant\tK14407 CSTF2; cleavage stimulation factor subunit 2" }, { "name":"228410 Cstf3; cleavage stimulation factor subunit 3 isoform 1\tK14408 CSTF3; cleavage stimulation factor subunit 3" }, { "name":"68188 Sympk; symplekin isoform 1\tK06100 SYMPK; symplekin" } ] }, { "name":"U7-dependent histone pre-mRNA processing factors", "children":[ { "name":"20638 Snrpb; small nuclear ribonucleoprotein-associated protein B isoform 1\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'" }, { "name":"67332 Snrpd3; small nuclear ribonucleoprotein Sm D3\tK11088 SNRPD3; small nuclear ribonucleoprotein D3" }, { "name":"20643 Snrpe; small nuclear ribonucleoprotein E\tK11097 SNRPE; small nuclear ribonucleoprotein E" }, { "name":"69878 Snrpf; small nuclear ribonucleoprotein F\tK11098 SNRPF; small nuclear ribonucleoprotein F" }, { "name":"108168465 Gm14846; small nuclear ribonucleoprotein G-like\tK11099 SNRPG; small nuclear ribonucleoprotein G" }, { "name":"68011 Snrpg; small nuclear ribonucleoprotein G\tK11099 SNRPG; small nuclear ribonucleoprotein G" }, { "name":"116748 Lsm10; U7 snRNA-associated Sm-like protein LSm10\tK25591 LSM10; U7 snRNA-associated Sm-like protein LSm10" }, { "name":"72290 Lsm11; U7 snRNA-associated Sm-like protein LSm11\tK25592 LSM11; U7 snRNA-associated Sm-like protein LSm11" }, { "name":"51786 Cpsf2; cleavage and polyadenylation specificity factor subunit 2\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2" }, { "name":"54451 Cpsf3; cleavage and polyadenylation specificity factor subunit 3 isoform 1\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]" }, { "name":"108062 Cstf2; cleavage stimulation factor subunit 2 isoform 1\tK14407 CSTF2; cleavage stimulation factor subunit 2" }, { "name":"83410 Cstf2t; cleavage stimulation factor subunit 2 tau variant\tK14407 CSTF2; cleavage stimulation factor subunit 2" }, { "name":"68188 Sympk; symplekin isoform 1\tK06100 SYMPK; symplekin" }, { "name":"20492 Slbp; histone RNA hairpin-binding protein isoform 1\tK18710 SLBP; histone RNA hairpin-binding protein" }, { "name":"666976 Gm8396; histone RNA hairpin-binding protein-like\tK18710 SLBP; histone RNA hairpin-binding protein" }, { "name":"26885 Casp8ap2; CASP8-associated protein 2\tK25593 CASP8AP2; CASP8-associated protein 2" } ] }, { "name":"DRB sensitivity inducing factor (DSIF) complex", "children":[ { "name":"100041294 Supt4b; transcription elongation factor SPT4-B\tK15171 SUPT4H1; transcription elongation factor SPT4" }, { "name":"20922 Supt4a; transcription elongation factor SPT4-A isoform 1\tK15171 SUPT4H1; transcription elongation factor SPT4" }, { "name":"20924 Supt5; transcription elongation factor SPT5 isoform a\tK15172 SUPT5H; transcription elongation factor SPT5" } ] }, { "name":"N6-methyltransferase complex", "children":[ { "name":"56335 Mettl3; N6-adenosine-methyltransferase subunit METTL3\tK05925 METTL3; mRNA m6A methyltransferase catalytic subunit [EC:2.1.1.348]" }, { "name":"210529 Mettl14; N6-adenosine-methyltransferase non-catalytic subunit\tK23960 METTL14; mRNA m6A methyltransferase non-catalytic subunit" }, { "name":"76781 Mettl4; N(6)-adenine-specific methyltransferase METTL4 isoform 1\tK24174 METTL4; N(6)-adenine-specific DNA methyltransferase [EC:2.1.1.72]" }, { "name":"67493 Mettl16; RNA N6-adenosine-methyltransferase METTL16\tK11393 METTL16; U6 snRNA m6A methyltransferase [EC:2.1.1.346]" }, { "name":"60532 Wtap; pre-mRNA-splicing regulator WTAP isoform b\tK22824 WTAP; pre-mRNA-splicing regulator WTAP" }, { "name":"66185 Virma; protein virilizer homolog isoform 2\tK22910 VIRMA; protein virilizer" }, { "name":"109095 Rbm15b; putative RNA-binding protein 15B\tK13190 RBM15; RNA-binding protein 15" }, { "name":"229700 Rbm15; RNA-binding protein 15\tK13190 RBM15; RNA-binding protein 15" }, { "name":"67302 Zc3h13; zinc finger CCCH domain-containing protein 13 isoform 2\tK22909 ZC3H13; zinc finger CCCH domain-containing protein 13" }, { "name":"104836 Cbll1; E3 ubiquitin-protein ligase Hakai isoform 1\tK15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]" } ] }, { "name":"Poly(A) addition factors", "children":[ { "name":"18789 Papola; poly(A) polymerase alpha isoform 1\tK14376 PAP; poly(A) polymerase [EC:2.7.7.19]" }, { "name":"216578 Papolg; poly(A) polymerase gamma\tK14376 PAP; poly(A) polymerase [EC:2.7.7.19]" }, { "name":"56522 Papolb; poly(A) polymerase beta\tK14376 PAP; poly(A) polymerase [EC:2.7.7.19]" }, { "name":"100715 Tent2; poly(A) RNA polymerase GLD2 isoform 1\tK14079 PAPD4; poly(A) RNA polymerase GLD2 [EC:2.7.7.19]" }, { "name":"70044 Tut1; speckle targeted PIP5K1A-regulated poly(A) polymerase\tK18709 TUT1; speckle targeted PIP5K1A-regulated poly(A) polymerase [EC:2.7.7.19 2.7.7.52]" } ] }, { "name":"Negative regulators of mRNA 3' end processing", "children":[ { "name":"12021 Bard1; BRCA1-associated RING domain protein 1 isoform 1\tK10683 BARD1; BRCA1-associated RING domain protein 1" }, { "name":"74213 Rbm26; RNA-binding protein 26 isoform 1\tK13192 RBM26; RNA-binding protein 26" }, { "name":"26383 Fto; alpha-ketoglutarate-dependent dioxygenase FTO\tK19469 FTO; mRNA N6-methyladenine demethylase [EC:1.14.11.53]" }, { "name":"268420 Alkbh5; RNA demethylase ALKBH5\tK10767 ALKBH5; mRNA N6-methyladenine demethylase [EC:1.14.11.53]" }, { "name":"230908 Tardbp; TAR DNA-binding protein 43 isoform 1\tK23600 TARDBP; TAR DNA-binding protein 43" } ] } ] }, { "name":"Other processing factors", "children":[ { "name":"67487 Dhx40; probable ATP-dependent RNA helicase DHX40\tK18711 DHX40; ATP-dependent RNA helicase DHX40 [EC:5.6.2.6]" }, { "name":"16588 Kin; DNA\/RNA-binding protein KIN17 isoform 1\tK13102 KIN; DNA\/RNA-binding protein KIN17" }, { "name":"228019 Mettl8; tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform b\tK24975 METTL8; mRNA N(3)-methylcytidine methyltransferase METTL8 [EC:2.1.1.-]" }, { "name":"239706 Mettl22; methyltransferase-like protein 22 isoform 1\tK23040 METTL22; methyltransferase-like protein 22 [EC:2.1.1.-]" }, { "name":"100342 Tent5b; terminal nucleotidyltransferase 5B\tK23033 TENT5A_B; terminal nucleotidyltransferase 5A\/B [EC:2.7.7.-]" }, { "name":"212943 Tent5a; terminal nucleotidyltransferase 5A isoform 1\tK23033 TENT5A_B; terminal nucleotidyltransferase 5A\/B [EC:2.7.7.-]" }, { "name":"74645 Tent5c; terminal nucleotidyltransferase 5C\tK23034 TENT5C; terminal nucleotidyltransferase 5C [EC:2.7.7.19]" }, { "name":"213449 Tent5d; terminal nucleotidyltransferase 5D\tK23035 TENT5D; terminal nucleotidyltransferase 5D [EC:2.7.7.19]" }, { "name":"75553 Zc3h14; zinc finger CCCH domain-containing protein 14 isoform a\tK23038 ZC3H14; zinc finger CCCH domain-containing protein 14" }, { "name":"83701 Srrt; serrate RNA effector molecule homolog isoform 1\tK27103 SRRT; serrate RNA effector molecule" } ] } ] }, { "name":"mRNA surveillance and transport factors", "children":[ { "name":"Transport factors", "children":[ { "name":"EJC complex", "children":[ { "name":"60365 Rbm8a; RNA-binding protein 8A isoform a\tK12876 RBM8A; RNA-binding protein 8A" }, { "name":"17149 Magoh; protein mago nashi homolog\tK12877 MAGOH; protein mago nashi" }, { "name":"66441 Magohb; protein mago nashi homolog 2 isoform 2\tK12877 MAGOH; protein mago nashi" }, { "name":"100043292 Gm4340; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"100861880 Gm21293; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"100861891 Gm21304; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"100861901 Gm21312; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"21681 Alyref; THO complex subunit 4\tK12881 THOC4; THO complex subunit 4" }, { "name":"56009 Alyref2; aly\/REF export factor 2\tK12881 THOC4; THO complex subunit 4" }, { "name":"627488 Gm6763; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"637578 Gm20765; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"667692 Gm8764; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"53817 Ddx39b; spliceosome RNA helicase Ddx39b\tK12812 DDX39B; ATP-dependent RNA helicase UAP56\/SUB2 [EC:5.6.2.7]" }, { "name":"192170 Eif4a3; eukaryotic initiation factor 4A-III\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]" }, { "name":"434050 Gm5576; eukaryotic initiation factor 4A-III-like\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]" }, { "name":"668137 Eif4a3l1; uncharacterized protein LOC668137\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]" }, { "name":"232236 Ccdc174; coiled-coil domain-containing protein 174\tK25178 CCDC174; coiled-coil domain-containing protein 174" }, { "name":"192160 Casc3; protein CASC3\tK14323 CASC3; protein CASC3" }, { "name":"100041953 Sap18b; Sin3-associated polypeptide 18-like\tK14324 SAP18; histone deacetylase complex subunit SAP18" }, { "name":"20220 Sap18; histone deacetylase complex subunit SAP18\tK14324 SAP18; histone deacetylase complex subunit SAP18" }, { "name":"18949 Pnn; pinin\tK13114 PNN; pinin" }, { "name":"56215 Acin1; apoptotic chromatin condensation inducer in the nucleus isoform 2\tK12875 ACIN1; apoptotic chromatin condensation inducer in the nucleus" }, { "name":"19826 Rnps1; RNA-binding protein with serine-rich domain 1 isoform 1\tK14325 RNPS1; RNA-binding protein with serine-rich domain 1" }, { "name":"51796 Srrm1; serine\/arginine repetitive matrix protein 1 isoform 2\tK13171 SRRM1; serine\/arginine repetitive matrix protein 1" } ] }, { "name":"TREX complex", "children":[ { "name":"225160 Thoc1; THO complex subunit 1 isoform 1\tK12878 THOC1; THO complex subunit 1" }, { "name":"100042165 Thoc2l; uncharacterized protein LOC100042165\tK12879 THOC2; THO complex subunit 2" }, { "name":"331401 Thoc2; THO complex subunit 2\tK12879 THOC2; THO complex subunit 2" }, { "name":"73666 Thoc3; THO complex subunit 3\tK12880 THOC3; THO complex subunit 3" }, { "name":"100043292 Gm4340; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"100861880 Gm21293; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"100861891 Gm21304; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"100861901 Gm21312; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"21681 Alyref; THO complex subunit 4\tK12881 THOC4; THO complex subunit 4" }, { "name":"56009 Alyref2; aly\/REF export factor 2\tK12881 THOC4; THO complex subunit 4" }, { "name":"627488 Gm6763; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"637578 Gm20765; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"667692 Gm8764; RNA and export factor-binding protein 2-like\tK12881 THOC4; THO complex subunit 4" }, { "name":"107829 Thoc5; THO complex subunit 5 homolog isoform 2\tK13174 THOC5; THO complex subunit 5" }, { "name":"386612 Thoc6; THO complex subunit 6 homolog\tK13175 THOC6; THO complex subunit 6" }, { "name":"66231 Thoc7; THO complex subunit 7 homolog isoform 1\tK13176 THOC7; THO complex subunit 7" }, { "name":"66511 Chtop; chromatin target of PRMT1 protein isoform 1\tK28424 CHTOP; chromatin target of PRMT1 protein" } ] }, { "name":"TREX-2 complex", "children":[ { "name":"234069 Pcid2; PCI domain-containing protein 2\tK23801 PCID2; nuclear mRNA export protein PCID2\/THP1" }, { "name":"20422 Sem1; 26S proteasome complex subunit SEM1\tK10881 SHFM1; 26 proteasome complex subunit DSS1" }, { "name":"108168387 Gm46629; transcription and mRNA export factor ENY2-like\tK11368 ENY2; enhancer of yellow 2 transcription factor" }, { "name":"223527 Eny2; transcription and mRNA export factor ENY2 isoform 1\tK11368 ENY2; enhancer of yellow 2 transcription factor" }, { "name":"26370 Cetn2; centrin-2\tK10840 CETN2; centrin-2" }, { "name":"12626 Cetn3; centrin-3\tK16466 CETN3; centrin-3" }, { "name":"54387 Mcm3ap; germinal-center associated nuclear protein\tK24317 MCM3AP; germinal-center associated nuclear protein [EC:2.3.1.48]" } ] }, { "name":"Nuclear pore complex", "children":[ { "name":"108989 Tpr; nucleoprotein TPR\tK09291 TPR; nucleoprotein TPR" }, { "name":"66679 Rae1; mRNA export factor\tK14298 RAE1; mRNA export factor" }, { "name":"110379 Sec13; protein SEC13 homolog\tK14004 SEC13; protein transport protein SEC13" }, { "name":"69736 Nup37; nucleoporin Nup37\tK14302 NUP37; nuclear pore complex protein Nup37" }, { "name":"445007 Nup85; nuclear pore complex protein Nup85\tK14304 NUP85; nuclear pore complex protein Nup85" }, { "name":"69912 Nup43; nucleoporin Nup43\tK14305 NUP43; nuclear pore complex protein Nup43" }, { "name":"18141 Nup50; nuclear pore complex protein Nup50\tK14295 NUP50; nuclear pore complex protein Nup50" }, { "name":"269113 Nup54; nuclear pore complex protein Nup54 isoform 2\tK14308 NUP54; nuclear pore complex protein Nup54" }, { "name":"18226 Nup62; nuclear pore glycoprotein p62\tK14306 NUP62; nuclear pore complex protein Nup62" }, { "name":"19069 Nup88; nuclear pore complex protein Nup88 isoform 2\tK14318 NUP88; nuclear pore complex protein Nup88" }, { "name":"71805 Nup93; nuclear pore complex protein Nup93 isoform 1\tK14309 NUP93; nuclear pore complex protein Nup93" }, { "name":"269966 Nup98; nuclear pore complex protein Nup98-Nup96 isoform 1 precursor\tK14297 NUP98; nuclear pore complex protein Nup98-Nup96" }, { "name":"103468 Nup107; nuclear pore complex protein Nup107 isoform 1\tK14301 NUP107; nuclear pore complex protein Nup107" }, { "name":"234865 Nup133; nuclear pore complex protein Nup133\tK14300 NUP133; nuclear pore complex protein Nup133" }, { "name":"227699 Nup188; nucleoporin NUP188 isoform 1\tK14311 NUP188; nuclear pore complex protein Nup188" }, { "name":"218210 Nup153; nuclear pore complex protein Nup153\tK14296 NUP153; nuclear pore complex protein Nup153" }, { "name":"170762 Nup155; nuclear pore complex protein Nup155\tK14312 NUP155; nuclear pore complex protein Nup155" }, { "name":"59015 Nup160; nuclear pore complex protein Nup160 isoform 1\tK14303 NUP160; nuclear pore complex protein Nup160" }, { "name":"69482 Nup35; nucleoporin NUP35 isoform 1\tK14313 NUP35; nuclear pore complex protein Nup53" }, { "name":"70699 Nup205; nuclear pore complex protein Nup205\tK14310 NUP205; nuclear pore complex protein Nup205" }, { "name":"54563 Nup210; nuclear pore membrane glycoprotein 210 precursor\tK14314 NUP210; nuclear pore complex protein Nup210" }, { "name":"77595 Nup210l; nuclear pore membrane glycoprotein 210-like precursor\tK14314 NUP210; nuclear pore complex protein Nup210" }, { "name":"227720 Nup214; nuclear pore complex protein Nup214 isoform 1\tK14317 NUP214; nuclear pore complex protein Nup214" }, { "name":"107939 Pom121; nuclear envelope pore membrane protein POM 121\tK14316 POM121; nuclear pore complex protein Nup121" }, { "name":"195236 Pom121l2; POM121-like protein 2 isoform 1\tK14316 POM121; nuclear pore complex protein Nup121" }, { "name":"71844 Nup58; nucleoporin p58\/p45 isoform 1\tK14307 NUPL1; nucleoporin p58\/p45" }, { "name":"231042 Nup42; nucleoporin NUP42 isoform 2\tK14321 NUPL2; nucleoporin-like protein 2" }, { "name":"72787 Ndc1; nucleoporin NDC1\tK14315 NDC1; nucleoporin NDC1" }, { "name":"72124 Seh1l; nucleoporin SEH1 isoform a\tK14299 SEH1; nucleoporin SEH1" }, { "name":"19386 Ranbp2; E3 SUMO-protein ligase RanBP2\tK12172 RANBP2; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]" }, { "name":"114671 Semp2l2b; SUMO\/sentrin specific peptidase-like\tK03345 SENP2; sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68]" }, { "name":"231201 Semp2l2a; SUMO-1 specific protease 4\tK03345 SENP2; sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68]" }, { "name":"408191 Semp2l1; SUMO\/sentrin specific peptidase 2-like 1\tK03345 SENP2; sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68]" }, { "name":"408192 Gm9839; sentrin 15\tK03345 SENP2; sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68]" }, { "name":"75826 Senp2; sentrin-specific protease 2 isoform 1\tK03345 SENP2; sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68]" }, { "name":"223921 Aaas; aladin\tK14320 AAAS; aladin" }, { "name":"12626 Cetn3; centrin-3\tK16466 CETN3; centrin-3" }, { "name":"74412 Gle1; mRNA export factor GLE1\tK18723 GLE1; nucleoporin GLE1" }, { "name":"170722 Nxf7; nuclear RNA export factor 7 isoform 2\tK14284 NXF; nuclear RNA export factor" }, { "name":"245610 Nxf3; nuclear RNA export factor 3\tK14284 NXF; nuclear RNA export factor" }, { "name":"53319 Nxf1; nuclear RNA export factor 1 isoform 1\tK14284 NXF; nuclear RNA export factor" }, { "name":"83454 Nxf2; nuclear RNA export factor 5 isoform 1\tK14284 NXF; nuclear RNA export factor" }, { "name":"237082 Nxt2; NTF2-related export protein 2 isoform a\tK14285 NXT1_2; NTF2-related export protein 1\/2" }, { "name":"56488 Nxt1; NTF2-related export protein 1\tK14285 NXT1_2; NTF2-related export protein 1\/2" } ] }, { "name":"Ran-mediated transport factors", "children":[ { "name":"19384 Ran; GTP-binding nuclear protein Ran\tK07936 RAN; GTP-binding nuclear protein Ran" }, { "name":"19428 Rasl2-9; GTP-binding nuclear protein Ran, testis-specific isoform\tK07936 RAN; GTP-binding nuclear protein Ran" }, { "name":"75471 1700009N14Rik; uncharacterized protein LOC75471\tK07936 RAN; GTP-binding nuclear protein Ran" }, { "name":"11737 Anp32a; acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 1\tK18646 ANP32A_C_D; acidic leucine-rich nuclear phosphoprotein 32 family member A\/C\/D" }, { "name":"67628 Anp32b; acidic leucine-rich nuclear phosphoprotein 32 family member B\tK18647 ANP32B; acidic leucine-rich nuclear phosphoprotein 32 family member B" }, { "name":"69583 Tnfsf13; tumor necrosis factor ligand superfamily member 13 isoform 1\tK05475 TNFSF13; tumor necrosis factor ligand superfamily member 13" }, { "name":"15568 Elavl1; ELAV-like protein 1\tK13088 ELAVL1; ELAV-like protein 1" }, { "name":"15569 Elavl2; ELAV-like protein 2 isoform 2\tK13208 ELAVL2_3_4; ELAV like protein 2\/3\/4" }, { "name":"15571 Elavl3; ELAV-like protein 3\tK13208 ELAVL2_3_4; ELAV like protein 2\/3\/4" }, { "name":"15572 Elavl4; ELAV-like protein 4 isoform a\tK13208 ELAVL2_3_4; ELAV like protein 2\/3\/4" }, { "name":"76577 Faf2; FAS-associated factor 2\tK18726 FAF2; FAS-associated factor 2" }, { "name":"269523 Vcp; transitional endoplasmic reticulum ATPase\tK13525 VCP; transitional endoplasmic reticulum ATPase" }, { "name":"207965 Vcpkmt; protein N-lysine methyltransferase METTL21D isoform 2\tK21806 VCPKMT; protein N-lysine methyltransferase METTL21D [EC:2.1.1.-]" }, { "name":"212999 Tnpo2; transportin-2 isoform 2\tK18727 TNPO2; transportin-2" }, { "name":"103573 Xpo1; exportin-1\tK14290 XPO1; exportin-1" }, { "name":"65246 Xpo7; exportin-7 isoform 2\tK18460 XPO7; exportin-7" }, { "name":"66011 Ranbp17; ran-binding protein 17 isoform 1\tK24115 RANBP17; Ran-binding protein 17" }, { "name":"19387 Rangap1; ran GTPase-activating protein 1 isoform 1\tK14319 RANGAP1; Ran GTPase-activating protein 1" }, { "name":"70439 Taf15; TATA-binding protein-associated factor 2N\tK14651 TAF15; transcription initiation factor TFIID subunit 15" }, { "name":"68051 Nutf2; nuclear transport factor 2\tK28773 NUTF2; nuclear transport factor 2" } ] }, { "name":"eIF4F and regulatory proteins", "children":[ { "name":"13684 Eif4e; eukaryotic translation initiation factor 4E isoform 1\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"218268 Eif4e1b; eukaryotic translation initiation factor 4E type 1B isoform 1\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"26987 Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform 1\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"13681 Eif4a1; eukaryotic initiation factor 4A-I isoform 1\tK03257 EIF4A; translation initiation factor 4A" }, { "name":"13682 Eif4a2; eukaryotic initiation factor 4A-II isoform a\tK03257 EIF4A; translation initiation factor 4A" }, { "name":"13690 Eif4g2; eukaryotic translation initiation factor 4 gamma 2 isoform 2\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"208643 Eif4g1; eukaryotic translation initiation factor 4 gamma 1 isoform a\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"230861 Eif4g3; eukaryotic translation initiation factor 4 gamma 3 isoform 2\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"75705 Eif4b; eukaryotic translation initiation factor 4B\tK03258 EIF4B; translation initiation factor 4B" }, { "name":"22384 Eif4h; eukaryotic translation initiation factor 4H isoform 1\tK24086 EIF4H; translation initiation factor 4H" }, { "name":"13685 Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1\tK07205 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1" }, { "name":"13688 Eif4ebp2; eukaryotic translation initiation factor 4E-binding protein 2\tK18644 EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2" }, { "name":"108112 Eif4ebp3; eukaryotic translation initiation factor 4E-binding protein 3\tK18645 EIF4EBP3; eukaryotic translation initiation factor 4E binding protein 3" }, { "name":"74203 Eif4enif1; eukaryotic translation initiation factor 4E transporter isoform a\tK18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter" }, { "name":"52477 Angel2; protein angel homolog 2 isoform 1\tK18729 ANGEL; protein angel" }, { "name":"68737 Angel1; protein angel homolog 1\tK18729 ANGEL; protein angel" }, { "name":"14265 Fmr1; fragile X messenger ribonucleoprotein 1 isoform 1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"14359 Fxr1; RNA-binding protein FXR1 isoform 1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"23879 Fxr2; RNA-binding protein FXR2\tK15516 FMR; fragile X mental retardation protein" }, { "name":"20430 Cyfip1; cytoplasmic FMR1-interacting protein 1 isoform a\tK05749 CYFIP; cytoplasmic FMR1 interacting protein" }, { "name":"76884 Cyfip2; cytoplasmic FMR1-interacting protein 2\tK05749 CYFIP; cytoplasmic FMR1 interacting protein" }, { "name":"216766 Gemin5; gem-associated protein 5 isoform 2\tK13133 GEMIN5; gem associated protein 5" }, { "name":"21335 Tacc3; transforming acidic coiled-coil-containing protein 3 isoform 2\tK14283 TACC3; transforming acidic coiled-coil-containing protein 3" }, { "name":"12877 Cpeb1; cytoplasmic polyadenylation element-binding protein 1 isoform 2\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"208922 Cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform a\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"231207 Cpeb2; cytoplasmic polyadenylation element-binding protein 2 isoform 2\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"67579 Cpeb4; cytoplasmic polyadenylation element-binding protein 4 isoform 1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"110957 D1Pas1; putative ATP-dependent RNA helicase Pl10\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]" }, { "name":"13205 Ddx3x; ATP-dependent RNA helicase DDX3X\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]" }, { "name":"227331 Gigyf2; GRB10-interacting GYF protein 2 isoform a\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein" }, { "name":"57330 Gigyf1; GRB10-interacting GYF protein 1 isoform a\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein" }, { "name":"18458 Pabpc1; polyadenylate-binding protein 1\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"18459 Pabpc2; poly A binding protein, cytoplasmic 2\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"230721 Pabpc4; polyadenylate-binding protein 4 isoform 3\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"241989 Pabpc4l; polyadenylate-binding protein 4-like\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"245545 Pabpc1l2a; poly(A) binding protein, cytoplasmic 1-like 2A\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"381404 Pabpc1l; polyadenylate-binding protein 1-like\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"668382 Pabpc1l2b; poly(A) binding protein, cytoplasmic 1-like 2B\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"67543 Pabpc6; poly(A) binding protein, cytoplasmic 3\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"93728 Pabpc5; polyadenylate-binding protein 5\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"218693 Paip1; polyadenylate-binding protein-interacting protein 1 isoform 1\tK14322 PAIP1; polyadenylate-binding protein-interacting protein 1" }, { "name":"232164 Paip2b; polyadenylate-binding protein-interacting protein 2B\tK27470 PAIP2; polyadenylate-binding protein-interacting protein 2" }, { "name":"67869 Paip2; polyadenylate-binding protein-interacting protein 2\tK27470 PAIP2; polyadenylate-binding protein-interacting protein 2" }, { "name":"108077 Skic2; superkiller complex protein 2\tK12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]" }, { "name":"54006 Deaf1; deformed epidermal autoregulatory factor 1 homolog isoform 1\tK23041 DEAF1; deformed epidermal autoregulatory factor 1" }, { "name":"66405 Mcts2; malignant T-cell-amplified sequence 2\tK07575 MCTS; malignant T-cell-amplified sequence" }, { "name":"68995 Mcts1; malignant T-cell-amplified sequence 1 isoform 1\tK07575 MCTS; malignant T-cell-amplified sequence" }, { "name":"68184 Denr; density-regulated protein isoform a\tK24272 DENR; density-regulated protein" } ] }, { "name":"APOBEC1-ACF complex", "children":[ { "name":"11810 Apobec1; C->U-editing enzyme APOBEC-1 isoform a\tK16932 APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]" }, { "name":"69865 A1cf; APOBEC1 complementation factor isoform 1\tK24978 A1CF; APOBEC1 complementation factor" } ] }, { "name":"Other transport factors", "children":[ { "name":"78428 Pym1; partner of Y14 and mago isoform 1\tK14294 WIBG; partner of Y14 and mago" }, { "name":"15382 Hnrnpa1; heterogeneous nuclear ribonucleoprotein A1 isoform a\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"229279 Hnrnpa3; heterogeneous nuclear ribonucleoprotein A3 isoform a\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"545091 Hnrnpa1l2-ps2; uncharacterized protein LOC545091\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"17690 Msi1; RNA-binding protein Musashi homolog 1 isoform 1\tK14411 MSI; RNA-binding protein Musashi" }, { "name":"70248 Dazap1; DAZ-associated protein 1 isoform b\tK14411 MSI; RNA-binding protein Musashi" }, { "name":"76626 Msi2; RNA-binding protein Musashi homolog 2 isoform 1\tK14411 MSI; RNA-binding protein Musashi" }, { "name":"56422 Hbs1l; HBS1-like protein isoform 1\tK14416 HBS1; elongation factor 1 alpha-like protein" }, { "name":"105083 Pelo; protein pelota homolog\tK06965 PELO; protein pelota" }, { "name":"382035 Pabpn1l; embryonic polyadenylate-binding protein 2\tK14396 PABPN1; polyadenylate-binding protein 2" }, { "name":"54196 Pabpn1; polyadenylate-binding protein 2\tK14396 PABPN1; polyadenylate-binding protein 2" }, { "name":"13680 Ddx19a; ATP-dependent RNA helicase DDX19A isoform 1\tK18655 DDX19; ATP-dependent RNA helicase DDX19\/DBP5 [EC:5.6.2.7]" }, { "name":"234733 Ddx19b; ATP-dependent RNA helicase DDX19B isoform 1\tK18655 DDX19; ATP-dependent RNA helicase DDX19\/DBP5 [EC:5.6.2.7]" }, { "name":"30959 Ddx25; ATP-dependent RNA helicase DDX25\tK18656 DDX25; ATP-dependent RNA helicase DDX25 [EC:5.6.2.7]" }, { "name":"67439 Xab2; pre-mRNA-splicing factor SYF1\tK12867 SYF1; pre-mRNA-splicing factor SYF1" }, { "name":"66118 Sarnp; SAP domain-containing ribonucleoprotein isoform 1\tK18732 SARNP; SAP domain-containing ribonucleoprotein" }, { "name":"100088 Rcc1; regulator of chromosome condensation isoform 2\tK11493 RCC1; regulator of chromosome condensation" }, { "name":"67557 Larp6; la-related protein 6\tK18733 LARP6; la-related protein 6" }, { "name":"19290 Pura; transcriptional activator protein Pur-alpha\tK21772 PURA; transcriptional activator protein Pur-alpha" }, { "name":"19291 Purb; transcriptional activator protein Pur-beta\tK21799 PURB; transcriptional activator protein Pur-beta" }, { "name":"73826 Poldip3; polymerase delta-interacting protein 3 isoform 1\tK22414 POLDIP3; polymerase delta-interacting protein 3" }, { "name":"70579 Zc3h11a; zinc finger CCCH domain-containing protein 11A\tK22415 ZC3H11; zinc finger CCCH domain-containing protein 11" }, { "name":"232798 Leng8; leukocyte receptor cluster member 8 homolog isoform 2\tK23802 LENG8; SAC3 family protein LENG8\/THP3" }, { "name":"67578 Patl2; protein PAT1 homolog 2\tK24823 PATL2; protein PAT1 homolog 2" }, { "name":"69823 Fyttd1; UAP56-interacting factor isoform 1\tK28772 FYTTD1; UAP56-interacting factor" } ] } ] }, { "name":"Surveillance factors", "children":[ { "name":"Surveillance complex", "children":[ { "name":"225363 Etf1; eukaryotic peptide chain release factor subunit 1\tK03265 ETF1; peptide chain release factor subunit 1" }, { "name":"14852 Gspt1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 1\tK03267 ERF3; peptide chain release factor subunit 3" }, { "name":"14853 Gspt2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B\tK03267 ERF3; peptide chain release factor subunit 3" }, { "name":"19704 Upf1; regulator of nonsense transcripts 1 isoform a\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]" }, { "name":"326622 Upf2; regulator of nonsense transcripts 2\tK14327 UPF2; regulator of nonsense transcripts 2" }, { "name":"67031 Upf3a; regulator of nonsense transcripts 3A\tK14328 UPF3; regulator of nonsense transcripts 3" }, { "name":"68134 Upf3b; regulator of nonsense transcripts 3B\tK14328 UPF3; regulator of nonsense transcripts 3" } ] }, { "name":"Protein phosphatase 2A", "children":[ { "name":"19052 Ppp2ca; serine\/threonine-protein phosphatase 2A catalytic subunit alpha isoform\tK04382 PPP2C; serine\/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]" }, { "name":"19053 Ppp2cb; serine\/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform 1\tK04382 PPP2C; serine\/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]" }, { "name":"51792 Ppp2r1a; serine\/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\tK03456 PPP2R1; serine\/threonine-protein phosphatase 2A regulatory subunit A" }, { "name":"73699 Ppp2r1b; serine\/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform b\tK03456 PPP2R1; serine\/threonine-protein phosphatase 2A regulatory subunit A" }, { "name":"269643 Ppp2r2c; serine\/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B" }, { "name":"52432 Ppp2r2d; serine\/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform 1\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B" }, { "name":"71978 Ppp2r2a; serine\/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B" }, { "name":"72930 Ppp2r2b; serine\/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B" }, { "name":"100039815 Gm2436; serine\/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma-like\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''" }, { "name":"100039830 Gm2446; serine\/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma-like\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''" }, { "name":"19054 Ppp2r3d; serine\/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform 1\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''" }, { "name":"235542 Ppp2r3a; serine\/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''" }, { "name":"59032 Ppp2r3c; serine\/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''" }, { "name":"21770 Ppp2r5d; serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 2\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" }, { "name":"225849 Ppp2r5b; serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" }, { "name":"226849 Ppp2r5a; serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" }, { "name":"26931 Ppp2r5c; serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform a\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" }, { "name":"26932 Ppp2r5e; serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" } ] }, { "name":"Other surveillance factors", "children":[ { "name":"233789 Smg1; serine\/threonine-protein kinase SMG1\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]" }, { "name":"229512 Smg5; nonsense-mediated mRNA decay factor SMG5\tK11125 SMG5; protein SMG5" }, { "name":"103677 Smg6; telomerase-binding protein EST1A\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]" }, { "name":"226517 Smg7; nonsense-mediated mRNA decay factor SMG7 isoform 2\tK14409 SMG7; protein SMG7" }, { "name":"74133 Smg8; nonsense-mediated mRNA decay factor SMG8\tK18734 SMG8; protein SMG8" }, { "name":"71997 Smg9; nonsense-mediated mRNA decay factor SMG9 isoform 1\tK18735 SMG9; protein SMG9" }, { "name":"227331 Gigyf2; GRB10-interacting GYF protein 2 isoform a\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein" }, { "name":"57330 Gigyf1; GRB10-interacting GYF protein 1 isoform a\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein" }, { "name":"70354 Secisbp2l; selenocysteine insertion sequence-binding protein 2-like isoform 3\tK19539 SECISBP2; selenocysteine insertion sequence-binding protein 2" }, { "name":"75420 Secisbp2; selenocysteine insertion sequence-binding protein 2 isoform 1\tK19539 SECISBP2; selenocysteine insertion sequence-binding protein 2" }, { "name":"71723 Dhx34; probable ATP-dependent RNA helicase DHX34\tK20101 DHX34; ATP-dependent RNA helicase DHX34 [EC:5.6.2.6]" }, { "name":"14904 Gtpbp1; GTP-binding protein 1\tK24887 GTPBP1; GTP-binding protein 1" } ] } ] }, { "name":"Factors involved in mRNA localization", "children":[ { "name":"Cargo complex", "children":[ { "name":"52874 Pum3; pumilio homolog 3\tK14844 PUF6; pumilio homology domain family member 6" }, { "name":"17918 Myo5a; unconventional myosin-Va\tK10357 MYO5; myosin V" }, { "name":"17919 Myo5b; unconventional myosin-Vb\tK10357 MYO5; myosin V" }, { "name":"208943 Myo5c; unconventional myosin-Vc\tK10357 MYO5; myosin V" }, { "name":"12121 Bicd1; protein bicaudal D homolog 1 isoform 2\tK18739 BICD; protein bicaudal D" }, { "name":"76895 Bicd2; protein bicaudal D homolog 2 isoform 2\tK18739 BICD; protein bicaudal D" }, { "name":"241624 Exd1; piRNA biogenesis protein EXD1\tK18740 EXD1; exonuclease 3'-5' domain-containing protein 1" } ] }, { "name":"Factors that have mRNA localization signals", "children":[ { "name":"11461 Actb; actin, cytoplasmic 1\tK05692 ACTB_G1; actin beta\/gamma 1" }, { "name":"11465 Actg1; actin, cytoplasmic 2 isoform 1\tK05692 ACTB_G1; actin beta\/gamma 1" }, { "name":"17196 Mbp; Golli-Mbp isoform 1\tK17269 MBP; myelin basic protein" }, { "name":"22352 Vim; vimentin\tK07606 VIM; vimentin" }, { "name":"17748 Mt1; metallothionein-1\tK14739 MT1_2; metallothionein 1\/2" }, { "name":"17750 Mt2; metallothionein-2\tK14739 MT1_2; metallothionein 1\/2" }, { "name":"17869 Myc; myc proto-oncogene protein isoform a\tK04377 MYC; Myc proto-oncogene protein" }, { "name":"14559 Gdf1; embryonic growth\/differentiation factor 1 precursor\tK05495 GDF1; growth differentiation factor 1" }, { "name":"21389 Tbx6; T-box transcription factor TBX6\tK10180 TBX6; T-box protein 6" }, { "name":"332397 Nanos1; nanos homolog 1\tK18741 NANOS1; protein nanos 1" } ] }, { "name":"Trans-acting binding proteins", "children":[ { "name":"58203 Zbp1; Z-DNA-binding protein 1 isoform 2\tK12965 ZBP1; Z-DNA binding protein 1" }, { "name":"16549 Khsrp; far upstream element-binding protein 2\tK13210 FUBP; far upstream element-binding protein" }, { "name":"320267 Fubp3; far upstream element-binding protein 3 isoform a\tK13210 FUBP; far upstream element-binding protein" }, { "name":"51886 Fubp1; far upstream element-binding protein 1 isoform 6\tK13210 FUBP; far upstream element-binding protein" }, { "name":"13627 Eef1a1; elongation factor 1-alpha 1\tK03231 EEF1A; elongation factor 1-alpha" }, { "name":"13628 Eef1a2; elongation factor 1-alpha 2\tK03231 EEF1A; elongation factor 1-alpha" }, { "name":"67160 Eef1g; elongation factor 1-gamma\tK03233 EEF1G; elongation factor 1-gamma" }, { "name":"53379 Hnrnpa2b1; heterogeneous nuclear ribonucleoproteins A2\/B1 isoform 3\tK13158 HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2\/B1" }, { "name":"23897 Hax1; HCLS1-associated protein X-1 isoform 1\tK16220 HAX1; HCLS1-associated protein X-1" }, { "name":"15463 Agfg1; arf-GAP domain and FG repeat-containing protein 1 isoform 4\tK15044 AGFG1; Arf-GAP domain and FG repeats-containing protein 1" }, { "name":"20853 Stau1; double-stranded RNA-binding protein Staufen homolog 1 isoform 3\tK17597 STAU; double-stranded RNA-binding protein Staufen" }, { "name":"29819 Stau2; double-stranded RNA-binding protein Staufen homolog 2 isoform 3\tK17597 STAU; double-stranded RNA-binding protein Staufen" }, { "name":"140488 Igf2bp3; insulin-like growth factor 2 mRNA-binding protein 3\tK13197 IGF2BP3; insulin-like growth factor 2 mRNA-binding protein 3" }, { "name":"19205 Ptbp1; polypyrimidine tract-binding protein 1 isoform 1\tK13218 PTBP1; polypyrimidine tract-binding protein 1" }, { "name":"12877 Cpeb1; cytoplasmic polyadenylation element-binding protein 1 isoform 2\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"208922 Cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform a\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"231207 Cpeb2; cytoplasmic polyadenylation element-binding protein 2 isoform 2\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"67579 Cpeb4; cytoplasmic polyadenylation element-binding protein 4 isoform 1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" } ] }, { "name":"Other mRNA localization factors", "children":[ { "name":"14265 Fmr1; fragile X messenger ribonucleoprotein 1 isoform 1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"14359 Fxr1; RNA-binding protein FXR1 isoform 1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"23879 Fxr2; RNA-binding protein FXR2\tK15516 FMR; fragile X mental retardation protein" }, { "name":"20430 Cyfip1; cytoplasmic FMR1-interacting protein 1 isoform a\tK05749 CYFIP; cytoplasmic FMR1 interacting protein" }, { "name":"76884 Cyfip2; cytoplasmic FMR1-interacting protein 2\tK05749 CYFIP; cytoplasmic FMR1 interacting protein" }, { "name":"18521 Pcbp2; poly(rC)-binding protein 2 isoform 1\tK13162 PCBP2; poly(rC)-binding protein 2" }, { "name":"59092 Pcbp4; poly(rC)-binding protein 4\tK21444 PCBP3_4; poly(rC)-binding protein 3\/4" }, { "name":"59093 Pcbp3; poly(rC)-binding protein 3 isoform 1\tK21444 PCBP3_4; poly(rC)-binding protein 3\/4" }, { "name":"53872 Caprin1; caprin-1 isoform a\tK18743 CAPRIN1; caprin-1" }, { "name":"232560 Caprin2; caprin-2 isoform 1\tK18744 CAPRIN2; caprin-2" }, { "name":"22608 Ybx1; Y-box-binding protein 1\tK09276 YBX1; Y-box-binding protein 1" } ] } ] }, { "name":"mRNA cycle factors", "children":[ { "name":"Common to processing body (P body) and stress granule", "children":[ { "name":"24127 Xrn1; 5'-3' exoribonuclease 1 isoform 2\tK12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]" }, { "name":"214150 Ago3; protein argonaute-3\tK11593 ELF2C; eukaryotic translation initiation factor 2C" }, { "name":"236511 Ago1; protein argonaute-1 isoform 1\tK11593 ELF2C; eukaryotic translation initiation factor 2C" }, { "name":"239528 Ago2; protein argonaute-2\tK11593 ELF2C; eukaryotic translation initiation factor 2C" }, { "name":"76850 Ago4; protein argonaute-4\tK11593 ELF2C; eukaryotic translation initiation factor 2C" }, { "name":"13684 Eif4e; eukaryotic translation initiation factor 4E isoform 1\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"218268 Eif4e1b; eukaryotic translation initiation factor 4E type 1B isoform 1\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"26987 Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform 1\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"19704 Upf1; regulator of nonsense transcripts 1 isoform a\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]" }, { "name":"110957 D1Pas1; putative ATP-dependent RNA helicase Pl10\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]" }, { "name":"13205 Ddx3x; ATP-dependent RNA helicase DDX3X\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]" }, { "name":"26900 Ddx3y; ATP-dependent RNA helicase DDX3Y\tK17642 DDX3Y; ATP-dependent RNA helicase DDX3Y [EC:5.6.2.7]" }, { "name":"13209 Ddx6; probable ATP-dependent RNA helicase DDX6\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]" }, { "name":"108797 Mex3b; RNA-binding protein MEX3B\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]" }, { "name":"237400 Mex3d; RNA-binding protein MEX3D\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]" }, { "name":"240396 Mex3c; RNA-binding E3 ubiquitin-protein ligase MEX3C\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]" }, { "name":"72640 Mex3a; RNA-binding protein MEX3A\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]" }, { "name":"66587 Fastk; fas-activated serine\/threonine kinase\tK08290 FASTK; Fas-activated serine\/threonine kinase [EC:2.7.11.8]" }, { "name":"241846 Lsm14b; protein LSM14 homolog B isoform 2\tK18749 LSM14; protein LSM14" }, { "name":"67070 Lsm14a; protein LSM14 homolog A isoform 1\tK18749 LSM14; protein LSM14" }, { "name":"23983 Pcbp1; poly(rC)-binding protein 1\tK12889 PCBP1; poly(rC)-binding protein 1" }, { "name":"18521 Pcbp2; poly(rC)-binding protein 2 isoform 1\tK13162 PCBP2; poly(rC)-binding protein 2" }, { "name":"22608 Ybx1; Y-box-binding protein 1\tK09276 YBX1; Y-box-binding protein 1" }, { "name":"101543 Wtip; Wilms tumor protein 1-interacting protein\tK16682 AJUBA; LIM domain-containing protein" }, { "name":"16475 Ajuba; LIM domain-containing protein ajuba\tK16682 AJUBA; LIM domain-containing protein" }, { "name":"29806 Limd1; LIM domain-containing protein 1 isoform 1\tK16682 AJUBA; LIM domain-containing protein" }, { "name":"11810 Apobec1; C->U-editing enzyme APOBEC-1 isoform a\tK16932 APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]" }, { "name":"80287 Apobec3; DNA dC->dU-editing enzyme APOBEC-3 isoform 1\tK18750 APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-]" }, { "name":"17454 Mov10; putative helicase MOV-10 isoform b\tK18422 MOV10; helicase MOV-10 [EC:5.6.2.5]" }, { "name":"52830 Pnrc2; proline-rich nuclear receptor coactivator 2\tK18751 PNRC2; proline-rich nuclear receptor coactivator 2" }, { "name":"238799 Tnpo1; transportin-1 isoform 1\tK18752 TNPO1; transportin-1" }, { "name":"233789 Smg1; serine\/threonine-protein kinase SMG1\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]" }, { "name":"229512 Smg5; nonsense-mediated mRNA decay factor SMG5\tK11125 SMG5; protein SMG5" }, { "name":"103677 Smg6; telomerase-binding protein EST1A\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]" }, { "name":"226517 Smg7; nonsense-mediated mRNA decay factor SMG7 isoform 2\tK14409 SMG7; protein SMG7" }, { "name":"22695 Zfp36; mRNA decay activator protein ZFP36\tK15308 TTP; tristetraprolin" }, { "name":"12192 Zfp36l1; mRNA decay activator protein ZFP36L1\tK18753 ZFP36L; butyrate response factor" }, { "name":"12193 Zfp36l2; mRNA decay activator protein ZFP36L2\tK18753 ZFP36L; butyrate response factor" }, { "name":"333473 Zfp36l3; mRNA decay activator protein ZFP36L3\tK18753 ZFP36L; butyrate response factor" }, { "name":"380669 Lin28b; protein lin-28 homolog B\tK18754 LIN28; protein lin-28" }, { "name":"83557 Lin28a; protein lin-28 homolog A\tK18754 LIN28; protein lin-28" }, { "name":"15194 Htt; huntingtin\tK04533 HD; huntingtin" }, { "name":"320727 Ipo8; importin-8 isoform 1\tK18755 IPO8; importin-8" }, { "name":"83675 Bicc1; protein bicaudal C homolog 1 isoform 1\tK18756 BICC1; protein bicaudal C" }, { "name":"15382 Hnrnpa1; heterogeneous nuclear ribonucleoprotein A1 isoform a\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"229279 Hnrnpa3; heterogeneous nuclear ribonucleoprotein A3 isoform a\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"545091 Hnrnpa1l2-ps2; uncharacterized protein LOC545091\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"18747 Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform 1\tK04345 PKA; protein kinase A [EC:2.7.11.11]" }, { "name":"18749 Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform 1\tK04345 PKA; protein kinase A [EC:2.7.11.11]" }, { "name":"214048 Larp1b; la-related protein 1B isoform 3\tK18757 LARP1; la-related protein 1" }, { "name":"73158 Larp1; la-related protein 1\tK18757 LARP1; la-related protein 1" }, { "name":"20239 Atxn2; ataxin-2 isoform 1\tK23625 ATXN2; ataxin-2" }, { "name":"233871 Atxn2l; ataxin-2-like protein isoform 1\tK23625 ATXN2; ataxin-2" } ] }, { "name":"P-body specific factors", "children":[ { "name":"70640 Dcp2; m7GpppN-mRNA hydrolase\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]" }, { "name":"75901 Dcp1a; mRNA-decapping enzyme 1A isoform 1\tK12610 DCP1A; mRNA-decapping enzyme 1A [EC:3.-.-.-]" }, { "name":"319618 Dcp1b; mRNA-decapping enzyme 1B\tK12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]" }, { "name":"67207 Lsm1; U6 snRNA-associated Sm-like protein LSm1\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1" }, { "name":"27756 Lsm2; U6 snRNA-associated Sm-like protein LSm2 isoform 2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2" }, { "name":"67678 Lsm3; U6 snRNA-associated Sm-like protein LSm3\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3" }, { "name":"50783 Lsm4; U6 snRNA-associated Sm-like protein LSm4 isoform 2\tK12623 LSM4; U6 snRNA-associated Sm-like protein LSm4" }, { "name":"66373 Lsm5; U6 snRNA-associated Sm-like protein LSm5\tK12624 LSM5; U6 snRNA-associated Sm-like protein LSm5" }, { "name":"78651 Lsm6; U6 snRNA-associated Sm-like protein LSm6\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6" }, { "name":"66094 Lsm7; U6 snRNA-associated Sm-like protein LSm7 isoform 4\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7" }, { "name":"76522 Lsm8; LSM8 homolog, U6 small nuclear RNA associated\tK12627 LSM8; U6 snRNA-associated Sm-like protein LSm8" }, { "name":"16593 Klc1; kinesin light chain 1 isoform 1B\tK10407 KLC; kinesin light chain" }, { "name":"16594 Klc2; kinesin light chain 2 isoform 1\tK10407 KLC; kinesin light chain" }, { "name":"232943 Klc3; kinesin light chain 3 isoform a\tK10407 KLC; kinesin light chain" }, { "name":"74764 Klc4; kinesin light chain 4\tK10407 KLC; kinesin light chain" }, { "name":"17918 Myo5a; unconventional myosin-Va\tK10357 MYO5; myosin V" }, { "name":"17919 Myo5b; unconventional myosin-Vb\tK10357 MYO5; myosin V" }, { "name":"208943 Myo5c; unconventional myosin-Vc\tK10357 MYO5; myosin V" }, { "name":"22142 Tuba1a; tubulin alpha-1A chain\tK07374 TUBA; tubulin alpha" }, { "name":"22143 Tuba1b; tubulin alpha-1B chain\tK07374 TUBA; tubulin alpha" }, { "name":"22144 Tuba3a; tubulin alpha-3 chain\tK07374 TUBA; tubulin alpha" }, { "name":"22145 Tuba4a; tubulin alpha-4A chain isoform 1\tK07374 TUBA; tubulin alpha" }, { "name":"22146 Tuba1c; tubulin alpha-1C chain\tK07374 TUBA; tubulin alpha" }, { "name":"22147 Tuba3b; tubulin alpha-3 chain\tK07374 TUBA; tubulin alpha" }, { "name":"238463 Tubal3; tubulin alpha chain-like 3 isoform 1\tK07374 TUBA; tubulin alpha" }, { "name":"53857 Tuba8; tubulin alpha-8 chain\tK07374 TUBA; tubulin alpha" }, { "name":"12877 Cpeb1; cytoplasmic polyadenylation element-binding protein 1 isoform 2\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"208922 Cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform a\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"231207 Cpeb2; cytoplasmic polyadenylation element-binding protein 2 isoform 2\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"67579 Cpeb4; cytoplasmic polyadenylation element-binding protein 4 isoform 1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"216766 Gemin5; gem-associated protein 5 isoform 2\tK13133 GEMIN5; gem associated protein 5" }, { "name":"21335 Tacc3; transforming acidic coiled-coil-containing protein 3 isoform 2\tK14283 TACC3; transforming acidic coiled-coil-containing protein 3" }, { "name":"213988 Tnrc6b; trinucleotide repeat-containing gene 6B protein isoform 1\tK18412 TNRC6; trinucleotide repeat-containing gene 6 protein" }, { "name":"217351 Tnrc6c; trinucleotide repeat-containing gene 6C protein isoform 1\tK18412 TNRC6; trinucleotide repeat-containing gene 6 protein" }, { "name":"233833 Tnrc6a; trinucleotide repeat-containing gene 6A protein\tK18412 TNRC6; trinucleotide repeat-containing gene 6 protein" }, { "name":"234594 Cnot1; CCR4-NOT transcription complex subunit 1 isoform 3\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1" }, { "name":"72068 Cnot2; CCR4-NOT transcription complex subunit 2 isoform a\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2" }, { "name":"232791 Cnot3; CCR4-NOT transcription complex subunit 3\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3" }, { "name":"53621 Cnot4; CCR4-NOT transcription complex subunit 4 isoform 2\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]" }, { "name":"104625 Cnot6; CCR4-NOT transcription complex subunit 6 isoform 1\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]" }, { "name":"231464 Cnot6l; CCR4-NOT transcription complex subunit 6-like isoform 2\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]" }, { "name":"18983 Cnot7; CCR4-NOT transcription complex subunit 7 isoform 1\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8" }, { "name":"69125 Cnot8; CCR4-NOT transcription complex subunit 8\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8" }, { "name":"233103 Garre1; granule associated Rac and RHOG effector protein 1\tK26671 GARRE1; granule associated Rac and RHOG effector protein 1" }, { "name":"208718 Dis3l2; DIS3-like exonuclease 2 isoform 2\tK18758 DIS3L2; DIS3-like exonuclease 2 [EC:3.1.13.-]" }, { "name":"103135 Pan2; PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 1\tK12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]" }, { "name":"72587 Pan3; PAN2-PAN3 deadenylation complex subunit Pan3 isoform 4\tK12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3" }, { "name":"12226 Btg1; protein BTG1\tK14443 TOB; protein Tob\/BTG" }, { "name":"12227 Btg2; protein BTG2\tK14443 TOB; protein Tob\/BTG" }, { "name":"12228 Btg3; protein BTG3\tK14443 TOB; protein Tob\/BTG" }, { "name":"194735 Btg1c; B cell translocation gene 1, anti-proliferative-like\tK14443 TOB; protein Tob\/BTG" }, { "name":"22057 Tob1; protein Tob1\tK14443 TOB; protein Tob\/BTG" }, { "name":"436199 Btg1b; B cell translocation gene 1, anti-proliferative-like\tK14443 TOB; protein Tob\/BTG" }, { "name":"56057 Btg4; protein BTG4\tK14443 TOB; protein Tob\/BTG" }, { "name":"57259 Tob2; protein Tob2\tK14443 TOB; protein Tob\/BTG" }, { "name":"74203 Eif4enif1; eukaryotic translation initiation factor 4E transporter isoform a\tK18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter" }, { "name":"225929 Patl1; protein PAT1 homolog 1 isoform 1\tK12617 PATL1; DNA topoisomerase 2-associated protein PAT1" }, { "name":"353190 Edc3; enhancer of mRNA-decapping protein 3 isoform 1\tK12615 EDC3; enhancer of mRNA-decapping protein 3" }, { "name":"234699 Edc4; enhancer of mRNA-decapping protein 4 isoform 1\tK12616 EDC4; enhancer of mRNA-decapping protein 4" }, { "name":"378430 Nanos2; nanos homolog 2\tK18760 NANOS2; protein nanos 2" }, { "name":"244551 Nanos3; nanos homolog 3 isoform 1\tK18761 NANOS3; protein nanos 3" }, { "name":"326622 Upf2; regulator of nonsense transcripts 2\tK14327 UPF2; regulator of nonsense transcripts 2" }, { "name":"67031 Upf3a; regulator of nonsense transcripts 3A\tK14328 UPF3; regulator of nonsense transcripts 3" }, { "name":"68134 Upf3b; regulator of nonsense transcripts 3B\tK14328 UPF3; regulator of nonsense transcripts 3" }, { "name":"20821 Trim21; E3 ubiquitin-protein ligase TRIM21\tK10651 TRIM21; tripartite motif-containing protein 21 [EC:2.3.2.27]" }, { "name":"636931 Trim71; E3 ubiquitin-protein ligase TRIM71\tK12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]" }, { "name":"67710 Polr2g; DNA-directed RNA polymerase II subunit RPB7\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7" }, { "name":"19106 Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase\tK16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]" }, { "name":"317755 Zar1; zygote arrest protein 1 isoform 1\tK18762 ZAR1; zygote arrest protein 1" }, { "name":"545824 Zar1l; protein ZAR1-like\tK18762 ZAR1; zygote arrest protein 1" }, { "name":"213541 Ythdf2; YTH domain-containing family protein 2\tK20102 YTHDF; YTH domain-containing family protein" }, { "name":"228994 Ythdf1; YTH domain-containing family protein 1\tK20102 YTHDF; YTH domain-containing family protein" }, { "name":"229096 Ythdf3; YTH domain-containing family protein 3 isoform 2\tK20102 YTHDF; YTH domain-containing family protein" } ] }, { "name":"Stress granule specific factors", "children":[ { "name":"21841 Tia1; cytotoxic granule associated RNA binding protein TIA1 isoform 1\tK13201 TIA1; nucleolysin TIA-1\/TIAR" }, { "name":"21843 Tial1; nucleolysin TIAR isoform 1\tK13201 TIA1; nucleolysin TIA-1\/TIAR" }, { "name":"18458 Pabpc1; polyadenylate-binding protein 1\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"18459 Pabpc2; poly A binding protein, cytoplasmic 2\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"230721 Pabpc4; polyadenylate-binding protein 4 isoform 3\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"241989 Pabpc4l; polyadenylate-binding protein 4-like\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"245545 Pabpc1l2a; poly(A) binding protein, cytoplasmic 1-like 2A\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"381404 Pabpc1l; polyadenylate-binding protein 1-like\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"668382 Pabpc1l2b; poly(A) binding protein, cytoplasmic 1-like 2B\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"67543 Pabpc6; poly(A) binding protein, cytoplasmic 3\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"93728 Pabpc5; polyadenylate-binding protein 5\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"20853 Stau1; double-stranded RNA-binding protein Staufen homolog 1 isoform 3\tK17597 STAU; double-stranded RNA-binding protein Staufen" }, { "name":"29819 Stau2; double-stranded RNA-binding protein Staufen homolog 2 isoform 3\tK17597 STAU; double-stranded RNA-binding protein Staufen" }, { "name":"14265 Fmr1; fragile X messenger ribonucleoprotein 1 isoform 1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"14359 Fxr1; RNA-binding protein FXR1 isoform 1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"23879 Fxr2; RNA-binding protein FXR2\tK15516 FMR; fragile X mental retardation protein" }, { "name":"58203 Zbp1; Z-DNA-binding protein 1 isoform 2\tK12965 ZBP1; Z-DNA binding protein 1" }, { "name":"15568 Elavl1; ELAV-like protein 1\tK13088 ELAVL1; ELAV-like protein 1" }, { "name":"27041 G3bp1; ras GTPase-activating protein-binding protein 1 isoform 1\tK17265 G3BP1; Ras GTPase-activating protein-binding protein 1 [EC:5.6.2.5 5.6.2.3]" }, { "name":"23881 G3bp2; ras GTPase-activating protein-binding protein 2 isoform a\tK24983 G3BP2; Ras GTPase-activating protein-binding protein 2" }, { "name":"229317 Eif2a; eukaryotic translation initiation factor 2A isoform 1\tK15026 EIF2A; translation initiation factor 2A" }, { "name":"27979 Eif3b; eukaryotic translation initiation factor 3 subunit B\tK03253 EIF3B; translation initiation factor 3 subunit B" }, { "name":"13681 Eif4a1; eukaryotic initiation factor 4A-I isoform 1\tK03257 EIF4A; translation initiation factor 4A" }, { "name":"13682 Eif4a2; eukaryotic initiation factor 4A-II isoform a\tK03257 EIF4A; translation initiation factor 4A" }, { "name":"192170 Eif4a3; eukaryotic initiation factor 4A-III\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]" }, { "name":"434050 Gm5576; eukaryotic initiation factor 4A-III-like\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]" }, { "name":"668137 Eif4a3l1; uncharacterized protein LOC668137\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]" }, { "name":"75705 Eif4b; eukaryotic translation initiation factor 4B\tK03258 EIF4B; translation initiation factor 4B" }, { "name":"13690 Eif4g2; eukaryotic translation initiation factor 4 gamma 2 isoform 2\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"208643 Eif4g1; eukaryotic translation initiation factor 4 gamma 1 isoform a\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"230861 Eif4g3; eukaryotic translation initiation factor 4 gamma 3 isoform 2\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"110651 Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform 1\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"20111 Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform b\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"20112 Rps6ka2; ribosomal protein S6 kinase alpha-2\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"67071 Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform 2\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"14694 Rack1; small ribosomal subunit protein RACK1\tK14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein" }, { "name":"22030 Traf2; TNF receptor-associated factor 2 isoform b\tK03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]" }, { "name":"170722 Nxf7; nuclear RNA export factor 7 isoform 2\tK14284 NXF; nuclear RNA export factor" }, { "name":"245610 Nxf3; nuclear RNA export factor 3\tK14284 NXF; nuclear RNA export factor" }, { "name":"53319 Nxf1; nuclear RNA export factor 1 isoform 1\tK14284 NXF; nuclear RNA export factor" }, { "name":"83454 Nxf2; nuclear RNA export factor 5 isoform 1\tK14284 NXF; nuclear RNA export factor" }, { "name":"15185 Hdac6; histone deacetylase 6 isoform 2\tK11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]" }, { "name":"219249 Tdrd3; tudor domain-containing protein 3 isoform 1\tK18404 TDRD3; tudor domain-containing protein 3" }, { "name":"207214 Larp4; la-related protein 4 isoform 1\tK18763 LARP4; la-related protein 4" }, { "name":"217980 Larp4b; la-related protein 4B isoform 1\tK18763 LARP4; la-related protein 4" } ] } ] } ] }, { "name":"mRNA degradation factors", "children":[ { "name":"5'-3' decay", "children":[ { "name":"Decapping complex", "children":[ { "name":"75901 Dcp1a; mRNA-decapping enzyme 1A isoform 1\tK12610 DCP1A; mRNA-decapping enzyme 1A [EC:3.-.-.-]" }, { "name":"319618 Dcp1b; mRNA-decapping enzyme 1B\tK12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]" }, { "name":"70640 Dcp2; m7GpppN-mRNA hydrolase\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]" }, { "name":"13209 Ddx6; probable ATP-dependent RNA helicase DDX6\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]" }, { "name":"353190 Edc3; enhancer of mRNA-decapping protein 3 isoform 1\tK12615 EDC3; enhancer of mRNA-decapping protein 3" }, { "name":"234699 Edc4; enhancer of mRNA-decapping protein 4 isoform 1\tK12616 EDC4; enhancer of mRNA-decapping protein 4" }, { "name":"225929 Patl1; protein PAT1 homolog 1 isoform 1\tK12617 PATL1; DNA topoisomerase 2-associated protein PAT1" } ] }, { "name":"Lsm complex", "children":[ { "name":"67207 Lsm1; U6 snRNA-associated Sm-like protein LSm1\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1" }, { "name":"27756 Lsm2; U6 snRNA-associated Sm-like protein LSm2 isoform 2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2" }, { "name":"67678 Lsm3; U6 snRNA-associated Sm-like protein LSm3\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3" }, { "name":"50783 Lsm4; U6 snRNA-associated Sm-like protein LSm4 isoform 2\tK12623 LSM4; U6 snRNA-associated Sm-like protein LSm4" }, { "name":"66373 Lsm5; U6 snRNA-associated Sm-like protein LSm5\tK12624 LSM5; U6 snRNA-associated Sm-like protein LSm5" }, { "name":"78651 Lsm6; U6 snRNA-associated Sm-like protein LSm6\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6" }, { "name":"66094 Lsm7; U6 snRNA-associated Sm-like protein LSm7 isoform 4\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7" }, { "name":"76522 Lsm8; LSM8 homolog, U6 small nuclear RNA associated\tK12627 LSM8; U6 snRNA-associated Sm-like protein LSm8" } ] }, { "name":"5' exonucleases", "children":[ { "name":"24127 Xrn1; 5'-3' exoribonuclease 1 isoform 2\tK12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]" }, { "name":"24128 Xrn2; 5'-3' exoribonuclease 2 isoform 1\tK12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]" }, { "name":"73532 Nudt16l2; U8 snoRNA-decapping enzyme-like\tK16855 NUDT16; U8 snoRNA-decapping enzyme [EC:3.6.1.62 3.6.1.64]" }, { "name":"75686 Nudt16; U8 snoRNA-decapping enzyme\tK16855 NUDT16; U8 snoRNA-decapping enzyme [EC:3.6.1.62 3.6.1.64]" } ] }, { "name":"Other 5'-3' decay factors", "children":[ { "name":"69305 Dcps; m7GpppX diphosphatase\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]" }, { "name":"78455 Helz; probable helicase with zinc finger domain isoform 2\tK25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]" } ] } ] }, { "name":"3'-5' decay", "children":[ { "name":"Core exosome factors", "children":[ { "name":"66583 Exosc1; exosome complex component CSL4 isoform 1\tK07573 CSL4; exosome complex component CSL4" }, { "name":"227715 Exosc2; exosome complex component RRP4\tK03679 RRP4; exosome complex component RRP4" }, { "name":"66362 Exosc3; exosome complex component RRP40 isoform 1\tK03681 RRP40; exosome complex component RRP40" }, { "name":"109075 Exosc4; exosome complex component RRP41\tK11600 RRP41; exosome complex component RRP41" }, { "name":"27998 Exosc5; exosome complex component RRP46\tK12590 RRP46; exosome complex component RRP46" }, { "name":"72544 Exosc6; exosome complex component MTR3\tK12587 MTR3; exosome complex component MTR3" }, { "name":"66446 Exosc7; exosome complex exonuclease RRP42 isoform 1\tK12589 RRP42; exosome complex component RRP42" }, { "name":"69639 Exosc8; exosome complex component RRP43 isoform 2\tK12586 RRP43; exosome complex component RRP43" }, { "name":"50911 Exosc9; exosome complex component RRP45\tK03678 RRP45; exosome complex component RRP45" } ] }, { "name":"Exosome cofactors", "children":[ { "name":"72662 Dis3; exosome complex exonuclease RRP44 isoform 1\tK12585 DIS3; exosome complex exonuclease DIS3\/RRP44 [EC:3.1.13.-]" }, { "name":"213550 Dis3l; DIS3-like exonuclease 1 isoform 1\tK18681 DIS3L; DIS3-like exonuclease 1 [EC:3.1.13.-]" }, { "name":"50912 Exosc10; exosome complex component 10 isoform 1\tK12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-]" }, { "name":"57316 C1d; nuclear nucleic acid-binding protein C1D\tK12592 C1D; exosome complex protein LRP1" }, { "name":"68533 Mphosph6; M-phase phosphoprotein 6 isoform 1\tK12593 MPHOSPH6; M-phase phosphoprotein 6, animal type" }, { "name":"234311 Ddx60; probable ATP-dependent RNA helicase DDX60\tK20103 DDX60; ATP-dependent RNA helicase DDX60 [EC:5.6.2.7]" } ] }, { "name":"TRAMP complex", "children":[ { "name":"210106 Tent4a; terminal nucleotidyltransferase 4A isoform 1\tK03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5\/7 [EC:2.7.7.19]" }, { "name":"214627 Tent4b; terminal nucleotidyltransferase 4B isoform e\tK03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5\/7 [EC:2.7.7.19]" }, { "name":"319885 Zcchc7; zinc finger CCHC domain-containing protein 7\tK12597 AIR1_2; protein AIR1\/2" }, { "name":"72198 Mtrex; exosome RNA helicase MTR4\tK12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]" } ] }, { "name":"Ski complex", "children":[ { "name":"108077 Skic2; superkiller complex protein 2\tK12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]" }, { "name":"218343 Skic3; superkiller complex protein 3 isoform 1\tK12600 SKI3; superkiller protein 3" }, { "name":"66317 Skic8; superkiller complex protein 8 isoform a\tK12602 WDR61; WD repeat-containing protein 61" } ] }, { "name":"Ccr4-NOT complex", "children":[ { "name":"104625 Cnot6; CCR4-NOT transcription complex subunit 6 isoform 1\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]" }, { "name":"231464 Cnot6l; CCR4-NOT transcription complex subunit 6-like isoform 2\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]" }, { "name":"234594 Cnot1; CCR4-NOT transcription complex subunit 1 isoform 3\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1" }, { "name":"72068 Cnot2; CCR4-NOT transcription complex subunit 2 isoform a\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2" }, { "name":"232791 Cnot3; CCR4-NOT transcription complex subunit 3\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3" }, { "name":"53621 Cnot4; CCR4-NOT transcription complex subunit 4 isoform 2\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]" }, { "name":"18983 Cnot7; CCR4-NOT transcription complex subunit 7 isoform 1\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8" }, { "name":"69125 Cnot8; CCR4-NOT transcription complex subunit 8\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8" }, { "name":"58184 Cnot9; CCR4-NOT transcription complex subunit 9\tK12606 RCD1; CCR4-NOT transcription complex subunit 9" }, { "name":"78893 Cnot10; CCR4-NOT transcription complex subunit 10\tK12607 CNOT10; CCR4-NOT transcription complex subunit 10" } ] }, { "name":"Pan complex", "children":[ { "name":"103135 Pan2; PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 1\tK12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]" }, { "name":"72587 Pan3; PAN2-PAN3 deadenylation complex subunit Pan3 isoform 4\tK12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3" } ] }, { "name":"Other 3'-5' decay factors", "children":[ { "name":"240023 Pnldc1; poly(A)-specific ribonuclease PNLDC1\tK01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]" }, { "name":"74108 Parn; poly(A)-specific ribonuclease PARN isoform 2\tK01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]" }, { "name":"72162 Dhx36; ATP-dependent DNA\/RNA helicase DHX36\tK14442 DHX36; ATP-dependent RNA helicase DHX36 [EC:5.6.2.6]" }, { "name":"12226 Btg1; protein BTG1\tK14443 TOB; protein Tob\/BTG" }, { "name":"12227 Btg2; protein BTG2\tK14443 TOB; protein Tob\/BTG" }, { "name":"12228 Btg3; protein BTG3\tK14443 TOB; protein Tob\/BTG" }, { "name":"194735 Btg1c; B cell translocation gene 1, anti-proliferative-like\tK14443 TOB; protein Tob\/BTG" }, { "name":"22057 Tob1; protein Tob1\tK14443 TOB; protein Tob\/BTG" }, { "name":"436199 Btg1b; B cell translocation gene 1, anti-proliferative-like\tK14443 TOB; protein Tob\/BTG" }, { "name":"56057 Btg4; protein BTG4\tK14443 TOB; protein Tob\/BTG" }, { "name":"57259 Tob2; protein Tob2\tK14443 TOB; protein Tob\/BTG" }, { "name":"12981 Csf2; granulocyte-macrophage colony-stimulating factor precursor\tK05427 CSF2; granulocyte-macrophage colony-stimulating factor" }, { "name":"12457 Noct; nocturnin\tK18764 NOCT; nocturnin [EC:3.1.3.108]" }, { "name":"67276 Eri1; 3'-5' exoribonuclease 1\tK18416 THEX1; 3'-5' exoribonuclease 1 [EC:3.1.-.-]" }, { "name":"71151 Eri2; ERI1 exoribonuclease 2 isoform 1\tK18417 ERI2; ERI1 exoribonuclease 2 [EC:3.1.-.-]" }, { "name":"69305 Dcps; m7GpppX diphosphatase\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]" }, { "name":"211948 Pde12; 2',5'-phosphodiesterase 12\tK19612 PDE12; 2',5'-phosphodiesterase [EC:3.1.13.4 3.1.4.-]" }, { "name":"64602 Ireb2; iron-responsive element-binding protein 2 isoform 1\tK22416 IREB2; iron-responsive element-binding protein 2" }, { "name":"78455 Helz; probable helicase with zinc finger domain isoform 2\tK25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]" }, { "name":"229003 Helz2; helicase with zinc finger domain 2\tK25165 HELZ2; 3'-5' exoribonuclease HELZ2 [EC:3.1.13.1 5.6.2.6]" }, { "name":"217827 Nrde2; nuclear exosome regulator NRDE2 isoform a\tK26109 NRDE2; nuclear exosome regulator NRDE2" }, { "name":"233033 Samd4b; protein Smaug homolog 2\tK27396 SMG; protein Smaug" }, { "name":"74480 Samd4; protein Smaug homolog 1 isoform 1\tK27396 SMG; protein Smaug" }, { "name":"230393 Focad; focadhesin isoform 1\tK27498 FOCAD; focadhesin" } ] } ] }, { "name":"Other degradation factors", "children":[ { "name":"RNases", "children":[ { "name":"19752 Rnase1; ribonuclease pancreatic precursor\tK01168 RNASE1_2; pancreatic ribonuclease [EC:4.6.1.18]" }, { "name":"54159 Rnase2b; ribonuclease 2B precursor\tK01168 RNASE1_2; pancreatic ribonuclease [EC:4.6.1.18]" }, { "name":"58809 Rnase4; ribonuclease 4 precursor\tK16632 RNASE4; ribonuclease 4 [EC:3.1.27.-]" }, { "name":"78416 Rnase6; ribonuclease K6 precursor\tK01172 RNASE6_7_8; ribonuclease 6\/7\/8 [EC:3.1.27.-]" }, { "name":"497113 Rnase11; putative inactive ribonuclease 11 precursor\tK16633 RNASE11; ribonuclease 11 [EC:3.1.27.-]" }, { "name":"230738 Zc3h12a; endoribonuclease ZC3H12A\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]" }, { "name":"237256 Zc3h12d; probable ribonuclease ZC3H12D\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]" }, { "name":"244871 Zc3h12c; probable ribonuclease ZC3H12C isoform 1\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]" }, { "name":"547176 Zc3h12b; probable ribonuclease ZC3H12B\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]" } ] } ] } ] } ] }, { "name":"Prokaryotic type", "children":[ { "name":"Bacterial mRNA degradation factors", "children":[ { "name":"RNA degradosome components", "children":[ { "name":"Ribonucreases", "children":[ { "name":"14000 Drosha; ribonuclease 3\tK03685 rnc; ribonuclease III [EC:3.1.26.3]" }, { "name":"104444 Rexo2; oligoribonuclease, mitochondrial isoform 1 precursor\tK13288 orn; oligoribonuclease [EC:3.1.-.-]" } ] }, { "name":"Helicases" }, { "name":"Other RNA degradosome components", "children":[ { "name":"13806 Eno1; alpha-enolase isoform 2\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"13807 Eno2; gamma-enolase isoform 1\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"13808 Eno3; beta-enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"433182 Eno1b; enolase 1B, retrotransposed\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"71701 Pnpt1; polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]" }, { "name":"18641 Pfkl; ATP-dependent 6-phosphofructokinase, liver type isoform 1\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]" }, { "name":"18642 Pfkm; ATP-dependent 6-phosphofructokinase, muscle type\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]" }, { "name":"56421 Pfkp; ATP-dependent 6-phosphofructokinase, platelet type isoform 1\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]" } ] } ] }, { "name":"Other RNA degradation factors", "children":[ { "name":"Chaperones", "children":[ { "name":"15526 Hspa9; stress-70 protein, mitochondrial\tK04043 dnaK; molecular chaperone DnaK" }, { "name":"15510 Hspd1; 60 kDa heat shock protein, mitochondrial\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" } ] }, { "name":"Others" }, { "name":"Bacterial Small RNA Regulators" } ] } ] }, { "name":"Archeal mRNA degradation factors", "children":[ { "name":"Exosome components", "children":[ { "name":"Core exosome", "children":[ { "name":"227715 Exosc2; exosome complex component RRP4\tK03679 RRP4; exosome complex component RRP4" }, { "name":"66583 Exosc1; exosome complex component CSL4 isoform 1\tK07573 CSL4; exosome complex component CSL4" } ] }, { "name":"Cofactors", "children":[ { "name":"109075 Exosc4; exosome complex component RRP41\tK11600 RRP41; exosome complex component RRP41" }, { "name":"66446 Exosc7; exosome complex exonuclease RRP42 isoform 1\tK12589 RRP42; exosome complex component RRP42" } ] }, { "name":"Others" } ] } ] } ] } ] }