{
	"name":"mox02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"DAMO_2735 CRISPR-associated protein Cas1\/Cas4\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"DAMO_2734 CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"DAMO_2739 conserved protein of unknown function\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors",
				"children":[
				{
					"name":"DAMO_2737 conserved protein of unknown function\tK19131 csb1; CRISPR-associated protein Csb1"
				},
				{
					"name":"DAMO_2736 conserved protein of unknown function\tK19132 csb2; CRISPR-associated protein Csb2"
				},
				{
					"name":"DAMO_2738 conserved protein of unknown function\tK19136 csx17; CRISPR-associated protein Csx17"
				}
				]
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"DAMO_1973 hsdR; Type I restriction enzyme EcoAI R protein (R.EcoAI)\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"DAMO_2320 Type I site-specific deoxyribonuclease, HsdR family\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"DAMO_1977 putative Restriction endonuclease S subunits\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"DAMO_2325 putative Restriction modification system DNA specificity domain\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"DAMO_1976 hsdM; Type I restriction enzyme EcoEI M protein (M.EcoEI)\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"DAMO_2330 N-6 DNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"DAMO_0433 DNA-methyltransferase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"DAMO_2668 DNA adenine methylase Dam\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"DAMO_2868 DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"DAMO_3047 Methyltransferase\tK24451 zim; modification methylase"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system",
			"children":[
			{
				"name":"DAMO_1348 Type III restriction protein res subunit (fragment)\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"DAMO_2049 Type III restriction enzyme, res subunit\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"DAMO_2835 conserved protein of unknown function\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"DAMO_2047 putative DNA methylase\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			},
			{
				"name":"DAMO_2836 Mod; Adenine specific DNA methylase Mod\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"DAMO_1172 exported protein of unknown function\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"DAMO_0770 protein of unknown function\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"DAMO_1477 conserved protein of unknown function\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"DAMO_1478 conserved protein of unknown function\tK26986 mazE6; antitoxin MazE6"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"DAMO_2230 Plasmid stabilization system\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"DAMO_2686 protein of unknown function\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"DAMO_2687 Prevent-host-death protein\tK28297 relB_F; antitoxin RelB\/F"
				}
				]
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"DAMO_0712 yafQ; toxin of the YafQ-DinJ toxin-antitoxin system\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"DAMO_0713 dinJ; antitoxin of YafQ-DinJ toxin-antitoxin system\tK07473 dinJ; DNA-damage-inducible protein J"
				}
				]
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"DAMO_0364 Addiction module toxin, Txe\/YoeB family\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"DAMO_3044 Addiction module toxin, Txe\/YoeB family\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"DAMO_0363 Prevent-host-death family protein\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"DAMO_2726 Death-on-curing family protein\tK07341 doc; death on curing protein"
				}
				]
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"DAMO_0382 Plasmid maintenance system killer\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"DAMO_0637 Plasmid maintenance system killer\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"DAMO_2506 higB; Toxin higB-1\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"DAMO_2879 Plasmid maintenance system killer\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"DAMO_3092 Transcriptional regulator\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"DAMO_0381 Transcriptional regulator, XRE family protein\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"DAMO_0389 Putative integron gene cassette protein (modular protein)\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"DAMO_0632 yddM; Uncharacterized HTH-type transcriptional regulator yddM\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"DAMO_0636 Helix-turn-helix motif\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"DAMO_1009 conserved protein of unknown function\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"DAMO_1479 protein of unknown function\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"DAMO_1484 conserved protein of unknown function\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"DAMO_1582 Transcriptional regulator, XRE family protein\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"DAMO_1679 Plasmid maintenance system antidote protein\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"DAMO_2507 higA; Antitoxin higA-1\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"DAMO_2878 conserved protein of unknown function\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"DAMO_3023 conserved protein of unknown function\tK28262 vapC7_13_23; ribonuclease VapC7\/13\/23 [EC:3.1.-.-]"
				},
				{
					"name":"DAMO_3024 protein of unknown function\tK28263 vapB7; antitoxin VapB7"
				},
				{
					"name":"DAMO_0789 PilT-like protein\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"DAMO_0790 Prevent-host-death family protein\tK28280 vapB22; antitoxin VapB22"
				},
				{
					"name":"DAMO_2676 conserved protein of unknown function\tK28143 vapC24S; ribonuclease VapC24\/25\/29\/31\/33\/37\/38\/39\/41\/43\/44\/48 [EC:3.1.-.-]"
				},
				{
					"name":"DAMO_2743 conserved protein of unknown function\tK28143 vapC24S; ribonuclease VapC24\/25\/29\/31\/33\/37\/38\/39\/41\/43\/44\/48 [EC:3.1.-.-]"
				},
				{
					"name":"DAMO_2746 Conserved membrane protein\tK28143 vapC24S; ribonuclease VapC24\/25\/29\/31\/33\/37\/38\/39\/41\/43\/44\/48 [EC:3.1.-.-]"
				},
				{
					"name":"DAMO_2675 conserved protein of unknown function\tK28144 vapB24S; antitoxin VapB24\/25\/29\/31\/33\/37\/38\/39\/41\/43\/44\/48"
				},
				{
					"name":"DAMO_2741 conserved protein of unknown function\tK28144 vapB24S; antitoxin VapB24\/25\/29\/31\/33\/37\/38\/39\/41\/43\/44\/48"
				},
				{
					"name":"DAMO_2745 protein of unknown function\tK28144 vapB24S; antitoxin VapB24\/25\/29\/31\/33\/37\/38\/39\/41\/43\/44\/48"
				},
				{
					"name":"DAMO_1710 conserved protein of unknown function\tK28275 vapC35S; ribonuclease VapC35\/45\/46\/47 [EC:3.1.-.-]"
				},
				{
					"name":"DAMO_2720 conserved protein of unknown function\tK28275 vapC35S; ribonuclease VapC35\/45\/46\/47 [EC:3.1.-.-]"
				},
				{
					"name":"DAMO_2721 conserved protein of unknown function\tK28276 vapB35S; antitoxin VapB35\/45\/46\/47"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"DAMO_2292 ftsZ; Cell division protein ftsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"DAMO_3131 mreB; Rod shape-determining protein mreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"DAMO_1550 gltX; Glutamyl-tRNA synthetase (Glutamate--tRNA ligase) (GluRS)\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA",
				"children":[
				{
					"name":"DAMO_1974 conserved protein of unknown function\tK28189 takA; serine protein kinase TakA antitoxin"
				}
				]
			},
			{
				"name":"HepT-MntA",
				"children":[
				{
					"name":"DAMO_0914 conserved protein of unknown function\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"DAMO_2201 conserved protein of unknown function\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"DAMO_0913 DNA polymerase, beta domain protein region\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				},
				{
					"name":"DAMO_2200 DNA polymerase, beta-like region\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				}
				]
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"DAMO_1607 nifS; cysteine desulfurase (Nitrogenase metalloclusters biosynthesis protein nifS)\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"DAMO_2957 nifS; cysteine desulfurase (Nitrogenase metalloclusters biosynthesis protein nifS)\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"DAMO_2869 conserved protein of unknown function\tK19169 dndB; DNA sulfur modification protein DndB"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}