{
	"name":"vpd04147",
	"children":[
	{
		"name":"Exosomal proteins",
		"children":[
		{
			"name":"Proteins found in most exosomes",
			"children":[
			{
				"name":"VAPA_1c51660 htpG; chaperone protein HtpG\tK04079 HSP90A; molecular chaperone HtpG"
			},
			{
				"name":"VAPA_1c25650 fructose-bisphosphate aldolase class 1\tK01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]"
			},
			{
				"name":"VAPA_1c35530 eno; enolase Eno\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
			},
			{
				"name":"VAPA_1c54680 gapA; glyceraldehyde-3-phosphate dehydrogenase GapA\tK00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]"
			},
			{
				"name":"VAPA_1c30890 pgk1; phosphoglycerate kinase Pgk\tK00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]"
			},
			{
				"name":"VAPA_1c52920 pgk2; phosphoglycerate kinase Pgk\tK00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]"
			},
			{
				"name":"VAPA_1c46560 pyk; pyruvate kinase Pyk\tK00873 PK; pyruvate kinase [EC:2.7.1.40]"
			},
			{
				"name":"VAPA_1c52910 pykA; pyruvate kinase PykA\tK00873 PK; pyruvate kinase [EC:2.7.1.40]"
			},
			{
				"name":"VAPA_1c31600 peptidyl-prolyl cis-trans isomerase\tK03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]"
			}
			]
		},
		{
			"name":"Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)",
			"children":[
			{
				"name":"VAPA_1c11740 groL; 60 kDa chaperonin GroL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"VAPA_2c03530 groL; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"VAPA_1c18010 dnaK; chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
			},
			{
				"name":"VAPA_1c11590 pgi; glucose-6-phosphate isomerase Pgi\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"VAPA_1c05360 putative gluconolactonase\tK01053 gnl; gluconolactonase [EC:3.1.1.17]"
			},
			{
				"name":"VAPA_1c07610 putative gluconolactonase\tK01053 gnl; gluconolactonase [EC:3.1.1.17]"
			},
			{
				"name":"VAPA_1c39240 putative gluconolaconase\tK01053 gnl; gluconolactonase [EC:3.1.1.17]"
			},
			{
				"name":"VAPA_2c03050 putative gluconolactonase\tK01053 gnl; gluconolactonase [EC:3.1.1.17]"
			},
			{
				"name":"VAPA_1c27970 guaB; inosine-5'-monophosphate dehydrogenase GuaB\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]"
			},
			{
				"name":"VAPA_1c07340 tuf1; elongation factor Tuf\tK02358 tuf; elongation factor Tu"
			},
			{
				"name":"VAPA_1c50990 tuf2; elongation factor Tu (EF-Tu)\tK02358 tuf; elongation factor Tu"
			},
			{
				"name":"VAPA_1c12380 putative histidine triad (HIT) protein\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
			}
			]
		},
		{
			"name":"Exosomal proteins of oligodendrocytes"
		},
		{
			"name":"Exosomal proteins of cortical neuronal cells"
		},
		{
			"name":"Exosomal proteins of microglial cells"
		},
		{
			"name":"Exosomal proteins of epithelial cells"
		},
		{
			"name":"Exosomal proteins of hepatic cells"
		},
		{
			"name":"Exosomal proteins of breast milk",
			"children":[
			{
				"name":"VAPA_1c04710 fadD; long-chain-fatty-acid--CoA ligase FadD\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c13890 putative acyl-CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c19260 putative long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c49250 acyl-CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c49590 putative ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c50670 putative acyl-CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c51180 putative acyl-CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c51950 putative acyl-CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_2c03570 putative acyl-CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_2c03700 putative long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			}
			]
		},
		{
			"name":"Exosomal proteins of other body fluids (saliva and urine)",
			"children":[
			{
				"name":"VAPA_1c11740 groL; 60 kDa chaperonin GroL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"VAPA_2c03530 groL; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"VAPA_1c19330 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"VAPA_1c21440 phbA1; acetyl-CoA acetyltransferase PhbA\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"VAPA_1c48890 phbA2; acetyl-CoA acetyltransferase PhbA\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"VAPA_2c02260 thiolase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"VAPA_2c04820 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"VAPA_1c48350 ahcY; adenosylhomocysteinase AhcY\tK01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1]"
			},
			{
				"name":"VAPA_1c29140 adk; adenylate kinase Adk\tK00939 adk; adenylate kinase [EC:2.7.4.3]"
			},
			{
				"name":"VAPA_1c07110 putative argininosuccinate lyase\tK01755 argH; argininosuccinate lyase [EC:4.3.2.1]"
			},
			{
				"name":"VAPA_1c14530 argH; argininosuccinate lyase ArgH\tK01755 argH; argininosuccinate lyase [EC:4.3.2.1]"
			},
			{
				"name":"VAPA_1c38960 argG; argininosuccinate synthase ArgG\tK01940 argG; argininosuccinate synthase [EC:6.3.4.5]"
			},
			{
				"name":"VAPA_1c01230 D-hydantoinase\tK01464 DPYS; dihydropyrimidinase [EC:3.5.2.2]"
			},
			{
				"name":"VAPA_1c21840 hyuA; D-hydantoinase HyuA\tK01464 DPYS; dihydropyrimidinase [EC:3.5.2.2]"
			},
			{
				"name":"VAPA_1c01060 fumarylacetoacetase\tK01555 FAH; fumarylacetoacetase [EC:3.7.1.2]"
			},
			{
				"name":"VAPA_1c03500 fumarylacetoacetase\tK01555 FAH; fumarylacetoacetase [EC:3.7.1.2]"
			},
			{
				"name":"VAPA_1c39150 fbp2; fructose-1,6-bisphosphatase, class 1\tK03841 FBP; fructose-1,6-bisphosphatase I [EC:3.1.3.11]"
			},
			{
				"name":"VAPA_1c04950 glgB1; 1,4-alpha-glucan-branching enzyme Glgb\tK00700 GBE1; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]"
			},
			{
				"name":"VAPA_1c21090 glgB2; 1,4-alpha-glucan-branching enzyme GlgB\tK00700 GBE1; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]"
			},
			{
				"name":"VAPA_1c34950 glpK; glycerol kinase GlpK\tK00864 glpK; glycerol kinase [EC:2.7.1.30]"
			},
			{
				"name":"VAPA_1c01730 putative glutamate--ammonia ligase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"VAPA_1c17380 glnA; glutamate-ammonia ligase GlnA\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"VAPA_1c11590 pgi; glucose-6-phosphate isomerase Pgi\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"VAPA_1c51080 hemB; delta-aminolevulinic acid dehydratase HemB\tK01698 hemB; porphobilinogen synthase [EC:4.2.1.24]"
			},
			{
				"name":"VAPA_1c49220 hpd; 4-hydroxyphenylpyruvate dioxygenase Hpd\tK00457 HPD; 4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]"
			},
			{
				"name":"VAPA_1c15730 putative pterin-4-alpha-carbinolamine dehydratase\tK01724 PCBD; 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]"
			},
			{
				"name":"VAPA_1c29180 putative D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"VAPA_1c42880 serA; D-3-phosphoglycerate dehydrogenase SerA\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"VAPA_2c01720 putative D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"VAPA_2c03090 putative D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"VAPA_2c08520 putative 2-hydroxyacid dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"VAPA_1c47730 purH; bifunctional purine biosynthesis protein PurH\tK00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase \/ IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]"
			},
			{
				"name":"VAPA_1c15740 putative peptidase, M48 family\tK06013 STE24; STE24 endopeptidase [EC:3.4.24.84]"
			}
			]
		},
		{
			"name":"Exosomal proteins of breast cancer cells",
			"children":[
			{
				"name":"VAPA_1c04710 fadD; long-chain-fatty-acid--CoA ligase FadD\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c13890 putative acyl-CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c19260 putative long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c49250 acyl-CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c49590 putative ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c50670 putative acyl-CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c51180 putative acyl-CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c51950 putative acyl-CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_2c03570 putative acyl-CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_2c03700 putative long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"VAPA_1c23430 pdhL; dihydrolipoyl dehydrogenase PdhL\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]"
			},
			{
				"name":"VAPA_1c23530 odhL; dihydrolipoyl dehydrogenase OdhL\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]"
			},
			{
				"name":"VAPA_1c34680 etfA; electron transfer flavoprotein, subunit alpha\tK03522 fixB; electron transfer flavoprotein alpha subunit"
			},
			{
				"name":"VAPA_1c49740 gdhA; glutamate dehydrogenase GdhA\tK00261 GLUD1_2; glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3]"
			},
			{
				"name":"VAPA_1c11520 glucose-6-phosphate 1-dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]"
			},
			{
				"name":"VAPA_1c27970 guaB; inosine-5'-monophosphate dehydrogenase GuaB\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]"
			},
			{
				"name":"VAPA_1c18010 dnaK; chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
			},
			{
				"name":"VAPA_1c11740 groL; 60 kDa chaperonin GroL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"VAPA_2c03530 groL; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"VAPA_1c07340 tuf1; elongation factor Tuf\tK02358 tuf; elongation factor Tu"
			},
			{
				"name":"VAPA_1c50990 tuf2; elongation factor Tu (EF-Tu)\tK02358 tuf; elongation factor Tu"
			}
			]
		},
		{
			"name":"Exosomal proteins of ovarian cancer cells"
		},
		{
			"name":"Exosomal proteins of colorectal cancer cells",
			"children":[
			{
				"name":"VAPA_1c11740 groL; 60 kDa chaperonin GroL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"VAPA_2c03530 groL; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"VAPA_1c11590 pgi; glucose-6-phosphate isomerase Pgi\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"VAPA_1c11520 glucose-6-phosphate 1-dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]"
			},
			{
				"name":"VAPA_1c18010 dnaK; chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
			},
			{
				"name":"VAPA_1c36210 tpiA; triosephosphate isomerase TpiA\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			},
			{
				"name":"VAPA_1c07340 tuf1; elongation factor Tuf\tK02358 tuf; elongation factor Tu"
			},
			{
				"name":"VAPA_1c50990 tuf2; elongation factor Tu (EF-Tu)\tK02358 tuf; elongation factor Tu"
			}
			]
		},
		{
			"name":"Exosomal proteins of pancreatic cancer cells"
		},
		{
			"name":"Exosomal proteins of bladder cancer cells",
			"children":[
			{
				"name":"VAPA_1c11740 groL; 60 kDa chaperonin GroL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"VAPA_2c03530 groL; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"VAPA_1c11520 glucose-6-phosphate 1-dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]"
			},
			{
				"name":"VAPA_1c42580 gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase GpmA\tK01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"
			},
			{
				"name":"VAPA_1c36210 tpiA; triosephosphate isomerase TpiA\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			}
			]
		},
		{
			"name":"Exosomal proteins of melanoma cells",
			"children":[
			{
				"name":"VAPA_1c42580 gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase GpmA\tK01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"
			},
			{
				"name":"VAPA_1c36210 tpiA; triosephosphate isomerase TpiA\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			}
			]
		},
		{
			"name":"Exosomal proteins of other cancer cells",
			"children":[
			{
				"name":"VAPA_1c11570 lipocalin-like protein\tK03098 APOD; apolipoprotein D and lipocalin family protein"
			}
			]
		}
		]
	},
	{
		"name":"Exosomal RNA",
		"children":[
		{
			"name":"Exosomal RNA of haemopoietic cells"
		},
		{
			"name":"Exosomal RNA of muscle cells"
		},
		{
			"name":"Exosomal RNA of hepatic cells"
		},
		{
			"name":"Exosomal RNA of pancreatic cells"
		},
		{
			"name":"Exosomal RNA of neural cells"
		},
		{
			"name":"Exosomal RNA of breast milk"
		},
		{
			"name":"Exosomal RNA of saliva"
		},
		{
			"name":"Exosomal RNA of breast cancer cells"
		},
		{
			"name":"Exosomal RNA of ovarian cancer cells"
		},
		{
			"name":"Exosomal RNA of colorectal cancer cells"
		},
		{
			"name":"Exosomal RNA of hepatic cancer cells"
		},
		{
			"name":"Exosomal RNA of renal carcinoma cells"
		},
		{
			"name":"Exosomal RNA of pancreatic cancer cells"
		},
		{
			"name":"Exosomal RNA of melanoma cells"
		},
		{
			"name":"Exosomal RNA of lung cancer cells"
		},
		{
			"name":"Exosomal RNA of other cancer cells"
		}
		]
	}
	]
}