+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Amycolatopsis keratiniphila

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APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS D Rapamycin PKS D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS D Polyene macrolide PKS D Pimaricinolide synthase D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS E AORI_3406 ppsD; phenolpthiocerol synthesis type-I polyketide synthase D K12443 ppsD; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292] C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) D AORI_5397 ppsA; iterative type I polyketide synthase K15320 ATX; 6-methylsalicylic acid synthase [EC:2.3.1.165] C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2] C Bacterial type D AORI_1840 type I polyketide synthase K15314 sgcE; enediyne polyketide synthase B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS C C7-C14 cyclized polyketide type D Octaketide PKS E AORI_0413 beta-lactamase class B K05555 actIV; cyclase [EC:4.-.-.-] E AORI_1562 beta-lactamase K05555 actIV; cyclase [EC:4.-.-.-] D Nonaketide PKS D Decaketide PKS B Type III PKS C Plant type C Fungal type C Bacterial type D AORI_1502 bcsA; chalcone synthase K16424 dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246] D AORI_5330 bcsA; chalcone synthase K16424 dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246] D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase D AORI_1478 amino acid adenylation K16428 cepA; nonribosomal peptide synthetase CepA D AORI_1479 amino acid adenylation K16429 cepB; nonribosomal peptide synthetase CepB D AORI_1480 amino acid adenylation K16430 cepC; nonribosomal peptide synthetase CepC D AORI_1493 amino acid adenylation domain-containing protein K16432 cepK; nonribosomal peptide synthetase CepK C Nocardicin synthetase D AORI_4675 mbtH; MbtH protein K05375 mbtH; MbtH protein D AORI_3676 mbtH; MbtH protein K05375 mbtH; MbtH protein D AORI_4539 mbtH; MbtH protein K05375 mbtH; MbtH protein D AORI_1481 mbtH; MbtH protein K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase D AORI_3540 entB; enterobactin isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14] D AORI_3539 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Bacillibactin synthetase D AORI_3540 entB; enterobactin isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14] D AORI_3539 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase C Mycobactin synthetase C Vibriobactin synthetase D AORI_3540 entB; enterobactin isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14] D AORI_3539 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Myxochelin synthetase D AORI_3539 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D AORI_3540 entB; enterobactin isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14] C Petrobacin synthetase C Syringomycin synthetase C Vanchrobactin synthetase D AORI_3540 entB; enterobactin isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14] D AORI_3539 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] # APolyketide tailoring proteins B Hydrolase C AORI_1841 ybgC; acyl-CoA thioester hydrolase K15315 sgcE10; enediyne core biosynthesis thioesterase B Ketoreductase C AORI_2196 hydroxylacyl-CoA dehydrogenase K05556 actVI1; ketoreductase RED1 [EC:1.1.1.-] B Oxygenase C AORI_4199 hypothetical protein K14632 actVA6; C-6 monooxygenase C AORI_4218 cytochrome P450 monooxygenase K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C AORI_4996 putative hydrolase K21159 sgcF; epoxide hydrolase C AORI_1791 microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase C AORI_1342 epoxide hydrolase domain-containing protein K21159 sgcF; epoxide hydrolase C AORI_0257 microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase C AORI_3919 putative hydrolase K21159 sgcF; epoxide hydrolase C AORI_5552 epoxide hydrolase domain-containing protein K21159 sgcF; epoxide hydrolase C AORI_3490 epoxide hydrolase K21159 sgcF; epoxide hydrolase C AORI_4379 epoxide hydrolase domain-containing protein K21159 sgcF; epoxide hydrolase C AORI_6592 microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase C AORI_1504 enoyl-CoA hydratase/isomerase K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] C AORI_5328 enoyl-CoA hydratase/isomerase K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] B Methylase C AORI_6472 O-methyltransferase family protein K20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303] B Glycosyltransferase B Halogenase C AORI_1485 tryptophan halogenase K16431 cepH; FAD-dependent halogenase [EC:1.14.19.-] C AORI_5364 tryptophan halogenase K16431 cepH; FAD-dependent halogenase [EC:1.14.19.-] B beta-Branched incorporating proteins B Others C AORI_2036 cyclase-dehydratase K14627 actVI3; dehydratase [EC:4.2.1.-] C AORI_1858 hypothetical protein K21160 sgcE2; enediyne biosynthesis protein E2 C AORI_1833 enediyne biosynthesis protein K21161 sgcE3; enediyne biosynthesis protein E3 C AORI_1834 ASPIC/UnbV domain-containing protein K21162 sgcE4; enediyne biosynthesis protein E4 C AORI_1835 hypothetical protein K21163 sgcE5; enediyne biosynthesis protein E5 C AORI_1836 cytochrome P450 K21164 sgcE7; enediyne biosynthesis protein E7 C AORI_1837 hypothetical protein K21165 sgcE8; enediyne biosynthesis protein E8 C AORI_1838 oxidoreductase K21166 sgcE9; enediyne biosynthesis protein E9 C AORI_6954 wyosine base formation K21167 sgcE11; enediyne biosynthesis protein E11 C AORI_1842 oxidoreductase K21185 sgcE6; flavin reductase C AORI_6598 dhbE; 2,3-dihydroxybenzoate-AMP ligase K20423 ncsB2; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase [EC:6.2.1.43] C AORI_5335 oxidase K21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36] # ANonribosomal peptide tailoring proteins B Reductase B Thioesterase C AORI_1492 hydrolase K16434 cepJ; thioesterase CepJ B Oxygenase C AORI_1482 cytochrome P450 FAS1 K16445 cepE; oxidation protein CepE C AORI_1483 cytochrome P450 FAS1 K16446 cepF; oxidation protein CepF C AORI_1484 cytochrome P450 FAS1 K16447 cepG; oxidation protein CepG B Glycosyltransferase C AORI_3038 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] C AORI_6511 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] C AORI_1487 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] C AORI_1486 glycosyl transferase K16443 gtfD; desvancosaminyl-vancomycin vancosaminetransferase [EC:2.4.1.322] B Aminotransferase C AORI_5327 aminotransferase K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103] C AORI_1491 transcriptional regulator K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103] B Others C AORI_1494 cytochrome P450 K16433 cepL; hydroxylation protein CepL C AORI_1495 hppD; 4-hydroxyphenylpyruvate dioxygenase K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46] C AORI_1496 glcD; glycolate oxidase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] C AORI_1503 paaG; enoyl-CoA hydratase K16425 dpgB; isomerase DpgB C AORI_5329 paaG; enoyl-CoA hydratase K16425 dpgB; isomerase DpgB C AORI_1504 enoyl-CoA hydratase/isomerase K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] C AORI_5328 enoyl-CoA hydratase/isomerase K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] C AORI_1505 caiD; carnitinyl-CoA dehydratase K16426 dpgD; dehydration protein DpgD C AORI_1490 hypothetical protein K16448 mtfA; methylation protein MtfA ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: July 4, 2022