+E Replication protein KO
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DNA Replication Proteins - Anopheles stephensi (Asian malaria mosquito)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 118511846 origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 118502915 origin recognition complex subunit 2 isoform X1 K02604 ORC2; origin recognition complex subunit 2
D 118504223 origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 118508938 origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 118516520 origin recognition complex subunit 5 isoform X1 K02607 ORC5; origin recognition complex subunit 5
D 118508172 origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 118509666 DNA replication factor Cdt1 isoform X1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 118512729 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 118508376 DNA replication licensing factor Mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 118517559 DNA replication licensing factor Mcm3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 118511849 DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 118503373 DNA replication licensing factor Mcm5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 118511036 DNA replication licensing factor Mcm6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 118514423 DNA replication licensing factor Mcm7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 118508050 G2/mitotic-specific cyclin-A K06627 CCNA; cyclin-A
D 118513659 G1/S-specific cyclin-E isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 118507495 cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 118504359 cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 118504853 DNA replication complex GINS protein PSF1-like isoform X1 K10732 GINS1; GINS complex subunit 1
D 118508932 probable DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 118507972 DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 118517542 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 118505037 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 118510330 uncharacterized protein LOC118510330 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 118507922 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 118503212 LOW QUALITY PROTEIN: DNA helicase MCM8-like K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 118503213 DNA helicase MCM8-like K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 118506616 DNA helicase MCM9-like isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 118511762 protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 118506590 DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 118517612 DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 118510491 DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 118516414 DNA primase large subunit-like K02685 PRI2; DNA primase large subunit
D 118509551 DNA primase large subunit-like K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 118507826 DNA polymerase epsilon catalytic subunit 1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 118507828 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 118509779 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 118511837 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 118505959 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 118515318 DNA polymerase delta subunit 2-like isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
D 118509849 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
D 118514706 neurofilament heavy polypeptide K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 118516488 DNA polymerase subunit gamma-1, mitochondrial K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 118516568 DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 118506450 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 118509143 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 118511128 replication protein A 14 kDa subunit B-like K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 118507123 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 118505412 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 118513239 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 118514558 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 118511536 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 118513770 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 118507432 uncharacterized protein LOC118507432 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 118513959 ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 118513688 ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 118508180 ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 118511037 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 118517714 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 118507297 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 118503277 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 118512576 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C DNA methylation enzymes
C Prevention of re-replication factors
D 118509819 multicilin K10749 GMNN; geminin
D 118511842 G2/mitotic-specific cyclin-B-like K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 118511843 G2/mitotic-specific cyclin-B-like K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 118508293 G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 118510754 cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 118503759 telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 118513668 LOW QUALITY PROTEIN: protein SMG5 K11125 SMG5; protein SMG5
D Dyskerin complex
E 118505657 probable H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 118517632 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 118511546 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 118512403 H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D Sm core complex
E 118512900 small nuclear ribonucleoprotein-associated protein B K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 118510225 probable small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 118502747 probable small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 118503366 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 118508102 probable small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 118504978 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 118505017 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 118505412 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 118513239 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 118514558 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 118511536 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 118511259 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 118507536 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 118504812 nibrin K10867 NBN; nibrin
C Other termination factors
D 118511628 serine/threonine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 118515312 Werner syndrome ATP-dependent helicase-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 118502686 Werner syndrome ATP-dependent helicase-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 118504501 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 118502668 DNA-dependent protein kinase catalytic subunit-like K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 118503249 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 118505793 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 118506568 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase tankyrase K10799 TNKS; tankyrase [EC:2.4.2.30]
D 118509267 PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1 K11135 PINX1; Pin2-interacting protein X1
D 118506047 regulator of telomere elongation helicase 1 homolog K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 118506350 telomere-associated protein RIF1 K11138 RIF1; telomere-associated protein RIF1
D 118513927 ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 118506077 transcriptional activator protein Pur-alpha-like K21772 PURA; transcriptional activator protein Pur-alpha
D 118516529 transcriptional activator protein Pur-alpha-like K21772 PURA; transcriptional activator protein Pur-alpha
D 118506637 telomerase Cajal body protein 1 homolog K23314 WRAP53; telomerase Cajal body protein 1
D 118512333 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 118511114 replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 118506893 DNA topoisomerase I, mitochondrial isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 118512026 DNA topoisomerase 2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 118507568 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 118510567 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 118508294 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 118513770 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 118507432 uncharacterized protein LOC118507432 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 118513770 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 118507432 uncharacterized protein LOC118507432 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 118517714 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 118507297 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 118512576 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022