+F Repair protein KO
#
DNA Repair and Recombination Proteins - Callorhinchus milii (elephant shark)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 103180335 mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 103184019 alkbh2; DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 103174969 alkbh3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 103182219 ascc3; activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 103184020 unga; uracil DNA glycosylase a isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 103177876 cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 103179828 LOW QUALITY PROTEIN: G/T mismatch-specific thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 103184976 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 103189317 smug1; single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 103182777 mutyh; LOW QUALITY PROTEIN: adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 103176743 methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 103190056 LOW QUALITY PROTEIN: methyl-CpG-binding domain protein 4-like K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 103176612 ogg1; N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 103189165 neil1; endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 103180213 neil3; endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 103189895 nthl1; LOW QUALITY PROTEIN: endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 103188060 apex2; DNA-(apurinic or apyrimidinic site) lyase 2 isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 103191080 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 103187779 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 103190605 pold3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 103184063 pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 103175351 pole2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 103182977 pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 103184515 pole4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 103179676 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 103173653 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D Short Patch-BER factors
E 103191220 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 103180521 lig3; LOW QUALITY PROTEIN: DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 103172277 tdp1; LOW QUALITY PROTEIN: tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 103187207 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 103177906 aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 103180230 hmgb2a; high mobility group protein B2 K10802 HMGB1; high mobility group protein B1
E 103190566 poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 103187622 parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 103176762 parp3; protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 103186505 parp4; protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 103176688 xpc; DNA repair protein complementing XP-C cells isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 103178064 UV excision repair protein RAD23 homolog B-like K10839 RAD23; UV excision repair protein RAD23
F 103183517 UV excision repair protein RAD23 homolog B isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 103173339 UV excision repair protein RAD23 homolog A K10839 RAD23; UV excision repair protein RAD23
F 103177340 centrin-1 isoform X1 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 103189242 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 103178581 cul4b; LOW QUALITY PROTEIN: cullin-4B K10609 CUL4; cullin 4
F 103185525 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 103174841 ddb1; DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 103177668 polr2b; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 103172396 polr2d; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 103189926 polr2e; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 103189399 polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 103172736 polr2g; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 103184435 polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 121851287 polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 103180526 polr2j; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 103180741 polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 103189242 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 103178581 cul4b; LOW QUALITY PROTEIN: cullin-4B K10609 CUL4; cullin 4
F 103185525 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 103174841 ddb1; DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
F 103177805 ercc8; DNA excision repair protein ERCC-8 isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 103185849 ercc6; DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 103191596 elof1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 103189811 ercc3; LOW QUALITY PROTEIN: general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 103174834 gtf2h1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 103182693 gtf2h2; general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 103188004 gtf2h3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 121852719 gtf2h4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 103178896 gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 103177774 cdk7; cyclin-dependent kinase 7 isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 103182666 ccnh; cyclin-H K06634 CCNH; cyclin H
E 103185378 mnat1; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 103179489 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 103185991 rpa3; replication protein A 14 kDa subunit isoform X1 K10740 RPA3; replication factor A3
D Other NER factors
E 103182143 xpa; DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 103178771 ercc4; LOW QUALITY PROTEIN: DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 103177579 ercc5; DNA excision repair protein ERCC-5 K10846 ERCC5; DNA excision repair protein ERCC-5
E 103186559 mms19; MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 103175388 cul3b; cullin-3b K03869 CUL3; cullin 3
E 103186531 cullin-5 K10612 CUL5; cullin 5
E 103174573 eloc; elongin-C K03872 ELOC; elongin-C
E 103171651 elob; elongin-B K03873 ELOB; elongin-B
E 103179006 eloal; elongin A, like K15076 ELOA; elongin-A
E 103188693 eloa; elongin-A isoform X1 K15076 ELOA; elongin-A
E 103180981 ubap2a; ubiquitin-associated protein 2a isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 103180793 msh2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 103182681 msh3; DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 103180839 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 103176529 pms1; PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 103185508 mlh1; DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 103178845 pms2; LOW QUALITY PROTEIN: mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 103189969 mlh3; DNA mismatch repair protein Mlh3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 103191080 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 103187779 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 103190605 pold3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 103179489 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 103185991 rpa3; replication protein A 14 kDa subunit isoform X1 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 103175893 rfc1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 103179892 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 103186896 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 103177200 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 103184384 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 103181773 exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 103180230 hmgb2a; high mobility group protein B2 K10802 HMGB1; high mobility group protein B1
E 103189261 wdr76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 103184180 mre11a; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 103184121 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 103184932 nbn; nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 103189703 breast cancer type 1 susceptibility protein homolog isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 103176560 bard1; BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 103189703 breast cancer type 1 susceptibility protein homolog isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 103187955 abraxas1; BRCA1-A complex subunit Abraxas 1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 103177323 BRCA1-A complex subunit RAP80 isoform X4 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 103182095 babam1; BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 103189612 babam2; BRISC and BRCA1-A complex member 2 isoform X1 K12173 BRE; BRCA1-A complex subunit BRE
E 103177251 brcc3; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 103189703 breast cancer type 1 susceptibility protein homolog isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 103180691 brip1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 103183386 topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 103189703 breast cancer type 1 susceptibility protein homolog isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 103183898 rbbp8; DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 103184180 mre11a; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 103184121 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 103184932 nbn; nibrin K10867 NBN; nibrin
D BRCA complex
E 103189703 breast cancer type 1 susceptibility protein homolog isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 103186650 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 103187515 rad51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 103187515 rad51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 103187521 rad51b; LOW QUALITY PROTEIN: DNA repair protein RAD51 homolog 2 K10869 RAD51L1; RAD51-like protein 1
E 103186931 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 103180679 rad51d; DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 103189433 xrcc2; DNA repair protein XRCC2 isoform X1 K10879 XRCC2; DNA-repair protein XRCC2
E 103175307 xrcc3; LOW QUALITY PROTEIN: DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 103181806 rad52; DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
E 103187721 rdm1; RAD52 motif-containing protein 1 isoform X1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 103174605 rad54l; DNA repair and recombination protein RAD54-like isoform X2 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 103176714 rad54l2; helicase ARIP4 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 103175136 rad54b; DNA repair and recombination protein RAD54B isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 103181075 recql; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 103187853 wrn; Werner syndrome ATP-dependent helicase homolog K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 103186352 blm; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 103179655 recql4; ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 103186352 blm; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 103191003 top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 103188678 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 103187360 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 103186064 rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 103179489 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 103185991 rpa3; replication protein A 14 kDa subunit isoform X1 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 103184800 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 103191588 ppp4r1l; serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 103181045 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 103179793 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 103177965 serine/threonine-protein phosphatase 4 regulatory subunit 3 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 103189664 smek1; serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 103185409 ppp4r4; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 103181349 ap5b1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 103178502 ap5m1; AP-5 complex subunit mu-1 isoform X1 K19023 AP5M1; AP-5 complex subunit mu-1
E 103181514 ap5s1; AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 103185123 ap5z1; AP-5 complex subunit zeta-1 isoform X1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 103187190 smc5; structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 103180931 smc6; structural maintenance of chromosomes protein 6 isoform X2 K22804 SMC6; structural maintenance of chromosomes protein 6
E 103180938 lratd1; protein LRATD1 K22805 FAM84A; protein FAM84A
E 103186637 nsmce1; non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 103185101 nsmce2; E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 103176271 ndnl2; non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 103185457 non-structural maintenance of chromosomes element 4 homolog A-like K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 103185428 non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 103178374 slf1; SMC5-SMC6 complex localization factor protein 1 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 103191422 SMC5-SMC6 complex localization factor protein 2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 103175743 eme1; crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 103188260 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 103178441 exd2; exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 103185981 sem1; 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 103178734 slx4; LOW QUALITY PROTEIN: structure-specific endonuclease subunit SLX4 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 103180929 flap endonuclease GEN homolog 1 isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 103186307 spg11; spatacsin K19026 SPG11; spatacsin
E 103175206 zfyve26; zinc finger FYVE domain-containing protein 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 103185573 rad51ap1; RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 103186276 morf4l1; mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 103188618 samhd1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 103181193 fignl1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 103175164 spidr; DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 103185097 lratd2; protein LRATD2 K22810 FAM84B; protein FAM84B
E 103186832 brat1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 103183584 hdgfl2; hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 103180546 zswim7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 103172135 emsy; BRCA2-interacting transcriptional repressor EMSY K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 103188731 heat shock factor 2-binding protein isoform X1 K25791 HSF2BP; heat shock factor 2-binding protein
E 103178289 mms22l; protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 103179680 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 103190859 tonsl; tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 103175796 biorientation of chromosomes in cell division protein 1-like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 103179869 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
E 103183834 hrob; homologous recombination OB-fold protein K27803 HROB; homologous recombination OB-fold protein
E 103181648 mcm8; DNA helicase MCM8 isoform X1 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E 103182591 mcm9; LOW QUALITY PROTEIN: DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 103189224 xrcc6; X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 103189646 xrcc5; LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 103175370 prkdc; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 103184180 mre11a; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 103184121 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 103178626 lig4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 103182673 xrcc4; DNA repair protein XRCC4 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 103191569 nhej1; non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 103190566 poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 103187767 polm; DNA-directed DNA/RNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 103180497 dntt; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 103191220 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 103187207 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 103177906 aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 103190717 dclre1c; LOW QUALITY PROTEIN: protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 103184922 tdp2b; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 103183455 smchd1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 103181938 pwwp3a; PWWP domain-containing DNA repair factor 3A K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 103183087 paxx; protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 103182309 shld2; shieldin complex subunit 2 isoform X1 K26129 SHLD2; shieldin complex subunit 2
E 103175897 BEN domain-containing protein 4 K27845 BEND4; BEN domain-containing protein 4
C FA (Fanconi anemia) pathway
D FA core complex
E 103176159 Fanconi anemia group A protein-like K10888 FANCA; fanconi anemia group A protein
E 103176160 Fanconi anemia group A protein-like K10888 FANCA; fanconi anemia group A protein
E 103177590 fancb; Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 103182826 fancc; Fanconi anemia group C protein K10890 FANCC; fanconi anemia group C protein
E 103179163 fance; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 103174994 fancf; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 103176874 fancg; Fanconi anemia group G protein isoform X1 K10894 FANCG; fanconi anemia group G protein
E 103177958 fancl; E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 103185355 fancm; Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
E 103188076 faap24; Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 103175480 faap100; Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 103187419 her9; hairy-related 9 K06054 HES1; hairy and enhancer of split 1
E 103173662 transcription factor HES-1-B K06054 HES1; hairy and enhancer of split 1
E 103184246 cenps; centromere protein S K11511 APITD1; centromere protein S
E 103175580 cenpx; centromere protein X K15360 STRA13; centromere protein X
E 103179093 ube2t; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 103186352 blm; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 103191003 top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 103188678 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 103187360 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 103186064 rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 103176637 fancd2; Fanconi anemia group D2 protein isoform X1 K10891 FANCD2; fanconi anemia group D2 protein
E 103188384 fanci; Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 103189703 breast cancer type 1 susceptibility protein homolog isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 103180691 brip1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 103186650 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 103189559 fan1; fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 103187515 rad51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 103186931 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 103178754 telo2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 103188830 usp1; ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 103188290 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 103189197 ppp6c; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 103189532 serine/threonine-protein phosphatase 6 regulatory subunit 3 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 103174940 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 103181260 ankrd28b; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X8 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 103176554 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 103172539 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 103177930 rnf8; E3 ubiquitin-protein ligase rnf8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 103173333 rnf168; E3 ubiquitin-protein ligase rnf168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 103177122 herc2; E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 103183095 tprn; LOW QUALITY PROTEIN: taperin K24164 TPRN; taperin
E 103172242 WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 103189261 wdr76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 103181661 polh; DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 103185498 poli; DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 103186374 polk; DNA polymerase kappa isoform X1 K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 103172634 rev1; DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 103178953 rev3l; LOW QUALITY PROTEIN: DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 103183110 poln; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 103179469 ube2a; ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 103177550 ube2al; ubiquitin conjugating enzyme E2 A, like K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 103183683 ubiquitin-conjugating enzyme E2 B K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 103176811 rad18; E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 103184447 hltf; helicase-like transcription factor isoform X1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 103175167 ube2v2; ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 103190912 ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 103188865 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 121849188 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 103179869 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 103181980 sprtn; DNA-dependent metalloprotease SPRTN K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 103189359 gcna; acidic repeat-containing protein isoform X1 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 103184393 cell cycle checkpoint control protein RAD9B K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 103181199 hus1; checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 103188096 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 103182689 rad17; cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 103179892 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 103186896 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 103177200 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 103184384 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 103188096 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 103186403 tipin; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 103185618 claspin K25773 CLSPN; claspin
C Triple T complex
D 103178754 telo2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 103191169 tti1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 103187828 tti2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 103178681 get4; Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 103178297 atr; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 103188773 ATR-interacting protein isoform X1 K10905 ATRIP; ATR interacting protein
D 103186517 atm; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 103180289 chek1; serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 103184008 chek2; serine/threonine-protein kinase Chk2 isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 103181515 cdc25b; M-phase inducer phosphatase 2 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 103177381 M-phase inducer phosphatase 1-B K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 103190535 LOW QUALITY PROTEIN: 14-3-3 protein zeta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 103187123 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 103185650 14-3-3 protein beta/alpha-A K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 103180696 14-3-3 protein gamma-B K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 103188669 LOW QUALITY PROTEIN: 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 103180570 ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 103175003 nav2a; neuron navigator 2 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 103185136 LOW QUALITY PROTEIN: wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 103175091 wee1; wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 103181896 wee1-like protein kinase 2-A K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 103187217 LOW QUALITY PROTEIN: wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 103175145 per2; period circadian protein homolog 2 isoform X1 K02633 PER2; period circadian protein 2
D 103177889 plastin-3 K17336 PLS3; plastin-3
D 103188365 apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 103188767 nek4; serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 103186328 nek1; serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 103177169 serine/threonine-protein kinase Nek5 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 103179961 nek10; serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 103184983 protein downstream neighbor of Son-like K22422 DONSON; protein downstream neighbor of Son
D 103186772 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 103191232 KN motif and ankyrin repeat domain-containing protein 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 103178100 kank1a; KN motif and ankyrin repeat domain-containing protein 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 103186899 schlafen family member 9 K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]
D 103180743 charged multivesicular body protein 4b K24782 CHMP4C; charged multivesicular body protein 4C
D 103188095 vps4a; vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 103183186 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 103187507 zfyve19; abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 103181652 sde2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 103188665 polq; DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 103186892 mybbp1a; myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 103178239 primpol; DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 103186552 dclre1a; DNA cross-link repair 1A protein isoform X1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 103179050 dclre1b; 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 103183315 exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 103175566 endonuclease V isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 103180384 zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 103182092 ankle1; ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 103187957 helq; helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 103182830 ercc6l2; DNA excision repair protein ERCC-6-like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 103184984 cdc5l; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 103189726 bcas2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 103189385 plrg1; LOW QUALITY PROTEIN: pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 103186606 nudt1; 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 103171789 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 103173097 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 103191328 rrm1; ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 103185624 rrm2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 103180951 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 103180335 mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 103184020 unga; uracil DNA glycosylase a isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 103189317 smug1; single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 103184976 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 103182777 mutyh; LOW QUALITY PROTEIN: adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 103189895 nthl1; LOW QUALITY PROTEIN: endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 103177329 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 103177329 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 103171789 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 103173097 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024