+F Repair protein KO #

  DNA Repair and Recombination Proteins - Esox lucius (northern pike)

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AEukaryotic type B SSBR (single strand breaks repair) C Direct repair D 105010578 mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] D 105025591 alkbh2; DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33] D 105006119 alkbh3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X1 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54] D 105026030 ascc3; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4] D 105028924 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] C BER (base exicision repair) D DNA glycosylases E 105025592 ung; uracil-DNA glycosylase isoform X2 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] E 105029173 ccno; cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-] E 105009540 tdg; G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29] E 105009541 G/T mismatch-specific thymine DNA glycosylase-like isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29] E 105013376 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] E 105016984 smug1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-] E 105030872 mutyh; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] E 109614631 mbd4; methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-] E 109614637 ogg1; N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18] E 105008268 neil1; endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18] E 105027604 neil3; endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18] E 105031539 nthl1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] D AP endonucleases E 105020316 apex1; DNA-(apurinic or apyrimidinic site) lyase K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2] E 105022379 apex2; DNA-(apurinic or apyrimidinic site) lyase 2 isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2] D Long Patch-BER factors E DNA polymerase delta complex F 105029055 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] F 105014404 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2 F 105010836 pold3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3 F 105022875 pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4 E DNA polymerase epsilon complex F 105014433 pole; DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7] F 105015984 pole2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7] F 105021784 pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7] F 105011481 pole4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7] E 105014323 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen E 105019536 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] E 105024554 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] D Short Patch-BER factors E 105014301 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-] E 105008516 xrcc1; DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1 E 105011066 lig3; DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1] D Other BER factors E 105015433 tdp1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-] E 105014574 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72] E 105021514 aplf; aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-] E 105011239 pnkp; bifunctional polynucleotide phosphatase/kinase isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78] E 105030409 high mobility group-T protein K10802 HMGB1; high mobility group protein B1 E 105030407 high mobility group protein 1.2-like K10802 HMGB1; high mobility group protein B1 E 105030464 high mobility group-T protein isoform X1 K10802 HMGB1; high mobility group protein B1 E 105012237 poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-] E 105006604 parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] E 105008840 parp3; protein mono-ADP-ribosyltransferase PARP3 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] E 105021741 parp2; poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] E 105016442 parp4; protein mono-ADP-ribosyltransferase PARP4 isoform X2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] C NER (nucleotide excision repair) D GGR (global genome repair) factors E XPC-HR23B-CETN2 complex F 105025256 xpc; DNA repair protein complementing XP-C cells isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein F 105011463 UV excision repair protein RAD23 homolog B isoform X1 K10839 RAD23; UV excision repair protein RAD23 F 105023538 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23 F 105013424 rad23a; UV excision repair protein RAD23 homolog A K10839 RAD23; UV excision repair protein RAD23 F 105025766 caltractin K10840 CETN2; centrin-2 E Cul4-DDB2 complex F 105025789 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] F 105020052 cul4a; cullin-4A K10609 CUL4; cullin 4 F 105025584 cul4b; cullin-4B isoform X1 K10609 CUL4; cullin 4 F 105025975 ddb1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1 F 105029687 ddb2; DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2 E NER4 complex D TCR (transcription coupled repair) factors E DNA-directed RNA polymerase II complex F 105020683 polr2a; DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6] F 105007541 polr2b; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6] F 105018551 polr2c; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3 F 105010716 polr2d; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4 F 105022321 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1 F 105011501 polr2e; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1 F 105025769 polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2 F 105029150 polr2g; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7 F 105026920 polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3 F 105006440 polr2i; DNA-directed RNA polymerase II subunit RPB9 isoform X1 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9 F 105022256 polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5 F 105011089 polr2j; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11 F 105027711 polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4 E Cul4-CSA complex F 105025789 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] F 105020052 cul4a; cullin-4A K10609 CUL4; cullin 4 F 105025584 cul4b; cullin-4B isoform X1 K10609 CUL4; cullin 4 F 105025975 ddb1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1 F 105014117 ercc8; DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8 E Other TCR factor F 105027238 ercc6; DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6 F 105026896 uvssa; UV-stimulated scaffold protein A isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A F 105012157 elof1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1 D TFIIH complex E 105020092 ercc3; general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4] E 105012725 ercc2; general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3] E 105029696 gtf2h1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1 E 105025392 gtf2h2c; general transcription factor IIH subunit 2-like protein isoform X3 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2 E 105026095 gtf2h3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3 E 105012338 gtf2h4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4 E 105030657 gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit E 109614561 cdk7; cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23] E 105014648 ccnh; cyclin-H isoform X1 K06634 CCNH; cyclin H E 105015562 mnat1; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1 D RPA (replication factor A) E 105028498 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1 E 105022935 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1 E 105006565 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2 E 105012379 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3 D Other NER factors E 105021082 DNA repair protein complementing XP-A cells homolog isoform X1 K10847 XPA; DNA-repair protein complementing XP-A cells E 105022897 xpa; DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells E 105029812 ercc1; DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1 E 105031067 ercc4; DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-] E 105020107 ercc5; DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5 E 105024554 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] E 105006528 mms19; MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19 E 105011392 cullin-3 isoform X1 K03869 CUL3; cullin 3 E 105024564 cullin-3 K03869 CUL3; cullin 3 E 105010654 cullin-5 K10612 CUL5; cullin 5 E 105011055 cullin-5 isoform X1 K10612 CUL5; cullin 5 E 105019655 eloc; transcription elongation factor B polypeptide 1 K03872 ELOC; elongin-C E 105012960 elongin-B isoform X1 K03873 ELOB; elongin-B E 105030139 elongin-B K03873 ELOB; elongin-B E 105027917 eloa; elongin-A K15076 ELOA; elongin-A E 105021357 elongin-A isoform X1 K15076 ELOA; elongin-A E 105014467 ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2 E 105016789 ubap2; ubiquitin-associated protein 2 isoform X6 K26545 UBAP2; ubiquitin-associated protein 2 C MMR (mismatch excision repair) D Mismatch and loop recognition factors E 105006146 msh2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2 E 105007963 msh3; DNA mismatch repair protein Msh3 K08736 MSH3; DNA mismatch repair protein MSH3 E 105028409 msh6; DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6 D MutL homologs E 105016165 pms1; PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1 E 105005798 mlh1; DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1 E 105031449 pms2; mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2 E 105026423 mlh3; DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3 D DNA polymerase delta complex E 105029055 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] E 105014404 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2 E 105010836 pold3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3 E 105022875 pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4 D RPA (replication factor A) E 105028498 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1 E 105022935 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1 E 105006565 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2 E 105012379 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3 D RFC (replication factor C) E 105009159 rfc1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1 E 105011707 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4 E 105023969 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4 E 105005894 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5 E 105011175 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5 D Other MMR factors E 105014323 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen E 105023232 exo1; exonuclease 1 isoform X3 K10746 EXO1; exonuclease 1 [EC:3.1.-.-] E 105030409 high mobility group-T protein K10802 HMGB1; high mobility group protein B1 E 105030407 high mobility group protein 1.2-like K10802 HMGB1; high mobility group protein B1 E 105030464 high mobility group-T protein isoform X1 K10802 HMGB1; high mobility group protein B1 E 105024554 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] E 105022676 wdr76; LOW QUALITY PROTEIN: WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76 B DSBR (double strand breaks repair) C HR (homologous recombination) D MRN(MRX) complex E 105024987 mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11 E 105011230 LOW QUALITY PROTEIN: DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] E 105029237 nbn; nibrin isoform X1 K10867 NBN; nibrin D BRCA1-core complex E 105030602 brca1; breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] E 105016143 BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1 D BRCA1-A complex E 105030602 brca1; breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] E 105014722 abraxas1; BRCA1-A complex subunit Abraxas 1 K20774 FAM175A; BRCA1-A complex subunit Abraxas E 105011127 uimc1; BRCA1-A complex subunit RAP80 isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80 E 105011998 babam1; BRISC and BRCA1-A complex member 1 isoform X2 K20776 BABAM; BRISC and BRCA1-A complex member 1 E 105023284 babam2; BRISC and BRCA1-A complex member 2 isoform X2 K12173 BRE; BRCA1-A complex subunit BRE E 105028082 brcc3; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-] D BRCA1-B complex E 105030602 brca1; breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] E 105009514 brip1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3] E 105027605 topbp1; DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1 D BRCA1-C complex E 105030602 brca1; breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] E 105031589 DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-] E 105024987 mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11 E 105011230 LOW QUALITY PROTEIN: DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] E 105029237 nbn; nibrin isoform X1 K10867 NBN; nibrin D BRCA complex E 105030602 brca1; breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] E 105007503 brca2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein E 105027482 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2 E 105017607 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51 D RecA family proteins E 105017607 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51 E 105017569 rad51b; DNA repair protein RAD51 homolog 2 isoform X1 K10869 RAD51L1; RAD51-like protein 1 E 105011104 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2 E 105011065 rad51d; DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3 E 105019548 xrcc2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2 E 105017656 xrcc3; DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3 D Rad52 family proteins E 105022162 rad52; DNA repair protein RAD52 homolog isoform X2 K10873 RAD52; DNA repair and recombination protein RAD52 E 105023356 rdm1; RAD52 motif-containing protein 1 isoform X1 K10874 RDM1; RAD52 motif-containing protein 1 D Rad54 family proteins E 105011887 rad54l; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-] E 105028120 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-] E 105025250 helicase ARIP4 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-] E 105018922 rad54b; DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-] D RecQ family DNA helicases E 105028196 recql; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4] E 105021732 wrn; Werner syndrome ATP-dependent helicase isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4] E 105025675 blm; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4] E 105022835 recql4; ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4] E 105012902 recql5; ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4] D Bloom's syndrome complex (BTR) E 105025675 blm; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4] E 105030479 top3a; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] E 105014540 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] E 105014451 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1 D RPA (replication factor A) E 105028498 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1 E 105022935 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1 E 105006565 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2 E 105012379 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3 D Protein phosphatase 4 E 105024361 serine/threonine-protein phosphatase 4 catalytic subunit B K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16] E 105030949 serine/threonine-protein phosphatase 4 catalytic subunit B-like K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16] E 105016684 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 E 105025731 ppp4r1; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 E 105029418 ppp4r2; serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 E 105013723 serine/threonine-protein phosphatase 4 regulatory subunit 2-A-like isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 E 105010520 ppp4r3b; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3 E 105021694 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X2 K17491 SMEK; protein phosphatase 4 regulatory subunit 3 E 105017661 ppp4r4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 D AP-5 complex E 105030004 ap5b1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1 E 105026449 ap5m1; AP-5 complex subunit mu-1 isoform X1 K19023 AP5M1; AP-5 complex subunit mu-1 E 105015859 ap5s1; AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1 E 105030520 ap5z1; AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1 D SMC5-SMC6 complex E 105015050 smc5; structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5 E 105015403 structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6 E 105030643 smc6; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6 E 105017991 lratd1; protein FAM84A K22805 FAM84A; protein FAM84A E 105013405 nsmce1; non-structural maintenance of chromosomes element 1 homolog isoform X1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27] E 105023506 nsmce2; E3 SUMO-protein ligase NSE2 isoform X1 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-] E 105013509 non-structural maintenance of chromosomes element 3 homolog isoform X1 K22823 NSMCE3; non-structural maintenance of chromosomes element 3 E 105027999 non-structural maintenance of chromosomes element 4 homolog A-like isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4 E 105027583 slf1; SMC5-SMC6 complex localization factor protein 1 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1 E 105021388 uncharacterized protein LOC105021388 isoform X1 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2 D Other HR factors E 105007197 eme1; crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-] E 105015906 exd2; exonuclease 3'-5' domain-containing protein 2 isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1] E 105029477 mus81; crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-] E 105030262 sem1; 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1 E 105014781 swi5; DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3 E 105010652 sfr1; swi5-dependent recombination DNA repair protein 1 homolog isoform X1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1 E 105020774 structure-specific endonuclease subunit slx1-like K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-] E 105012110 slx4; structure-specific endonuclease subunit SLX4 isoform X1 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) E 105030644 gen1; flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-] E 105030593 spg11; spatacsin K19026 SPG11; spatacsin E 105015936 zfyve26; zinc finger FYVE domain-containing protein 26 isoform X2 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26 E 105018232 rad51ap1; RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1 E 105020245 RAD51-associated protein 1 K20778 RAD51AP1; RAD51-associated protein 1 E 105013992 mortality factor 4-like protein 1 isoform X2 K11339 MORF4L1; mortality factor 4-like protein 1 E 105005845 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1 E 105010006 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-] E 105013972 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-] E 105009594 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-] E 105013927 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-] E 114840479 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-] E 105008888 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-] E 105026553 fignl1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-] E 105019506 spidr; DNA repair-scaffolding protein K22806 SPIDR; DNA repair-scaffolding protein E 105010304 protein FAM84B K22810 FAM84B; protein FAM84B E 105023507 lratd2; protein FAM84B K22810 FAM84B; protein FAM84B E 105006304 brat1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1 E 105007836 cfap410; cilia- and flagella-associated protein 410 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein E 105011599 hdgfl2; hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2 E 105027550 zswim7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7 E 105013432 ATPase SWSAP1 isoform X1 K25771 SWSAP1; ATPase SWSAP1 E 105028752 emsy; BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY E 105031007 hsf2bp; heat shock factor 2-binding protein isoform X2 K25791 HSF2BP; heat shock factor 2-binding protein E 105006860 mms22l; protein MMS22-like K26125 MMS22L; protein MMS22-like E 105016041 tonsl; tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2 E 105030412 bod1l1; biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 C NHEJ (non-homologous end-joining) D DNA-PK complex E 105025074 xrcc6; X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1 E 105029886 xrcc5; X-ray repair cross-complementing protein 5 isoform X1 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2 E 105019560 prkdc; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1] D MRX complex E 105024987 mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11 E 105011230 LOW QUALITY PROTEIN: DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] D DNA Ligase 4 complex E 105007451 lig4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1] E 105015205 DNA repair protein XRCC4 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4 E 105027579 DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4 E 105023171 nhej1; non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1 D X-family DNA polymerases E 105012237 poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-] E 105007342 polm; DNA-directed DNA/RNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7] E 105025934 dntt; DNA nucleotidylexotransferase isoform X1 K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31] E 105014301 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-] D Other NHEJ factors E 105014574 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72] E 105021514 aplf; aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-] E 105015375 dclre1c; protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-] E 105008404 tdp2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-] E 105019233 tyrosyl-DNA phosphodiesterase 2 isoform X1 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-] E 105019337 smchd1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 E 105022732 mucin-17 K23386 PWWP3; PWWP domain-containing DNA repair factor 3 E 105023326 paxx; protein PAXX K25772 PAXX; protein PAXX E 105030231 uncharacterized protein LOC105030231 isoform X4 K26155 CYREN; cell cycle regulator of non-homologous end joining E 105007711 jmjd8; jmjC domain-containing protein 8 K25792 JMJD8; jumonji domain-containing protein 8 E 105010703 shld2; shieldin complex subunit 2 K26129 SHLD2; shieldin complex subunit 2 E 105025379 shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3 C FA (Fanconi anemia) pathway D FA core complex E 105018563 fanca; Fanconi anemia group A protein isoform X1 K10888 FANCA; fanconi anemia group A protein E 105016450 fancb; Fanconi anemia group B protein isoform X1 K10889 FANCB; fanconi anemia group B protein E 105014108 fancc; Fanconi anemia group C protein isoform X1 K10890 FANCC; fanconi anemia group C protein E 105023847 fance; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein E 105018191 fancf; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein E 105025567 fancg; Fanconi anemia group G protein isoform X3 K10894 FANCG; fanconi anemia group G protein E 105030345 fancl; E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27] E 105016002 fancm; Fanconi anemia group M protein isoform X1 K10896 FANCM; fanconi anemia group M protein E 105018093 faap24; Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein E 105005808 faap100; Fanconi anemia core complex-associated protein 100 isoform X1 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit D FA core complex binding factors E 105011317 hes1; transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1 E 105013779 hes4; transcription factor HES-4 isoform X1 K06054 HES1; hairy and enhancer of split 1 E 105030365 transcription factor HES-1-B isoform X1 K06054 HES1; hairy and enhancer of split 1 E 105025426 centromere protein S K11511 APITD1; centromere protein S E 105013044 cenpx; centromere protein X K15360 STRA13; centromere protein X E 105030755 ube2t; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23] D Bloom's syndrome complex (BTR) E 105025675 blm; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4] E 105030479 top3a; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] E 105014540 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] E 105014451 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1 D FANCD2-I complex E 105017169 fancd2; Fanconi anemia group D2 protein isoform X2 K10891 FANCD2; fanconi anemia group D2 protein E 105018415 fanci; Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein D Downstream FA components E 105030602 brca1; breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] E 105007503 brca2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein E 105009514 brip1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3] E 105027482 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2 D Other FA pathway factors E 105018353 fan1; fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1] E 105017607 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51 E 105011104 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2 E 105021267 telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein E 105011905 usp1; ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12] E 105030615 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48 E 105022936 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48 C Other DSBR factors D Protein phosphatase 6 E 105006805 ppp6c; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16] E 105014157 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16] E 105020220 serine/threonine-protein phosphatase 6 regulatory subunit 2 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 E 105022203 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 E 105026613 ppp6r3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 E 105018821 ankrd28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A E 105012459 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A E 105016283 ankrd44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B E 105022303 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C E 105017093 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C D Ubiquitin ligases E 105015317 rnf8; E3 ubiquitin-protein ligase RNF8 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27] E 105026805 rnf168; E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31] E 105026791 rnf169; E3 ubiquitin-protein ligase RNF169 isoform X1 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31] E 105027381 E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26] D Others E 105029892 wrap53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1 E 105015040 tprn; taperin K24164 TPRN; taperin E 109615227 zcwpw1; zinc finger CW-type PWWP domain protein 1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1 E 105025156 wdr70; WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70 E 105022676 wdr76; LOW QUALITY PROTEIN: WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76 B TLS (translesion DNA synthesis) factors C Y-family DNA polymerases D 105010668 polh; DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7] D 105014328 polk; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7] D 105016617 rev1; DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-] C B-family DNA polymerases D 105017891 rev3l; DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7] C A-family DNA polymerase D 105020573 poln; LOW QUALITY PROTEIN: DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7] D 114834888 DNA polymerase nu-like K16618 POLN; DNA polymerase nu [EC:2.7.7.7] C Rad6 epistasis group D 105016494 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23] D 105007763 ube2a; ubiquitin-conjugating enzyme E2A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23] D 105025433 ube2a; ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23] D 105026696 ube2b; ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23] D 105017026 rad18; E3 ubiquitin-protein ligase RAD18 isoform X2 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27] D 105021191 hltf; helicase-like transcription factor isoform X2 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27] D 105019525 ube2v2; ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant D 105016719 ubiquitin-conjugating enzyme E2 variant 1 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant D 105005930 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] D 105022147 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] C Other TLS factors D 105014323 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen D 105017715 sprtn; sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan D 105025781 gcna; acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein B Check point factors C Rad9-Hus1-Rad1 complex D 105028603 rad9a; cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2] D 105014189 rad9b; cell cycle checkpoint control protein RAD9B isoform X1 K10995 RAD9B; cell cycle checkpoint control protein RAD9B D 105019563 hus1; checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein D 105031366 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] C HRAD17(Rad24)-RFC complex D 105025397 rad17; cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein D 105011707 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4 D 105023969 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4 D 105005894 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5 D 105011175 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5 C Rad17-Mec3-Ddc1 complex D 105031366 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] C FPC (fork protection complex) D 105016962 timeless; protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1 D 105026504 tipin; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3 D 105027901 clspn; claspin isoform X1 K25773 CLSPN; claspin C Triple T complex D 105021267 telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein D 105022763 tti1; TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1 D 105014048 tti2; TELO2-interacting protein 2 isoform X1 K23115 TTI2; TELO2-interacting protein 2 C BAG6-UBL4A-GET4 complex D 105012399 large proline-rich protein BAG6-like isoform X1 K23390 BAG6; large proline-rich protein BAG6 D 105021907 large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6 D 105014038 ubl4a; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4 D 105006518 get4; Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4 C Other check point factors D 105019805 atr; serine/threonine-protein kinase ATR isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1] D 105013510 atrip; ATR-interacting protein isoform X1 K10905 ATRIP; ATR interacting protein D 105021770 atm; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1] D 105008589 cellular tumor antigen p53-like isoform X1 K04451 TP53; tumor protein p53 D 105020676 cellular tumor antigen p53 K04451 TP53; tumor protein p53 D 105009476 chek1; serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1] D 105014423 chek2; serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1] D 105015857 cdc25b; M-phase inducer phosphatase 2 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48] D 105010884 cdc25c; M-phase inducer phosphatase 3 K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48] D 105008384 14-3-3 protein beta/alpha-2 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta D 105016475 14-3-3 protein beta/alpha-A K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta D 105017807 14-3-3 protein zeta/delta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta D 105016074 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta D 105029674 14-3-3 protein beta/alpha-1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta D 105006556 14-3-3 protein beta/alpha-1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta D 114829438 14-3-3 protein zeta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta D 105014973 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta D 105027777 14-3-3 protein gamma-1 K16198 YWHAG_H; 14-3-3 protein gamma/eta D 105025792 14-3-3 protein gamma-2 K16198 YWHAG_H; 14-3-3 protein gamma/eta D 105005922 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon D 105024110 ywhae; 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon D 105028420 nav2; neuron navigator 2 isoform X9 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4] D 105015279 wee1-like protein kinase 1-A K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] D 105018118 wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] D 105018641 wee1-like protein kinase 1-A K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] D 105020739 period circadian protein homolog 1 isoform X1 K21944 PER1; period circadian protein 1 D 105024595 period circadian protein homolog 1 isoform X1 K21944 PER1; period circadian protein 1 D 105018507 period circadian protein homolog 2 isoform X1 K02633 PER2; period circadian protein 2 D 105029130 period circadian protein homolog 2 K02633 PER2; period circadian protein 2 D 105019227 mdc1; mediator of DNA damage checkpoint protein 1 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1 D 105007727 plastin-3 isoform X1 K17336 PLS3; plastin-3 D 105026974 plastin-3 K17336 PLS3; plastin-3 D 105028547 apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-] D 105022688 serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21] D 105016320 nek5; serine/threonine-protein kinase Nek5 isoform X2 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] D 105028383 nek4; serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] D 105011810 nek1; serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] D 105021908 nek10; serine/threonine-protein kinase Nek10 isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1] D 105018865 nek11; serine/threonine-protein kinase Nek11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1] D 105019776 donson; protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son D 105011932 kank4; KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein D 105024663 KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein D 105027274 KN motif and ankyrin repeat domain-containing protein 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein D 105027785 kank2; KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein D 105029304 kank3; KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein D 105030218 kank1; KN motif and ankyrin repeat domain-containing protein 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein D 105029440 charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C D 105018959 vps4b; vacuolar protein sorting-associated protein 4B isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4 D 105018559 vps4a; vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4 D 105015643 zfyve19; abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator D 105027156 sde2; replication stress response regulator SDE2 isoform X2 K25059 SDE2; replication stress response regulator SDE2 B Other factors with a suspected DNA repair function C DNA polymerases D 105006433 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7] D 105023967 mybbp1a; myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7] D 105006734 primpol; DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7] C Nucleases D 105026232 dclre1a; DNA cross-link repair 1A protein isoform X1 K15340 DCLRE1A; DNA cross-link repair 1A protein D 105023798 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-] D 105006737 exo5; exonuclease V isoform X1 K17815 EXO5; exonuclease V [EC:3.1.-.-] D 105021638 endov; endonuclease V isoform X4 K21813 ENDOV; endonuclease V [EC:3.1.26.-] D 105022554 zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-] D 105026907 ankle1; ankyrin repeat and LEM domain-containing protein 1 isoform X1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1 C Helicases D 105014723 helq; helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4] D 105014104 ercc6l2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-] C PSO4 complex D 105029954 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27] D 105022889 prpf19; pre-mRNA-processing factor 19 isoform X1 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27] D 105005602 cdc5l; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1 D 105026944 bcas2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27 D 105022867 plrg1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1 C Modulation of nucleotide pools D 105019754 nudt15; nucleotide triphosphate diphosphatase NUDT15 isoform X2 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] D 105013216 nudt1; 7,8-dihydro-8-oxoguanine triphosphatase isoform X1 K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56] D 105031473 nudt18; 8-oxo-dGDP phosphatase NUDT18 isoform X1 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58] D 105022665 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23] D 105023907 rrm1; ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] D 105017811 rrm2; ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] D 105027716 rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] # AProkaryotic type B SSBR (single strand breaks repair) C Direct repair D 105010578 mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] D 105028924 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] C BER (base exicision repair) D DNA glycosylases E 105025592 ung; uracil-DNA glycosylase isoform X2 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] E 105016984 smug1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-] E 105013376 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] E 105030872 mutyh; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] E 105031539 nthl1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] D AP endonucleases D RecJ D DNA ligase D DNA polymerase I C NER (nucleotide excision repair) D GGR (global genome repair) factors D TCR (transcription coupled repair) factors E DNA-directed RNA polymerase complex (RNAP) E TRCF (transcription-repair coupling factor) C MMR (mismatch excision repair) D Mismatch and loop recognition factors D Molecular matchmaker D Strand discrimination factor D DNA exonucleases D DNA polymerase III holoenzyme D DNA ligase D Other MMR factors E 105025665 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein B DSBR (double strand breaks repair) C HR (homologous recombination) D RecBC pathway proteins D RecFOR pathway proteins D AddAB pathway proteins D Other HR factor D Archaeal homologous recombinant proteins C NHEJ (non-homologous end-joining) D Two-component NHEJ DNA repair complex D SHIIR (short-homology-independent illegitimate recombination) E Facilitator E Supressor D SHDIR (short-homology-dependent illegitimate recombination) E RecET pathway E Facilitator E Supressor B TLS (translesion DNA synthesis) factors C Y-family DNA polymerases C Other SOS response factors D 105025665 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein B Other factors with a suspected DNA repair function C DNA polymerase C DNA helicases C Modulation of nucleotide pools D 105019754 nudt15; nucleotide triphosphate diphosphatase NUDT15 isoform X2 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] D 105022665 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23] C Others ! #
#[ BRITE | KEGG2 | KEGG ]
#Last updated: February 5, 2024