+C GAG KO
### Glycosaminoglycan Binding Proteins - Homo sapiens (human)

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A**Heparan sulfate / Heparin**
B Cytokines
C 3553 IL1B; interleukin 1 beta K04519 IL1B; interleukin 1 beta
C 3558 IL2; interleukin 2 K05429 IL2; interleukin 2
C 3562 IL3; interleukin 3 K04736 IL3; interleukin 3
C 3565 IL4; interleukin 4 K05430 IL4; interleukin 4
C 3567 IL5; interleukin 5 K05428 IL5; interleukin 5
C 3574 IL7; interleukin 7 K05431 IL7; interleukin 7
C 3586 IL10; interleukin 10 K05443 IL10; interleukin 10
C 3592 IL12A; interleukin 12A K05406 IL12A; interleukin 12A
C 3593 IL12B; interleukin 12B K05425 IL12B; interleukin 12B
C 1437 CSF2; colony stimulating factor 2 K05427 CSF2; granulocyte-macrophage colony-stimulating factor
C 3458 IFNG; interferon gamma K04687 IFNG; interferon gamma
C 7124 TNF; tumor necrosis factor K03156 TNF; tumor necrosis factor superfamily, member 2
B Chemokines
C 6347 CCL2; C-C motif chemokine ligand 2 K14624 CCL2; C-C motif chemokine 2
C 6348 CCL3; C-C motif chemokine ligand 3 K05408 CCL3; C-C motif chemokine 3
C 6349 CCL3L1; C-C motif chemokine ligand 3 like 1 K05408 CCL3; C-C motif chemokine 3
C 414062 CCL3L3; C-C motif chemokine ligand 3 like 3 K05408 CCL3; C-C motif chemokine 3
C 6352 CCL5; C-C motif chemokine ligand 5 K12499 CCL5; C-C motif chemokine 5
C ------ CCL12; C-C motif chemokine 12 [MMU:20293] [KO:K14624]
C 6357 CCL13; C-C motif chemokine ligand 13 K16595 CCL13; C-C motif chemokine 13
C 5196 PF4; platelet factor 4 K05407 PF4; platelet factor 4
C 5197 PF4V1; platelet factor 4 variant 1 K05407 PF4; platelet factor 4
C 3576 CXCL8; C-X-C motif chemokine ligand 8 K10030 IL8; interleukin 8
C 3627 CXCL10; C-X-C motif chemokine ligand 10 K12671 CXCL10; C-X-C motif chemokine 10
C 6387 CXCL12; C-X-C motif chemokine ligand 12 K10031 CXCL12; C-X-C motif chemokine 12
B Adhesion molecules of cell surface
C 6402 SELL; selectin L K06495 SELL; selectin, lymphocyte
C 6403 SELP; selectin P K06496 SELP; selectin, platelet
C 3684 ITGAM; integrin subunit alpha M K06461 ITGAM; integrin alpha M
C 4684 NCAM1; neural cell adhesion molecule 1 K06491 NCAM; neural cell adhesion molecule
C 4685 NCAM2; neural cell adhesion molecule 2 K06491 NCAM; neural cell adhesion molecule
C 5175 PECAM1; platelet and endothelial cell adhesion molecule 1 K06471 PECAM1; platelet/endothelial cell adhesion molecule
B Morphogens
C 650 BMP2; bone morphogenetic protein 2 K21283 BMP2; bone morphogenetic protein 2
C 652 BMP4; bone morphogenetic protein 4 K04662 BMP4; bone morphogenetic protein 4
C 655 BMP7; bone morphogenetic protein 7 K16621 BMP7; bone morphogenetic protein 7
C 6469 SHH; sonic hedgehog signaling molecule K11988 SHH; sonic hedgehog
C 7471 WNT1; Wnt family member 1 K03209 WNT1; wingless-type MMTV integration site family, member 1
C 7472 WNT2; Wnt family member 2 K00182 WNT2; wingless-type MMTV integration site family, member 2
C 7482 WNT2B; Wnt family member 2B K00182 WNT2; wingless-type MMTV integration site family, member 2
C 7473 WNT3; Wnt family member 3 K00312 WNT3; wingless-type MMTV integration site family, member 3
C 89780 WNT3A; Wnt family member 3A K00312 WNT3; wingless-type MMTV integration site family, member 3
C 54361 WNT4; Wnt family member 4 K00408 WNT4; wingless-type MMTV integration site family, member 4
C 7474 WNT5A; Wnt family member 5A K00444 WNT5; wingless-type MMTV integration site family, member 5
C 81029 WNT5B; Wnt family member 5B K00444 WNT5; wingless-type MMTV integration site family, member 5
C 7475 WNT6; Wnt family member 6 K00445 WNT6; wingless-type MMTV integration site family, member 6
C 7476 WNT7A; Wnt family member 7A K00572 WNT7; wingless-type MMTV integration site family, member 7
C 7477 WNT7B; Wnt family member 7B K00572 WNT7; wingless-type MMTV integration site family, member 7
C 7478 WNT8A; Wnt family member 8A K00714 WNT8; wingless-type MMTV integration site family, member 8
C 7479 WNT8B; Wnt family member 8B K00714 WNT8; wingless-type MMTV integration site family, member 8
C 7483 WNT9A; Wnt family member 9A K01064 WNT9; wingless-type MMTV integration site family, member 9
C 7484 WNT9B; Wnt family member 9B K01064 WNT9; wingless-type MMTV integration site family, member 9
C 7480 WNT10B; Wnt family member 10B K01357 WNT10; wingless-type MMTV integration site family, member 10
C 80326 WNT10A; Wnt family member 10A K01357 WNT10; wingless-type MMTV integration site family, member 10
C 7481 WNT11; Wnt family member 11 K01384 WNT11; wingless-type MMTV integration site family, member 11
C 51384 WNT16; Wnt family member 16 K01558 WNT16; wingless-type MMTV integration site family, member 16
B Growth factors/receptors
C 374 AREG; amphiregulin K09782 AREG; amphiregulin
C 685 BTC; betacellulin K09783 BTC; betacellulin
C 2246 FGF1; fibroblast growth factor 1 K18496 FGF1; fibroblast growth factor 1
C 2247 FGF2; fibroblast growth factor 2 K18497 FGF2; fibroblast growth factor 2
C 2248 FGF3; fibroblast growth factor 3 K04358 FGF; fibroblast growth factor
C 2249 FGF4; fibroblast growth factor 4 K04358 FGF; fibroblast growth factor
C 8822 FGF17; fibroblast growth factor 17 K04358 FGF; fibroblast growth factor
C 2251 FGF6; fibroblast growth factor 6 K04358 FGF; fibroblast growth factor
C 2252 FGF7; fibroblast growth factor 7 K04358 FGF; fibroblast growth factor
C 2253 FGF8; fibroblast growth factor 8 K04358 FGF; fibroblast growth factor
C 2254 FGF9; fibroblast growth factor 9 K04358 FGF; fibroblast growth factor
C 2255 FGF10; fibroblast growth factor 10 K04358 FGF; fibroblast growth factor
C 8823 FGF16; fibroblast growth factor 16 K04358 FGF; fibroblast growth factor
C 2250 FGF5; fibroblast growth factor 5 K04358 FGF; fibroblast growth factor
C 8817 FGF18; fibroblast growth factor 18 K04358 FGF; fibroblast growth factor
C 26281 FGF20; fibroblast growth factor 20 K04358 FGF; fibroblast growth factor
C 27006 FGF22; fibroblast growth factor 22 K04358 FGF; fibroblast growth factor
C 2256 FGF11; fibroblast growth factor 11 K22413 FGF11_12_13; fibroblast growth factor 11/12/13
C 2257 FGF12; fibroblast growth factor 12 K22413 FGF11_12_13; fibroblast growth factor 11/12/13
C 2258 FGF13; fibroblast growth factor 13 K22413 FGF11_12_13; fibroblast growth factor 11/12/13
C 2259 FGF14; fibroblast growth factor 14 K23920 FGF14; fibroblast growth factor 14
C 9965 FGF19; fibroblast growth factor 19 K22603 FGF19; fibroblast growth factor 19
C 26291 FGF21; fibroblast growth factor 21 K22429 FGF21; fibroblast growth factor 21
C 8074 FGF23; fibroblast growth factor 23 K22428 FGF23; fibroblast growth factor 23
C 2260 FGFR1; fibroblast growth factor receptor 1 K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
C 2263 FGFR2; fibroblast growth factor receptor 2 K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
C 1839 HBEGF; heparin binding EGF like growth factor K08523 HBEGF; heparin-binding EGF-like growth factor
C 3082 HGF; hepatocyte growth factor K05460 HGF; hepatocyte growth factor
C 4192 MDK; midkine K06828 MDK; midkine
C 3481 IGF2; insulin like growth factor 2 K13769 IGF2; insulin-like growth factor 2
C 3084 NRG1; neuregulin 1 K05455 NRG1; neuregulin 1
C 3068 HDGF; heparin binding growth factor K16641 HDGF; hepatoma-derived growth factor
C 154150 HDGFL1; HDGF like 1 K16641 HDGF; hepatoma-derived growth factor
C 5154 PDGFA; platelet derived growth factor subunit A K04359 PDGFA; platelet-derived growth factor subunit A
C 5155 PDGFB; platelet derived growth factor subunit B K17386 PDGFB; platelet-derived growth factor subunit B
C 7040 TGFB1; transforming growth factor beta 1 K13375 TGFB1; transforming growth factor beta-1
C 7042 TGFB2; transforming growth factor beta 2 K13376 TGFB2; transforming growth factor beta-2
C 5764 PTN; pleiotrophin K16642 PTN; pleiotrophin
C 7422 VEGFA; vascular endothelial growth factor A K05448 VEGFA; vascular endothelial growth factor A
C 80739 MPIG6B; megakaryocyte and platelet inhibitory receptor G6b K25640 MPIG6B; megakaryocyte and platelet inhibitory receptor G6b
B Extracellular matrix molecules
C 2243 FGA; fibrinogen alpha chain K03903 FGA; fibrinogen alpha chain
C 2244 FGB; fibrinogen beta chain K03904 FGB; fibrinogen beta chain
C 2266 FGG; fibrinogen gamma chain K03905 FGG; fibrinogen gamma chain
C 2335 FN1; fibronectin 1 K05717 FN1; fibronectin 1
C 2200 FBN1; fibrillin 1 K06825 FBN1; fibrillin 1
C 2201 FBN2; fibrillin 2 K23342 FBN2_3; fibrillin 2/3
C 84467 FBN3; fibrillin 3 K23342 FBN2_3; fibrillin 2/3
C ------ LAMA5; laminin, alpha 5 [HSA:3911] [KO:K06240]
C 3371 TNC; tenascin C K06252 TN; tenascin
C 63923 TNN; tenascin N K06252 TN; tenascin
C 7143 TNR; tenascin R K06252 TN; tenascin
C 7148 TNXB; tenascin XB K06252 TN; tenascin
C 64093 SMOC1; SPARC related modular calcium binding 1 K24354 SMOC; SPARC-related modular calcium-binding protein
C 64094 SMOC2; SPARC related modular calcium binding 2 K24354 SMOC; SPARC-related modular calcium-binding protein
C 7057 THBS1; thrombospondin 1 K16857 THBS1; thrombospondin 1
C 1311 COMP; cartilage oligomeric matrix protein K04659 THBS2S; thrombospondin 2/3/4/5
C 7058 THBS2; thrombospondin 2 K04659 THBS2S; thrombospondin 2/3/4/5
C 7059 THBS3; thrombospondin 3 K04659 THBS2S; thrombospondin 2/3/4/5
C 7060 THBS4; thrombospondin 4 K04659 THBS2S; thrombospondin 2/3/4/5
C 7448 VTN; vitronectin K06251 VTN; vitronectin
C 1277 COL1A1; collagen type I alpha 1 chain K06236 COL1A; collagen type I alpha
C 1278 COL1A2; collagen type I alpha 2 chain K06236 COL1A; collagen type I alpha
C 1280 COL2A1; collagen type II alpha 1 chain K19719 COL2A; collagen type II alpha
C 1281 COL3A1; collagen type III alpha 1 chain K19720 COL3A; collagen type III alpha
C 1284 COL4A2; collagen type IV alpha 2 chain K06237 COL4A; collagen type IV alpha
C 1286 COL4A4; collagen type IV alpha 4 chain K06237 COL4A; collagen type IV alpha
C 1288 COL4A6; collagen type IV alpha 6 chain K06237 COL4A; collagen type IV alpha
C 1282 COL4A1; collagen type IV alpha 1 chain K06237 COL4A; collagen type IV alpha
C 1287 COL4A5; collagen type IV alpha 5 chain K06237 COL4A; collagen type IV alpha
C 1285 COL4A3; collagen type IV alpha 3 chain K06237 COL4A; collagen type IV alpha
C 1289 COL5A1; collagen type V alpha 1 chain K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha
C 1290 COL5A2; collagen type V alpha 2 chain K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha
C 50509 COL5A3; collagen type V alpha 3 chain K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha
C 1301 COL11A1; collagen type XI alpha 1 chain K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha
C 255631 COL24A1; collagen type XXIV alpha 1 chain K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha
C 85301 COL27A1; collagen type XXVII alpha 1 chain K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha
C 1302 COL11A2; collagen type XI alpha 2 chain K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha
C 1291 COL6A1; collagen type VI alpha 1 chain K06238 COL6A; collagen type VI alpha
C 1292 COL6A2; collagen type VI alpha 2 chain K06238 COL6A; collagen type VI alpha
C 1293 COL6A3; collagen type VI alpha 3 chain K06238 COL6A; collagen type VI alpha
C 131873 COL6A6; collagen type VI alpha 6 chain K06238 COL6A; collagen type VI alpha
C 256076 COL6A5; collagen type VI alpha 5 chain K06238 COL6A; collagen type VI alpha
C 1305 COL13A1; collagen type XIII alpha 1 chain K16617 COL13A; collagen type XIII alpha
C 80781 COL18A1; collagen type XVIII alpha 1 chain K06823 COL18A; collagen type XVIII alpha
C 1310 COL19A1; collagen type XIX alpha 1 chain K24340 COL19A; collagen type XIX alpha
C 91522 COL23A1; collagen type XXIII alpha 1 chain K24355 COL23A; collagen type XXIII alpha
C 84570 COL25A1; collagen type XXV alpha 1 chain K24356 COL25A; collagen type XXV alpha
B Axon guidance molecules
C 1942 EFNA1; ephrin A1 K05462 EFNA; ephrin-A
C 1943 EFNA2; ephrin A2 K05462 EFNA; ephrin-A
C 1944 EFNA3; ephrin A3 K05462 EFNA; ephrin-A
C 1945 EFNA4; ephrin A4 K05462 EFNA; ephrin-A
C 1946 EFNA5; ephrin A5 K05462 EFNA; ephrin-A
C 9423 NTN1; netrin 1 K06843 NTN1; netrin 1
C 6585 SLIT1; slit guidance ligand 1 K06838 SLIT1; slit 1
C 9353 SLIT2; slit guidance ligand 2 K06839 SLIT2; slit 2
C 6586 SLIT3; slit guidance ligand 3 K06850 SLIT3; slit 3
C ------ SEMA5A; semaphorin 5A [HSA:9037] [KO:K06841]
B Coagulation and fibrinolysis
C 2147 F2; coagulation factor II, thrombin K01313 F2; coagulation factor II (thrombin) [EC:3.4.21.5]
C 2159 F10; coagulation factor X K01314 F10; coagulation factor X [EC:3.4.21.6]
C 5104 SERPINA5; serpin family A member 5 K03913 SERPINA5; protein C inhibitor
C 462 SERPINC1; serpin family C member 1 K03911 SERPINC1; antithrombin III
C 3053 SERPIND1; serpin family D member 1 K03912 SERPIND1; heparin cofactor II
C 5054 SERPINE1; serpin family E member 1 K03982 SERPINE1; plasminogen activator inhibitor 1
C 5270 SERPINE2; serpin family E member 2 K16643 SERPINE2; glia-derived nexin
C 5327 PLAT; plasminogen activator, tissue type K01343 PLAT; tissue plasminogen activator [EC:3.4.21.68]
C 5328 PLAU; plasminogen activator, urokinase K01348 PLAU; urokinase plasminogen activator [EC:3.4.21.73]
C 7035 TFPI; tissue factor pathway inhibitor K03909 TFPI; tissue factor pathway inhibitor
B Enzymes
C 1991 ELANE; elastase, neutrophil expressed K01327 ELANE; leukocyte elastase [EC:3.4.21.37]
C 10855 HPSE; heparanase K07964 HPSE; heparanase [EC:3.2.1.166]
C 60495 HPSE2; heparanase 2 (inactive) K07965 HPSE2; heparanase 2 [EC:3.2.1.-]
C 8692 HYAL2; hyaluronidase 2 K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35]
C 3373 HYAL1; hyaluronidase 1 K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35]
C 6677 SPAM1; sperm adhesion molecule 1 K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35]
C 23553 HYAL4; hyaluronidase 4 K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35]
C 8372 HYAL3; hyaluronidase 3 K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35]
C 4023 LPL; lipoprotein lipase K01059 LPL; lipoprotein lipase [EC:3.1.1.34]
C 6649 SOD3; superoxide dismutase 3 K16627 SOD3; superoxide dismutase, Cu-Zn family [EC:1.15.1.1]
B Microbial pathogens
C ------ Dengue virus, envelope protein
C ------ Foot-and-mouth disease virus - type O, VP3
C ------ penetrin
C ------ Borrelia burgdorferi
C ------ Chlamydia trachomatis
C ------ Neisseria gonorrhoeae
C ------ Leishmania amazonensis
B Others
C 283 ANG; angiogenin K16631 ANG; angiogenin [EC:3.1.27.-]
C 308 ANXA5; annexin A5 K16646 ANXA5; annexin A5
C 116519 APOA5; apolipoprotein A5 K09025 APOA5; apolipoprotein A-V
C 338 APOB; apolipoprotein B K14462 APOB; apolipoprotein B
C 348 APOE; apolipoprotein E K04524 APOE; apolipoprotein E
C 351 APP; amyloid beta precursor protein K04520 APP; amyloid beta A4 protein
C 1508 CTSB; cathepsin B K01363 CTSB; cathepsin B [EC:3.4.22.1]
C 1511 CTSG; cathepsin G K01319 CTSG; cathepsin G [EC:3.4.21.20]
C 5621 PRNP; prion protein K05634 PRNP; prion protein
C 6546 SLC8A1; solute carrier family 8 member A1 K05849 SLC8A; solute carrier family 8 (sodium/calcium exchanger)
C 6543 SLC8A2; solute carrier family 8 member A2 K05849 SLC8A; solute carrier family 8 (sodium/calcium exchanger)
C 6547 SLC8A3; solute carrier family 8 member A3 K05849 SLC8A; solute carrier family 8 (sodium/calcium exchanger)
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A**Hyaluronan**
B Cell surface receptors
C 952 CD38; CD38 molecule K01242 CD38; ADP-ribosyl cyclase 1 [EC:3.2.2.6 2.4.99.20]
C 960 CD44; CD44 molecule (Indian blood group) K06256 CD44; CD44 antigen
C 3161 HMMR; hyaluronan mediated motility receptor K06267 HMMR; hyaluronan-mediated motility receptor
C 3383 ICAM1; intercellular adhesion molecule 1 K06490 ICAM1; intercellular adhesion molecule 1
C 7097 TLR2; toll like receptor 2 K10159 TLR2; toll-like receptor 2
C 7099 TLR4; toll like receptor 4 K10160 TLR4; toll-like receptor 4
C 143903 LAYN; layilin K10077 LAYN; layilin
C 10894 LYVE1; lymphatic vessel endothelial hyaluronan receptor 1 K19012 LYVE1; lymphatic vessel endothelial hyaluronan receptor 1
C 23166 STAB1; stabilin 1 K19020 STAB1; stabilin-1
C 55576 STAB2; stabilin 2 K19013 STAB2; stabilin-2
C 57214 CEMIP; cell migration inducing hyaluronidase 1 K19031 CEMIP; cell migration-inducing and hyaluronan-binding protein [EC:3.2.1.35]
C 23670 CEMIP2; cell migration inducing hyaluronidase 2 K22144 TEME2; cell surface hyaluronidase [EC:3.2.1.35]
B Extracellular matrix or blood plasma proteins
C 176 ACAN; aggrecan K06792 AGC1; aggrecan 1
C 63827 BCAN; brevican K06795 BCAN; brevican
C 708 C1QBP; complement C1q binding protein K15414 C1QBP; complement component 1 Q subcomponent-binding protein, mitochondrial
C 1291 COL6A1; collagen type VI alpha 1 chain K06238 COL6A; collagen type VI alpha
C 1292 COL6A2; collagen type VI alpha 2 chain K06238 COL6A; collagen type VI alpha
C 1293 COL6A3; collagen type VI alpha 3 chain K06238 COL6A; collagen type VI alpha
C 131873 COL6A6; collagen type VI alpha 6 chain K06238 COL6A; collagen type VI alpha
C 256076 COL6A5; collagen type VI alpha 5 chain K06238 COL6A; collagen type VI alpha
C 2243 FGA; fibrinogen alpha chain K03903 FGA; fibrinogen alpha chain
C 2244 FGB; fibrinogen beta chain K03904 FGB; fibrinogen beta chain
C 2266 FGG; fibrinogen gamma chain K03905 FGG; fibrinogen gamma chain
C 3026 HABP2; hyaluronan binding protein 2 K08648 HABP2; hyaluronan binding protein 2 [EC:3.4.21.-]
C 1404 HAPLN1; hyaluronan and proteoglycan link protein 1 K06848 HAPLN1; hyaluronan and proteoglycan link protein 1
C 60484 HAPLN2; hyaluronan and proteoglycan link protein 2 K06851 HAPLN2; hyaluronan and proteoglycan link protein 2
C 404037 HAPLN4; hyaluronan and proteoglycan link protein 4 K06853 HAPLN4; hyaluronan and proteoglycan link protein 4
C 3263 HPX; hemopexin K18977 HPX; hemopexin
C 3697 ITIH1; inter-alpha-trypsin inhibitor heavy chain 1 K19014 ITIH1; inter-alpha-trypsin inhibitor heavy chain H1
C 3698 ITIH2; inter-alpha-trypsin inhibitor heavy chain 2 K19015 ITIH2; inter-alpha-trypsin inhibitor heavy chain H2
C 3699 ITIH3; inter-alpha-trypsin inhibitor heavy chain 3 K24513 ITIH3; inter-alpha-trypsin inhibitor heavy chain H3
C 1463 NCAN; neurocan K06794 NCAN; neurocan core protein
C 3617 IMPG1; interphotoreceptor matrix proteoglycan 1 K19016 IMPG1; interphotoreceptor matrix proteoglycan 1
C 50939 IMPG2; interphotoreceptor matrix proteoglycan 2 K19017 IMPG2; interphotoreceptor matrix proteoglycan 2
C 7130 TNFAIP6; TNF alpha induced protein 6 K19018 TNFAIP6; tumor necrosis factor-inducible gene 6 protein
C 1462 VCAN; versican K06793 VCAN; versican core protein
B Intracellular proteins
C 11140 CDC37; cell division cycle 37, HSP90 cochaperone K09554 CDC37; cell division cycle protein 37
C 22927 HABP4; hyaluronan binding protein 4 K19019 HABP4; intracellular hyaluronan-binding protein 4
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#[ BRITE | KEGG2 | KEGG ]

#Last updated: March 1, 2022