+E Messenger RNA Biogenesis KO
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Messenger RNA Biogenesis - Plasmodium gaboni
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AEukaryotic type
B mRNA processing factors
C 5' end processing
D Capping factors
E PGSY75_0021000 protein kinase 5 K04563 CDC28; cyclin-dependent kinase [EC:2.7.11.22]
E PGSY75_1014400 MO15-related protein kinase K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E PGSY75_1414600 RNA guanylyltransferase K00987 CEG1; mRNA guanylyltransferase [EC:2.7.7.50]
D Cap binding complex
E PGSY75_0415500 putative nuclear cap-binding protein K12883 NCBP2; nuclear cap-binding protein subunit 2
C 3' end processing
D Pre-mRNA cleavage factor Im (CFIm)
E PGSY75_0109200 putative mRNA cleavage factor-like protein K14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5
D Pre-mRNA cleavage factor IIm (CFIIm)
E PGSY75_0821600 putative clp1-related protein K14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]
D Cleavage and polyadenylation specificity factor (CPSF) complex
E PGSY75_1438500 putative cleavage and polyadenylation specificity factor K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E PGSY75_1243800 putative microtubule associated katanin K14962 WDR82; COMPASS component SWD2
E PGSY75_1414400 serine/threonine protein phosphatase PP1 K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
D Cleavage stimulation factor (CSTF) complex
E PGSY75_0620500 putative cleavage stimulation factor subunit 1 K14406 CSTF1; cleavage stimulation factor subunit 1
D U7-dependent histone pre-mRNA processing factors
E PGSY75_1414800 putative small nuclear ribonucleoprotein-associated protein B K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E PGSY75_0909800 putative small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E PGSY75_1350200 putative small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E PGSY75_0822300 putative small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
E PGSY75_1438500 putative cleavage and polyadenylation specificity factor K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E PGSY75_0519000 hypothetical protein K18710 SLBP; histone RNA hairpin-binding protein
D DRB sensitivity inducing factor (DSIF) complex
E PGSY75_1030000 putative transcription elongation factor SPT4 K15171 SUPT4H1; transcription elongation factor SPT4
E PGSY75_0610900 putative transcription elongation factor SPT5 K15172 SUPT5H; transcription elongation factor SPT5
D N6-methyltransferase complex
E PGSY75_0729500 putative mRNA (N6-adenosine)-methyltransferase K05925 METTL3; mRNA m6A methyltransferase catalytic subunit [EC:2.1.1.348]
E PGSY75_1235500 putative mRNA methyltransferase K23960 METTL14; mRNA m6A methyltransferase non-catalytic subunit
E PGSY75_1230800 hypothetical protein K22824 WTAP; pre-mRNA-splicing regulator WTAP
D Poly(A) addition factors
E PGSY75_0625600 putative poly(A) polymerase PAP K14376 PAP; poly(A) polymerase [EC:2.7.7.19]
D Negative regulators of mRNA 3' end processing
C Other processing factors
D PGSY75_1467500 putative DNA/RNA-binding protein KIN17 K13102 KIN; DNA/RNA-binding protein KIN17
D PGSY75_0623100 putative coronin binding protein K23038 ZC3H14; zinc finger CCCH domain-containing protein 14
B mRNA surveillance and transport factors
C Transport factors
D EJC complex
E PGSY75_1406000 putative RNA-binding protein K12876 RBM8A; RNA-binding protein 8A
E PGSY75_0725200 mago nashi protein-like protein K12877 MAGOH; protein mago nashi
E PGSY75_0615700 putative RNA and export factor binding protein K12881 THOC4; THO complex subunit 4
E PGSY75_0209800 ATP-dependent RNA helicase UAP56 K12812 DDX39B; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7]
E PGSY75_0422700 putative eukaryotic initiation factor K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]
D TREX complex
E PGSY75_0615700 putative RNA and export factor binding protein K12881 THOC4; THO complex subunit 4
D TREX-2 complex
E PGSY75_0721800 hypothetical protein K10881 SHFM1; 26 proteasome complex subunit DSS1
E PGSY75_1027700 centrin-3 K16466 CETN3; centrin-3
D Nuclear pore complex
E PGSY75_1230700 protein transport protein SEC13 K14004 SEC13; protein transport protein SEC13
E PGSY75_1027700 centrin-3 K16466 CETN3; centrin-3
D Ran-mediated transport factors
E PGSY75_1117700 GTP-binding nuclear protein RAN/TC4 K07936 RAN; GTP-binding nuclear protein Ran
E PGSY75_1427900 conserved protein, unknown function K18647 ANP32B; acidic leucine-rich nuclear phosphoprotein 32 family member B
E PGSY75_0934700 putative UBX domain K18726 FAF2; FAS-associated factor 2
E PGSY75_0619400 cell division cycle protein 48-like protein K13525 VCP; transitional endoplasmic reticulum ATPase
E PGSY75_0302900 putative exportin-1 K14290 XPO1; exportin-1
E PGSY75_0910100 putative Ran-binding protein K18460 XPO7; exportin-7
D eIF4F and regulatory proteins
E PGSY75_0315100 translation initiation factor 4E K03259 EIF4E; translation initiation factor 4E
E PGSY75_1468700 eukaryotic initiation factor 4A K03257 EIF4A; translation initiation factor 4A
E PGSY75_0810600 putative RNA helicase K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E PGSY75_1031500 putative DEAD/DEAH box helicase K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E PGSY75_1224300 putative polyadenylate-binding protein K13126 PABPC; polyadenylate-binding protein
E PGSY75_0529500 putative cell cycle regulator protein K07575 MCTS; malignant T-cell-amplified sequence
E PGSY75_0813600 putative translation initiation factor SUI1 K24272 DENR; density-regulated protein
D APOBEC1-ACF complex
D Other transport factors
E PGSY75_1209000 hypothetical protein K14294 WIBG; partner of Y14 and mago
E PGSY75_0414500 putative RNA-binding protein K14411 MSI; RNA-binding protein Musashi
E PGSY75_0722100 PelOta protein-like protein K06965 PELO; protein pelota
E PGSY75_1459000 ATP-dependent RNA helicase DBP5 K18655 DDX19; ATP-dependent RNA helicase DDX19/DBP5 [EC:5.6.2.7]
E PGSY75_1235900 putative pre-mRNA-splicing factor SYF1 K12867 SYF1; pre-mRNA-splicing factor SYF1
E PGSY75_0912500 hypothetical protein K18732 SARNP; SAP domain-containing ribonucleoprotein
E PGSY75_0711500 putative regulator of chromosome condensation K11493 RCC1; regulator of chromosome condensation
C Surveillance factors
D Surveillance complex
E PGSY75_0212300 putative peptide chain release factor subunit 1 K03265 ETF1; peptide chain release factor subunit 1
E PGSY75_1123400 putative translation elongation factor EF-1, subunit alpha K03267 ERF3; peptide chain release factor subunit 3
E PGSY75_1005500 putative regulator of nonsense transcripts K14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]
E PGSY75_0925800 hypothetical protein K14327 UPF2; regulator of nonsense transcripts 2
D Protein phosphatase 2A
E PGSY75_0925400 protein phosphatase-beta K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
E PGSY75_1356400 putative phosphatase 2A regulatory subunit-related protein K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
D Other surveillance factors
E PGSY75_0309700 putative SECIS-binding protein 2 K19539 SECISBP2; selenocysteine insertion sequence-binding protein 2
C Factors involved in mRNA localization
D Cargo complex
E PGSY75_0621300 putative mRNA binding PUM-HD domain protein-like protein K14844 PUF6; pumilio homology domain family member 6
E PGSY75_0204800 putative 3'-5' exonuclease K18740 EXD1; exonuclease 3'-5' domain-containing protein 1
D Factors that have mRNA localization signals
D Trans-acting binding proteins
E PGSY75_0021200 elongation factor 1-alpha K03231 EEF1A; elongation factor 1-alpha
E PGSY75_1338300 putative elongation factor 1-gamma K03233 EEF1G; elongation factor 1-gamma
D Other mRNA localization factors
C mRNA cycle factors
D Common to processing body (P body) and stress granule
E PGSY75_0315100 translation initiation factor 4E K03259 EIF4E; translation initiation factor 4E
E PGSY75_1005500 putative regulator of nonsense transcripts K14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]
E PGSY75_0810600 putative RNA helicase K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E PGSY75_1031500 putative DEAD/DEAH box helicase K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E PGSY75_0320800 ATP-dependent RNA helicase DDX6 K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
E PGSY75_1474900 trailer hitch-like protein K18749 LSM14; protein LSM14
E PGSY75_0627700 transportin K18752 TNPO1; transportin-1
E PGSY75_0934800 cAMP-dependent protein kinase catalytic subunit K04345 PKA; protein kinase A [EC:2.7.11.11]
D P-body specific factors
E PGSY75_1308900 putative mRNA-decapping enzyme 2 K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E PGSY75_1124400 putative U6 snRNA-associated Sm-like protein LSm1 K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E PGSY75_0520300 putative U6 snRNA-associated Sm-like protein LSm2 K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E PGSY75_0819900 putative U6 snRNA-associated Sm-like protein LSm3 K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E PGSY75_1107000 putative U6 snRNA-associated Sm-like protein LSm4 K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E PGSY75_1443300 putative U6 snRNA-associated Sm-like protein LSm5 K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E PGSY75_1325000 putative U6 snRNA-associated Sm-like protein LSm6 K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E PGSY75_1209200 putative U6 snRNA-associated Sm-like protein LSm7 K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E PGSY75_0829300 putative U6 snRNA-associated Sm-like protein LSm8 K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
E PGSY75_0422300 alpha tubulin 2 K07374 TUBA; tubulin alpha
E PGSY75_1103800 putative CCR4-NOT transcription complex subunit 1 K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E PGSY75_1128600 putative CCR4-NOT transcription complex subunit 2 K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E PGSY75_0519500 putative carbon catabolite repressor protein 4 K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E PGSY75_0811300 CCR4-associated factor 1 K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E PGSY75_0925800 hypothetical protein K14327 UPF2; regulator of nonsense transcripts 2
E PGSY75_1027400 putative DNA-directed RNA polymerase II K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
D Stress granule specific factors
E PGSY75_1224300 putative polyadenylate-binding protein K13126 PABPC; polyadenylate-binding protein
E PGSY75_0024100B putative eukaryotic translation initiation factor eIF2A K15026 EIF2A; translation initiation factor 2A
E PGSY75_0517700 putative eukaryotic translation initiation factor K03253 EIF3B; translation initiation factor 3 subunit B
E PGSY75_1468700 eukaryotic initiation factor 4A K03257 EIF4A; translation initiation factor 4A
E PGSY75_0422700 putative eukaryotic initiation factor K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]
E PGSY75_0826700 receptor for activated c kinase K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein
B mRNA degradation factors
C 5'-3' decay
D Decapping complex
E PGSY75_1308900 putative mRNA-decapping enzyme 2 K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E PGSY75_0320800 ATP-dependent RNA helicase DDX6 K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
D Lsm complex
E PGSY75_1124400 putative U6 snRNA-associated Sm-like protein LSm1 K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E PGSY75_0520300 putative U6 snRNA-associated Sm-like protein LSm2 K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E PGSY75_0819900 putative U6 snRNA-associated Sm-like protein LSm3 K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E PGSY75_1107000 putative U6 snRNA-associated Sm-like protein LSm4 K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E PGSY75_1443300 putative U6 snRNA-associated Sm-like protein LSm5 K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E PGSY75_1325000 putative U6 snRNA-associated Sm-like protein LSm6 K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E PGSY75_1209200 putative U6 snRNA-associated Sm-like protein LSm7 K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E PGSY75_0829300 putative U6 snRNA-associated Sm-like protein LSm8 K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
D 5' exonucleases
E PGSY75_0909400 putative exoribonuclease K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
D Other 5'-3' decay factors
C 3'-5' decay
D Core exosome factors
E PGSY75_0720000 putative exosome complex component CSL4 K07573 CSL4; exosome complex component CSL4
E PGSY75_0410400 putative exosome complex component RRP4 K03679 RRP4; exosome complex component RRP4
E PGSY75_1307000 putative exosome complex component RRP40 K03681 RRP40; exosome complex component RRP40
E PGSY75_1427800 putative exosome complex exonuclease RRP41 K11600 RRP41; exosome complex component RRP41
E PGSY75_1364500 putative exosome complex component RRP45 K03678 RRP45; exosome complex component RRP45
D Exosome cofactors
E PGSY75_1359300 exosome complex exonuclease RRP44 K12585 DIS3; exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-]
E PGSY75_1445500 hypothetical protein K12592 C1D; exosome complex protein LRP1
E PGSY75_0903400 putative DEAD/DEAH box helicase K20103 DDX60; ATP-dependent RNA helicase DDX60 [EC:5.6.2.7]
D TRAMP complex
E PGSY75_1332400 putative nucleotidyltransferase K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
E PGSY75_0602100 putative ATP-dependent RNA helicase K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
D Ski complex
D Ccr4-NOT complex
E PGSY75_0519500 putative carbon catabolite repressor protein 4 K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E PGSY75_1103800 putative CCR4-NOT transcription complex subunit 1 K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E PGSY75_1128600 putative CCR4-NOT transcription complex subunit 2 K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E PGSY75_0811300 CCR4-associated factor 1 K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E PGSY75_0507600 putative cell differentiation protein K12606 RCD1; CCR4-NOT transcription complex subunit 9
E PGSY75_1434000 putative CCR4-associated factor 16 K12608 CAF16; CCR4-NOT complex subunit CAF16
D Pan complex
D Other 3'-5' decay factors
E PGSY75_1443500 putative poly(A)-specific ribonuclease PARN K01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]
E PGSY75_0821300 putative ATP-dependent RNA helicase prh1 K14442 DHX36; ATP-dependent RNA helicase DHX36 [EC:5.6.2.6]
C Other degradation factors
D RNases
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AProkaryotic type
B Bacterial mRNA degradation factors
C RNA degradosome components
D Ribonucreases
D Helicases
D Other RNA degradosome components
E PGSY75_1015900 enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
C Other RNA degradation factors
D Chaperones
E PGSY75_1134000 heat shock protein 70 K04043 dnaK; molecular chaperone DnaK
E PGSY75_1015600 heat shock protein 60 K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
E PGSY75_1232100 60 kDa chaperonin K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D Others
D Bacterial Small RNA Regulators
B Archeal mRNA degradation factors
C Exosome components
D Core exosome
E PGSY75_0410400 putative exosome complex component RRP4 K03679 RRP4; exosome complex component RRP4
E PGSY75_0720000 putative exosome complex component CSL4 K07573 CSL4; exosome complex component CSL4
D Cofactors
E PGSY75_1427800 putative exosome complex exonuclease RRP41 K11600 RRP41; exosome complex component RRP41
D Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 25, 2024