+D Chaperone KO
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Chaperones and Folding Catalysts - Komagataella phaffii
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AHeat shock proteins
B HSP110
C PAS_chr1-3_0063 Molecular chaperone of the endoplasmic reticulum lumen K09486 HYOU1; hypoxia up-regulated 1
B HSP100
C PAS_chr1-3_0102 Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) K03695 clpB; ATP-dependent Clp protease ATP-binding subunit ClpB
C PAS_chr2-1_0324 Oligomeric mitochondrial matrix chaperone K03695 clpB; ATP-dependent Clp protease ATP-binding subunit ClpB
C PAS_chr3_0928 Mitochondrial ATP-binding protein K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX
B HSP90
C PAS_chr1-4_0130 Heat shock protein Hsp90 K04079 HSP90A; molecular chaperone HtpG
B HSP70 / DNAK
C PAS_chr3_0731 Cytoplasmic ATPase that is a ribosome-associated molecular chaperone K03283 HSPA1s; heat shock 70kDa protein 1/2/6/8
C PAS_chr4_0552 ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport K03283 HSPA1s; heat shock 70kDa protein 1/2/6/8
C PAS_chr3_0230 ATPase involved in protein folding and the response to stress K03283 HSPA1s; heat shock 70kDa protein 1/2/6/8
C PAS_chr2-1_0140 ATPase involved in protein import into the ER K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
C PAS_chr3_0365 Mitochondrial matrix ATPase K04043 dnaK; molecular chaperone DnaK
C PAS_chr3_0402 Mitochondrial matrix ATPase K04043 dnaK; molecular chaperone DnaK
B HSP60 / Chaperonin
C PAS_chr2-1_0113 Alpha subunit of chaperonin-containing T-complex K09493 CCT1; T-complex protein 1 subunit alpha
C PAS_chr4_0121 Subunit beta of the cytosolic chaperonin Cct ring complex K09494 CCT2; T-complex protein 1 subunit beta
C PAS_chr2-2_0402 Subunit of the cytosolic chaperonin Cct ring complex K09495 CCT3; T-complex protein 1 subunit gamma
C PAS_chr3_0571 Subunit of the cytosolic chaperonin Cct ring complex K09496 CCT4; T-complex protein 1 subunit delta
C PAS_chr2-1_0555 Subunit of the cytosolic chaperonin Cct ring complex K09497 CCT5; T-complex protein 1 subunit epsilon
C PAS_chr4_0513 Subunit of the cytosolic chaperonin Cct ring complex K09498 CCT6; T-complex protein 1 subunit zeta
C PAS_chr2-1_0079 Subunit of the cytosolic chaperonin Cct ring complex K09499 CCT7; T-complex protein 1 subunit eta
C PAS_chr3_0300 Subunit of the cytosolic chaperonin Cct ring complex K09500 CCT8; T-complex protein 1 subunit theta
C PAS_chr4_0158 Tetradecameric mitochondrial chaperonin K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
B HSP47
B HSP40 / DNAJ
C PAS_chr2-2_0066 Protein chaperone involved in regulation of the HSP90 and HSP70 functions K09503 DNAJA2; DnaJ homolog subfamily A member 2
C PAS_chr3_0480 Putative chaperone K09503 DNAJA2; DnaJ homolog subfamily A member 2
C PAS_chr1-4_0519 Co-chaperone that stimulates the ATPase activity of Ssa1p K09506 DNAJA5; DnaJ homolog subfamily A member 5
C PAS_chr2-2_0151 Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p K09510 DNAJB4; DnaJ homolog subfamily B member 4
C PAS_chr1-1_0086 Co-chaperone for Hsp40p K09518 DNAJB12; DnaJ homolog subfamily B member 12
C PAS_chr2-1_0282 Cytosolic ribosome-associated chaperone K09522 DNAJC2; DnaJ homolog subfamily C member 2
C PAS_chr2-2_0015 One of several homologs of bacterial chaperone DnaJ K09523 DNAJC3; DnaJ homolog subfamily C member 3
C PAS_chr2-1_0157 hypothetical protein K09528 DNAJC8; DnaJ homolog subfamily C member 8
C PAS_chr4_0417 hypothetical protein K09529 DNAJC9; DnaJ homolog subfamily C member 9
C PAS_chr1-3_0089 Protein chaperone involved in regulation of the HSP90 and HSP70 functions K09537 DNAJC17; DnaJ homolog subfamily C member 17
C PAS_chr2-2_0413 J-protein co-chaperone of the mitochondrial import motor K09539 DNAJC19; DnaJ homolog subfamily C member 19
C PAS_chr2-1_0691 Constituent of the mitochondrial import motor associated with the presequence translocase K09539 DNAJC19; DnaJ homolog subfamily C member 19
C PAS_chr4_0395 Essential subunit of Sec63 complex (Sec63p K09540 SEC63; translocation protein SEC63
C PAS_chr2-2_0323 Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p K03686 dnaJ; molecular chaperone DnaJ
C PAS_chr4_0353 Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria K04082 hscB; molecular chaperone HscB
B HSP33
B HSP24
C PAS_chr1-4_0272 GrpE protein homolog K03687 GRPE; molecular chaperone GrpE
B HSP20
B HSP15
B HSP10
C PAS_chr1-4_0163 hypothetical protein K04078 groES; chaperonin GroES
B GimC
C PAS_chr2-1_0833 hypothetical protein K09549 PFDN2; prefoldin subunit 2
C PAS_chr1-1_0405 Subunit of the heterohexameric cochaperone prefoldin complex K09550 PFDN4; prefoldin subunit 4
C PAS_chr2-1_0194 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic C K04797 pfdA; prefoldin alpha subunit
C PAS_chr1-4_0405 Subunit of the heterohexameric Gim/prefoldin protein complex K04798 pfdB; prefoldin beta subunit
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AOther chaperones and cochaperones
B Calnexin / calreticulin
C PAS_chr2-1_0322 Calnexin K08054 CANX; calnexin
B DegP / HtrA
B AAA proteases
C PAS_chr1-4_0649 Mitochondrial respiratory chain complexes assembly protein RCA1 K08956 AFG3; AFG3 family protein [EC:3.4.24.-]
C PAS_chr4_0856 Component K08956 AFG3; AFG3 family protein [EC:3.4.24.-]
B PapD
B SecB
B Sti1 / p60
C PAS_chr2-1_0518 Hsp90 cochaperone K09553 STIP1; stress-induced-phosphoprotein 1
B Cdc37 / p50
C PAS_chr2-1_0828 hypothetical protein K09554 CDC37; cell division cycle protein 37
B BAG
B Others
C PAS_chr2-1_0042 Hsp70 (Ssa1p) nucleotide exchange factor K09562 HSPBP1; hsp70-interacting protein
C PAS_chr1-1_0486 hypothetical protein K23327 HIKESHI; protein Hikeshi
C PAS_chr3_0470 hypothetical protein K21804 METTL21A; protein N-lysine methyltransferase METTL21A [EC:2.1.1.-]
C PAS_chr2-1_0320 Protein containing a UCS (UNC-45/CRO1/SHE4) domain K21991 UNC45; protein unc-45
C PAS_chr1-4_0113 hypothetical protein K16365 SGTA; small glutamine-rich tetratricopeptide repeat-containing protein alpha
C PAS_chr2-1_0849 hypothetical protein K24927 TTC4; tetratricopeptide repeat protein 4
C PAS_chr3_0464 Putative protein of unknown function K24962 CCDC47; PAT complex subunit CCDC47
C PAS_chr1-4_0072 Co-chaperone that binds to Hsp82p and activates its ATPase activity K26216 AHSA1; activator of Hsp90 ATPase protein 1
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AIntramolecular chaperones
B Subtilisin family
C PAS_chr1-4_0548 Vacuolar proteinase B (YscB) K01336 PRB1; cerevisin [EC:3.4.21.48 3.4.21.-]
C PAS_chr1-1_0226 Vacuolar proteinase B (YscB) K01336 PRB1; cerevisin [EC:3.4.21.48 3.4.21.-]
C PAS_chr1-4_0251 hypothetical protein K14644 OSW3; subtilase-type proteinase RRT12 [EC:3.4.21.-]
C PAS_chr2-1_0304 Kex2 proprotein convertase K01341 KEX2; kexin [EC:3.4.21.61]
B Papain family
B Other peptidases
C PAS_chr1-4_0013 carboxypeptidase Y K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
C PAS_chr4_0584 Aspartic protease K06009 YPS1_2; yapsin 1/2 [EC:3.4.23.41]
B Others
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AProtein folding catalysts
B Peptidyl prolyl isomerase
C Cyclophilin
D PAS_chr1-1_0267 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
D PAS_chr4_0545 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
D PAS_chr3_0567 Peptidyl-prolyl cis-trans isomerase (cyclophilin) K05864 PPID; peptidyl-prolyl isomerase D [EC:5.2.1.8]
D PAS_chr3_0378 Peptidyl-prolyl cis-trans isomerase (cyclophilin) K05864 PPID; peptidyl-prolyl isomerase D [EC:5.2.1.8]
D PAS_chr1-3_0129 hypothetical protein K12735 PPIL4; peptidyl-prolyl cis-trans isomerase-like 4 [EC:5.2.1.8]
C FKBP
D PAS_chr2-2_0375 Peptidyl-prolyl cis-trans isomerase (PPIase) K09568 FKBP1; FK506-binding protein 1 [EC:5.2.1.8]
D PAS_c131_0001 hypothetical protein K09569 FKBP2; FK506-binding protein 2 [EC:5.2.1.8]
C Parvulin
D PAS_chr2-2_0381 Peptidylprolyl-cis/trans-isomerase (PPIase) K09578 PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8]
B Protein disulfide isomerase
C PAS_chr4_0284 Cytoplasmic thioredoxin isoenzyme of the thioredoxin system K03671 trxA; thioredoxin 1
C PAS_chr4_0725 Cytoplasmic thioredoxin isoenzyme of the thioredoxin system K03671 trxA; thioredoxin 1
C PAS_chr3_0670 Cytoplasmic thioredoxin isoenzyme of the thioredoxin system K03671 trxA; thioredoxin 1
C PAS_chr4_0840 Cytoplasmic glutaredoxin K03676 grxC; glutaredoxin 3
C PAS_chr1-4_0207 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase K07390 grxD; monothiol glutaredoxin
C PAS_chr4_0844 Protein disulfide isomerase K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
C PAS_chr1-1_0160 Protein disulfide isomerase K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C PAS_chr1-3_0125 Member of the protein disulfide isomerase (PDI) family K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C PAS_chr4_0991 hypothetical protein K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C PAS_chr2-1_0421 ER protein with chaperone and co-chaperone activity K13996 EPS1; protein disulfide-isomerase [EC:5.3.4.1]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: January 6, 2023