+E Replication protein KO
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DNA Replication Proteins - Parasteatoda tepidariorum (common house spider)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 107442530 origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 107452014 origin recognition complex subunit 3 isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 107446884 origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 107444300 origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 122268365 DNA replication factor Cdt1-like K10727 CDT1; chromatin licensing and DNA replication factor 1
D 107449967 DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 107451340 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 107455396 DNA replication licensing factor mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 107438264 zygotic DNA replication licensing factor mcm3 isoform X1 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 107441637 DNA replication licensing factor mcm4-A K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 107452194 DNA replication licensing factor mcm5-A K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 107440560 DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 107446628 DNA replication licensing factor mcm7-B isoform X1 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 107448094 cyclin-A1 K06627 CCNA; cyclin-A
D 107455437 G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 122270415 G1/S-specific cyclin-E1-like isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 107443618 cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 107441524 cell division cycle 7-related protein kinase isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 107446925 DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 107445639 DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 107447926 DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 107447539 DNA replication complex GINS protein SLD5 isoform X1 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 107436104 DNA topoisomerase 2-binding protein 1-A K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 107456458 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 107439546 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 107447175 DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 107454765 DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 107452565 protein MCM10 homolog isoform X1 K10736 MCM10; minichromosome maintenance protein 10
D 107443016 cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 107447399 mdm2-binding protein isoform X1 K26116 MTBP; Mdm2-binding protein
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 107452759 DNA polymerase alpha catalytic subunit isoform X1 K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 107445887 DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 107445730 DNA primase large subunit isoform X1 K02685 PRI2; DNA primase large subunit
D 107449975 DNA primase large subunit K02685 PRI2; DNA primase large subunit
D 107447263 DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 107437269 DNA polymerase epsilon catalytic subunit A-like K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 107451467 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 107454393 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 107441768 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 107436816 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 107457511 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 107439327 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 107437377 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 107455983 DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
C RPA (replication protein A)
D 107449115 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 107438833 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
C RFC (replication factor C)
D 107447890 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 107439251 replication factor C subunit 4 isoform X2 K10755 RFC2_4; replication factor C subunit 2/4
D 107449545 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 107454092 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 107440488 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 107448464 ribonuclease H2 subunit A isoform X1 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 107449007 ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 107441149 ribonuclease H2 subunit C-like K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 107441171 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 107437510 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 107448823 flap endonuclease 1 isoform X2 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 107446642 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 107438179 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C DNA methylation enzymes
D 107449723 DNA (cytosine-5)-methyltransferase PliMCI K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
D 107442000 geminin K10749 GMNN; geminin
D 107456309 G2/mitotic-specific cyclin-B K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 107440123 G2/mitotic-specific cyclin-B3 isoform X3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
C Telomere proteins
D Shelterin complex
E 107448995 uncharacterized protein LOC107448995 isoform X1 K11109 POT1; protection of telomeres protein 1
D TERB1-TERB2-MAJIN complex
E 107445686 telomere repeats-binding bouquet formation protein 1 isoform X1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 107457373 protein SMG5 K11125 SMG5; protein SMG5
D 107451625 telomerase protein component 1 isoform X1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 107436380 H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 107452518 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 122268242 H/ACA ribonucleoprotein complex subunit 3-like K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 107437367 H/ACA ribonucleoprotein complex subunit 4 isoform X1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D Sm core complex
E 107454658 small nuclear ribonucleoprotein-associated protein B K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 107441101 small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 107456256 small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 107438325 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 107448885 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 107451553 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 107440251 small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 107441500 probable small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 107456459 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 107457392 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 107453687 small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 107439251 replication factor C subunit 4 isoform X2 K10755 RFC2_4; replication factor C subunit 2/4
D 107449545 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 107454092 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 107440488 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 107455570 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
D 107455150 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 107441573 nibrin isoform X1 K10867 NBN; nibrin
C Other termination factors
D 107436518 Werner syndrome ATP-dependent helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 107439561 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 107443732 DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 107438009 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 107443764 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 107456154 poly [ADP-ribose] polymerase tankyrase-2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 107444468 regulator of telomere elongation helicase 1 homolog K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 107441420 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 107441579 telomerase RNA component interacting RNase K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 107442904 telomere-associated protein RIF1 K11138 RIF1; telomere-associated protein RIF1
D 107438391 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 122270371 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 107439511 ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 122268855 ATP-dependent DNA helicase pif1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 122271465 uncharacterized protein LOC122271465 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 122272542 ATP-dependent DNA helicase pif1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 107441635 transcriptional activator protein Pur-beta isoform X1 K21772 PURA; transcriptional activator protein Pur-alpha
D 107454884 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 107455026 replication stress response regulator SDE2 isoform X1 K25059 SDE2; replication stress response regulator SDE2
D 107453853 replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 107437765 DNA topoisomerase 1-like K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 107445015 DNA topoisomerase I, mitochondrial K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 107455161 DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 107436803 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 107456424 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 107454100 single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
D RFC (replication factor C)
D Other elongation factors
E 107437510 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 107448823 flap endonuclease 1 isoform X2 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 107438179 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022