+F Repair protein KO
#
DNA Repair and Recombination Proteins - Rattus norvegicus (rat)
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 25332 Mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 304578 Alkbh2; DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 362169 Alkbh3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 309887 Ascc3; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 304577 Ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 114521 Tdg; G/T mismatch-specific thymine DNA glycosylase isoform 1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 24561 Mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 315344 Smug1; single-strand selective monofunctional uracil-DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 170841 Mutyh; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 680915 Mbd4; methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 81528 Ogg1; N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 367090 Neil1; endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 305957 Neil2; endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 290729 Neil3; endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 29541 Nthl1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 79116 Apex1; DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 317628 Apex2; DNA-(apurinic or apyrimidinic site) endonuclease 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
E 289662 Apex2l1; DNA-(apurinic or apyrimidinic site) lyase 2-like K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 59294 Pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 289758 Pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 293144 Pold3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
F 361698 Pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 304573 Pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 299112 Pole2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 298098 Pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 362385 Pole4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 25737 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 84490 Fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 81513 Lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 29240 Polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 84495 Xrcc1; DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 303369 Lig3; DNA ligase 3 isoform 1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 314380 Tdp1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 259271 Aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 500247 Aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 308576 Pnkp; bifunctional polynucleotide phosphatase/kinase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 25459 Hmgb1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 108348989 Hmgb1l1; high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 108349189 Hmgb1l2; high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 497907 Hmgb1l5; high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 690521 Hmgb1l3; high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 108350839 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 134478941 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 134483981 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 134485624 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 134486889 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 361767 Poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 25591 Parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 290027 Parp2; poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 300985 Parp3; protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 361046 Parp4; poly [ADP-ribose] polymerase 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 312560 Xpc; DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 298012 Rad23b; UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 361381 Rad23a; UV excision repair protein RAD23 homolog A isoform 1 K10839 RAD23; UV excision repair protein RAD23
F 84593 Cetn2; centrin-2 isoform 1 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 300084 Rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 302502 Cul4b; cullin-4B K10609 CUL4; cullin 4
F 361181 Cul4a; cullin-4A K10609 CUL4; cullin 4
F 64470 Ddb1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 100362121 Ddb2; DNA damage-binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 363633 Polr2a; DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 289561 Polr2b; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 361365 Polr2c; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 364834 Polr2d; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 690966 Polr2e; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 83503 Polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 117017 Polr2g; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 498109 Polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 120098305 DNA-directed RNA polymerases I, II, and III subunit RPABC3-like K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 292778 Polr2i; DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 681193 Polr2sl1; DNA-directed RNA polymerases I, II, and III subunit RPABC5-like K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 502374 Polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 288588 Polr2j; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 100361574 Polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 300084 Rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 302502 Cul4b; cullin-4B K10609 CUL4; cullin 4
F 361181 Cul4a; cullin-4A K10609 CUL4; cullin 4
F 64470 Ddb1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 310071 Ercc8; DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 306274 Ercc6; DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 314061 Uvssa; UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 691193 Elof1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 291703 Ercc3; general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 308415 Ercc2; general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 361580 Gtf2h1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 294693 Gtf2h2; general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 288651 Gtf2h3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 294236 Gtf2h4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 502227 Gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 120103497 general transcription factor IIH subunit 5-like K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 171150 Cdk7; cyclin-dependent kinase 7 isoform 1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 84389 Ccnh; cyclin-H K06634 CCNH; cyclin H
E 266713 Mnat1; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 287524 Rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 59102 Rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 296883 Rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 100362927 Rpa3l1; replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D Other NER factors
E 298074 Xpa; DNA repair protein complementing XP-A cells isoform 1 K10847 XPA; DNA-repair protein complementing XP-A cells
E 292673 Ercc1; DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 304719 Ercc4; DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 103693257 Ercc4l1; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 81513 Lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 171124 Mms19; MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 301555 Cul3; cullin-3 K03869 CUL3; cullin 3
E 64624 Cul5; cullin-5 K10612 CUL5; cullin 5
E 64525 Eloc; elongin-C K03872 ELOC; elongin-C
E 134482479 elongin-C-like K03872 ELOC; elongin-C
E 134482480 elongin-C-like K03872 ELOC; elongin-C
E 134482485 elongin-C-like K03872 ELOC; elongin-C
E 103691088 Elocl1; elongin-C-like K03872 ELOC; elongin-C
E 120097475 elongin-C-like K03872 ELOC; elongin-C
E 120099279 elongin-C-like K03872 ELOC; elongin-C
E 81807 Elob; elongin-B K03873 ELOB; elongin-B
E 134486081 elongin-B-like K03873 ELOB; elongin-B
E 120101893 Elob-ps3; elongin-B-like K03873 ELOB; elongin-B
E 134486082 elongin-B-like K03873 ELOB; elongin-B
E 690241 Elob-ps14; elongin-B-like K03873 ELOB; elongin-B
E 502620 Elob-ps8; elongin-B-like K03873 ELOB; elongin-B
E 134486083 elongin-B-like K03873 ELOB; elongin-B
E 120101899 Elob-ps15; elongin-B-like K03873 ELOB; elongin-B
E 134486084 elongin-B-like K03873 ELOB; elongin-B
E 120101894 Elob-ps13; elongin-B-like K03873 ELOB; elongin-B
E 120101896 Elob-ps7; elongin-B-like K03873 ELOB; elongin-B
E 120101895 Elob-ps5; elongin-B-like K03873 ELOB; elongin-B
E 134486085 elongin-B-like K03873 ELOB; elongin-B
E 25562 Eloa; elongin-A K15076 ELOA; elongin-A
E 361984 Ubap2l; ubiquitin-associated protein 2-like K26545 UBAP2; ubiquitin-associated protein 2
E 313169 Ubap2; ubiquitin-associated protein 2 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 81709 Msh2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 499505 Msh3; DNA mismatch repair protein Msh3 K08736 MSH3; DNA mismatch repair protein MSH3
E 100360342 Msh6; DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 494322 Pms1; PMS1 protein homolog 1 K10864 PMS1; DNA mismatch repair protein PMS1
E 81685 Mlh1; DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 314320 Mlh3; DNA mismatch repair protein Mlh3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 59294 Pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 289758 Pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 293144 Pold3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E 361698 Pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 287524 Rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 59102 Rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 296883 Rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 100362927 Rpa3l1; replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 89809 Rfc1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 288003 Rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 116468 Rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 304528 Rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 288414 Rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 25737 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 305000 Exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 25459 Hmgb1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 108348989 Hmgb1l1; high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 108349189 Hmgb1l2; high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 497907 Hmgb1l5; high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 690521 Hmgb1l3; high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 108350839 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 134478941 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 134483981 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 134485624 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 134486889 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 81513 Lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 311361 Wdr76; WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 64046 Mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 64012 Rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 85482 Nbn; nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 497672 Brca1; breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 64557 Bard1; BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 497672 Brca1; breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 289468 Abraxas1; BRCA1-A complex subunit Abraxas 1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 290997 Uimc1; BRCA1-A complex subunit RAP80 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 290631 Babam1; BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 362704 Babam2; BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 316794 Brcc3; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 103692848 Brcc3dc; BRCA1/BRCA2-containing complex, subunit 3, domain containing K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 497672 Brca1; breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 360588 Brip1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 315969 Topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 497672 Brca1; breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 291787 Rbbp8; DNA endonuclease RBBP8 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 64046 Mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 64012 Rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 85482 Nbn; nibrin K10867 NBN; nibrin
D BRCA complex
E 497672 Brca1; breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 360254 Brca2; breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
E 293452 Palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 499870 Rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 499870 Rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 500679 Rad51b; DNA repair protein RAD51 homolog 2 K10869 RAD51L1; RAD51-like protein 1
E 497976 Rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 303375 Rad51d; DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 499966 Xrcc2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 102551085 Xrcc3; DNA repair protein XRCC3 isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 297561 Rad52; DNA repair protein RAD52 homolog K10873 RAD52; DNA repair and recombination protein RAD52
E 287726 Rdm1; RAD52 motif-containing protein 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 298429 Rad54l; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 363135 Rad54l2; helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 313063 Rad54b; fibrinogen silencer-binding protein K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 312824 Recql; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 290805 Wrn; bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 308755 Blm; BLM RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 300057 Recql4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 287834 Recql5; ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 308755 Blm; BLM RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 303194 Top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 287930 Top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 306734 Rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 497856 Rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 287524 Rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 59102 Rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 296883 Rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 100362927 Rpa3l1; replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 171366 Ppp4c; serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 140943 Ppp4r1; serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 297486 Ppp4r2; serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 100909486 Ppp4r3cl3; protein PPP4R3C-like K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 302447 Ppp4r3cl2; protein PPP4R3C K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 302756 Ppp4r3c; protein phosphatase 4 regulatory subunit 3C K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 314388 Ppp4r3a; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 2 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 317272 Ppp4r3cl1; protein PPP4R3C K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 360993 Ppp4r3b; serine/threonine-protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 500711 Ppp4r4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 2 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 361709 Ap5b1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 305861 Ap5m1; AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 499893 Ap5s1; AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 641386 Ap5z1; AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 293967 Smc5; structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 313961 Smc6; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 313969 Lratd1; protein LRATD1 K22805 FAM84A; protein FAM84A
E 361645 Nsmce1; non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 299957 Nsmce2; E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 309259 Nsmce3; non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 102551929 Mageb10; melanoma-associated antigen G1-like K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 293528 Nsmce4a; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 691688 Eid3; EP300-interacting inhibitor of differentiation 3 K22826 EID3; EP300-interacting inhibitor of differentiation 3
E 294601 Slf1; SMC5-SMC6 complex localization factor protein 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 499360 Slf2; SMC5-SMC6 complex localization factor protein 2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 287634 Eme1; crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 302982 Eme2; probable crossover junction endonuclease EME2 isoform 1 K10883 EME2; crossover junction endonuclease EME2
E 362759 Exd2; exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 293678 Mus81; crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 680532 Sem1; 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 499779 Swi5; DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 294030 Sfr1; swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 293489 Slx1b; structure-specific endonuclease subunit SLX1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 302953 Slx4; structure-specific endonuclease subunit SLX4 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 298884 Gen1; flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 311372 Spg11; spatacsin K19026 SPG11; spatacsin
E 314265 Zfyve26; zinc finger FYVE domain-containing protein 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 689055 Rad51ap1; RAD51-associated protein 1 isoform 2 K20778 RAD51AP1; RAD51-associated protein 1
E 300891 Morf4l1; mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 311580 Samhd1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 289777 Fignl1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 498119 Spidr; DNA repair-scaffolding protein K22806 SPIDR; DNA repair-scaffolding protein
E 120093666 Lratd2; protein LRATD2 K22810 FAM84B; protein FAM84B
E 498150 Brat1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 309681 Cfap410; cilia and flagella associated protein 410 K23456 CFAP410; cilla- and flagella-associated protein
E 171073 Hdgfl2; hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 287388 Zswim7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 363029 Swsap1; ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 361607 Emsy; BRCA2-interacting transcriptional repressor EMSY K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 499413 Hsf2bp; heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 313108 Mms22l; protein MMS22-like K26125 MMS22L; protein MMS22-like
E 366953 Tonsl; tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 207118 Bod1l1; biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 100310874 Parpbp; PCNA-interacting partner isoform 3 K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 25019 Xrcc6; X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 363247 Xrcc5; X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 360748 Prkdc; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 64046 Mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 64012 Rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 290907 Lig4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 309995 Xrcc4; DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
E 363251 Nhej1; non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 361767 Poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 289757 Polm; DNA-directed DNA/RNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 294051 Dntt; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 29240 Polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 259271 Aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 500247 Aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 259171 Dclre1c; protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 498749 Tdp2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 316732 Smchd1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 362838 Pwwp3a; PWWP domain-containing DNA repair factor 3A K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 501630 Pwwp3b; PWWP domain-containing DNA repair factor 3B K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 690082 Pwwp4; PWWP domain-containing DNA repair factor 4 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 134484029 PWWP domain-containing DNA repair factor 4-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 134484031 PWWP domain-containing DNA repair factor 4-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 500077 Cyren; cell cycle regulator of non-homologous end joining K26155 CYREN; cell cycle regulator of non-homologous end joining
E 360498 Jmjd8; jmjC domain-containing protein 8 precursor K25792 JMJD8; jumonji domain-containing protein 8
E 681292 Shld1; shieldin complex subunit 1 K26128 SHLD1; shieldin complex subunit 1
E 364514 Shld2; shieldin complex subunit 2 K26129 SHLD2; shieldin complex subunit 2
E 120101079 Shld3; shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 361435 Fanca; Fanconi anemia group A protein K10888 FANCA; fanconi anemia group A protein
E 501552 Fancb; Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 24361 Fancc; Fanconi anemia group C protein homolog K10890 FANCC; fanconi anemia group C protein
E 309643 Fance; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 499155 Fancf; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 691105 Fancg; Fanconi anemia group G protein isoform X1 K10894 FANCG; fanconi anemia group G protein
E 305600 Fancl; E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 502320 Faap24; Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 303742 Faap100; Fanconi anemia core complex-associated protein 100 isoform X1 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 29577 Hes1; transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 100534597 Cenps; centromere protein S K11511 APITD1; centromere protein S
E 688314 Cenpx; centromere protein X isoform 1 K15360 STRA13; centromere protein X
E 360847 Ube2t; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 308755 Blm; BLM RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 303194 Top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 287930 Top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 306734 Rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 497856 Rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 312641 Fancd2; Fanconi anemia group D2 protein homolog K10891 FANCD2; fanconi anemia group D2 protein
E 100360594 Fanci; Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 497672 Brca1; breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 360254 Brca2; breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
E 360588 Brip1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 293452 Palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 309256 Fan1; fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 499870 Rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 497976 Rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 302986 Telo2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 313387 Usp1; ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 363164 Wdr48; WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 171121 Ppp6c; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 361502 Ppp6r1; serine/threonine-protein phosphatase 6 regulatory subunit 1 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 300146 Ppp6r2; serine/threonine-protein phosphatase 6 regulatory subunit 2 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 309144 Ppp6r3; serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 306264 Ankrd28; ankyrin repeat domain 28 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 301415 Ankrd44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 362811 Ankrd52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 361815 Rnf8; E3 ubiquitin-protein ligase RNF8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 690043 Rnf168; E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 685009 Rnf169; E3 ubiquitin-protein ligase RNF169 isoform X1 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 308669 Herc2; E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 287432 Wrap53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 499749 Tprn; taperin K24164 TPRN; taperin
E 304368 Zcwpw1; zinc finger CW-type PWWP domain protein 1 isoform X3 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 294783 Wdr70; WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 311361 Wdr76; WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 316235 Polh; DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 291526 Poli; DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 171525 Polk; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 316344 Rev1; DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 309812 Rev3l; DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 298317 Ube2a; ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 81816 Ube2b; ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 362412 Rad18; E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 295568 Hltf; helicase-like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 296390 Ube2v1; ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 287927 Ube2v2; ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 679539 Ube2v1l1; ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 689904 Ube2v1-ps22; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 134481246 ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 680951 Ube2v1-ps20; ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 100359732 Ube2v1l2; ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 116725 Ube2n; ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 103690504 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 100910895 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 25737 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 100310874 Parpbp; PCNA-interacting partner isoform 3 K27412 PARPBP; PCNA-interacting partner
D 292101 Sprtn; DNA-dependent metalloprotease SPRTN K24051 SPRTN; SprT-like domain-contaning protein Spartan
B Check point factors
C Rad9-Hus1-Rad1 complex
D 100361529 Rad9a; RAD9 checkpoint clamp component A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 363924 Rad9b; cell cycle checkpoint control protein RAD9B K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 498411 Hus1; checkpoint protein HUS1 isoform 1 K10903 HUS1; HUS1 checkpoint protein
D 691382 Hus1b; checkpoint protein HUS1B K10996 HUS1B; checkpoint protein HUS1B
D 294800 Rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 310034 Rad17; cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 288003 Rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 116468 Rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 304528 Rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 288414 Rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 294800 Rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 83508 Timeless; protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 363076 Tipin; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 100359731 Tipinl1; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 120094818 TIMELESS-interacting protein-like K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 298534 Clspn; claspin K25773 CLSPN; claspin
C Triple T complex
D 302986 Telo2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 499935 Tti1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 290811 Tti2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 94342 Bag6; large proline-rich protein BAG6 isoform 1 K23390 BAG6; large proline-rich protein BAG6
D 293864 Ubl4a; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 120100913 Ubl4b; ubiquitin-like protein 4B K23388 UBL4; ubiquitin-like protein 4
D 288518 Get4; Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 685055 Atr; serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 301014 Atrip; ATR-interacting protein K10905 ATRIP; ATR interacting protein
D 300711 Atm; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 24842 Tp53; cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 140583 Chek1; serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 114212 Chek2; serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 171102 Cdc25a; M-phase inducer phosphatase 1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 171103 Cdc25b; M-phase inducer phosphatase 2 isoform 1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 25578 Ywhaz; 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 56011 Ywhab; 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 25577 Ywhaq; 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 25576 Ywhah; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 56010 Ywhag; 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 29753 Ywhae; 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 171563 Nav2; neuron navigator 2 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 308937 Wee1; wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 502750 Wee2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 287422 Per1; period circadian protein homolog 1 K21944 PER1; period circadian protein 1
D 63840 Per2; period circadian protein homolog 2 K02633 PER2; period circadian protein 2
D 78962 Per3; period circadian protein homolog 3 K21945 PER3; period circadian protein 3
D 309595 Mdc1; mediator of DNA damage checkpoint protein 1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 81748 Pls3; plastin-3 K17336 PLS3; plastin-3
D 361594 Aen; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 58936 Plk3; serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 314627 Plk5; inactive serine/threonine-protein kinase PLK5 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 290705 Nek1; serine/threonine-protein kinase Nek1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 685440 Nek5; serine/threonine-protein kinase Nek5 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 306252 Nek4; serine/threonine-protein kinase Nek4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 305710 Nek10; serine/threonine-protein kinase Nek10 isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 315978 Nek11; serine/threonine-protein kinase Nek11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 288257 Donson; protein downstream neighbor of Son isoform 2 K22422 DONSON; protein downstream neighbor of Son
D 100361376 Kank2; KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 309429 Kank1; KN motif and ankyrin repeat domain-containing protein 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 313385 Kank4; KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 366848 Kank3; KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 361916 Chmp4c; charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 360834 Vps4b; vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 246772 Vps4a; vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 499871 Zfyve19; abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 289315 Sde2; UBL fusion protein SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 288079 Polq; DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 60571 Mybbp1a; myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 361147 Primpol; DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 100049583 Trex1; three-prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 309275 Trex2; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 292127 Dclre1a; DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 310745 Dclre1b; 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 313563 Exo5; exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 304761 Zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 361122 Ankle1; ankyrin repeat and LEM domain-containing protein 1 isoform X3 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 360912 Helq; helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 361197 Ercc6l2; DNA excision repair protein ERCC-6-like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 246216 Prpf19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 85434 Cdc5l; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 295334 Bcas2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 60376 Plrg1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 290365 Nudt15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 117260 Nudt1; oxidized purine nucleoside triphosphate hydrolase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 361068 Nudt18; 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 497778 Dut; deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 685579 Rrm1; ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 299976 Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 362720 Rrm2; ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 100359539 Rrm2l1; ribonucleoside-diphosphate reductase subunit M2-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 25332 Mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 304577 Ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 315344 Smug1; single-strand selective monofunctional uracil-DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 24561 Mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 170841 Mutyh; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 29541 Nthl1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 54304 Ssbp1; single-stranded DNA-binding protein, mitochondrial precursor K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 54304 Ssbp1; single-stranded DNA-binding protein, mitochondrial precursor K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 290365 Nudt15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 497778 Dut; deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024